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The Composition and Development of Moisturizers

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Abstract

“Moisturizer” is such a commonplace term undoubtedly meaning many things to different people. So while the common feature of skin needing moisturization is a loss of the natural stratum corneum moisture content, the quantitative and qualitative extent will vary. According to Marie Lodén, moisturizers “should be tailored with respect to the dermatological abnormality” [1]. Defining “the dermatological abnormality” may help understand the consumer need, but acceptance by the end user, whether patient or cosmetic user, may be driven by other factors. Individuals with a “xerosis” arising from pathology – e.g. ichthyosis or eczema – may have similar needs to someone with senile xerosis, but the intensity, persistence and cosmetic properties of the treatment may vary, as may the appropriate ingredients. Likewise, there may be subtle differences between the needs of those who seek improvement in “skin moisturization” as a result of environmental challenges such as surfactant drying, short-term sun exposure and ageing. The concept of the “dry-skin cycle” has shifted thinking on the “dermatological abnormality” from a “dry versus moisturised” state to a dynamic model [2, 3]. This helps explain why moisturization remains the top unmet consumer skin needs, a constant point of reference in this chapter and further defined in Sect. 21.2.

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References

  1. Lodén M (2003) Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. Am J Clin Dermatol 11(4):771–788

    Article  Google Scholar 

  2. Lodén M (2003) Do moisturizers work? J Cosmet Dermatol 2(3–4):141–149

    Article  PubMed  Google Scholar 

  3. Rawlings AV, Matts PJ (2005) Stratum corneum moisturization at the molecular level: an update in relation to the dry skin cycle. J Invest Dermatol 124(6):1099–1110

    Article  PubMed  CAS  Google Scholar 

  4. de Polo KF (1998) Chapter 8 Cosmetic emulsions. In: A short textbook of cosmetology. Verlag fur Chemische Industrie, H Ziolkowsky GmbH, pp 234–299

    Google Scholar 

  5. Hunting ALL (1993) Creams, lotions and milks: a formulary of cosmetic preparations, vol 2. Micelle Press, Dorset, UK

    Google Scholar 

  6. http://media.allured.com/documents/CT0801+Formulary.fcx-WEB.pdf

  7. http://www.cosmeticsandtoiletries.com/formulating/category/skincare/13041522.html?utm_source=Most+Read&utm_medium=website&utm_campaign=Most+Read

  8. http://www.happi.com/formulary/2009/01/

  9. Barton S (2002) Formulation of skin moisturizers. In: Leyden JJ, Rawlings AV (eds) Skin moisturization, vol 25, Cosmetic science and technology series. Marcel Dekker, New York, pp 547–584

    Google Scholar 

  10. Cork MJ, Britton J, Butler L, Young S, Murphy R, Keohane SG (2003) Comparison of parent knowledge, therapy utilization and severity of atopic eczema before and after explanation and demonstration of topical therapies by a specialist dermatology nurse. Br J Dermatol 149(3):582–589

    Article  PubMed  CAS  Google Scholar 

  11. Mahado M, Hadgraft J, Lane ME (2010) Assessment of the variation of skin barrier function with anatomic site, age, gender and ethnicity. Int J Cosmet Sci 323(6):397–409

    Article  Google Scholar 

  12. Blank IH (1953) Further observations on factors which influence the water content of the stratum corneum. J Invest Dermatol 21:259–271

    PubMed  CAS  Google Scholar 

  13. Auriol F, Vaillant L, Machet L et al (1993) Effects of short-time hydration on skin extensibility. Acta Derm Venereol 73:344–347

    PubMed  CAS  Google Scholar 

  14. Warner RR, Boissy YL, Lilly NA, McKillop K, Marshall JL, Stone KJ (1999) Water disrupts stratum corneum lipid lamellae: damage is similar to surfactants. J Invest Dermatol 113(6):960–966

    Article  PubMed  CAS  Google Scholar 

  15. Byrne AJ (2010) Bioengineering and subjective approaches to the clinical evaluation of dry skin. Int J Cosmet Sci 32:410–421

    Article  Google Scholar 

  16. Crowther JM, Sieg A, Blenkiron P, Marcott C, Matts PJ, Kaczvinsky JR, Rawlings AV (2008) Measuring the effects of topical moisturizers on changes in stratum corneum thickness, water gradients and hydration in vivo. Br J Dermatol 159(3):567–577

