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Summary

Cholescintigraphy plays a pivotal role in the evaluation of various biliary tract diseases, particularly when coupled with pharmacological intervention. The physician monitoring the study should be familiar with the most optimal technique for the pharmacological intervention and with conditions and medications that affect gall bladder contraction. It is also important to be aware of the various physiological and pharmacological effects on imaging findings, i.e., not only those findings that are normal but also the undesirable variants [253]. Failure to recognize such effects can lead to incorrect interpretation.

Radionuclide imaging of the liver using the various tracers provides unique functional information, i.e., the functional reserve, presence or absence of hepatocytes/Kupffer’s cells, and RBC pooling. This has been augmented further by the improved resolution with multi-head SPECT systems. Advances in instrumentation such as PET and development of new radiopharmaceuticals, including PET tracers specifically for the evaluation of the liver, will likely expand clinical applications further.

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References

  1. Harvey E, Loberg M, Ryan J (1979) Hepatic clearance mechanism of Tc-99m-HIDA and its effect on quantitation of hepatobiliary function: concise communication. J Nucl Med 20:310–313

    PubMed  CAS  Google Scholar 

  2. Loberg MD, Cooper M, Harvey E, et al (1976) Development of new radiopharmaceuticals based on N-substitution of iminodiacetic acid. J Nucl Med 17:633–638

    PubMed  CAS  Google Scholar 

  3. Krishnamurthy S, Krishnamurthy GT (1988) Quantitative assessment of hepatobiliary disease with Tc-99m-IDA scintigraphy. In: Freeman LM, Weissman HS (eds) Nuclear medicine annual. Raven, New York, pp 309–330

    Google Scholar 

  4. Doo E, Krishnamurthy GT, Eklem MJ, Gilbert S, Brown PH (1991) Quantification of hepatobiliary function as an integral part of imaging with technetium-99m-mebrofenin in health and disease. J Nucl Med 32:48–57

    PubMed  CAS  Google Scholar 

  5. Stadalnik RC, Vera DR, Woodle ES, Trudeau WL, Porter BA, Ward RE, Krohn KA, O’Grady LF (1985) Technetium-99m NGA functional hepatic imaging: preliminary clinical experience. J Nucl Med 26:1233–1242

    PubMed  CAS  Google Scholar 

  6. Woodle ES, Vera DR, Stadalnik RC, Ward RE (1987) Tc-NGA imaging in liver transplantation: preclinical studies. Surgery 102:55–62

    PubMed  CAS  Google Scholar 

  7. Nagasue N, Yukaya H, Ogawa Y, Kohno H, Nakamura T (1987) Human liver regeneration after major hepatic resection. A study of normal liver and livers with chronic hepatitis and cirrhosis. Ann Surg 206:30–39

    PubMed  CAS  Google Scholar 

  8. Henderson JM, Heymsfield SB, Horowitz J, Kutner MH (1981) Measurement of liver and spleen volume by computed tomography. Assessment of reproducibility and changes found following a selective distal splenorenal shunt. Radiology 141:525–527

    PubMed  CAS  Google Scholar 

  9. Imaeda T, Kanematsu M, Asada S, Seki M, Doi H, Saji S (1995) Utility of Tc-99m GSA SPECT imaging in estimation of functional volume of liver segments in health and liver diseases. Clin Nucl Med 20:322–328

    PubMed  CAS  Google Scholar 

  10. Bennink RJ, Dinant S, Erdogan D, Heijnen BH, Straatsburg IH, van Vliet AK, van Gulik TM (2004) Preoperative assessment of postoperative remnant liver function using hepatobiliary scintigraphy. J Nucl Med 45:965–971

    PubMed  Google Scholar 

  11. Erdogan D, Heijnen BH, Bennink RJ, Kok M, Dinant S, Straatsburg IH, Gouma DJ, van Gulik TM (2004) Preoperative assessment of liver function: a comparison of 99mTc-Mebrofenin scintigraphy with indocyanine green clearance test. Liver Int 24:117–123

    PubMed  CAS  Google Scholar 

  12. Stadalnik RC, Kudo M, Eckelman WC, Vera DR (1993) In vivo functional imaging using receptor-binding radio-pharmaceuticals. Technetium 99m-galactosyl-neoglycoalbumin as a model. Invest Radiol 28:64–70

    PubMed  CAS  Google Scholar 

  13. Kudo M, Todo A, Ikekubo K, Yamamoto K, Vera DR, Stadalnik RC (1993) Quantitative assessment of hepatocellular function through in vivo radioreceptor imaging with technetium 99m galactosyl human serum albumin. Hepatology 17:814–819

    PubMed  CAS  Google Scholar 

  14. Hwang EH, Taki J, Shuke N, Nakajima K, Kinuya S, Konishi S, Michigishi T, Aburano T, Tonami N (1999) Preoperative assessment of residual hepatic functional reserve using 99mTc-DTPA-galactosyl-human serum albumin dynamic SPECT. J Nucl Med 40:1644–1651

    PubMed  CAS  Google Scholar 

  15. Sasaki N, Hobo S, Yoshihara T (1999) Clinical usefulness of scintigraphy with 99mTc-galactosyl-human serum albumin for prognosis of cirrhosis of the liver. J Nucl Med 40:1652–1656

    PubMed  CAS  Google Scholar 

  16. Nishiyama Y, Yamamoto Y, Hino I, Satoh K, Wakabayashi H, Ohkawa M (2003) 99mTc galactosyl human serum albumin liver dynamic SPET for pre-operative assessment of hepatectomy in relation to percutaneous transhepatic portal embolization. Nucl Med Commun 24:809–817

    PubMed  CAS  Google Scholar 

  17. Kwon AH, Matsui Y, Kaibori M, Kamiyama Y (2004) Functional hepatic regeneration following hepatectomy using galactosyl-human serum albumin liver scintigraphy. Transplant Proc 36:2257–2260

    PubMed  Google Scholar 

  18. Hirai I, Kimura W, Fuse A, Suto K, Urayama M (2003) Evaluation of preoperative portal embolization for safe hepatectomy, with special reference to assessment of nonembolized lobe function with 99mTc-GSA SPECT scintigraphy. Surgery 133:495–506

    PubMed  Google Scholar 

  19. Kira T, Tomiguchi S, Kira M, Ohyama Y, Takahashi M (1997) Quantitative evaluation of the hepatic functional reserve using technetium-99m DTPA-galactosyl human serum albumin before and after transjugular intrahepatic portosystemic shunt. Eur J Nucl Med 24:1268–1272

    PubMed  CAS  Google Scholar 

  20. Miki K, Kubota K, Kokudo N, Inoue Y, Bandai Y, Makuuchi M (1997) Asialoglycoprotein receptor and hepatic blood flow using technetium-99m-DTPA-galactosyl human serum albumin. J Nucl Med 38:1798–1807

    PubMed  CAS  Google Scholar 

  21. Koizumi K, Uchiyama G, Arai T, Ainoda T, Yoda Y (1992) A new liver functional study using Tc-99m DTPA-galactosyl human serum albumin: evaluation of the validity of several functional parameters. Ann Nucl Med 6:83–87

    PubMed  CAS  Google Scholar 

  22. Mitsumori A, Nagaya I, Kimoto S, Akaki S, Togami I, Takeda Y, Joja I, Hiraki Y (1998) Preoperative evaluation of hepatic functional reserve following hepatectomy by technetium-99m galactosyl human serum albumin liver scintigraphy and computed tomography. Eur J Nucl Med 25:1377–1382

    PubMed  CAS  Google Scholar 

  23. Fujimoto H, Uchiyama G, Araki T, et al (1991) Exophytic regenerating nodule of the liver: misleading appearance on iodized-oil CT. J Comput Assist Tomogr 15:495–497

    PubMed  CAS  Google Scholar 

  24. Calvet X, Pons F, Bruix J, et al (1988) Technetium-99m DIS-IDA hepatobiliary agent in diagnosis of hepatocellular carcinoma: relationship between detectability and tumor differentiation. J Nucl Med 29:1916–1920

