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The Transthyretin—Retinol-Binding Protein Complex

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Recent Advances in Transthyretin Evolution, Structure and Biological Functions

Abstract

Retinol-binding protein (RBP), the specific transporter in plasma of retinol and transthyretin (TTR), transporter of thyroid hormones, form in higher vertebrates under physiological conditions, a macromolecular complex that prevents glomerular filtration of the low molecular mass RBP. The crystal structures of two RBP–TTR complexes have shed light on many aspects of the interaction between the two transporters and explained observations made with other experimental methods. Since higher levels of RBP are associated with insulin resistance in obesity and type 2 diabetes it has been suggested that dissociation of the complex with the consequent renal elimination of RBP might be a way to treat the disease.

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Acknowledgements

I thank Dr. Massimiliano Perduca for his help in preparing the figures of this chapter

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Authors and Affiliations

  1. Biocrystallography Laboratory, Department of Biotechnology, University of Verona, Strada Le Grazie 15, 37134, Verona, Italy

    Hugo L. Monaco

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  1. Hugo L. Monaco
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Correspondence to Hugo L. Monaco .

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Editors and Affiliations

  1. School of Medical Sciences, RMIT University, Bundoora, VIC 3083, Bundoora West Campus, Australia

    Samantha J. Richardson

  2. Medical Research Institute, Hauptman-Woodward, 700 Elliott Street, Buffalo, NY, 14203, USA

    Vivian Cody

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Monaco, H.L. (2009). The Transthyretin—Retinol-Binding Protein Complex. In: Richardson, S.J., Cody, V. (eds) Recent Advances in Transthyretin Evolution, Structure and Biological Functions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00646-3_8

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