    PubMed  CAS  Google Scholar 

  17. Förster M, Bolzinger MA, Ach D, Montagnac G, Briançon S (2011) Ingredients tracking of cosmetic formulations in the skin: a confocal Raman microscopy investigation. Pharm Res 28(4):858–872

    Article  PubMed  CAS  Google Scholar 

  18. Jemec GB, Wulf HC (1999) Correlation between the greasiness and the plasticizing effect of moisturizers. Acta Derm Venereol 799(2):115–117

    Google Scholar 

  19. Wiechers JW, Barlow T (1999) Skin moisturization and elasticity originate from at least two different mechanisms. Int J Cosmet Sci 21:425

    Article  PubMed  CAS  Google Scholar 

  20. Choi EH, Man MQ, Wang F et al (2005) Is endogenous glycerol a determinant of stratum corneum hydration in humans? J Invest Dermatol 125(2):288–293

    PubMed  CAS  Google Scholar 

  21. Sagiv AE, Marcus Y (2003) The connection between in vitro water uptake and in vivo skin moisturization. Skin Res Technol 9(4):306–311

    Article  PubMed  Google Scholar 

  22. Takahashi M, Yamada M, Machida Y (1984) A new method to evaluate softening effects of cosmetic ingredients on the skin. J Soc Cosmet Chem 35:171–181

    CAS  Google Scholar 

  23. Pedersen LK, Jemec GB (1999) Plasticising effect of water and glycerin on human skin in vivo. J Dermatol Sci 19(1):8–52

    Article  Google Scholar 

  24. Smith W (1999) Stratum corneum barrier integrity controls skin homeostasis. Int J Cosmet Sci 21:99–106

    Article  PubMed  CAS  Google Scholar 

  25. Rawlings AV, Watkinson A, Harding CR et al (1995) Changes in stratum corneum lipid and desmosome structure together with water barrier function during mechanical stress. J Soc Cosmet Chem 46:151

    Google Scholar 

  26. Batt M et al (1988) Changes in physical properties of stratum corneum following treatment with glycerol. J Soc Cosmet Chem 39:367–381

    Google Scholar 

  27. Rawlings AV, Scott IR, Harding CR et al (1994) Stratum corneum moisturization at the molecular level. J Invest Dermatol 103:731–741

    Article  PubMed  CAS  Google Scholar 

  28. Rawlings A, Harding C, Watkinson A et al (1995) The effect of glycerol and humidity on desmosome degradation in stratum corneum. Arch Dermatol Res 287:457–464

    Article  PubMed  CAS  Google Scholar 

  29. Chander P et al (1996) Superiority of glycerol containing moisturisers on desquamation and desmosome hydrolysis. J Invest Dermatol 106:919

    Google Scholar 

  30. Faergemann J, Wahlstrand B, Hedner T, Johnsson J, Neubert RH, Nystrom L, Maibach H (2005) Pentane-1,5-diol as a percutaneous absorption enhancer. Arch Dermatol Res 297(6):261–265

    Article  PubMed  CAS  Google Scholar 

  31. Gehring W, Gloor M (2000) Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study. Arzneimittelforschung 50(7):659–663

    PubMed  CAS  Google Scholar 

  32. Jacobi O (1959) About the mechanism of moisture regulation in the horny layer of the skin. Proc Sci Sect Toilet Goods Assoc 31:22–26

    Google Scholar 

  33. Scott IR, Harding CR (1986) Filaggrin breakdown to water binding compounds during development of the rat stratum corneum is controlled by the water activity of the environment. Dev Biol 115(1):84–92

    Article  PubMed  CAS  Google Scholar 

  34. Kligman AM (2011) Corneobiology and corneotherapy – the final chapter. Int J Cosmet Sci 33:197–209

    Article  PubMed  CAS  Google Scholar 

  35. Horii I, Nakayama Y, Obata M et al (1989) Stratum corneum hydration and amino acid content in xerotic skin. Br J Dermatol 121:587–592

    Article  PubMed  CAS  Google Scholar 

  36. Kezic S, Kemperman PM, Koster ES et al (2008) Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum. J Invest Dermatol 128(8):2117–2119

