Zusammenfassung
Ein 37-jähriger Patient, verheiratet, Vater von zwei Kindern, seit 5 Wochen in psychiatrischer Behandlung aufgrund einer rezidivierenden depressiven Störung ohne somatische Symptome, kommt kurz vor Entlassung aus der stationären Behandlung zur neuropsychologischen Untersuchung mit der Fragestellung der beruflichen Wiedereingliederung. Als selbständiger Versicherungskaufmann ist er auf sein Kraftfahrzeug angewiesen, er hat täglich mehrere Kundenkontakte, in denen neben selbstsicherem Auftreten erwartet wird, dass er kompetent auch zu komplexen Fragen Stellung beziehen kann. Mit dem Kraftfahrzeug legt er berufsbedingt täglich oftmals mehr als 200 km zurück. Zur Untersuchung kommt er unter medikamentösen Steady-state-Bedingungen (Citalopram 40 mg); die depressive Symptomatik ist weitgehend remittiert (HAMD-17=12). Im Anamnesegespräch gibt er zu verstehen, dass er die Befürchtung habe, dass trotz deutlicher Verbesserung der affektiven Symptomatik seine Leistungsfähigkeit noch beeinträchtigt sei.
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25.8 Literatur
Alexopoulos GS, Kiosses DN, Klimstra S et al. (2002) Clinical presentation of the „depression-executive-dysfunction-syndrome“ of late life. Am J Geriatr Psychiatry 10: 98–106
Amado-Boccara I, Gougoulis N, Poirier Littre MF et al. (1995) Effects of antidepressants on cognitive functions: a review. Neurosci Biobehav Rev 19: 479–493
Arzneimittelkommission der deutschen Ärzteschaft (2005) Empfehlungen zur Therapie der Demenz. Arzneiverordnung in der Praxis. 3.Aufl., Köln
Barbee JG (1993) Memory, benzodiazepines, and anxiety: integration of theoretical and clinical perspectives. J Clin Psychiatry 54 (suppl 10): 86–97, discussion 98–101
Barbone F, McMahon A, Davey P et al. (1998) Association of road-traffic accidents with benzodiazepine use. Lancet 352: 1331–1336
Barker MJ, Greenwood KM, Jackson M et al. (2004a) Cognitive effects of long-term benzodiazepine use: a meta-analysis. CNS Drugs 18: 37–48
Barker MJ, Greenwood KM, Jackson M et al. (2004b) Persistence of cognitive effects after withdrawal from long-term benzodiazepine use: a meta-analysis. Arch Clin Neuropsychol 19: 437–454
Bilder RM, Goldman RS, Robinson D et al. (2000) Neuropsychology of first-episode schizophrenia: Initial characterization and clinical correlates. Am J Psychiatry 157: 549–559
Bilder RM, Goldman RS, Volavka J et al.(2002) Neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorder. Am J Psychiatry 159: 1018–1028
Birks J (2006) Cholinesterase inhibitors for Alzheimer’s disease. Cochrane Database of Systematic Reviews 1: CD005593
Birks J, Flicker L (2003) Selegiline for Alzheimer’s disease. Cochrane Database Syst Rev 1: CD000442
Birks J, Grimley EV, Van Dongen M (2002) Gingko biloba for cognitive impairment in dementia. Cochrane Database Syst Rev 4: CD003120
Bowie CR, Harvey PD (2006) Treatment of cognitive deficits in schizophrenia. Curr Opin Investig Drugs 7: 608–613
Brunnauer A, Laux G (2006) Fahrtüchtigkeit, schizophrene Psychosen und Neuroleptika. In: M Schmauß (Hrsg.) Schizophrenie — Pathogenese, Diagnostik und Therapie. UNI-MED Verlag AG Bremen (383–392)
Brunnauer A, Laux G, Geiger E et al. (2006) Antidepressants and driving ability: results from a clinical study. J Clin Psychiatry 67: 1776–1781
Buchanan RW, Holstein C, Breier A (1994) The comparative efficacy and long-term effect of clozapine treatment on neuropsychological test performance. Biol Psychiatry 36:717–725
Buffet-Jerrot SE, Stewart SH, Bird S et al. (1998) An examination of differences in the time course of oxazepam’s effects on implicit vs. explicit memory. J Psychopharmacol 12: 338–347
Cassano GB, Puca F, Scappichio PL et al. (2002) Paroxetine and fluoxetine effects on mood and cognitive functions in depressed nondemented elderly patients. J Clin Psychiatry 63: 396–402
