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Silica-Based Nanoparticles: Design and Properties

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Book cover Advanced Fluorescence Reporters in Chemistry and Biology II

Part of the book series: Springer Series on Fluorescence ((SS FLUOR,volume 9))

Abstract

A number of dye-doped silica nanoparticles (DDSNs) have been developed by encapsulating various fluorophores into silica nanomatrixes. These DDSNs have shown great potential as highly sensitive fluorescent labeling agents for biosensing and bioimaging. The silica nanomatrix affects the radiative properties and reactivity of doped fluorophores and endows the DDSN surface properties of silica. Compared with molecular fluorophores, the DDSNs exhibit advantageous properties such as high fluorescence intensity, good photostability, and biological compatibility. In this chapter, methods for silica nanoparticle synthesis and approaches for doping dye molecules within the silica nanomatrixes are overviewed. Various advantageous properties of DDSNs are discussed including reaction kinetics, solubility, photostability, quantum yield, lifetime, and toxicity.

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Authors and Affiliations

  1. Department of Chemistry, University of North Dakota, Grand Forks, ND, 58202, USA

    Song Liang, Carrie L. John, Jiao Chen, Yuhui Jin & Julia Xiaojun Zhao

  2. State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, 130012, P. R. China

    Shuping Xu

  3. Department of Chemistry, University of Florida, Gainesville, FL, 32611, USA

    Quan Yuan & Weihong Tan

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  1. Song Liang
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  2. Carrie L. John
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Correspondence to Julia Xiaojun Zhao .

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  1. , Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev, 01601, Ukraine

    Alexander P. Demchenko

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Liang, S. et al. (2010). Silica-Based Nanoparticles: Design and Properties. In: Demchenko, A. (eds) Advanced Fluorescence Reporters in Chemistry and Biology II. Springer Series on Fluorescence, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04701-5_7

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