    PubMed  CAS  Google Scholar 

  25. Hasegawa Y, Nakano S, Hiyama T, et al (1991) Relationship of uptake of technetium-99m(Sn)-N-pyridoxyl-5-methyl-tryptophan by hepatocellular carcinoma to prognosis. J Nucl Med 32:228–235

    PubMed  CAS  Google Scholar 

  26. Boulahdour H, Cherqui D, Charlotte F, et al (1993) The hot spot hepatobiliary scan in focal nodular hyperplasia. J Nucl Med 34:2105–2110

    PubMed  CAS  Google Scholar 

  27. Kotzerke J, Schwarzrock R, Krischek O, et al (1989) Technetium-99m DISIDA hepatobiliary agent in diagnosis of hepatocellular carcinoma, adenoma, and focal nodular hyperplasia (letter). J Nucl Med 30:1278–1280

    PubMed  CAS  Google Scholar 

  28. Barwick KW, Rosai J (1996) Liver (non-neoplastic disease). In: Rosai J (ed) Ackerman’s surgical pathology. Mos-by-Year Book, St Louis, pp 857–942

    Google Scholar 

  29. Brant WE, Floyd JL, Jackson DE, et al (1987) The radiological evaluation of hepatic cavernous hemangioma. JAMA 257:2471–2474

    PubMed  CAS  Google Scholar 

  30. Ziessman HA, Silverman PM, Patterson J, et al (1991) Improved detection of small cavernous hemangiomas of the liver with high-resolution three-headed SPECT. J Nucl Med 32:2086–2091

    PubMed  CAS  Google Scholar 

  31. Kudo M, Ikekubo K, Yamamoto K, et al (1989) Distinction between hemangioma of the liver and hepatocellular carcinoma: value of labeled RBC-SPECT scanning. AJR 152: 977–983

    PubMed  CAS  Google Scholar 

  32. Langsteger W, Lind P, Eber B, et al (1989) Diagnosis of hepatic hemangioma with 99mTc-labeled red cells: single photon emission computed tomography (SPECT) versus planar imaging. Liver 9:288–293

    PubMed  CAS  Google Scholar 

  33. Farlow DC, Chapman PR, Gruenewald SM, et al (1990) Investigation of focal hepatic lesions: is tomographic red blood cell imaging useful? World J Surg 14:463–467

    PubMed  CAS  Google Scholar 

  34. Krause T, Hauenstein K, Studier-Fischer B, et al (1993) Improved evaluation of technetium-99m-red blood cell SPECT in hemangioma of the liver. J Nucl Med 34:375–380

    PubMed  CAS  Google Scholar 

  35. Bonanno N, Baldari S, Cerrito A, et al (1991) Diagnosis of hepatic hemangiomas with 99mTc-labeled red blood cell scanning: value of SPECT. J Nucl Biol Med 35:135–140

    PubMed  CAS  Google Scholar 

  36. Moon DH, Lee MH, Yang SK, et al (1992) Diagnosis of hepatic hemangioma (HH) with triple-head (3H) high-resolution SPECT. J Nucl Med 33:918 (abstract)

    Google Scholar 

  37. Birnbaum BA, Weinreb JC, Megibow AJ, et al (1990) Definitive diagnosis of hepatic hemangiomas: MR imaging versus Tc-99m-labeled red blood cell SPECT. Radiology 176:95–101

    PubMed  CAS  Google Scholar 

  38. Kim CK (1998) Scintigraphic evaluation of the liver and biliary tract. In: Gazelle SG, Saini S, Mueller PR (eds) Hepatobiliary and pancreatic radiology: imaging and interventions. Thieme, New York, pp 108–153

    Google Scholar 

  39. Siegel A, Mazurek R (1997) Early dynamic SPECT acquisition for the imaging of hepatic hemangiomas utilizing Tc-99m-labeled red blood cells. Clin Nucl Med 22:745–748

    PubMed  CAS  Google Scholar 

  40. Rabinowitz SA, McKusick KA, Strauss HW (1984) Technetium-99m red blood cell scintigraphy in evaluating focal liver lesions. AJR 143:63–68

    PubMed  CAS  Google Scholar 

  41. Ginsberg F, Stavin JD, Spencer RP (1986) Hepatic angiosarcoma: mimicking of hemangioma on three-phase technetium-99m red blood cell scintigraphy. J Nucl Med 27:1861–1863

    PubMed  CAS  Google Scholar 

  42. Swayne LC, Diehl WL, Brown TD, et al (1991) False-positive hepatic blood pool scintigraphy in metastatic colon carcinoma. Clin Nucl Med 16:630–632

    PubMed  CAS  Google Scholar 

  43. Hod N, Pour MC, Juven Y, Horne T (2004) “Positive” Tc-99m red blood cell scintigraphy in a patient with hepatic lymphoma. Clin Nucl Med 29:272–274

    PubMed  Google Scholar 

  44. Solomon RW, Palestro C, Kim CK, et al. (1989) Tc-99m-labeled red blood cell scintigraphy for hepatic hemangioma: are flow and early blood pool phases necessary? Clin Nucl Med 14:232 (abstract)

    Google Scholar 

  45. Zheng JG, Yao ZM, Shu CY, Zhang Y, Zhang X (2005) Role of SPECT/CT in diagnosis of hepatic hemangiomas. World J Gastroenterol 11:5336–5341

    PubMed  Google Scholar 

  46. Schillaci O, Danieli R, Manni C, Capoccetti F, Simonetti G (2004) Technetium-99m-labelled red blood cell imaging in the diagnosis of hepatic haemangiomas: the role of SPECT/CT with a hybrid camera. Eur J Nucl Med Mol Imaging 31:1011–1015

    PubMed  Google Scholar 

  47. Tanasescu D, Brachman M, Rigby J, et al (1984) Scintigraphic triad in focal nodular hyperplasia. Am J Gastroenterol 79:61–64

    PubMed  CAS  Google Scholar 

  48. Rogers JV, Mack LA, Freeny PC, et al (1981) Hepatic focal nodular hyperplasia: angiography, CT, sonography, and scintigraphy. AJR 137:983–990

    PubMed  CAS  Google Scholar 

  49. Welch TJ, Sheedy PF Jr, Johnson CM, et al (1985) Focal nodular hyperplasia and hepatic adenoma: comparison of angiography, CT, US, and scintigraphy. Radiology 156: 593–595

    PubMed  CAS  Google Scholar 

  50. Salvo AF, Schiller A, Athanasoulis C, et al (1977) Hepatoadenoma and focal nodular hyperplasia; pitfalls in radio-colloid imaging. Radiology 125:451–455

    PubMed  CAS  Google Scholar 

  51. Lubbers PR, Ros PR, Goodman ZD, et al (1987) Accumulation of technetium-99m sulfur colloid by hepatocellular adenoma: scintigraphic-pathologic correlation. AJR 148: 1105–1108

    PubMed  CAS  Google Scholar 

  52. Schein CJ (1972) Acute cholecystitis. Harper and Row, New York, p 40

    Google Scholar 

  53. Sjodahl R, Wetterfors J (1974) Lysolecithin and lecithin in the gall bladder wall and bile; their possible roles in the pathogenesis of acute cholecystitis. Scand J Gastroenterol 9:519–525

    PubMed  CAS  Google Scholar 

  54. Truedson H, Elmros T, Holm S (1983) The incidence of bacteria in gall bladder bile at acute and elective cholecystectomy. Acta Chir Scand 149:307–313

    PubMed  CAS  Google Scholar 

  55. Jivegard L, Thornell E, Svanvik J (1987) Pathophysiology of acute obstructive cholecystitis: implications for non-operative management. Br J Surg 74:1084–1086

