Skip to main content

Nano Metal Particles for Biomedical Applications

  • Chapter
NanoScience in Biomedicine
  • 1594 Accesses

Abstract

In the management of human health, nano-sized tools are usually more effective than larger ones because they can be incorporated into the systems more in a fundamental (cellular or molecular) level, causing less negative side effects. One of these nano tools that are currently getting much attention is nanometal particle (NMPs). NMPs have many unique properties that are not present in their bulk form. When these unique properties are positively utilized in biological systems they can be very effective for the diagnosis and/or treatment for various diseases. In this article, examples of various applications of NMPs in biomedical sciences and technology are reviewed and a few examples that are currently studied in our research group are demonstrated. It should be noted that, in this article, only a limited publications are cited out of the large volume of NMP related ones, and the readers should not assume that the examples listed in this article are representing all of the currently available NMP tools used in biomedical field. It should also be noted that the authors for this articles are not experts in nanotechnology but are bioengineers.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Abudabi, T. and R.R. Beitle, J. Chromatogr. A 795: 211 (1998).

    Article  Google Scholar 

  • Acar, H., R.S. Garass, F. Syud, P. Bonitatebus and A.M. Kulkarni. J. Magn. Magn. Mater. 293(1): 1 (2005).

    Article  CAS  Google Scholar 

  • Achilefu, S., R.B. Dorshow, J.E. Bugaj, R. Rajagopalan. Invest Radiol. 35: 479 (2000).

    Article  CAS  PubMed  Google Scholar 

  • Akerman M.E., W.C. Chan, P. Laakkonen, S.N. Bhatia and E. Ruoslahti. Proc. Natl. Acad. Sci. USA 99: 12,617 (2002).

    Article  CAS  PubMed  Google Scholar 

  • Anderson, G.P. and N.L. Nerurkar. J. Immunol Methods. 271: 17 (2002).

    Article  CAS  PubMed  Google Scholar 

  • Andra, W. and H. Nowak. Magnetism in Medicine. Berlin: Wiley-VCH (2007).

    Google Scholar 

  • Bahadur, D. and J. Giri. Sadhana 28(3&4): 639 (2003).

    Article  CAS  Google Scholar 

  • Berlier, J.E., A. Rothe, G. Buller, J. Bradford, D.R. Gray, B.J. Filanoski, W.G. Telford, S. Yue, J. Liu, C-Y Cheung, W. Chang, J.D. Hirsch, J.M. Beechem, R.P. Haugland and R.P. Haugland. Journal of Histochemistry and Cytochemistry 51(12): 1699 (2003).

    CAS  PubMed  Google Scholar 

  • Bulte, J.W.M., S.C. Zhang, P. van Gelderen, V. Herynek, E.K. Jordan and I.D. Duncan. Proc. Natl. Acad. Sci. USA 96(26): 15,256–15,261 (1999)

    Article  CAS  PubMed  Google Scholar 

  • Bulte, W.M.J., T. Douglas, B. Witwer, S-C. Zhang, E. Strable, B.K. Lewis, H. Zywicke, B. Miller, P. van Gelderen, B.M. Moskowitz, I.D. Duncan and J.A. Frank. Nat. Biotechnol. 19: 1141 (2001).

    Article  CAS  PubMed  Google Scholar 

  • Chang, E., J.S. Miller, J. Sun, W.W. Yu, V.L. Colvin, R. Drezek and J.L. West. Biochemical and Biophysical Research Communications 334(4): 1317 (2005).

    Article  CAS  PubMed  Google Scholar 

  • Choi, J., K.W. Oh, J.H. Thomas, W.R. Heineman, H.B. Halsall, J.H. Nevin, A.J. Helmicki, H.T. Henderson, C.H. Ahn. Lab Chip 2: 27 (2002).

    Article  CAS  PubMed  Google Scholar 

  • Cocker, T. M., J.F. Conan and A.E. Rachel. Biotechnol. Bioeng. 53: 79 (1997).

    Article  CAS  PubMed  Google Scholar 

  • Connolly, J. and T.G. St Pierre. J. Magn. Magn. Mater. 225: 156 (2001).

    Article  CAS  Google Scholar 

  • Dubertret, B., M. Calame, A.J. Libchaber. Nat. Biotechnol. 19: 3659 (2001).

    Article  Google Scholar 

  • Gao, X.H., Y.Y. Cui, R.M. Levenson, L.W.K. Chung and S.M. Nie. Nat. Biotechnol. 22: 969 (2004).

    Article  CAS  PubMed  Google Scholar 

  • Geddes, C.D., A. Parfenov, D. Roll, M. J. Uddin, and J. R. Lakowicz. Journal of Fluorescence 13(6): 453 (2003).