    Article  PubMed  CAS  Google Scholar 

  37. Middleton JD, Roberts ME (1978) Effect of a skin cream containing the sodium salt of pyrollidone carboxylic acid on dry and flaky skin. J Soc Cosmet Chem 29(4):201–205

    Google Scholar 

  38. Loden M, Andersson AC, Andersson C, Frodin T, Oman H, Lindberg M (2001) Instrumental and dermatologist evaluation of the effect of glycerine and urea on dry skin in atopic dermatitis. Skin Res Technol 7(4):209–213

    Article  PubMed  CAS  Google Scholar 

  39. Byrne AJ, Davis M, Laloeuf A, Rawlings AV (2009) Glycerol-containing moisturizers are more effective than urea-containing moisturizers in the relief of soap induced winter xerosis. Poster presentation Stratum Corneum VI, Boston

    Google Scholar 

  40. Loden M, Andersson AC, Lindberg M (1999) Improvement in skin barrier function in patients with atopic dermatitis after treatment with a moisturizing cream (Canoderm). Br J Dermatol 140(2):264–267

    Article  PubMed  CAS  Google Scholar 

  41. Serup J (1992) A double-blind comparison of two creams containing urea as the active ingredient. Assessment of efficacy and side-effects by non-invasive techniques and a clinical scoring scheme. Acta Derm Venereol Suppl (Stockh) 177:34–43

    CAS  Google Scholar 

  42. Bettinger JG (1995) Influence of emulsions with and without urea on water- binding capacity of the stratum corneum. J Soc Cosmet Chem 46:247–254

    CAS  Google Scholar 

  43. Kuzmina N, Hagstromer L, Entestam L (2002) Urea and sodium chloride in moisturisers for skin of the elderly–a comparative, double-blind, randomised study. Skin Pharmacol Appl Skin Physiol 15(3):166–174

    PubMed  CAS  Google Scholar 

  44. Gloor M, Fluhr J, Lehmann L, Gehring W, Thieroff-Ekerdt R (2002) Do urea/ammonium lactate combinations achieve better skin protection and hydration than either component alone? Skin Pharmacol Appl Skin Physiol 15(1):35–43

    PubMed  CAS  Google Scholar 

  45. Serup J (1992) A three hour test for rapid comparion of effects of moisturisers and active ingredients (urea). Measurement of hydration, scaling and skin surface lipidisation by noninvasive techniques. Acta Derm Venereol 177(Suppl):29–33

    CAS  Google Scholar 

  46. Van Scott EJ, Yu RJ (1989) Alpha hydroxy acids: procedures for use in clinical practice. Cutis 43:222–228

    PubMed  Google Scholar 

  47. Hachem JP et al (2010) Acute acidification of stratum corneum membrane domains using polyhydroxyl acids improves lipid processing and inhibits degradation of corneodesmosomes. J Invest Dermatol 130(2):500–510

    Article  PubMed  CAS  Google Scholar 

  48. Takahashi M, Machida Y, Tsuda Y (1985) The influence of hydroxy acids on the rheological properties of stratum corneum. J Soc Cosmet Chem 36:177–187

    CAS  Google Scholar 

  49. Thueson DO, Chan EK, Oechsli LM et al (1998) The roles of pH and concentration in lactic acid-induced stimulation of epidermal turnover. Dermatol Surg 24:641–645

    Article  PubMed  CAS  Google Scholar 

  50. Berardesca E, Distante F, Vignoli GP et al (1997) Alpha hydroxyacids modulate stratum corneum barrier function. Br J Dermatol 137:934–938

    Article  PubMed  CAS  Google Scholar 

  51. Fartasch M, Teal J, Menon GK (1997) Mode of action of glycolic acid on stratum corneum: ultrastructural and functional evaluation of the epidermal barrier. Arch Dermatol Res 289:404–409

    Article  PubMed  CAS  Google Scholar 

  52. Smith WP (1996) Comparative effectiveness of alpha-hydroxy acids on skin properties. Int J Cosmet Sci 18:75–83

    Article  PubMed  CAS  Google Scholar 

  53. Rawlings AV, Davies A, Carlomusto M et al (1996) Effect of lactic acid isomers on keratinocyte ceramide synthesis, stratum corneum lipid levels and stratum corneum barrier function. Arch Dermatol Res 288:383–390