    PubMed  CAS  Google Scholar 

  56. Jivegard L, Thornell E, Bjorck S, Svanvik J (1985) The effects of morphine and enkephaline on gall bladder function in experimental cholecystitis. Inhibition of inflammatory gall bladder secretion. Scand J Gastroenterol 20:1049–1056

    PubMed  CAS  Google Scholar 

  57. Greenberger NJ, Isselbacher KJ (1991) Diseases of the gallbladder and bile ducts. In: Wilson JD, Braunwald E, Isselbacher KJ, et al (eds) Harrison’s principles of internal medicine, 12th edn. McGraw-Hill, New York, pp 1358–1368

    Google Scholar 

  58. Freitas JE (1994) Cholescintigraphy. In: Murray IPC, Ell PJ (eds) Nuclear medicine in clinical diagnosis and treatment. Churchill Livingstone, London, pp 77–86

    Google Scholar 

  59. Cotran RS, Kumar V, Robbins SL (1989) Pathologic basis of disease. Saunders, Philadelphia, p 971

    Google Scholar 

  60. Shea JA, Berlin JA, Escarce JJ, et al (1994) Revised estimates of diagnostic test sensitivity and specificity in suspected biliary tract disease. Arch Intern Med 154:2573–2581

    PubMed  CAS  Google Scholar 

  61. Weissmann HS, Badia J, Sugarman LA, et al (1981) Spectrum of 99m-Tc-IDA cholescintigraphic patterns in acute cholecystitis. Radiology 138:167–175

    PubMed  CAS  Google Scholar 

  62. Drane WE, Nelp WB, Rudd TG (1984) The need for routine delayed radionuclide hepatobiliary imaging in patients with intercurrent disease. Radiology 151:763–769

    PubMed  CAS  Google Scholar 

  63. Choy D, Shi EC, McLean RG, et al (1984) Cholescintigraphy in acute cholecystitis: use of intravenous morphine. Radiology 151:203–207

    PubMed  CAS  Google Scholar 

  64. Fink-Bennett D (1991) Augmented cholescintigraphy: its role in detecting acute and chronic disorders of the hepatobiliary tree. Semin Nucl Med 21:128–139

    PubMed  CAS  Google Scholar 

  65. Weissmann HS, Freeman LM (1984) The biliary tract. In: Freeman LM (ed): Freeman and Johnson’s clinical radio-nuclide imaging. Grune and Stratton, Orlando, pp 879–1049

    Google Scholar 

  66. Kalimi R, Gecelter GR, Caplin D, Brickman M, Tronco GT, Love C, Yao J, Simms HH, Marini CP (2001) Diagnosis of acute cholecystitis: sensitivity of sonography, cholescintigraphy, and combined sonography-cholescintigraphy. J Am Coll Surg 193:609–613

    PubMed  CAS  Google Scholar 

  67. Alobaidi M, Gupta R, Jafri SZ, Fink-Bennet DM (2004) Current trends in imaging evaluation of acute cholecystitis. Emerg Radiol 10:256–258

    PubMed  Google Scholar 

  68. Torsoli A, Corazziari E, Habib FI, Cicala M (1990) Pressure relationships within the human bile tract. Normal and abnormal physiology. Scand J Gastroenterol [Suppl] 175: 52–57

    CAS  Google Scholar 

  69. Murphy P, Solomon J, Roseman DL (1980) Narcotic anesthetic drugs: their effect on biliary dynamics. Arch Surg 115:710–711

    PubMed  CAS  Google Scholar 

  70. Dedrick DF, Tanner WW, Bushkin FL (1980) Commonbile duct pressure during enflurane anesthesia: effects of morphine and subsequent naloxone.Arch Surg 115:820–821

    PubMed  CAS  Google Scholar 

  71. Kistler AM, Ziessman HA, Gooch D, et al (1991) Morphine-augmented cholescintigraphy in acute cholecystitis: a satisfactory alternative to delayed imaging. Clin Nucl Med 16:404–406

    PubMed  CAS  Google Scholar 

  72. Fink-Benett D, Balon H, Robins T, et al (1991) Morphineaugmented cholescintigraphy: its efficacy in detecting acute cholecystitis. J Nucl Med 32:1231–1233

    Google Scholar 

  73. Vasquez TE, Greenspan G, Evans DG, et al (1988) Clinical efficacy of intravenous morphine administration in hepatobiliary imaging for acute cholecystitis. Clin Nucl Med 13:4–6

    PubMed  CAS  Google Scholar 

  74. Fink-Bennett D, Balon HR (1993) The role of morphineaugmented cholescintigraphy in the detection of acute cholecystitis. Clin Nucl Med. 18:891–897

    PubMed  CAS  Google Scholar 

  75. Ziessman HA (1992) Scintigraphy in the gastrointestinal tract. Curr Opin Radiol 4:105–116

    PubMed  CAS  Google Scholar 

  76. Kim EE, Pjura G, Lowery P, et al (1986) Morphine-augmented cholescintigraphy in the diagnosis of acute cholecystitis. AJR 147:1177–1179

    PubMed  CAS  Google Scholar 

  77. Keslar PJ, Turbiner E (1987) Hepatobiliary imaging and the use of intravenous morphine. Clin Nucl Med 12: 592–596

    PubMed  CAS  Google Scholar 

  78. Flancbaum L, Choban PS, Sinha R, Jonasson O (1994) Morphine cholescintigraphy in the evaluation of hospitalized patients with suspected acute cholecystitis. Ann Surg 220:25–31

    PubMed  CAS  Google Scholar 

  79. Kim CK, Juweid M, Woda A, et al (1993) Hepatobiliary scintigraphy: morphine-augmented versus delayed imaging in patients with suspected acute cholecystitis. J Nucl Med 34:506–509

    PubMed  CAS  Google Scholar 

  80. Kim CK, Tse KM, Juweid M, et al (1993) Cholescintigraphy in the diagnosis of acute cholecystitis: morphine-augmentation is superior to delayed imaging. J Nucl Med 34:1866–1870

    PubMed  CAS  Google Scholar 

  81. Cabana MD, Alavi A, Berlin JA, et al (1995) Morphine-augmented hepatobiliary scintigraphy: a meta-analysis. Nucl Med Commun 16:1068–1071

    PubMed  CAS  Google Scholar 

  82. Fig LM, Wahl RL, Stewart RE, et al (1990) Morphine-augmented hepatobiliary scintigraphy in the severely ill: caution is in order. Radiology 175:467–473

    PubMed  CAS  Google Scholar 

  83. Klingensmith WC III, Turner WM (1990) Cholescintigraphy for acute cholecystitis: false-positive results caused by chronic cholecystitis. Gastrointest Radiol 15:129–132

    PubMed  Google Scholar 

  84. Carballo R, Worsch L, Bushnell D, et al (1992) Results of cholescintigraphy in a VA hospital. J Surg Res 53:4–6

    PubMed  CAS  Google Scholar 

  85. Freeman LM, Sugarman LA, Weissmann HS (1981) Role of cholecystokinetic agents in 99mTc-IDA cholescintigraphy. Semin Nucl Med 11:186–193

    PubMed  CAS  Google Scholar 

  86. Eikman EA, Cameron JL, Colman M, et al (1975) A test for patency of the cystic duct in acute cholecystitis. Ann Intern Med 82:318–322

    PubMed  CAS  Google Scholar 

  87. Kim CK, Palestro CJ, Solomon RW, et al (1990) Delayed biliary-to-bowel transit in cholescintigraphy after cholecystokinin treatment. Radiology 176:553–556

    PubMed  CAS  Google Scholar 

  88. Larsen MJ, Klingensmith WC, Kuni CC (1982) Radionuclide hepatobiliary imaging: nonvisualization of the gallbladder secondary to prolonged fasting. J Nucl Med 23: 1003–1005

    PubMed  CAS  Google Scholar 

  89. Shuman WP, Gibbs P, Rudd TG, et al (1982) PIPIDA scintigraphy for cholecystitis: false positives in alcoholism and total parenteral nutrition. AJR 138:1–5