Corey-Bloom J, Anand R, Veach J (1998) A randomized trial evaluating the efficacy and safety of ENA 713 (rivastigmine tartrate), a new acethylcholinesterase inhibitor, in patients with mild to moderately severe Alzheimer’s disease. Int J Geriatr Psychopharmacol 1: 55–65
Cowley DS, Roy-Byrne PP, Radant A et al. (1995) Benzodiazepine sensitivity in panic disorder: effects of chronic alprazolam treatment. Neuropsychopharmacology 12: 147–157
Cuesta MJ, Peralta V, Zarzuela A (2001) Effects of olanzapine and other antipsychotics on cognitive function in chronic schizophrenia: a longitudinal study. Schizophr Res 48: 17–28
Curran HV, Sakulsripong M, Lader M (1988) Antidepressants and human memory: An investigation of four drugs with different sedative and anticholinergic profiles. Psychopharmacol 95: 520–527
Curran HV, Schiwy W, Lader M (1987) Differential amnestic effects of benzodiazepines: A dose-response comparison of two drugs with similar elimination half-lives. Psychopharmacol 92: 358–364
Curran HV (1986) Tranquilising memories: a review of the effects of benzodiazepines on human memory. Biol Psychol 23: 179–213
Currie D, Hashemi K, Fothergill J et al. (1995) The use of antidepressants and benzodiazepines in the perpetrators and victims of accident. Occup Med (Lond) 45: 323–325
Doraiswamy PM, Krishnan KR, Oxman T et al. (2003) Does antidepressant therapy improve cognition in elderly depressed patients? J Gerontol A Biol Sci Med Sci 58: 1137–1144
Dubini A, Bosc M, Polin V (1997) Noradrenaline-selective versus serotonin-selective antidepressant therapy: differential effects on social functioning. J Psychopharmacol 11: 17–23
Edwards JG (1995) Drug choice in depression. Selective serotonin reuptake inhibitors or tricyclic antidepressants. CNS Drugs 4: 141–159
Fagerlund B, Mackeprang D, Gade A et al. (2004) Effects of low-dose risperidone and low-dose zuclopenthixol on cognitive functions in first episode drug naive schizophrenic patients. CNS Spectr 9: 364–374
Förstl H (2003) Antidementiva. Urban & Fischer, München Gladsjo JA, Rapaport MH, McKinney R et al. (2001) Absence of neuropsychologic deficits in patients receiving long-term treatment with alprazolam-XR for panic disorder. J Clin Psychopharmacol 21: 131–138
Good KP, Kiss I, Buiteman C et al. (2002) Improvement in cognitive functioning in patients with first-episode psychosis during treatment with quetiapine: an interim analysis. Br J Psychiatry 43: 45–49
Goldberg TE, Greenberg RD, Griffin SJ et al. (1993) The effects of clozapine on cognition and psychiatric symptoms in patients with schizophrenia. Br J Psychiatry 162: 43–48
Goldberg TE, Gold JM (1995) Neurocognitive functioning in patients with schizophrenia. In: FE Bloom, DJ Kupfer Hrsg Psychopharmacology —The fourth generation of progress. Raven Press, New York, 1245–1257
Green MF (1996) What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry 151: 357–362
Green MF (2002) Recent studies on the neurocognitive effects of second generation antipsychotic medications. Curr Opin Psychiatry 15: 25–29
Green MF, Marshal BD Jr, Wirshing WC et al. (1997) Does risperidone improve verbal working memory in treatment-resistant schizophrenia? Am J Psychiatry 154:799–804
Green MF, Kern RS, Heaton RK (2004) Longitudinal studies of cognition and functional outcome in schizophrenia: Implications for MATRICS. Schizophr Res 72: 41–51
Hoch I, Rentsch A, Krappweis J et al. (2004) Psychopharmakaverordnungen an älteren Menschen. Ein Vergleich zwischen Patienten aus Alten-und Pflegeheimen, ambulant behandelten Pflegefällen und ambulanten Patienten ohne Pflegebedarf. Z Gerontol Geriat 37: 214–220
Häussler B, Höer A, Hempel E et al. (2007) Arzneimittel-Atlas 2006. Die Entwicklung des Arzneimittelverbrauchs in der GKV. Urban & Vogel, München
