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Flavonoids as Antifungal Agents

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Abstract

Flavonoids are phenolic compounds widely distributed in the plant kingdom. These natural compounds have been known to be active against a variety of microorganisms. This chapter aims to report the efforts of the scientific discoveries and developments of new antifungal flavonoid molecules and also to understand the flavonoids chemistry. An overview of the recent papers on the antifungal activity of flavonoids which represent a potential alternative to conventional fungicides is presented.

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References

  • Ahmidi F, Sadeghi S, Nodarresi M, Abiri R, Mikaeli A (2010) Chemical composition, in vitro anti-microbial, antifungal and antioxidant activities of essential oil and methanolic extracts of Hoymenociater longiflones Benth. Food Chem Toxicol 48(5):1137–1144

    Article  Google Scholar 

  • Bassetti M, Ginocchio F, Mikulska M (2011) New treatment option against gram-negative organisms. Crit Care 15(215):1–9

    Google Scholar 

  • Batista LM, Almeida ABA, Magri LP, Toma W, Calvo TR, Vilegas W, Souza –Brito ARM (2004) Gastric antiulcer activity of Syngonanthus arthrotrichus silveira. Biol Pharm Bull 27(3):328–332

    Article  PubMed  CAS  Google Scholar 

  • Bueno JM, Ramos-Escudero F, Sáez-Plaza P, Munhoz AM, Navas MM, Asuero AG (2012) Analysis and antioxidant capacity of anthocyanin pigments. Part I: general considerations concerning polyphenols and flavonoids. Crit Rev Anal Chem 20(2):102–125

    Article  Google Scholar 

  • Buer CS, Imin N, Djordjevic A (2010) Flavonoids: new roles for old molecules. J Integr Plant Biol 52(1):98–111

    Article  PubMed  CAS  Google Scholar 

  • Cesco S, Mimmo T, Tonon G, Tomasi N, Pinton R, Terzano R, Neumann G, Weisskopf L, Renella G, Landi L, Nannipieri P (2012) Plant-borne flavonoids released into rhizosphere: impact on soil bio-activities related to plant nutrition. A review. Biol Fertil Soils 48(2):123–149

    Article  CAS  Google Scholar 

  • Cowan MM (1999) Plant products as antimicrobial agents. Clin Microbiol Rev 12(4):564–582

    PubMed  CAS  Google Scholar 

  • Cushinie TTP, Lamb AJ (2005) Antimicrobial activity of flavonoids. Int J Antimicrob Agents 26(5):343–356

    Article  Google Scholar 

  • Estelle G, Edwige N, Ahcere B (2011) Flavonoids as antimicrobial agents: recent progress and state of the art. Curr Org Chem 15(15):2608–2615

    Article  Google Scholar 

  • Fraga CG, Galleano M, Verstraeten SV, Oteiza PI (2010) Basic biochemical mechanisms behind the health benefits of polyphenols. Mol Aspects Med 31(6):435–445

    Article  PubMed  CAS  Google Scholar 

  • Friedman M (2007) Overview of antimicrobial, antitoxin, antiviral, and antifungal activities of tea flavonoids and teas. Mol Nutr Food Res 51(1):116–134

    Article  PubMed  CAS  Google Scholar 

  • Harborne JB, Williams CA (2000) Advances in flavonoid research since 1992. Phytochemistry 55(6):481–504

    Article  PubMed  CAS  Google Scholar 

  • Himesh S, Sarvesh S, Sharan PS, Mishra K, Singai AK (2011) Preliminary phytochemical screening and HPLC analysis of flavonoid from methanolic extract of leaves of Annona squamosal. Int Res J Pharm 2(5):242–246

    Google Scholar 

  • Jagtap UB, Bapat VA (2010) Artocarpus: a review of its traditional uses, phytochemistry and pharmacology. J Ethnopharmacol 129(2):142–166

    Article  PubMed  CAS  Google Scholar 

  • Kaefer CM, Milner JA (2008) The role of herbs and species in cancer prevention. J Nutr Biochem 19(6):347–361

    Article  PubMed  CAS  Google Scholar 

  • Kanwal Q, Hussain I, Siddiqui HL, Javaid A (2011) Antimicrobial activity screening of isolated flavonoids from Azadirachta indica leaves. J Serb Chem Soc 76(3):375–384

    Article  CAS  Google Scholar 

  • Karimi E, Jafar HZE, Ahmad S (2011) Phenolics and flavonoids profiling and antioxidant activity of three varieties of Malaysian indigenous medicinal herb Labisia pumila Benth. J Med Plants Res 5(7):1200–1206