    PubMed  CAS  Google Scholar 

  90. Krishnamurthy S, Krishnamurthy GT (1996) Cholecystokinin and morphine pharmacological intervention during 99mTc-HIDA cholescintigraphy: a rational approach. Semin Nucl Med 26:16–24

    PubMed  CAS  Google Scholar 

  91. Chen CC, Holder LE, Maunoury C, et al (1997) Morphine augmentation increases gall bladder visualization in patients pretreated with cholecystokinin. J Nucl Med 38: 644–647

    PubMed  CAS  Google Scholar 

  92. Kim CK, Goyal M, San Pedro E, et al (1995) The effect of CCK pretreatment on gall bladder visualization on delayed or morphine-augmented imaging (abstract). J Nucl Med 36:74

    CAS  Google Scholar 

  93. Klingensmith WC, Spitzer VM, Fritzberg AR (1981) The normal fasting and postprandial Tc-99m-diisopropyl-IDA hepatobiliary study. J Nucl Med 22:7

    Google Scholar 

  94. Freitas JE (9182) Cholescintigraphy in acute and chronic cholecystitis. Semin Nucl Med 12:18–26

    Google Scholar 

  95. Keller IA, Weissmann HS, Kaplun LL, et al (1984) The use of water ingestion to distinguish the gall bladder and duodenum on cholescintigrams. Radiology 152:811–813

    PubMed  CAS  Google Scholar 

  96. Coleman RE, Freitas JE, Fink-Bennett D, Bree RL (1984) The dilated cystic duct sign—a potential cause of falsenegative cholescintigraphy. Clin Nucl Med 9:134–136

    PubMed  CAS  Google Scholar 

  97. Holbrook RF, Jacobson FL, Pezzuti RT, et al (1991) Biliary patency imaging after endoscopic retrograde sphincterotomy with gall bladder in situ. Clinical impact of nonvisualization. Arch Surg 126:738–741

    PubMed  CAS  Google Scholar 

  98. Chandramouli B, Gupta SM, Cohen GE (1994) Scintigraphic evaluation of bile dynamics before and after endoscopic sphincterotomy. Clin Nucl Med 19:800–802

    PubMed  CAS  Google Scholar 

  99. Jacobson AF, Teefey SA, Lee SP, et al (1993) Frequent occurrence of new hepatobiliary abnormalities after bone marrow transplantation: results of a prospective study using scintigraphy and sonography. Am J Gastroenterol 88:1044–1049

    PubMed  CAS  Google Scholar 

  100. Klingensmith WC (1988) Hepatobiliary imaging: normal appearance and normal variations. In: Gottschalk A, Hoffer PB, Potchen J (eds) Diagnostic nuclear medicine. Williams and Wilkins, Baltimore, pp 575–581

    Google Scholar 

  101. Blue PW (1985) Biliary scanning interpretations using technetium-99m DISIDA. Clin Nucl Med 10:742–751

    PubMed  CAS  Google Scholar 

  102. Lee SO, Kim CK, Palestro CJ, et al (1991) Is CCK necessary to separate normal from CBD obstruction when prompt gall bladder filling but no bowel activity is seen during cholescintigraphy (abstract)? J Nucl Med 32:976

    Google Scholar 

  103. Oates E, Achong DM (1992) Incidence and significance of enterogastric reflux during morphine-augmented cholescintigraphy. Clin Nucl Med 17:926–928

    PubMed  CAS  Google Scholar 

  104. Shih WJ, Lee JK, Magoun S, et al (1995) Morphine-augmented cholescintigraphy enhances duodenogastric reflux. Ann Nucl Med 9:225–228

    PubMed  CAS  Google Scholar 

  105. Kim CK, Lim JK, Machac J (1996) Variable bile retention on cholescintigraphy after morphine administration. Eur J Nucl Med 23:1464–1467

    PubMed  CAS  Google Scholar 

  106. Kim CK, Yun M, Lim JK, Lin X, Krynyckyi BR, Machac J (2000) Refinement of the positive-predictive value of gallbladder non-visualization after morphine administration for acute cholecystitis based on the temporal pattern of common bile duct activity. Clin Nucl Med 25:603–607

    PubMed  CAS  Google Scholar 

  107. Colletti PM, Cirimelli KM, Radin DR, et al (1989) Radionuclide angiography in suspected acute cholecystitis: further observations. Clin Nucl Med 14:867–873

    PubMed  CAS  Google Scholar 

  108. Swayne LC, Ginsberg HN (1989) Diagnosis of acute cholecystitis by cholescintigraphy: significance of pericholecystic hepatic uptake. AJR 152:1211–1213

    PubMed  CAS  Google Scholar 

  109. Meekin GK, Ziessman HA, Klappenbach RS (1987) Prognostic value and pathophysiologic significance of the rim sign in cholescintigraphy. J Nucl Med 28:1679–1682

    PubMed  CAS  Google Scholar 

  110. Aburano T, Yokoyama K, Taniguchi M, et al (1990) Diagnostic values of gall bladder hyperperfusion and the rim sign in radionuclide angiography and hepatobiliary imaging. Gastrointest Radiol 15:229–232

    PubMed  CAS  Google Scholar 

  111. Bohdiewicz PJ (1993) The diagnostic value of grading hyperperfusion and the rim sign in cholescintigraphy. Clin Nucl Med 18:867–871

    PubMed  CAS  Google Scholar 

  112. Brachman MB, Goodman MD, Waxman AD (1993) The rim sign in acute cholecystitis. Comparison of radionuclide, surgical, and pathologic findings. Clin Nucl Med 18:863–866

    PubMed  CAS  Google Scholar 

  113. Oates E, Selland DL, Chin CT, Achong DM (1996) Gallbladder nonvisualization with pericholecystic rim sign: morphine-augmentation optimizes diagnosis of acute cholecystitis. J Nucl Med 37:267–269

    PubMed  CAS  Google Scholar 

  114. Nahrwold DL (1991) Chronic cholecystitis and cholelithiasis. In: Sabiston DC (ed) Textbook of surgery, 14th edn. Saunders, Philadelphia, pp 1057–1063

    Google Scholar 

  115. Hopman WP, Jansen JB, Rosenbusch G, Lamers CB (1986) Gall bladder contraction induced by cholecystokinin: bolus injection or infusion? Br Med J 292:375–376

    CAS  Google Scholar 

  116. Courtney DF, Clanachan AS, Scott GW (1983) Cholecystokinin constricts the canine cystic duct. Gastroenterology 85:1154–1159

    PubMed  CAS  Google Scholar 

  117. Fink-Bennett D, DeRidder P, Kolozsi WZ, et al (1991) Cholecystokinin cholescintigraphy: detection of abnormal gall bladder motor function in patients with chronic acalculous gall bladder disease. J Nucl Med 32:1695–1699

    PubMed  CAS  Google Scholar 

  118. Halverson JD, Garner BA, Siegel BA, et al (1992) The use of hepatobiliary scintigraphy in patients with acalculous biliary colic. Arch Intern Med 152:1305–1307

    PubMed  CAS  Google Scholar 

  119. Reed DN Jr, Fernandez M, Hicks RD (1993) Kinevac-assisted cholescintigraphy as an accurate predictor of chronic acalculous gall bladder disease and the likelihood of symptom relief with cholecystectomy. Am Surg 5: 273–277

    Google Scholar 

  120. Pickleman J, Peiss RL, Henkin R, et al (1985) The role of sincalide cholescintigraphy in the evaluation of patients with acalculus gall bladder disease. Arch Surg 120:693–697

    PubMed  CAS  Google Scholar 

  121. Zech ER, Simmons LB, Kendrick RR, et al (1991) Cholecystokinin enhanced hepatobiliary scanning with ejection fraction calculation as an indicator of disease of the gall bladder. Surg Gynecol Obstet 17:21–24

