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Asbestos-Induced Oxidative Stress in Lung Pathogenesis

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Systems Biology of Free Radicals and Antioxidants

Abstract

Asbestos exposure causes multiple nonmalignant and malignant diseases through complex mechanisms that are not fully understood. Oxidant generation is strongly implicated in the pathogenesis of asbestos-related diseases by evidence from various in vitro and in vivo studies. We will first describe how asbestos fibers generate oxidants, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), through direct and indirect interactions with target cells. Next, we will describe how asbestos-induced oxidants influence multiple downstream biological processes involved in DNA damage, apoptosis, mitogen-activated protein kinase (MAPK) signaling, and inflammation. Elucidating the redox-regulated pathways involved in asbestos-related disease causation is complex but will likely lead us to future biomarkers and therapeutic targets.

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Acknowledgments

We thank Dr. Kelly Butnor, MD (Pathologist, FAHC, University of Vermont) for providing diseased and normal lung images for this manuscript and Maximilian MacPherson for illustrations. Work by our group is supported by RO1 ES021110 and T32 ES007122 from NIEHS and a grant from Mesothelioma Applied Research Foundation.

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  1. Department of Pathology, University of Vermont, College of Medicine, Burlington, VT, 05405, USA

    Jill Miller, Joyce Thompson & Arti Shukla

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  1. Jill Miller
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  2. Joyce Thompson
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  3. Arti Shukla
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Correspondence to Arti Shukla .

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  1. Department of Pharmacology and Therapeutics, University of British Colombia, Vancouver, British Columbia, Canada

    Ismail Laher

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© 2014 Springer-Verlag Berlin Heidelberg

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Miller, J., Thompson, J., Shukla, A. (2014). Asbestos-Induced Oxidative Stress in Lung Pathogenesis. In: Laher, I. (eds) Systems Biology of Free Radicals and Antioxidants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30018-9_201

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