    CAS  Google Scholar 

  • Katerere DR, Gray AI, Nash RJ, Waigh RD (2012) Phytochemical and antimicrobial investigation of stilbenoids and flavonoids isolated from three species of Combretaceae. Fitoterapia 83(5):932–940

    Article  PubMed  CAS  Google Scholar 

  • Kyselova Z (2011) Toxicological aspects of the use of phenolic compounds in disease prevention. Interdiscip Toxicol 4(4):173–183

    Article  PubMed  CAS  Google Scholar 

  • Krishna PM, Rao KNV, Sandhya S, Banji D (2012) A review on phytochemical, ethnomedicinal and pharmacological studies on genus Sophora Fabaceae. Braz J Pharmacog 22(5):1145–1154

    CAS  Google Scholar 

  • Kuete V, Wiench B, Hegazy MEF, Mohamed TA, Fankan AG, Shahat AA, Efferth T (2012) Antibacterial activity and cytotoxicity of selected egyptian medicinal plants. Planta Med 78(2):193–199

    Article  PubMed  CAS  Google Scholar 

  • Kumar PV, Chauhan NS, Padh H, Rajani M (2006) Search for antibacterial and antifungal agents selected Indian medicinal plants. J Ethnopharmacol 107:182–188

    Article  PubMed  Google Scholar 

  • Lakshmipathy DP, Kannabiran K (2010) Review on dermatomycosis: pathogenesis and treatment. Nat Sci 2(7):726–731

    CAS  Google Scholar 

  • Martínez Ruiz MG, Richard-Greenblatt M, Juárez ZN, Av-Gay Y, Bach H, Hernández LR (2012) Antimicrobial, anti-inflammatory and cytotoxic activities of Laennecia confuse. Sci World J 2012:1–8

    Article  Google Scholar 

  • Ndhlala AR, Moyo M, Van Staden J (2010) Natural antioxidants: fascinating or mythical biomolecules? Molecules 15(10):6905–6930

    Article  PubMed  CAS  Google Scholar 

  • Nijveldt RJ, van Nood E, van Hoorn DEC, Boelens PG, van Norren K, van Leeuwen PA (2010) Flavonoids: a review of probable mechanisms of action and potential applications. Am J Clin Nutr 74(4):418–425

    Google Scholar 

  • Ojewole JAO, Mawoza T, Chiwororo WDH, Owira PMO (2010) Sclerocarya birrea (A. Rich) Hochst. [‘Marula’] (Anacardiaceae): a review of its phytochemistry, pharmacology, and toxicology and its ethnomedicinal uses. Phytother Res 24:633–639

    PubMed  CAS  Google Scholar 

  • Orhan DD, Özcelik B, Ózgen S, Ergum F (2010) Antibacterial, antifungal and antiviral activities of some flavonoids. Microbiol Res 165(6):496–504

    Article  PubMed  CAS  Google Scholar 

  • Pandley AK, Mishra AK, Mishra A, Kumar S, Chandra A (2010) Therapeutic potential of C. zeylanicum extracts: an antifungal and antioxidant perspective. Int J Biol Med Res 1(4):228–233

    Google Scholar 

  • Patel JR, Tripathi P, Sharma V, Chauhan NS, Dixit VK (2011) Phyllanthus amarus: ethnomedicinal uses, phytochemistry and pharmacology: a review. J Ethnopharmacol 138(4):286–313

    Article  PubMed  CAS  Google Scholar 

  • Pierson JT, Dietzgen RG, Shaw PN, Roberts-Thomson S, Montheith GR, Gidley J (2012) Major Australian tropical fruits biodiversity: Bioactive compounds and their bioactivities. Mol Nutr Food Res 56(3):357–387

    Article  PubMed  CAS  Google Scholar 

  • Pinheiro PF, Justino GC (2010) Structural analysis of flavonoids and related compounds—a review of spectroscopic applications. In: Rao V (ed) Phytochemicals—A global perspective of their roles in nutrition health, InTech. CRC press, Boca Raton, USA

    Google Scholar 

  • Ponnusamy K, Petchiammal C, Mohankumer R, Hopper W (2010) In vitro antifungal activity of indirubin isolated from South Indian ethnomedicinal plant Wrightia tinctoria R. Br. J Ethnopharmacol 132(1):349–354

    Article  PubMed  CAS  Google Scholar 

  • Recio MC, Rios JL (1989) A Review of Some Antimicrobial Compounds Isolated from Medicinal Plants Reported in the Literature 1978–1988. Phythother Res 3(4):125