    Google Scholar 

  122. Ziessman HA, Fahey FH, Hixson DJ (1992) Calculation of a gall bladder ejection fraction: advantage of continuous sincalide infusion over the three-minute infusion method. J Nucl Med 33:537–541

    PubMed  CAS  Google Scholar 

  123. Kim CK, Worsley DF, Machac J (1996) Interventions in gastrointerventional nuclear medicine. In: Freeman LM (ed) Nuclear medicine annual. Raven, New York pp 213–257

    Google Scholar 

  124. Ziessman HA, Muenz LR, Agarwal AK, ZaZa AA (2001) Normal values for sincalide cholescintigraphy: comparison of two methods. Radiology 221:404–410

    PubMed  CAS  Google Scholar 

  125. Krishnamurthy GT, Krishnamurthy S, Brown PH (2004) Constancy and variability of gall bladder ejection fraction: impact on diagnosis and therapy. J Nucl Med 45:1872–1877

    PubMed  Google Scholar 

  126. Yap L, Wycherley AG, Morphett AD, et al (1991) Acalculous biliary pain: cholecystectomy alleviates symptoms in patients with abnormal cholescintigraphy. Gastroenterology 101:786–793

    PubMed  CAS  Google Scholar 

  127. Raymond F, Lepanto L, Rosenthall L, et al (1988) Tc-99m-IDA gall bladder kinetics and response to CCK in chronic cholecystitis. Eur J Nucl Med 14:378–381

    PubMed  CAS  Google Scholar 

  128. Watson A, Better N, Kalff V, et al (1994) Cholecystokinin (CCK)-HIDA scintigraphy in patients with suspected gall-bladder dysfunction. Austr Radiol 38:30–33

    CAS  Google Scholar 

  129. Ryu JS, Moon DH, Lee MH, Lee SK, Kim MH, Min YI (1993) Gallbladder emptying in normal healthy volunteers (abstract). J Nucl Med 34:76P

    Google Scholar 

  130. Ziessman HA, Jones DA, Muenz LR, Agarval AK (2003) Cholecystokinin cholescintigraphy: methodology and normal values using a lactose-free fatty-meal food supplement. J Nucl Med 44:1263–1266

    PubMed  Google Scholar 

  131. Hadigan C, Fishman SJ, Connolly LP, Treves ST, Nurko S (2003) Stimulation with fatty meal (Lipomul) to assess gall bladder emptying in children with chronic acalculous cholecystitis. J Pediatr Gastroenterol Nutr 37:178–182

    PubMed  Google Scholar 

  132. Krishnamurthy GT, Brown PH (2002) Comparison of fatty meal and intravenous cholecystokinin infusion for gall bladder ejection fraction. J Nucl Med 43:1603–1610

    PubMed  CAS  Google Scholar 

  133. Fisher RS, Rock E, Malmud LS (1987) Effects of meal composition on gallbladder and gastric emptying in man. Dig Dis Sci 32:337–344

    Google Scholar 

  134. Maton PN, Selden AC, Fitzpatrick ML, Chadwick VS (1985) Defective gallbladder emptying and cholecystokinin release in celiac disease: reversal by gluten-free diet Gastroenterology 88:391–396

    PubMed  CAS  Google Scholar 

  135. Masclee AA, Jansen JB, Corstens FHM, Lamers CBHW (1989) Reversible gallbladder dysfunction in severe pancreatic insufficiency. Gut 30:866–872

    PubMed  CAS  Google Scholar 

  136. Masclee AA, Jansen JB, Driessen WM, Geuskens LM, Lamers CB (1991) Gallbladder sensitivity to cholecystokinin in coeliac disease. Coirelation of gallbladder contraction with plasma cholecystokinin-like immunoreactivity during infusion of cerulein. Scand J Gastroenterol 26:1279–1284

    PubMed  CAS  Google Scholar 

  137. Oster-Jorgensen E, Qvist N, Pedersen SA, Rasmussen L, Hovendal CP (1992) Postprandial gallbladder emptying is related to intestinal motility at the time of mealingestion. Scand J Gastroenterol 27:699–702

    PubMed  CAS  Google Scholar 

  138. Kloiber R, Molnar CP, Shaffer EA (1992) Chronic biliary-type pain in the absence of gallstones: the value of cholecystokinin cholescintigraphy. AJR 159:509–513

    PubMed  CAS  Google Scholar 

  139. Brugge WR (1991) Motor function of the gallbladder: measurement and clinical significance. Semin Roentgenol 16:226–231

    Google Scholar 

  140. Weedon D (1984) Pathology of the gall bladder. Masson, New York

    Google Scholar 

  141. Cozzolino HJ, Goldstein F, Greening RR, et al (1963) The cystic duct syndrome. JAMA 185:100–104

    Google Scholar 

  142. Baxter JN, Grime JS, Critchley M, et al (1984) Gallbladder emptying. Nucl Med Commun 5:477–478

    PubMed  CAS  Google Scholar 

  143. Bolen G, Javitt NB (1982) Biliary dyskinesia: mechanisms and management. Hosp Pract 17:115–130

    CAS  Google Scholar 

  144. Robbins SL, Cotran RS, Kumar V (1984) Pathologic basis of disease, 3rd edn. Saunders, Philadelphia

    Google Scholar 

  145. Misra DC Jr, Blossom GB, Fink-Bennett D, et al (1991) Results of surgical therapy for biliary dyskinesia. Arch Surg 126:957–960

    PubMed  Google Scholar 

  146. Smith A, Chapman C, Cunningham P (1995) The utility of the CCK DISIDA scan in the treatment of occult biliary tract disease. Am Surg 6:220–225

    Google Scholar 

  147. Westlake PJ, Hershfield NB, Kelly JK, et al (1990) Chronic right upper quadrant pain without gallstones: does HIDA scan predict outcome after cholecystectomy? Am J Gastroenterol 85:986–990

    PubMed  CAS  Google Scholar 

  148. DeCamp JR, Tabatowski K, Schauwecker DS, et al (1992) Comparison of gall bladder ejection fraction with histopathologic changes in acalculous biliary disease. Clin Nucl Med 17:784–786

    Google Scholar 

  149. Patel NA, Lamb JJ, Hogle NJ, Fowler DL (2004) Therapeutic efficacy of laparoscopic cholecystectomy in the treatment of biliary dyskinesia. Am J Surg 187:209–212

    PubMed  Google Scholar 

  150. Sorenson MK, Fancher S, Lang NP, et al (1993) Abnormal gall bladder nuclear ejection fraction predicts success of cholecystectomy in patients with biliary dyskinesia. Am J Surg 166:672–674

    PubMed  CAS  Google Scholar 

  151. Middleton GW, Williams JH (1993) Is gall bladder ejection fraction a reliable predictor of acalculous gall bladder disease? Nucl Med Commun 14:509–510

    Google Scholar 

  152. Majeski J (2003) Gall bladder ejection fraction: an accurate evaluation of symptomatic acalculous gall bladder disease. Int Surg 88:95–99

    PubMed  Google Scholar 

  153. Campbell BT, Narasimhan NP, Golladay ES, Hirschl RB (2004) Biliary dyskinesia: a potentially unrecognized cause of abdominal pain in children. Pediatr Surg Int 20:579–581

    PubMed  Google Scholar 

  154. Nora PF, Davis RP, Fernandez MJ (1984) Chronic calculous gall bladder disease: a clinical enigma. World J Surg 8:106–112

    PubMed  CAS  Google Scholar 

  155. Davis GB, Berk RN, Scheible FW, et al (1982) Cholecystokinin cholecystography, sonography, and scintigraphy: detection of chronic acalculous cholecystitis. AJR 139:1117–1121

    PubMed  CAS  Google Scholar 

  156. Garrigues V, Ponce J, Cano C, et al (1992) Effect of selective and nonselective muscarinic blockade on cholecystokinin-induced gall bladder emptying in man. Dig Dis Sci 37:101–104

