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Cell Cycle Control pp 181–197Cite as

Control of Cell Proliferation by Myc Proteins

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Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 22))

Abstract

myc genes were discovered as the transforming genes of four chicken retroviruses; soon cellular homologues were identified in a number of organisms ranging from birds and mammals to fish and sea urchins. The most recent addition to the list of organisms in which myc genes have been found is Drosophila melanogaster, opening up the possibility of a genetic analysis of Myc function (Gallant et al., 1996). Furthermore, genes encoding members of the Myc network of proteins have been identified in Caenorhabditis elegans, demonstrating an unexpected degree of evolutionary conservation (M. Cole, pers.comm.). No myc genes are present in Saccharomyces cerevisiae and they appear to be absent from Schizosaccharomyces pombe.

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  1. Institut für Molekularbiologie und Tumorforschung (IMT), Universität Marburg, Emil-Mann-kopff-Straße, 35033, Marburg, Germany

    A. Bürgin

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  2. C. Bouchard
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  1. Department of Pathology, MSB 548, New York University School of Medicine, 550 First Avenue, New York, NY, 10016, USA

    Michele Pagano

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Bürgin, A., Bouchard, C., Eilers, M. (1998). Control of Cell Proliferation by Myc Proteins. In: Pagano, M. (eds) Cell Cycle Control. Results and Problems in Cell Differentiation, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69686-5_8

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