    Article  PubMed  CAS  Google Scholar 

  54. Ditre CM, Griffin TD, Murphy GF et al (1996) Effects of alpha-hydroxy acids on photoaged skin: a pilot clinical, histologic, and ultrastructural study. J Am Acad Dermatol 34:187–195

    Article  PubMed  CAS  Google Scholar 

  55. Bernstein EF, Underhill CB, Lakkakorpi J et al (1997) Citric acid increases viable epidermal thickness and glycosaminoglycan content of sun-damaged skin. Dermatol Surg 23:689–694

    Article  PubMed  CAS  Google Scholar 

  56. Kaidbey K et al (2003) Topical gycolic acid enhances photodamage by ultraviolet light. Photodermatol Photoimmunol Photomed 19(1):21–27

    Article  PubMed  CAS  Google Scholar 

  57. Kornhauser A, Coelho SG, Hearing VJ (2010) Applications of hydroxyacids: classification, mechanisms and photoactivity. Clin Cosmet Invest Dermatol 24(3):135–142

    Article  CAS  Google Scholar 

  58. Green BA, Yu RJ, Van Scott EJ (2009) Clinical and cosmeceutical uses of hydroxyl acids. Clin Dermatol 27(5):495–501

    Article  PubMed  Google Scholar 

  59. Merinville E et al (2010) Three clinical studies showing anti-aging benefits of sodium salicylate in human skin. J Cosmet Dermatol 9(3):174–184

    Article  PubMed  Google Scholar 

  60. Reynolds T, Dweck AC (1999) Aloe vera leaf gel: a review update. J Ethnopharmacol 68(1–3):3–37

    Article  PubMed  CAS  Google Scholar 

  61. Fujimura T et al (2002) Treatment of human skin with an extract of Fucus vesiculosus changes its thickness and mechanical properties. J Cosmet Sci 53(1):1–9

    PubMed  Google Scholar 

  62. Kurtz ES (2007) Colloidal oatmeal: history, chemistry and clinical properties. J Drugs Dermatol 6(2):167–170

    PubMed  Google Scholar 

  63. Cerio R et al (2010) Mechanism of action and clinical benefits of colloidal oatmeal for dermatologic practice. J Drugs Dermatol 9(9):1116–1120

    PubMed  Google Scholar 

  64. Soma Y, Kashima M, Imaizumi A, Takahama H, Kawakami T, Mizoguchi M (2005) Moisturizing effects of topical nicotinamide on atopic dry skin. Int J Dermatol 44(3):197–202

    Article  PubMed  CAS  Google Scholar 

  65. Kligman A (1978) Regression method for assessing the efficacy of moisturisers. Cosmet Toilet 93:27

    Google Scholar 

  66. Clark S (1993) Investigations into biomechanisms of the moisturising function of lanolin. J Soc Cosmet Chem 44:181–195

    CAS  Google Scholar 

  67. Wertz PW (2009) Human synthetic sebum formulation and stability under conditions of use and storage. Int J Cosmet Sci 31(1):21–25

    Article  PubMed  CAS  Google Scholar 

  68. Smith TJ (2000) Squalene: potential chemopreventive agent. Expert Opin Investig Drugs 9(8):1841–1848

    Article  PubMed  CAS  Google Scholar 

  69. Agero AL, Verallo-Rowell VM (2004) A randomized double-blind controlled trial comparing extra virgin coconut oil with mineral oil as a moisturizer for mild to moderate xerosis. Dermatitis 159(3):109–116

    Google Scholar 

  70. Verallo-Rowell VM, Dillague KM, Syah-Tjundawan BS (2008) Novel antibacterial and emollient effects of coconut and virgin olive oils in adult atopic dermatitis. Dermatitis 19(6):308–315

    PubMed  Google Scholar 

  71. Ichihashi M, Ahmed NU, Budiyanto A, Wu A, Bito T, Ueda M, Osawa T (2000) Preventive effect of antioxidant on ultraviolet-induced skin cancer in mice. J Dermatol Sci 23(Suppl 1):S45–S50

    Article  PubMed  CAS  Google Scholar 

  72. Kiechl-Kohlendorfer U, Berger C, Inzinger R (2008) The effect of daily treatment with an olive oil/lanolin emollient on skin integrity in preterm infants: a randomized controlled trial. Pediatr Dermatol 25(2):174–178