    PubMed  CAS  Google Scholar 

  157. Zhu XF, Harris AG, Yang MF, et al (1994) Effect of octreotide on dynamic excretion of bile in Chinese acromegalic patients assessed by [99mTc]EHIDA hepatobiliary scan. Dig Dis Sci 39:284–288

    PubMed  CAS  Google Scholar 

  158. Grimaldi C, Darcourt J, Harris AG, et al (1993) Cholescintigraphic study of effect of somatostatin analog, octreotide, on bile secretion and gall bladder emptying in normal subjects. Dig Dis Sci 38:1718–1721

    PubMed  CAS  Google Scholar 

  159. Morton JM, Bowers SP, Lucktong TA, Mattar S, Bradshaw WA, Behrns KE, Koruda MJ, Herbst CA, McCartney W, Halkar RK, Smith CD, Farrell TM (2002) Gall bladder function before and after fundoplication. J Gastrointest Surg 6:806–810

    PubMed  Google Scholar 

  160. Annese V, Caruso N, Accadia L, et al (1991) Gall bladder function and gastric liquid emptying in achalasia. Dig Dis Sci 36:1116–1120

    PubMed  CAS  Google Scholar 

  161. Pechlivanides G, Xynos E, Chrysos E, et al (1994) Gallbladder emptying after antiulcer gastric surgery. Am J Surg 168:335–339

    PubMed  CAS  Google Scholar 

  162. Steinberg WM (1988) Sphincter of Oddi dysfunction: a clinical controversy. Gastroenterology 95:1409–1415

    PubMed  CAS  Google Scholar 

  163. Bar Meir S, Halpern Z, Barden E, et al (1984) Frequency of papillary dysfunction among cholecystectomized patients. Hepatology 4:328–330

    PubMed  CAS  Google Scholar 

  164. Guelrud M (1988) Papillary stenosis. Endoscopy 20:193–202

    PubMed  Google Scholar 

  165. Hogan WJ, Geenen JE (1988) Biliary dyskinesia. Endoscopy 20:179–183

    PubMed  Google Scholar 

  166. Toouli J, Baker RA (1991) Innervation of the sphincter of Oddi: physiology and considerations of pharmacological intervention in biliary dyskinesia. Pharmacol Ther 49: 269–281

    PubMed  CAS  Google Scholar 

  167. Lans JL, Parikh NP, Geenen JE (1991) Application of sphincter of Oddi manometry in routine clinical investigations. Endoscopy 23:139–143

    PubMed  CAS  Google Scholar 

  168. Coelho JC, Wiederkehr JC (1996) Motility of Oddi’s sphincter: recent developments and clinical applications. Am J Surg 172:48–51

    PubMed  CAS  Google Scholar 

  169. Khuroo MS, Zargar SA, Yattoo GN (1992) Efficacy of nifedipine therapy in patients with sphincter of Oddi dysfunction: a prospective, double-blind, randomized, placebo-controlled, crossover trial. Br J Clin Pharmacol 33:477–485

    PubMed  CAS  Google Scholar 

  170. Elta GH, Barnett JL, Ellis JH, et al (1992) Delayed biliary drainage is common in asymptomatic post-cholecystectomy volunteers. Gastrointest Endosc 38:435–439

    PubMed  CAS  Google Scholar 

  171. King CE, Kalvaria I, Sininsky CA (1988) Pancreatitis due to endoscopic biliary manometry. Proceed with caution (abstract). Gastroenterology 94:A227

    Google Scholar 

  172. Sostre S, Kalloo AN, Spiegler EJ, et al (1992) A noninvasive test of sphincter of Oddi dysfunction in postcholecystectomy patients: the scintigraphic score. J Nucl Med 33:1216–1222

    PubMed  CAS  Google Scholar 

  173. Shaffer EA, Hershfield NB, Logan K, et al (1986) Cholescintigraphic detection of functional obstruction of the sphincter of Oddi. Effect of papillotomy. Gastroenterology 90:728–733

    PubMed  CAS  Google Scholar 

  174. Grimon G, Buffet C, Andre L, et al (1991) Biliary pain in postcholecystectomy patients without biliary obstruction. A prospective radionuclide study. Dig Dis Sci 36:317–320

    PubMed  CAS  Google Scholar 

  175. Darweesh RMA, Dodds WJ, Hogan WJ, et al (1988) Efficacy of quantitative hepatobiliary scintigraphy and fatty meal sonography for evaluating patients with partial common bile duct obstruction. Gastroenterology 94: 779–785

    PubMed  CAS  Google Scholar 

  176. Persson B, Axelsson B, Jacobsson H (1993) Cholescintigraphy in the diagnosis and assessment of benign papillary stenosis. Eur J Nucl Med 20:770–775

    PubMed  CAS  Google Scholar 

  177. Kloiber R, AuCoin R, Hershfield NB, et al (1988) Biliary obstruction after cholecystectomy: diagnosis with quantitative cholescintigraphy. Radiology 169:643–647

    PubMed  CAS  Google Scholar 

  178. Fullarton GM, Allan A, Hilditch T, et al (1988) Quantitative 99mTc-DISIDA scanning and endoscopic biliary manometry in sphincter of Oddi dysfunction. Gut 29:1397–1401

    PubMed  CAS  Google Scholar 

  179. Farup PG, Tjora S (1989) Sphincter of Oddi dysfunction: dynamic cholescintigraphy and endoscopic retrograde cholangiopancreatography with papillotomy in diagnosis, treatment and follow up study. Scand J Gastroenterol 24:956–960

    PubMed  CAS  Google Scholar 

  180. Corazziari E, Cicala M, Habib FI, et al (1994) Hepatoduodenal bile transit in cholecystectomized subjects. Relationship with sphincter of Oddi function and diagnostic value. Dig Dis Sci 39:1985–1993

    PubMed  CAS  Google Scholar 

  181. Cicala M, Habib FI, Vavassori P, Pallotta N, Schillaci O, Costamagna G, Guarino MP, Scopinaro F, Fiocca F, Torsoli A, Corazziari E (2002) Outcome of endoscopic sphincterotomy in post cholecystectomy patients with sphincter of Oddi dysfunction as predicted by manometry and quantitative choledochoscintigraphy. Gut 50:665–668

    PubMed  CAS  Google Scholar 

  182. Roberts-Thomson IC, Toouli J, Blanchett W, Lichtenstein M, Andrews JT (1986) Assessment of bile flow by radio-scintigraphy in patients with biliary-type pain after cholecystectomy. Aust NZ J Med 16:788–793

    CAS  Google Scholar 

  183. Craig AG, Peter D, Saccone GT, Ziesing P, Wycherley A, Toouli J (2003) Scintigraphy versus manometry in patients with suspected biliary sphincter of Oddi dysfunction. Gut 52:352–357

    PubMed  CAS  Google Scholar 

  184. Madácsy L, Szepes A, Bertalan V, Funch-Jensen P (2003) Is hepatobiliary scintigraphy insensitive for the diagnosis of sphincter of Oddi dysfunction? Gut 52:1385–1386

    PubMed  Google Scholar 

  185. Ziessman HA (1992) Atlas of cholescintigraphy: selective update. In: Ziessman HA, Van Nostrand D (eds) Selected atlas of gastrointestinal scintigraphy. Springer, Berlin Heidelberg New York, pp 1–34

    Google Scholar 

  186. Madacsy L, Velosy B, Lonovics J, et al (1994) Differentiation between organic stenosis and functional dyskinesia of the sphincter of Oddi with amyl nitrite-augmented quantitative hepatobiliary scintigraphy. Eur J Nucl Med 21:203–208

    PubMed  CAS  Google Scholar 

  187. Sostre S, Spiegler E, Kallo A, Camargo E (1990) Cholecystokinin-stimulated biliary scintigraphy in patients with sphincter of Oddi dysfunction (abstract). Radiology 177:322

    Google Scholar 

  188. Tanaka M, Ikeda S, Nakayama F (1984) Change in bile duct pressure responses after cholecystectomy: loss of gall bladder as a pressure reservoir. Gasteroenterology 87:1154–1159