Hagger C, Buckley P, Kenny JT et al. (1993) Improvement in cognitive functions and psychiatric symptoms in treatment-refractory schizophrenic patients receiving clozapine. Biol Psychiatry 34: 702–712
Hamilton SH, Edgell ET, Revicki DA et al. (2000) Functional outcomes in schizophrenia. A comparison of olanzapine and haloperidol in a European sample. Int Clin Psychopharmacol 15: 245–255
Harvey PD, Siu CO, Romano S (2004a) Randomized, controlled, doubleblind, multicenter comparison of the cognitive effects of ziprasidone versus olanzapine in acutely ill inpatients with schizophrenia or schizoaffective disorder. Psychopharmacology (Berl) 172: 324–332
Harvey PD, Meltzer H, Simpson GM et al. (2004b) Improvement in cognitive function following a switch to ziprasidone from conventional antipsychotics, olanzapine, or risperidone in outpatients with schizophrenia. Schizophr Res 66: 101–113
Hemmelgarn B, Suissa S, Huang A et al. (1997) Benzodiazepine use and the risk of motor vehicle crash in the elderly. JAMA 278: 27–31
Herrschaft H (2001) Antidementiva in der Praxis — Pharmakologie, Indikationen, Therapie. Uni-Med, Bremen
Hirschfeld RMA, Montgomery SA, Keller MB et al. (2000). Social functioning in depression: a review. J Clin Psychiatry 61: 268–275
Hindmarch I (1995) The behavioural toxicity of the selective serotonin reuptake inhibitors. Int Clin Psychopharmacol 9: 13–17
Kasper S, Resinger E (2003) Cognitive effects and antipsychotic treatment. Psychoneuroendocrinology 28: 27–38
Keefe RSE, Silva SG, Perkins DO, Liebermann J (1999) The effects of atypical antipsychotic drugs on neurocognitive impairment in schizophrenia: a review and meta-analysis. Schizophr Bull 25: 201–222
Keefe RS, Seidmann LJ, Christensen BK et al. (2006) Long-term neurocognitive effects of olanzapine or low-dose haloperidol in first episode psychosis. Biol Psychiatry 59: 97–105
Kern RS, Green MF, Cornblatt BA et al. (2006) The neurocognitive effects of aripiprazole: an open-label comparison with olanzapine. Psychopharmacology (Berl) 187: 312–320
Kern RS, Green MF, Marshall BD et al. (1998) Risperidone vs. Haloperidol on reaction time, manual dexterity, and motor learning in treatment resistant schizophrenia patients. Biol Psychiatry 44: 726–732
Kerr JS, Hindmarch I (1996) Citalopram and other antidepressants: Comparative effects on cognitive function and psychomotor performance. Journal of Serotonin Research 3: 123–129
Kessler H, Supprian T, Rösler M (2003) Antidementive Pharmakotherapie. Ein Update. Psychopharmakotherapie 10: 132–140
Kilic C, Curran HV, Noshirvani H et al. (1999) Long term effects of alprazolam on memory: a 3.5 year follow up of agoraphobia/panic patients. Psychol Med 29: 225–231
Klotz U, Laux G (1996) Tranquillantien. Therapeutischer Einsatz und Pharmakologie. 2. Aufl. Wiss Verlagsges Stuttgart
Knegtering H, Eijck M, Huijsman A (1994) Effects of antidepressants on cognitive functioning of elderly patients. A review. Drugs Aging 5: 192–199
Kocsis JH, Zisook S, Davidson J et al. (1997) Double-blind comparison of sertraline, imipramine, and placebo in the treatment of dysthymia: Psychosocial outcomes. Am J Psychiatry 154: 390–395
van Laar M, Volkerts E (1998) Driving and benzodiazepine use. CNS Drugs 10: 383–396
Lagnaoui R, Begaud B, Moore N et al. (2002) Benzodiazepine use and risk of dementia: a nested case-control sudy. J Clin Epidemiol 55: 314–318
Lane RM, O’Hanlon JF (1999) Cognitive and psychomotor effects of antidepressants with emphasis on selective serotonin reuptake inhibitors and the depressed elderly patient. German Journal of Psychiatry 2:1–42
Laux G (1995) Aktueller Stand der Therapie mit Benzodiazepinen. Eine Übersicht. Nervenarzt 66: 311–322
Laux G (2010) Nomenklatur, Einteilung von Psychopharmaka. In: P Riederer, G Laux (Hg.) Grundlagen der Neurospychopharmakologie. Wien: Springer. S. 353–367.