    Article  CAS  Google Scholar 

  • Fortina, P., L.J. Kricha, D.J. Graves, J. Park, T. Hyslop, F. Tam, N. Halas, S. Surrey, S.A. Waldman. Trends Biotechnol. 25(4): 145 (2007).

    Article  CAS  PubMed  Google Scholar 

  • Gilchrist, R.K., R. Medal, W.D. Shorey, R.C. Hanselman, J.C. Parrott and C.B. Taylor. Ann Surg. 146(4): 596 (1957).

    Article  CAS  PubMed  Google Scholar 

  • Gorschlüter, A., C. Sundermeier, B. Roß and M. Knoll. Sens. Actuators B 85: 158 (2002a).

    Article  Google Scholar 

  • Gorschlüter, A., L.H. Mak, C. Sundermeier, B. Roß and M. Knoll. Biomed. Tech. 47: 213 (2002b).

    Article  Google Scholar 

  • Graham, D.L., H.A. Ferreira, P.P. Freitas, and J.M.S. Cabral. Biosensors and Bioelectronics. 18: 483 (2003).

    Article  CAS  PubMed  Google Scholar 

  • Gruttner, C., K. Muller, J. Teller, F. Westphala, A. Foreman and R. Ivkovb. J. Magn. Magn. Mater. 311: 181 (2007).

    Article  Google Scholar 

  • Hama, Y., Y. Koyama, Y. Urano, P.L. Choyke and H. Kobayashi. Breast Cancer Res Treat. 17(6): 1426 (2006).

    CAS  Google Scholar 

  • Hamaguchi, S., I. Tohnai, A. Ito, K. Mitsudo, T. Shigetomi, M. Ito, H. Honda, T. Kobayashi and M. Ueda. Cancer Sci. 94(9): 834 (2003).

    Article  CAS  PubMed  Google Scholar 

  • Harisinghani, M.G., S. Saini, R. Weissleder, P.F. Hanh, R.K. Yantiss, C. Tempany, B.J. Wood and P.R. Mueller. Am. J. Roentgenol. 172: 1347 (1999).

    CAS  Google Scholar 

  • Hergt, R., W. Andra, C.G. d’Ambly, I. Hilger, W.A. Kaiser, U. Richter, and H. Schmidt. IEEE Trans. Magn. 34(5): 3745 (1998).

    Article  CAS  Google Scholar 

  • Hergt, R., R. Hiergeist, I. Hilger and W.A. Kaiser. Recent Res. Dev. Mater. Sci. 3: 723 (2002).

    CAS  Google Scholar 

  • Hilger, I., R. Hergt and W.A. Kaiser. J. Magn. Magn. Mater. 293: 314 (2005).

    Article  CAS  Google Scholar 

  • Hirsch L.R., R.J. Stafford, J.A. Bankson, S.R. Sershen, B. Rivera, R.E. Price, J.D., Hazle, N.J., Halas, J.L. West. Proc. Natl. Acad. Sci. USA 100(23): 13,549 (2003).

    Article  CAS  PubMed  Google Scholar 

  • Hong, B. and K.A. Kang. Biosensor and Bioelectronics 21: 1333 (2006).

    Article  CAS  Google Scholar 

  • Inoue, S., M. Goda, H. Du, M.D. Disney, B.L. Miller and T.D. Krauss. Biol. Bull. 201: 231 (2001).

    Article  CAS  PubMed  Google Scholar 

  • Jin, H. and K.A. Kang. Advances in Experimental Medicine and Biology 566: 167 (2005).

    Article  PubMed  Google Scholar 

  • Jin, H. and K.A. Kang. Advances in Experimental Medicine and Biology, 599: 45 (2007).

    Article  PubMed  Google Scholar 

  • Jin, H, B. Hong, S.S. Kakar and K.A. Kang. Advances in Experimental Medicine and Biology, 614: 275 (2008).

    Article  PubMed  Google Scholar 

  • Jozefczak, A. and A. Skumiel. J. Magn. Magn. Mater. 311(1): 193 (2007).

    Article  CAS  Google Scholar 

  • Jordan, A., R. Scholz, P. Wust, H. Fahling and R. Felix. J. Magn. Magn. Mater. 201: 413 (1999).

    Article  CAS  Google Scholar 

  • Josephson, L., C.H., Tung, A. Moore, R. Weissleder. Bioconjuate Chem. 10: 186 (1999).

    Article  CAS  Google Scholar 

  • Kakar, S.S., S.J. Winters, W. Zacharias, D.M. Miller and S. Flynn. Gene 308: 67 (2003).