    CAS  Google Scholar 

  189. Kalloo AN, Sostre S, Meyerrose GE, et al (1994) Gallbladder ejection fraction. Nondiagnostic for sphincter of Oddi dysfunction in patients with intact gall bladders. Clin Nucl Med 19:713–719

    PubMed  CAS  Google Scholar 

  190. Ruffolo TA, Sherman S, Lehman GA, et al (1994) Gallbladder ejection fraction and its relationship to sphincter of Oddi dysfunction. Dig Dis Sci 39:289–292

    PubMed  CAS  Google Scholar 

  191. Zeman RK, Lee C, Jaffe MH, et al (1984) Hepatobiliary scintigraphy and sonography in early biliary obstruction. Radiology 153:793–798

    PubMed  CAS  Google Scholar 

  192. Miller DR, Egbert RM, Braunstein P (1984) Comparison of ultrasound and hepatobiliary imaging in the early detection of acute total common bile duct obstruction. Arch Surg 119:1233–1237

    PubMed  CAS  Google Scholar 

  193. Kaplun L, Weissmann HS, Rosenblatt RR, et al (1985) The early diagnosis of common bile duct obstruction using cholescintigraphy. JAMA 254:2431–2434

    PubMed  CAS  Google Scholar 

  194. Klingensmith WC III, Ashdown B (1991) Cholescintigraphy in the diagnosis of intrahepatic cholestasis. How specific is it? Clin Nucl Med 16:621–626

    PubMed  Google Scholar 

  195. Krishnamurthy GT, Lieberman DA, Brar HS (1985) Detection, localization, and quantitation of degree of common bile duct obstruction by scintigraphy. J Nucl Med 26:726–735

    PubMed  CAS  Google Scholar 

  196. Itoh H, Murase K, Hamamoto K (1989) Reflux sign in cholescintigraphy after administration of a gall bladder contracting agent. J Nucl Med 30:1192–1197

    PubMed  CAS  Google Scholar 

  197. Itoh H, Shimono R, Hamamoto K (1988) Evaluation of common bile duct stenosis in chronic pancreatitis using cholescintigraphy. Eur J Nucl Med 14:137–140

    PubMed  CAS  Google Scholar 

  198. Brown PH, Juni JE, Lieberman DA, et al (1988) Hepatocyte versus biliary disease: a distinction by deconvolutional analysis of technetium-99m IDA time-activity curves. J Nucl Med 29:623–630

    PubMed  CAS  Google Scholar 

  199. Juni JE, Reichle R (1990) Measurement of hepatocellular function with deconvolutional analysis: application in the differential diagnosis of acute jaundice. Radiology 177:171–175

    PubMed  CAS  Google Scholar 

  200. Lieberman DA, Brown PH, Krishnamurthy GT (1990) Improved scintigraphic assessment of severe cholestasis with the hepatic extraction fraction. Dig Dis Sci 35:1385–1390

    PubMed  CAS  Google Scholar 

  201. Balistreri WF, Grand R, Hoomagle JH, et al (1996) Biliary atresia: current concepts and research directions. Summary of a Symposium. Hepatology 23:1682–1692

    PubMed  CAS  Google Scholar 

  202. Bezerra JA, Tiao G, Ryckman FC, et al (2002) Genetic induction of proinflammatory immunity in children with biliary atresia. Lancet 360:1653–1659

    PubMed  Google Scholar 

  203. Perlmutter DH, Shepherd RW (2002) Extrahepatic biliary atresia: a disease or a phenotype? Hepatology 35:1297–1304

    PubMed  Google Scholar 

  204. Miyano T, Fujimoto T, Ohya T, Shimomura H (1993) Current concept of the treatment of biliary atresia. World J Surg 17:332–336

    PubMed  CAS  Google Scholar 

  205. McEvoy CF, Suchy FJ (1996) Biliary tract disease in children. Pediatr Clin North Am 43:75–98

    PubMed  CAS  Google Scholar 

  206. Kasai M, Suzuki K, Ohashi E, et al (1978) Technique and results of operative management of biliary atresia. World J Surg 2:571–580

    PubMed  CAS  Google Scholar 

  207. Gerhold JP, Klingensmith WC III, Kuni CC, et al (1983) Diagnosis of biliary atresia with radionuclide hepatobiliary imaging. Radiology 146:499–504

    PubMed  CAS  Google Scholar 

  208. Spivak W, Sarkar S, Winter D, et al (1987) Diagnostic utility of hepatobiliary scintigraphy with 99mTc-DISIDA in neonatal cholestasis. J Pediatr 110:855–861

    PubMed  CAS  Google Scholar 

  209. Ben-Haim S, Seabold JE, Kao SC, et al (1995) Utility of Tc-99m mebrofenin scintigraphy in the assessment of infantile jaundice. Clin Nucl Med 20:153–163

    PubMed  CAS  Google Scholar 

  210. Cox KL, Stadalnik RC, McGahan JP, et al (1987) Hepatobiliary scintigraphy with technetium-99m disofenin in the evaluation of neonatal cholestasis. J Pediatr Gastroenterol Nutr 6:885–891

    PubMed  CAS  Google Scholar 

  211. Howman-Giles R, Moase A, Gaskin K, Uren R (1993) Hepatobiliary scintigraphy in a pediatric population: determination of hepatic extraction fraction by deconvolution analysis. J Nucl Med 34:214–221

    PubMed  CAS  Google Scholar 

  212. Howman-Giles R, Uren R, Bernard E, Dorney S (1998) Hepatobiliary scintigraphy in infancy. J Nucl Med 39:311–319

    PubMed  CAS  Google Scholar 

  213. Majd M, Reba RC, Altman RP (1981) Effect of phenobarbital on 99mTc-IDA scintigraphy in the evaluation of neonatal jaundice. Semin Nucl Med 11:194–204

    PubMed  CAS  Google Scholar 

  214. Balistreri WF (1985) Neonatal cholestasis. J Pediatr 106:171–184

    PubMed  CAS  Google Scholar 

  215. Larrosa-Haro A, Caro-Lopez AM, Coello-Ramirez P, et al (2001) Duodenal tube test in the diagnosis of biliary atresia. J Pediatr Gastroenterol Nutr 32:311–315

    PubMed  CAS  Google Scholar 

  216. Lin WY, Liu CG, Changlai SP, et al (1997) Comparison technetium of Tc-99m disofenin cholescintigraphy with ultrasonography in the differentiation of biliary atresia from other forms of neonatal jaundice. Pediatr Surg Int 12(1):30–33

    PubMed  CAS  Google Scholar 

  217. Johnson K, Alton HM, Chapman S (1998) Evaluation of mebrofenin hepatoscintigraphy in neonatal-onset jaundice. Pediatr Radiol 28:937–941

    PubMed  CAS  Google Scholar 

  218. Thaler MM (1972) Effect of phenobarbital on hepatic transport and excretion of 131I-rose bengal in children with cholestasis. Pediatr Res 6:100–110

    PubMed  CAS  Google Scholar 

  219. Heyman S, Chapman PR (1990) The extraction ratio, initial uptake and visual grading (using 99mic DISIDA) in the differential diagnosis of neonatal hyperbilirubinemia. J Nucl Med 31:742 (abstr)

    Google Scholar 

  220. Gilmour SM, Hershkop M, Reifen R, Gilday D, Roberts EA (1997) Outcome of hepatobiliary scanning in neonatal hepatitis syndrome. J Nucl Med 38:1279–1282

    PubMed  CAS  Google Scholar 

  221. Tolia V, Kottamasu SR, Tabassum D et al (1999) The use of hepatocyte extraction fraction to evaluate neonatal cholestasis. Clin Nucl Med 24:655–659

    PubMed  CAS  Google Scholar 

  222. Kim CK, Heyman S (1994) Scintigraphic evaluation of livertransplants. In: Murray IPC, Ell PJ (eds) Nuclearmedicine in clinical diagnosis and treatment. Churchill Livingstone, London, pp 69–75