Laux G, Dietmaier O (2006) Praktische Psychopharmakotherapie. Urban & Fischer Verlag, München, Jena
Le Bars PL, Katz MM, Berman N et al. (1997) A placebo-controlled, doubleblind, randomized trial of an extract of Gingko biloba for dementia. JAMA 278: 1327–1332
Leveille SG, Buchner DM, Koepsell TD et al. (1994) Psychoactive medications and injurious motor vehicle collissions involving older drivers. Epidemiology 5: 591–598
Lewrenz H (2000) Begutachtungs-Leitlinien zur Kraftfahrereignung. Wirtschaftsverlag, Bremerhaven
Lister RG, File SE (1984) The nature of lorazepam-induced amnesia. Psychopharmacol 83: 183–187
McGurk S R, Lee MA, Jayathilake K et al. (2004) Cognitive effects of olanzapine treatment in schizophrenia. Med Gen Med 10: 27
McShane R, Areosa Sastre A, Minakaran N (2006). Memantine for dementia. Cochrane Database Syst Rev 19: CD003154
Meltzer HY, McGurk SR (1999) The effects of clozapine, risperidone, and olanzapine on cognitive functioning in schizophrenia. Schiophr Bull 25: 233–255
Mishara A L, Goldberg TE (2004) A meta analysis and critical review of the effects of conventional neuroleptic treatment on cognition in schizophrenia: opening a closed book. Biol Psychiatry 55: 1013–1022
Mowia A, Mosavinasab M, Pani A (2007) Does fluoxetine have any effect on the cognition of patients with mild cognitive impairment?: a double blind, placebo-controlled, clinical trial. J Clin Psychopharmacol 27: 67–70
Möller HJ (2000) Are all antidepressants the same? J Clin Psychiatry 61: 24–28
Müller WE (1995) Benzodiazepine. Experimentelle und klinische Pharmakologie. In: Riederer P, Laux G, Pöldinger W (Hrsg) Neuro-Psychopharmaka. Ein Therapie-Handbuch. Bd. 2 Tranquilizer und Hypnotika. Springer, Wien
Müller U, Fletcher PC, Steinberg H (2006) The origin of pharmacopsychology: Emil Kraepelin’s experiments in Leipzig, Dorpat and Heidelberg (1882–1892). Psychopharmacology 184: 131–138
Naber D, Lambert M, Krausz M et al. (2002) Atypische Neuroleptika in der Behandlung schizophrener Patienten. 2.Aufl. Uni-Med, Bremen
Nathan PJ, Sitaram G, Stough C et al. (2000) Serotonin, noradrenaline and cognitive function: a preliminary investigation of the acute pharmacodynamic effects of a serotonin versus a serotonin and noradrenaline reuptake inhibitor. Behav Pharmacol 11: 639–642
Paterniti S, Duffouil C, Alperovitch A (2002) Long-term benzodiazepine use and cognitive decline in the elderly: the Epidemiology of Vascular Aging Study. J Clin Psychopharmacol 22: 285–293
Petersen RC, Thomas RG, Grundmann M et al. (2005) Vitamin E and Donepezil for the treatment of mild cognitive impairment. N Engl J Med 352: 2379–2388
Peuskens J, Demily C, Thibaut F (2005) Treatment of cognitiv dysfunction in schizophrenia. Clin Ther 27: S25–S37
Potter GG, Kittinger JD, Wagner HR, Steffens DC, Krishnan KR (2004) Prefrontal neuropsychological predictors of treatment remission in late-life depression. Neuropsychopharmacology 29: 2226–2271
Purdon SE, Jones BDW, Stip E et al. (2000) Neuropsychological change in early phase schizophrenia during 12 month of treatment with olanzapine, risperidone, or haloperidole. Arch Gen Psychiatr 57: 249–258
Purdon SE, Malla A, Labelle A et al. (2001) Neuropsychological change in patients with schizophrenia after treatment with quetiapine or haloperidol. J Psychiatry Neurosci 26: 137–149
Ramaekers JG (2003) Antidepressants and driver impairment: emprirical evidence from a standard on-the-road test. J Clin Psychiatry 64: 20–29