    Article  CAS  PubMed  Google Scholar 

  • Kakar, S.S, H. Jin, B. Hong, J.W. Eaton and K.A. Kang. Proceeding of the 2006 Annual Conference on the International Society of Oxygen Transport to Tissue, August 2006, Louisville, KY (Accepted).

    Google Scholar 

  • Kang, K.A. and B. Hong, Critical Reviews TM in Eukaryotic Gene Expression 16(1): 45 (2006).

    CAS  Google Scholar 

  • Kaul, Z., T. Yaguchi, S.C. Kaul, T. Hirano, R. Wadhwa and K. Taira. Cell. Res. 13: 503 (2003).

    Article  PubMed  Google Scholar 

  • Kawai, N., A. Ito, Y. Nakahara, M. Futakuchi, T. Shirai, H. Honda, T. Kobayashi and K. Kohri. The Prostate 64: 373 (2005).

    Article  CAS  PubMed  Google Scholar 

  • Kim, S., Y.T. Lim, E.G. Soltesz, A.M. De Grand, J. Lee, A. Nakayama, J.A. Parker, T. Mihaljevic, R.G. Laurence, D.M. Dor, L.H. Cohn, M.G. Bawendi and J.V. Frangioni. Nat. Biotechnol. 22: 93 (2004).

    Article  CAS  PubMed  Google Scholar 

  • Larson D.R., W.R. Zipfel, R.M. Williams, S.W. Clark, M.P. Bruchez, F.W. Wise and W.W. Webb. Science 300: 1434 (2003).

    Article  CAS  PubMed  Google Scholar 

  • Lawson, W.D., F.A. Smith and A.S. Young. J. Electrochem. Soci. 107: 206 (1960).

    Article  CAS  Google Scholar 

  • Lermo, A., S. Campoy, J. Barbé, S. Hernández, S. Alegret and M.I. Pividori. Biosens. Bioelectro. 22(9-10): 2010 (2007).

    Article  CAS  Google Scholar 

  • Leuschner, C., C. Kumar, M.O. Urbina, J. Zhou, W. Soboyejo, W. Hansel and F. Hormes. Nanotech. Technical Proceedings for the 2005 NSTI Nanotechnolgy Conference and Trade Show, 1: 5 (2005).

    CAS  Google Scholar 

  • Licha, K., R. Riefke, V. Ntziachristos, A. Becker, B. Chance and W. Semmler. Photochem. Photobiol. 72: 392 (2000).

    Article  CAS  PubMed  Google Scholar 

  • Loo, C., A. Lin, L. Hirsch, M.H. Lee, J. Barton, N. Halas, J. West and R. Drezek. Technology in Cancer Research and Treatment 3: 33 (2004).

    CAS  PubMed  Google Scholar 

  • Loo, C., A. Lowery, N. Halas, J. West and R. Drezek. Nano Lett. 5: 709 (2005).

    Article  CAS  PubMed  Google Scholar 

  • Majoros, J.J., T.P. Thomas, C.B. Mehta and J.R. Baker, Jr. J. Med. Chem. 48(19): 5892 (2005).

    Article  CAS  PubMed  Google Scholar 

  • Matsuoka, F., M. Shinkai, H. Honda, T. Kubo, T. Sugita and T. Kobayasi. Biomagn. Res. Technol. 2(1): 3 (2004).

    Article  PubMed  Google Scholar 

  • Meyer, H.F.M., M. Hartmann, H.-J. Krause, G. Blankenstein, B. Mueller-Chorus, J. Oster, P. Miethe and M. Keusgen, Biosensors and Bioelectronics 22: 973, (2007a).

    Article  CAS  PubMed  Google Scholar 

  • Meyer, H.F.M., H.-J. Krause, M. Hartmann, P. Miethe, J. Oster and M. Keusgen, Journal of Magnetism and Magnetic Materials, 68(2): 218, (2007b).

    CAS  Google Scholar 

  • Meyer, H.F.M., M. Stehr, S. Bhuju, H.-J. Krause, M. Hartmann, P. Miethe, M. Singh and M. Keusgen, Journal of Microbiological Methods, 311(1): 259, (2007c).

    CAS  Google Scholar 

  • Mornet, S., S. Vasseur, F. Grasset and E. Duguet. J. Mater. Chem. 14: 2161 (2004).

    Article  CAS  Google Scholar 

  • Reddy, G.R., M.S. Bhojani, P. McConville, J. Moody, B.A. Moffat, D.A., Haoo, G. Kim, Y-E L., Koo, M.J., Wooliscroft, J.V. Sugai, T.D., Johnson, M.A. Philbert, R. Kopelman, A. Rehemtulla and B.D. Ross. Clin. Cancer Res. 12(22): 6677 (2006).