    Article  PubMed  Google Scholar 

  73. Prottey C, Hastop PJ, Press M (1975) Correction of the cutaneous manifestations of essential fatty acid deficiency in man by application of sunflower seed oil to the skin. J Invest Dermatol 64:228–234

    Article  PubMed  CAS  Google Scholar 

  74. Lovell CR, Burton JL, Horrobin DF (1981) Treatment of atopic eczema with evening primrose oil. Lancet 1(8214):278

    Article  PubMed  CAS  Google Scholar 

  75. Gehring W, Bopp R, Rippke F, Gloor M (1999) Effect of topically applied evening primrose oil on epidermal barrier function in atopic dermatitis as a function of vehicle. Arzneimittelforschung 49(7):635–642

    PubMed  CAS  Google Scholar 

  76. Morris GM, Hopewell JW, Harold M et al (1997) Modulation of the cell kinetics of pig skin by the topical application of evening primrose oil or lioxasol. Cell Prolif 30:311–323

    Article  PubMed  CAS  Google Scholar 

  77. Delair V (1997) The usefulness of topical application of essential fatty acids (EFA) to prevent pressure ulcers. Ostomy Wound Manage 43(5):48–52

    Google Scholar 

  78. Haley AC, Calahan C, Gandhi M et al (2011) Skin care management in cancer patients: an evaluation of quality of life and tolerability. Support Care Cancer 19(4):545–554

    Article  PubMed  Google Scholar 

  79. Ibrahim SA, Li S (2010) Efficiency of fatty acids as chemical penetration enhancers: mechanisms and structure enhancement relationship. Pharm Res 27(1):115–125

    Article  PubMed  CAS  Google Scholar 

  80. Levi K, Kwan A, Rhines AS, Gorcea M, Moore DJ, Dauskardt RH (2010) Emollient molecule effects on the drying stresses in human stratum corneum. Br J Dermatol 163(4):695–703

    Article  PubMed  CAS  Google Scholar 

  81. Nasirullah LRB (2009) Storage stability of sunflower oil with added natural antioxidant concentrate from sesame seed oil. J Oleo Sci 58(9):453–459

    Article  PubMed  CAS  Google Scholar 

  82. Yang B, Kallio HP (2001) Fatty acid composition of lipids in sea buckthorn (Hippophae rhamnoides L.) berries of different origins. J Agric Food Chem 49(4):1939–1947

    Article  PubMed  CAS  Google Scholar 

  83. Kahkonen MP, Hopia AI, Heinonen M (2010) Berry phenolics and their antioxidant activity. J Agric Food Chem 49(8):4076–4082

    Article  CAS  Google Scholar 

  84. Kasparaviciene G, Briedis V, Ivanauskas L (2004) Influence of sea buckthorn oil production technology on its antioxidant activity. [Article in Lithuanian] Medicina (Kaunas) 40(8):753–757

    Google Scholar 

  85. Andersson SC, Rumpunen K, Johansson E, Olsson ME (2008) Tocopherols and tocotrienols in sea buckthorn (Hippophae rhamnoides L.) berries during ripening. J Agric Food Chem 56(15):6701–6706

    Article  PubMed  CAS  Google Scholar 

  86. Kochhar SP, Henry CJ (2009) Oxidative stability and shelf-life evaluation of selected culinary oils. Int J Food Sci Nutr 60(Suppl 7):289–296

    Article  PubMed  CAS  Google Scholar 

  87. Lalouef A (2006) Patent – WO 2006134583 (A1) – cosmetic compositions containing lingonberry (vaccinium vitis idea) extracts

    Google Scholar 

  88. Vacata V, Gertchen OB, Ghyczy M (2001) Topical formulations conforming to the structure of the skin. Cosmet Toilet 5(116):67–74

    Google Scholar 

  89. Imokawa G, Akasaki S, Minematsu Y et al (1989) Importance of intercellular lipids in water-retention properties of the stratum corneum: induction and recovery study of surfactant dry skin. Arch Dermatol Res 281:45–51

    Article  PubMed  CAS  Google Scholar 

  90. Friberg SE, Kayali I, Rhein LD et al (1990) The importance of lipids for water uptake in stratum corneum (L’importance des lipides dans l’absorption d’eau par le stratum corneum). Int J Cosmet Sci 12:5–12