Ray WA, Fought WL, Decker MD (1992) Psychoactive drugs and the risk of injurious motor vehicle crashes in elderly drivers. Am J Epidemiol 136: 873–883
Riederer P, Laux G, Pöldinger W (Hrsg) (2002) Neuro-Psychopharmaka. Ein Therapie-Handbuch. Bd. 3 Antidepressiva. 2.Aufl. Springer, Wien
Rocca P, Calvarese P, Fagiano F et al. (2005). Citalopram versus sertraline in late life nonmajor clinically significant depression: a 1-year followup clinical trial. J Clin Psychiatry 66: 360–369
Rossi A, Manchini F, Stratta P et al. (1997) Risperidone, negative symptoms and cognitive deficits in schizophrenia: an open study. Acta Psychiatr Scand 95: 40–43
Sax KW, Strakowski SM, Keck PE (1998) Attentional improvement following quetiapine fumarate treatment in schizophrenia. Schizophr Res 33: 151–155
Schwabe, U., Paffrath, D. (Hrsg.) (2009): Arzneiverordnungs-Report 2008. Springer, Heidelberg.
Simpson SW, Baldwin RC, Burns A et al. (2001) Regional cerebral volume measurements in late-life depression: relationship to clinical correlates, neuropsychological impairment and response to treatment. Int J Geriatr Psychiatry 16: 469–476
Stein RA, Strickland TL (1998) A review of the neuropsychological effects of commonly used prescription medications. Arch Clin Neuropsychol 13: 258–284
Stratta P, Donda P, Rossi A et al. (2005) Executive function assessment of patients with schizophrenic disorder residual type in olanzapine treatment: an open study. Hum Psychopharmacol 20: 401–408
Tabet N, Birks J, Grimley Evans J (2000) Vitamin E for Alzheimer’s disease. Cochrane Database Syst Review 4: CD002854
Tamminga CA (2006) The neurobiology of cognition in schizophrenia. J Clin Psychiatry 67 (supplement 9): 9–13
Tariot PN, Solomon PR, Morris JC et al. (2000) A 5-month, randomized, plazebo-controlled trial of galantamine in AD. Neurology 54: 2269–2276
Tölle, R, Schott H (2010) Historischer Abriss: Geschichte der Psychopharmaka. In P Riederer, G Laux (Hg.) Grundlagen der Neuropsychopharmakologie. Wien: Springer. S. 11–29.
Velligan DI, Prihoda DJ, Sui D et al. (2003) The effectiveness of quetiapine versus conventional antipsychotics in improving cognitive and functional outcomes in standard treatment settings. J Clin Psychiatry 64: 524–531
Velligan DI, Newcomer J, Pultz J et al. (2002) Does cognitive function improve with quetiapine in comparison to haloperidol? Schizophr Res 53: 239–248
Verdoux H, Lagnaoui R, Begaud B (2004) Is benzodiazepine use a risk factor for cognitive decline and dementia ? A literature review of epidemiological data. Psychol Med 35: 307–315
Verster JC, Veldhuijzen DS, Volkerts RE (2004) Residual effect of sleep medication on driving ability: Sleep Med Rev 8: 309–325
Wagner M, Quednow BB, Westheide J et al. (2005) Cognitive improvement in schizophrenia does not require a serotonergic mechanism: randomized controlled trial of olanzapine vs amisulpride. Neuropsychopharmacology 30: 381–390
Winblad B, Poritis N (1999) Memantine in severe dementia: results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine). Int Geriat Psychiatry 14: 135–146
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Brunnauer, A., Laux, G. (2010). Klinisch-Neuropsychologische Aspekte der Therapie mit Psychopharmaka. In: Lautenbacher, S., Gauggel, S. (eds) Neuropsychologie psychischer Störungen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72340-0_25
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