    Article  CAS  PubMed  Google Scholar 

  • Ruppin R. Phys Rev B. 11(8): 2871 (1975).

    Article  CAS  Google Scholar 

  • Saito, R., J.R. Bringas, T.R. McKnight, M.F. Wendland, C. Mamot, D.C. Drummond, D.B. Kirpotin, J.W., Park, M.S., Berger and K.S. Bankiewicz. Cancer Res. 64(7): 2573 (2004).

    Article  Google Scholar 

  • Sinha, R., G.J. Kim, S. Nie and D.M. Shin. Mol. Cancer Ther. 5(8): 1909 (2006).

    Article  CAS  PubMed  Google Scholar 

  • Shinkai, M., L. Biao, H. Honda, K. Yoshikawa, K. Shimizu, S. Saga, T. Wakabayashi, J. Yoshida and T. Kobayashi. Cancer Science 92(10): 1138 (2001).

    Article  CAS  Google Scholar 

  • Shultz, M.D, S. Calvin, P.P. Fatouros, S.A. Morrison and E.E. Carpenter. J. Magn. Magn. Mater. 311(1): 464 (2007).

    Article  CAS  Google Scholar 

  • Smith, AM, S. Dave, S. Nie, L. True and X. Gao. Expert Rev Mol Diagn. 6(2): 231 (2006).

    Article  CAS  PubMed  Google Scholar 

  • Soltesz E.G., S. Kim, R.G. Laurence, A.M. DeGrand, C.P. Parungo, D.M. Dor, L.H. Cohn, M.G. Bawendi, J.V. Frangioni and T. Mihaljevic. Ann. Thorac. Surg. 79(1): 269 (2005).

    Article  PubMed  Google Scholar 

  • Storm, F.K. Hyperthermia in Cancer Therapy. Boston: G. K. Hall Medical Publishers (1983).

    Google Scholar 

  • Stroh, M., J.P. Zimmer, D.G. Duda, T.S. Levchenko, K.S. Cohen, E.B. Brown, D.T. Scadden, V.P. Torchilin, M.G. Bawendi, D. Fukumura and R.K. Jain. Nat. Med. 11: 678 (2005).

    Article  CAS  PubMed  Google Scholar 

  • Tanaka, K., A. Ito, T. Kobayashi, T. Kawamura, S. Shimada, K. Matsumoto, T. Saida and H. Honda. J. BioSci. Bioengr. 100(1): 112 (2005).

    Article  CAS  Google Scholar 

  • Tartaj, P., M.P. Morales, S. Veintemillas-Verdaguer, T. Gonzalez-Carreno and C.J. Serna. J. Phys. D: Appl. Phys. 36: R182 (2003).

    Article  CAS  Google Scholar 

  • Torchilin, V.P., European. J. Pharma. Sci. 11(Supplement 2): S81 (2000).

    CAS  Google Scholar 

  • Varshney M. and Li, Y. Biosensors and Bioelectronics, 22(11): 2408 (2007).

    Article  CAS  PubMed  Google Scholar 

  • Weissleder R., G. Elizondo, J. Wittenberg, C.A. Babito, H.H. Bengele and L. Josephson. Radiol. 175: 489 (1990).

    CAS  Google Scholar 

  • Yan, S., D. Zhang, N. Gu, J. Zheng, A. Ding and Z. Wang. J. Nanosci. Nanotechnol. 5(5): 1185 (2005).

    Article  CAS  PubMed  Google Scholar 

  • Yanase, M., M. Shinkai, H. Honda, T. Wakabayashi, J. Yoshida and T. Kobayshi. Jpn. J. Cancer Res. 89: 463 (1998).

    CAS  PubMed  Google Scholar 

  • Yang, C., J. Xing, Y. Guan and H. Liu. Appl. Microbiolo and Biotechnol. 72(3): 616 (2006).

    Article  CAS  Google Scholar 

  • Zhang, L.Y., H.C. Gu and X.M. Wang. J. Magn. Magn. Mater. 311: 228 (2007).

    Article  CAS  Google Scholar 

  • Zhao, A.J., P. Yao, C.S. Kang, X. Yuan, J. Chang and P. Pu. J. Magn. Magn. Mater. 295(1): 37 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kyung A. Kang .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Tsinghua University Press, Beijing and Springer-Verlag GmbH Berlin Heidelberg

About this chapter

Cite this chapter

Kang, K.A., Hong, B., Jin, H. (2009). Nano Metal Particles for Biomedical Applications. In: Shi, D. (eds) NanoScience in Biomedicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-49661-8_12

Download citation

Publish with us

Policies and ethics