    Google Scholar 

  • Rios JL, Recio MC (2005) Medicinal plants and antimicrobial activity. J Ethnopharmacol 100:80–84

    Article  PubMed  CAS  Google Scholar 

  • Rokaya MB, Münzbergová Z, Timsina B, Bhattarai KR (2012) Rheum austral D. Don: a review of its botany, ethnobotany, phytochemistry and pharmacology. J Ethnopharmacol 141(3):761–774

    Article  PubMed  CAS  Google Scholar 

  • Ruddock PS, Charland M, Ramirez S, López A, Towers N, Arnason JT, Liao M, Dillon JAR (2011) Antimicrobial activity of flavonoids from Piper Ianceaefolium and other Colombian medicinal plants against antibiotic susceptive and resistant strains of Neisseria gonohhoeae. Sex Transm Dis 38(2):82–88

    Article  PubMed  CAS  Google Scholar 

  • Sandhar HK, Kumar B, Prasher S, Tiwari P, Salhan M, Sharma P (2011) A review of phytochemistry and pharmacology of flavonoids. Int Pharm Sci 1(1):25–37

    CAS  Google Scholar 

  • Sharma A, Tyagi S, Nag R, Chaturvedi A, Nag TN (2011) Antimicrobial activity and celular toxicity of flavonoid extracts from Pongamia pinnata and Vitex negundo. Rom Biotechnol Lett 16(4):6396–6400

    CAS  Google Scholar 

  • Sher A (2009) Antimicrobial activity of natural products from medicinal plants. Gomal J Med Sci 7(1):72–78

    Google Scholar 

  • Sohn HY, Son KH, Kwon CS, Kwon GS, Kang SS (2004) Antimicrobial and cytotoxic activity of 18 prenylated flavonoids isolated from medicinal plants: Morus alba L., Morus mongolica Schneider, Broussnetia papyrifera (L.) Vent, Sophora flavescens Ait and Echinosophora koreensis Nakai. Phytomedicine 11(7/8):666–672

    Article  PubMed  CAS  Google Scholar 

  • Su BL, Chen JY, Chen CY, Guo JH, Chang-Gan H (2012) Antioxidant and antimicrobial properties of various solvent extracts from Impatiens balsamina L. stems. J Food Sci 77(6):C614–C619

    Article  PubMed  CAS  Google Scholar 

  • Tapas AR, Sakarkar DM, Kakde RB (2008) Flavonoids as nutraceuticals: a review. Trop J Pharm Res 7(3):1089–1099

    Article  Google Scholar 

  • Verma DL, Kabdwal L (2010) Flavonoids from Cheilanthes dubia Hope. Nat Sci 8(10):306–310

    Google Scholar 

  • Wächter GA, Hoffmann JJ, Furbacher T, Blake ME, Timmermann BA (1999) Antibacterial and antifungal flavonones from Eysenhardtia texana. Phytochemistry 52(8):1469–1471

    Article  PubMed  Google Scholar 

  • Wang X, Wei X, Tian Y, Shen L, Shu H (2010) Antifungal flavonoids from Ficus sarmentosa var. henry (King) corner. Agr Sci China 8(5):690–694

    Article  Google Scholar 

  • Wink M, Ashour ML, El-Readi (2012) Secondary metabolites from plants inhibiting ABC transporters and microbes to cytotoxic and antimicrobial agents. Front Microbiol 3(130):1–15

    Google Scholar 

  • Yang N, Kim DJ, Kim BH, Sohn M, Choi MJ, Choi YH (2010) Aloe-iduced toxic hepatitis. J Korean Med Sci 25:492–495

    Article  PubMed  Google Scholar 

  • Zampini IC, Villena J, Salva S, Herrera M, Isla MI, Alvarez S (2012) Potentiality of standardized extract and isolated flavonoids from Zuccagnia punctata for the treatment of respiratory infections by Streptococcus pneumonia: in vitro and in vivo studies. J Ethnopharmacol 140(2):287–292

    Article  PubMed  CAS  Google Scholar 

  • Zheng N, Wang Z, Shi Y, Lin J (2012) Evaluation of the antifungal activity of total flavonoids extract from Patrinia villosa Juss and optimization by response surface methodology. Afr J Microbiol Res 6(3):586–593

    Article  Google Scholar 

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Correspondence to Roseli Maria De Conti Lourenço .

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De Conti Lourenço, R.M., da Silva Melo, P., de Almeida, A.B.A. (2013). Flavonoids as Antifungal Agents. In: Razzaghi-Abyaneh, M., Rai, M. (eds) Antifungal Metabolites from Plants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38076-1_10

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