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Total-Internal-Reflection Platforms for Chemical and Biological Sensing Applications

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Optical Guided-wave Chemical and Biosensors I

Part of the book series: Springer Series on Chemical Sensors and Biosensors ((SSSENSORS,volume 7))

Abstract

Sensing platforms based on the principle of total internal reflection (TIR) represent a fairly mature yet still expanding and exciting field of research. Sensor development has mainly been driven by the need for rapid, stand-alone, automated devices for application in the fields of clinical diagnosis and screening, food and water safety, environmental monitoring, and chemical and biological warfare agent detection. The technologies highlighted in this chapter are continually evolving, taking advantage of emerging advances in microfabrication, lab-on-a-chip, excitation, and detection techniques. This chapter describes many of the underlying principles of TIR-based sensing platforms and additionally focusses on planar TIR fluorescence (TIRF)-based chemical and biological sensors.

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Abbreviations

AWACSS:

Automated water analyzer computer supported system

CMOS:

Complementary metal oxide semiconductor

DCC:

Dicyclohexylcarbodiimide

DNA:

Deoxyribonucleic acid

EDC:

1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride

ELISA:

Enzyme-linked immunosorbant assay

IgG:

Immunoglobulin G

IOW:

Integrated optical waveguide

IR:

Infrared

IRE:

Internal reflection elements

ITO:

Indium tin oxide

LED:

Light emitting diode

LOD:

Limit of detection

MCLW:

Metal clad leaky waveguides

MEF:

Metal-enhanced fluorescence

NHS:

N-hydroxysuccinimde

Ni-NTA:

Nickel-nitriloacetic acid

NRL:

Naval Research Laboratory

OW:

Optical waveguide

PDMS:

Polydimethylsiloxane

RNA:

Ribonucleic acid

SEB:

Staphylococcal enterotoxin B

TIR:

Total internal reflection

TIRF:

Total internal reflection fluorescence

UV:

Ultra Violet

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Authors and Affiliations

  1. Division of Biology, Office of Science and Engineering, Food and Drug Administration (FDA), Silver Spring, MD, 20993, USA

    Kim E. Sapsford

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Correspondence to Kim E. Sapsford .

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  1. GDG Environnement Ltée, rue St-Laurent, 2e étage 430, Trois-Rivieres, G8T 6H3, Canada

    Mohammed Zourob

  2. Dept. Engineering Science &, Pennsylvania State University, University Park, 16802, U.S.A.

    Akhlesh Lakhtakia

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Sapsford, K.E. (2010). Total-Internal-Reflection Platforms for Chemical and Biological Sensing Applications. In: Zourob, M., Lakhtakia, A. (eds) Optical Guided-wave Chemical and Biosensors I. Springer Series on Chemical Sensors and Biosensors, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-88242-8_1

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