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Systems Biology of Free Radicals and Antioxidants pp 137–151Cite as

Free Radicals in Aging – An Evolutionary Perspective

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Abstract

Evidence supporting the role of oxidative stress in the aging process is presented in detail in this chapter. We also provide an overview of recent studies using novel animal models of successful aging, which have provided valuable additional information to support or counter the oxidative stress hypothesis of aging. We focus on comparative studies using three long-lived but mouse-sized mammalian species, the naked mole rat (Heterocephalus glaber), the white-footed mouse (Peromyscus leucopus), and the little brown bat (Myotis lucifugus), cells of long-lived and short-lived primates, and bivalve models of exceptional longevity to test predictions of the oxidative stress theory of aging. It is concluded that studies examining cellular and mitochondrial free radical generation and oxidative stress resistance in a broad array of successfully aging species seem to concur in general with predictions based upon the oxidative stress theory of aging. Further studies are evidently needed to investigate mechanisms related to ROS homeostasis, protein recycling, and DNA repair that might be informative about successful aging of these species.

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Acknowledgments

This work was supported by grants from the American Heart Association (to ZU, PT, and AC), American Federation for Aging Research (to AC), the Oklahoma Center for the Advancement of Science and Technology (to AC and ZU), the NIH (AG031085 to AC; AT006526 to ZU), and the Arkansas Claude Pepper Older Americans Independence Center at University of Arkansas Medical Center (to AC). The authors would like to express their gratitude for the support of the Donald W. Reynolds Foundation, which funds aging research at the University of Oklahoma Health Sciences Center under its Aging and Quality of Life Program.

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  1. Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, 975 N. E. 10th Street - BRC 1303, Oklahoma City, OK, 73104, USA

    Anna Csiszar & Zoltan Ungvari

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  1. Anna Csiszar
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  2. Zoltan Ungvari
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Correspondence to Anna Csiszar .

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  1. Department of Pharmacology and Therapeutics, University of British Colombia, Vancouver, British Columbia, Canada

    Ismail Laher

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Csiszar, A., Ungvari, Z. (2014). Free Radicals in Aging – An Evolutionary Perspective. In: Laher, I. (eds) Systems Biology of Free Radicals and Antioxidants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30018-9_14

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