    CAS  Google Scholar 

  91. Loden M, Barany E (2000) Skin-identical lipids versus petrolatum in the treatment of tape-stripped and detergent-perturbed human skin. Acta Derm Venereol 80(6):412–415

    Article  PubMed  CAS  Google Scholar 

  92. Zettersten EM, Ghadially R, Feingold KR et al (1997) Optimal ratios of topical stratum corneum lipids improve barrier recovery in chronologically aged skin. J Am Acad Dermatol 37:403–408

    Article  PubMed  CAS  Google Scholar 

  93. Man MQ, Feingold KR, Thornfeldt CR et al (1996) Optimization of physiological lipid mixtures for barrier repair. J Invest Dermatol 106:1096–1101

    Article  Google Scholar 

  94. de Paepe K, Roseeuw D, Rogiers V (2002) Repair of acetone- and sodium lauryl sulphate-damaged human skin barrier function using topically applied emulsions containing barrier lipids. J Eur Acad Dermatol Venereol 16(6):587–594

    Article  PubMed  Google Scholar 

  95. Yang L, Mao QM, Taljebini M et al (1995) Topical stratum corneum lipids accelerate barrier repair after tape stripping, solvent treatment and some but not all types of detergent treatment. Br J Dermatol 133:679–685

    Article  PubMed  CAS  Google Scholar 

  96. Kucharekova M, van der Kerkhof PC, van der Valk PG (2003) A randomized comparison of an emollient containing skin-related lipids with a petrolatum-based emollient as adjunct in the treatment of chronic hand dermatitis. Contact Dermatitis 48(6):293–299

    Article  PubMed  CAS  Google Scholar 

  97. Kucharekova M, Schalkwijk J, van der Kerkhof PC, van der Valk PG (2002) Effect of a lipid-rich emollient containing ceramide 3 in experimentally induced skin barrier dysfunction. Contact Dermatitis 46(6):331–338

    Article  PubMed  CAS  Google Scholar 

  98. Lintner K, Mondon P, Girard F et al (1997) The effect of a synthetic ceramide-2 on transepidermal water loss after stripping or sodium lauryl sulfate treatment: an in vivo study. Int J Cosmet Sci 1:15–25

    Article  Google Scholar 

  99. Glombitza B, Muller-Goymann CC (2001) Investigation of interactions between silicones and stratum corneum lipids. Int J Cosmet Sci 23:25–34

    Article  PubMed  CAS  Google Scholar 

  100. Arbuckle R, Atkinson MJ, Clark M et al (2008) Patient experiences with oily skin: the qualitative development of content for two new patient reported outcome questionnaires. Health Qual Life Outcomes 6:80

    Article  PubMed  Google Scholar 

  101. Meilgaard M, Civille GV, Carr BT (2007) Sensory evaluation techniques, 4th edn. Taylor & Francis, Boca Raton

    Google Scholar 

  102. Kemp S, Hollowood T, Hort J (2009) Sensory ­evaluation: a practical handbook. Wiley-Blackwell, Oxford, UK

    Google Scholar 

  103. Balfagon AC et al (2010) Comparative study of neural networks and lest mean square algorithm applied to optimisation of cosmetic formulations. Int J Cosmet Sci 32:376–386

    Article  CAS  Google Scholar 

  104. Trapp M (2007) Is there room for improvement in the emollients for adjuvant therapy? J Eur Acad Dermatol Venereol 21(Suppl 2):14–18

    Article  PubMed  Google Scholar 

  105. Petersen EN (1991) The hydrating effect of a cream and white petrolatum measured by optothermal infrared spectrometry in vivo. Acta Derm Venereol 71(5):373–376

    PubMed  CAS  Google Scholar 

  106. Summers RS, Summers B, Chandar P et al (1996) The effect of lipids, with and without humectant, on skin xerosis. J Soc Cosmet Chem 47:27–39

    CAS  Google Scholar 

  107. Auguste F, Levy F (2009) Emulsion science and technology. Wiley-VCH Verlag GmbH & Co, KGaA, Weinheim

    Google Scholar 

  108. Tsang M, Guy RH (2010) Effect of aqueous cream BP on human stratum corneum in vivo. Br J Dermatol 163(5):954–958

    Article  PubMed  CAS  Google Scholar 

  109. Griffin WC (1949) Classification of surface-active agents by ‘HLB’. J Soc Cosmet Chem 1:311

    Google Scholar 

  110. Faivre V, Rosilio V (2010) Interest of glycolipids in drug delivery: from physicochemical properties to drug targeting. Expert Opin Drug Deliv 7(9):1031–1048

