Definition
THR; molecules that receive a thyroid hormone and permit it to dock on the nuclear membrane of a cell. Belong to a family of nuclear receptors that function as hormone-activated transcription factors and act by modulating the expression of genes. THRs bind DNA in the absence of hormone, usually suppressing the transcription of genes. Hormone binding involves a conformational change in the receptor that lets it to activate transcription.
There are two THR genes: THR alpha and THR beta.
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© 2011 Springer-Verlag Berlin Heidelberg
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(2011). Thyroid Hormone Receptors. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16483-5_5809
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DOI: https://doi.org/10.1007/978-3-642-16483-5_5809
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Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-16482-8
Online ISBN: 978-3-642-16483-5
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