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Encyclopedia of Ophthalmology pp 1–2Cite as

Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

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Synonyms

Nonsteroidal anti-inflammatory agents; NSAIDS

Definition

Nonsteroidal anti-inflammatory drugs are a heterogeneous group that block COX enzymes and reduce prostaglandin production. They have analgesic, antipyretic, and anti-inflammatory effects. In addition, some NSAIDs prevent platelet aggregation, which can lead increased bleeding time.

Indications

This group of drugs is used in the treatment of acute and chronic pain, inhibition of platelet aggregation, and reduction of fever. Although most NSAIDs possess anti-inflammatory properties others, such as acetaminophen, do not display clinically significant effects. Topical flurbiprofen is used to prevent papillary constriction during intraocular surgery.

Contraindications

Oral nonsteroidal anti-inflammatory agents are contraindicated in patient with a history of allergic reaction to aspirin or aspirin-like products. They should also be used with caution in individuals with severe asthma and congestive heart failure. They should...

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Further Reading

  • Burke A, Smyth E, Fitzgerald GA (2006) Analgesic-antipyretic agents; pharmacotherapy of gout. In: Brunton LL, Lazo JS, Parker KL (eds) Goodman and Gilman’s the pharmacological basis of therapeutics, 11th edn. McGraw-Hill, New York, pp 673–712

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  • To K, Abelson MB, Neufeld A (2008) Nonsteroidal anti-inflammatory drugs. In: Albert D, Miller J, Azar D, Blodi B (eds) Albert and Jokobiec’s principles and practice of ophthalmology, 3rd edn. Saunders, Philadelphia

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, Vanderbilt University Medical Center, Vanderbilt Eye Institute, 2311 Pierce Avenue, Nashville, TN, 37232, USA

    Laura L. Wayman

Authors
  1. Laura L. Wayman
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Corresponding author

Correspondence to Laura L. Wayman .

Editor information

Editors and Affiliations

  1. Dept of Ophthal & Optometry,AKH, Medical University of Wien Dept of Ophthal & Optometry,AKH, Wien, Austria

    Ursula Schmidt-Erfurth

  2. Department of Ophthalmology, Goethe University of Frankfurt am Main Department of Ophthalmology, Frankfurt am Main, Germany

    Thomas Kohnen

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© 2015 Springer-Verlag Berlin Heidelberg

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Wayman, L.L. (2015). Nonsteroidal Anti-inflammatory Drugs (NSAIDs). In: Schmidt-Erfurth, U., Kohnen, T. (eds) Encyclopedia of Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35951-4_109-2

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  • DOI: https://doi.org/10.1007/978-3-642-35951-4_109-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-35951-4

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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