    Article  PubMed  CAS  Google Scholar 

  111. Lourith N, Kanlayavattanakul M (2009) Natural surfactants used in cosmetics: glycolipids. Int J Cosmet Sci 31(4):255–261

    Article  PubMed  CAS  Google Scholar 

  112. Kanlayavattanakul M, Lourith N (2010) Lipopeptides in cosmetics. Int J Cosmet Sci 32(1):1–8

    Article  PubMed  CAS  Google Scholar 

  113. Gloor M (2004) How do dermatological vehicles influence the horny layer. Skin Pharmacol Physiol 17(6):267–273

    Article  PubMed  CAS  Google Scholar 

  114. Barany E, Lindberg M, Loden M (2000) Unexpected skin barrier influence from nonionic emulsifiers. Int J Pharm 195(1–2):189–195

    Article  PubMed  CAS  Google Scholar 

  115. Held E, Sveinsdottir S, Agner T (1999) Effect of long-term use of moisturizer on skin hydration, barrier function and susceptibility to irritants. Acta Derm Venereol 79:49–51

    Article  PubMed  CAS  Google Scholar 

  116. Wirén K, Frithiof H, Sjöqvist C, Lodén M (2009) Enhancement of bioavailability by lowering of fat content in topical formulations. Br J Dermatol 160(3):552–556

    Article  PubMed  Google Scholar 

  117. Richert S, Schrader A, Schrader K (2003) Transdermal delivery of two antioxidants from different cosmetic formulations. Int J Cosmet Sci 25(1–2):5–13

    Article  PubMed  CAS  Google Scholar 

  118. Wiechers JW, Kelly CL, Blease TG, Dederen JC (2004) Formulating for efficacy. Int J Cosmet Sci 26(4):173–182

    Article  PubMed  CAS  Google Scholar 

  119. Caussin J, Rozema E, Gooris GS et al (2009) Hydrophilic and lipophilic moisturizers have similar penetration profiles but different effects on SC water distribution in vivo. Exp Dermatol 18(11):954–961

    Article  PubMed  CAS  Google Scholar 

  120. Blichmann CW, Serup J, Winther A (1989) Effects of single application of a moisturizer: evaporation of emulsion water, skin surface temperature, electrical conductance, electrical capacitance, and skin surface (emulsion) lipids. Acta Derm Venereol 69:327–330

    PubMed  CAS  Google Scholar 

  121. Serup J, Winther A, Blichmann CW (1989) Effects of repeated application of a moisturizer. Acta Derm Venereol 69(5):457–459

    PubMed  CAS  Google Scholar 

  122. Serup J, Winther A, Blichmann C (1980) A simple method for the study of scale pattern and effects of a moisturizer–qualitative and quantitative evaluation by D-squame tape compared with parameters of epidermal hydration. Clin Exp Dermatol 14:277–282

    Article  Google Scholar 

  123. Otto A, du Plessis J, Wiechers JW (2009) Formulation effects of topical emulsions on transdermal and dermal delivery. Int J Cosmet Sci 31(1):1–19

    Article  PubMed  CAS  Google Scholar 

  124. Loden M (1992) The increase in skin hydration after application of emollients with different amounts of lipids. Acta Derm Venereol 72(5):327–330

    PubMed  CAS  Google Scholar 

  125. Machado M, Bronze MR, Ribeiro H (2007) New cosmetic emulsions for dry skin. J Cosmet Dermatol 6(4):239–242

    Article  PubMed  CAS  Google Scholar 

  126. Dayan N, Sivalenka R, Chase J (2009) Skin moisturization by hydrogenated polyisobutene–quantitative and visual evaluation. J Cosmet Sci 60(1):15–24

    PubMed  CAS  Google Scholar 

  127. Friberg SE (1990) Micelles, microemulsions, liquid crystals and the structure of the stratum corneum lipids. J Soc Cosmet Chem 41:155–171

    CAS  Google Scholar 

  128. Chorillia M, Prestesb PS, Rigonb RB et al (2011) Structural characterization and in vivo evaluation of retinyl palmitate in non-ionic lamellar liquid crystalline system. Colloids Surf B Biointerfaces 85(2):182–188

