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Intracellular Trafficking of HIV-1 Cores: Journey to the Center of the Cell

  • Chapter
Cellular Factors Involved in Early Steps of Retroviral Replication

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 281))

Abstract

After entry into the cytoplasm, many diverse viruses, including both RNA and DNA viruses, require import into the nucleus and access to the cellular nuclear machinery for productive replication to proceed. Because diffusion through the crowded cytoplasmic environment is greatly restricted, most (if not all) of these viruses must first be actively transported from the site of cytoplasmic entry to the nuclear periphery (Luby-Phelps 2000; Lukacs et al. 2000; Sodeik 2000). Having reached the nucleus, viruses have evolved assorted methods to overcome the formidable physical barrier that is presented by the nuclear envelope. This review examines how these issues relate to human immunodeficiency virus type-1 (HIV-1) infection. Specifically, HIV-1 uncoating, cytoplasmic transport, and nuclear entry are addressed.

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Authors and Affiliations

  1. Department of Microbiology and Cell and Molecular Biology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104-6148, USA

    J. D. Dvorin

  2. Department of Infectious Diseases, Guy’s, King’s and St. Thomas’ School of Medicine, King’s College London, London, SE1 9RT, UK

    M. H. Malim

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  1. J. D. Dvorin
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  1. Department of Oncology McArdle Laboratory for Cancer Research, University Wisconsin, Madison, 1400 University Avenue, Madison, WI, 53706, USA

    John A. T. Young (The Howard M. Temin, Professor in Cancer Research) (The Howard M. Temin, Professor in Cancer Research)

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Dvorin, J.D., Malim, M.H. (2003). Intracellular Trafficking of HIV-1 Cores: Journey to the Center of the Cell. In: Young, J.A.T. (eds) Cellular Factors Involved in Early Steps of Retroviral Replication. Current Topics in Microbiology and Immunology, vol 281. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19012-4_5

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