    Article  CAS  Google Scholar 

  129. Farahmand S, Tajerzadeh H, Farboud ES (2006) Formulation and evaluation of a vitamin C multiple emulsion. Pharm Dev Technol 11(2):255–261

    Article  PubMed  CAS  Google Scholar 

  130. Shinoda K, Friberg S (1986) Emulsions and solubilisation. Wiley, New York

    Google Scholar 

  131. Yilmaz E, Borchert HH (2006) Effect of lipid-containing, positively charged nanoemulsions on skin hydration, elasticity and erythema–an in vivo study. Int J Pharm 307(2):232–238

    Article  PubMed  CAS  Google Scholar 

  132. Boonme P (2007) Applications of microemulsions in cosmetics. J Cosmet Dermatol 6(4):223–228

    Article  PubMed  Google Scholar 

  133. Kogan A, Garti N (2006) Microemulsions as transdermal drug delivery vehicles. Adv Colloid Interface Sci 123–126:369–385

    Article  PubMed  CAS  Google Scholar 

  134. Bergamaschi MM, Santos OD, Rocha-Filho PA et al (2008) A simple analysis of the changes during evaporation of a commercial emulsion of unknown composition. J Cosmet Sci 59(1):15–32

    PubMed  Google Scholar 

  135. Jemec GB, Na R, Wulf HC (2000) The inherent capacitance of moisturising creams: a source of false positive results? Skin Pharmacol Appl Skin Physiol 13(3–4):182–187

    PubMed  CAS  Google Scholar 

  136. Mehling A, Haake H-M, Poly W (2010) Differential deposition of emollients from tripartite formulation systems. Int J Cosmet Sci 32:117–125

    Article  PubMed  CAS  Google Scholar 

  137. Loden M (1997) Barrier recovery and influence of irritant stimuli in skin treated with a moisturizing cream. Contact Dermatitis 36(5):256–260

    Article  PubMed  CAS  Google Scholar 

  138. Ramsing DW, Agner T (1997) Preventive and therapeutic effects of a moisturizer. An experimental study of human skin. Acta Derm Venereol 77:335–337

    PubMed  CAS  Google Scholar 

  139. Nogueira A, Sidou F, Brocard S (2010) Effect of a new moisturizing lotion on immediate and cumulative skin hydration: two randomized, intra-individual, vehicle- and comparator-controlled studies. J Dermatolog Treat. doi:10.3109/09546631003762647

  140. Tadros T (2006) Principles of emulsion stabilization with special reference to polymeric surfactants. J Cosmet Sci 57(2):153–169

    PubMed  CAS  Google Scholar 

  141. Wirén K, Nohlgård C, Nyberg F et al (2009) Treatment with a barrier-strengthening moisturizing cream delays relapse of atopic dermatitis: a prospective and randomized controlled clinical trial. J Eur Acad Dermatol Venereol 23(11):1267–1272

    Article  PubMed  CAS  Google Scholar 

  142. Cork MJ, Danby S (2009) Skin barrier breakdown: a renaissance in emollient therapy. Br J Nurs 18(14):872–877

    PubMed  Google Scholar 

  143. Hjalte F, Asseburg C, Tennvall GR (2010) Cost-effectiveness of a barrier-strengthening moisturizing cream as maintenance therapy vs. no treatment after an initial steroid course in patients with atopic dermatitis in Sweden – with model applications for Denmark, Norway and Finland. J Eur Acad Dermatol Venereol 24(4):474–480

    Article  PubMed  CAS  Google Scholar 

  144. Simpson EL, Berry TM, Brown PA, Hanifin JM (2010) A pilot study of emollient therapy for the primary prevention of atopic dermatitis. J Am Acad Dermatol 63:587–593

    Article  PubMed  Google Scholar 

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Acknowledgments

I would like to thank my colleagues Adam Muggleton and Mark Hanlon in preparing the figures and tables, Alain Mavon and Aurelie Laloeuf for helpful comments on the text and my wife Julia for assistance in preparing the document.

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Barton, S. (2012). The Composition and Development of Moisturizers. In: Lodén, M., Maibach, H. (eds) Treatment of Dry Skin Syndrome. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27606-4_21

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