    Google Scholar 

  223. Rayter Z, Tonge C, Bennett C, et al (1991) Ultrasound and HIDA: scanning in evaluating bile leaks after cholecystectomy. Nucl Med Commun 12:197–202

    PubMed  CAS  Google Scholar 

  224. Brugge WR, Rosenberg DJ, Alavi A (1994) Diagnosis of postoperative bile leaks. Am J Gastroenterol 89:2178–2183

    PubMed  CAS  Google Scholar 

  225. Walker AT, Shapiro AW, Brooks DC, et al (1992) Bile duct disruption and biloma after laparoscopic cholecystectomy: imaging evaluation. AJR 158:785–789

    PubMed  CAS  Google Scholar 

  226. Banzo I, Blanco I, Gutierrez-Mendiguchia C, Gomez-Barquin R, Quirce R, Carril JM (1998) Hepatobiliary scintigraphy for the diagnosis of bile leaks produced after T-tube removal in orthotopic liver transplantation. Nucl Med Commun 19:229–236

    PubMed  CAS  Google Scholar 

  227. Worsley DF, Kim CK (1994) Hepatic and splenic trauma. In: Murray IPC, Ell PJ (eds) Nuclear medicine in clinical diagnosis and treatment. Churchill Livingstone, London, pp 63–67

    Google Scholar 

  228. Trerotola SO, Savader SJ, Lund GB, et al (1992) Biliary tract complications following laparoscopic cholecystectomy: imaging and intervention. Radiology 184:195–200

    PubMed  CAS  Google Scholar 

  229. Peters JH, Ollila D, Nichols KE, et al (1994) Diagnosis and management of bile leaks following laparoscopic cholecystectomy. Surg Laparosc Endosc 4:163–170

    PubMed  CAS  Google Scholar 

  230. Brugge WR, Alavi A (1993) Cholescintigraphy in the diagnosis of the complications of laparoscopic cholecystectomy. Semin Ultrasound CT MR 14:368–374

    PubMed  CAS  Google Scholar 

  231. Rosenthall L, Fonseca C, Arzoumanian A, et al (1979) 99mTc-IDA hepatobiliary imaging following upper abdominal surgery. Radiology 130:735–739

    PubMed  CAS  Google Scholar 

  232. Zeman RK, Lee C, Stahl RS, et al (1982) Ultrasonography and hepatobiliary scintigraphy in the assessment of biliary-enteric anastomoses. Radiology 145:109–115

    PubMed  CAS  Google Scholar 

  233. Weissmann HS, Gliedman ML, Wilk PJ, et al (1982) Evaluation of the postoperative patient with 99mTc-IDA cholescintigraphy. Semin Nucl Med 12:27–52

    PubMed  CAS  Google Scholar 

  234. Belli G, Romano G, Monaco A, et al (1988) HIDA scan in the follow-up of biliary-enteric anastomoses. HPB Surg 1:29–32

    PubMed  CAS  Google Scholar 

  235. Aigner RM, Fueger GF, Schimpl G, Sauer H, Nicoletti R (1997) Cholescintigraphy in the evaluation of bile flow after Roux-en-Y hepatico-jejunostomy and hepatico-antrostomy in infants with choledochal cysts. Pediatr Radiol 27:850–854

    PubMed  CAS  Google Scholar 

  236. Lucas MH, Elgazzar AH, Cummings DD (1995) Positional biliary stasis: scintigraphic findings following biliary-enteric bypass surgery. J Nucl Med 36:104–106

    PubMed  CAS  Google Scholar 

  237. Isayama H, Komatsu Y, Inoue Y, Toda N, Shiratori Y, Tsujino T, Yamada H, Saitou K, Kawabe T, Omata M (2003) Preserved function of the Oddi sphincter after endoscopic papillary balloon dilation. Hepatogastroenterology 50:1787–1791

    PubMed  Google Scholar 

  238. Wickremesinghe PC, Dayrit PQ, Manfredi OL, et al (1983) Quantitative evaluation of bile diversion surgery utilizing 99mTc HIDA scintigraphy. Gastroenterology 84:354–363

    PubMed  CAS  Google Scholar 

  239. Sousa JE, Troncon LE, Andrade JI, et al (1988) Comparison between Henley jejunal interposition and Roux-en-Y anastomosis as concerns enterogastric biliary reflux levels. Ann Surg 208:597–600

    PubMed  CAS  Google Scholar 

  240. Vogel SB, Drane WE, Woodward ER (1994) Clinical and radionuclide evaluation of bile diversion by Braun enteroenterostomy: prevention and treatment of alkaline reflux gastritis. An alternative to Roux-en-Y diversion. Ann Surg 219:458–465

    PubMed  CAS  Google Scholar 

  241. Adachi S, Takeda T, Fukao K (1999) Evaluation of esophageal bile reflux after total gastrectomy by gastrointestinal and hepatobiliary dual scintigraphy. Surg Today 29:301–306

    PubMed  CAS  Google Scholar 

  242. Hashimoto N (2005) Hepatobiliary imaging after pancreaticoduodenectomy—a comparative study on Billroth I and Billroth II reconstruction. Hepatogastroenterology 52:1023–1025

    PubMed  Google Scholar 

  243. Hashimoto N, Kotoura Y, Ohyanag H (2005) Hepatobiliary scintigraphy after biliary reconstruction-Roux Y and RY-DJ. Hepatogastroenterology 52:200–202

    PubMed  Google Scholar 

  244. Rodman CA, Keeffe EB, Lieberman DA, et al (1987) Diagnosis of sclerosing cholangitis with technetium 99m-labeled iminodiacetic acid planar and single photon emission computed tomographic scintigraphy. Gastroenterology 92:777–785

    PubMed  CAS  Google Scholar 

  245. O’Brien S, Keogan M, Casey M, et al (1992) Biliary complications of cystic fibrosis. Gut 33:387–391

    PubMed  CAS  Google Scholar 

  246. Colombo C, Castellani MR, Balistreri WF, et al (1992) Scintigraphic documentation of an improvement in hepatobiliary excretory function after treatment with ursodeoxycholic acid in patients with cystic fibrosis and associated liver disease. Hepatology 15:677–684

    PubMed  CAS  Google Scholar 

  247. Dogan AS, Conway JJ, Lloyd-Till JD (1994) Hepatobiliary scintigraphy in children with cystic fibrosis and liver disease. J Nucl Med 35:432–435

    PubMed  CAS  Google Scholar 

  248. O’Connor PJ, Southern KW, Bowler IM, et al (1996) The role of hepatobiliary scintigraphy in cystic fibrosis. Hepatology 23:281–287

    PubMed  CAS  Google Scholar 

  249. Buscombe JR, Miller RF, Ell PJ (1992) Hepatobiliary scintigraphy in the diagnosis of AIDS-related sclerosing cholangitis. Nucl Med Commun 13:154–160

    PubMed  CAS  Google Scholar 

  250. Quinn D, Pocock N, Freund J, et al (1993) Radionuclide hepatobiliary scanning in patients with AIDS-related sclerosing cholangitis. Cli Nucl Med 18:417–422

    CAS  Google Scholar 

  251. Kim OH, Chung HJ, Choi BG (1995) Imaging of the choledochal cyst. Radiographics 15:69–88

    PubMed  CAS  Google Scholar 

  252. Camponovo E, Buck JL, Drane WE (1989) Scintigraphic features of choledochal cyst. J Nucl Med 30:622–628

    PubMed  CAS  Google Scholar 

  253. Kim CK (1997) Pharmacologic intervention for the diagnosis of acute cholecystitis: cholecystokinin pretreatment or morphine, or both? (Editorial) J Nucl Med 38:647–649

    PubMed  CAS  Google Scholar 

  254. Kim CK, Worsley WF, Lentle B (1998) Scintigraphic evaluation of tumors of the liver. In: Murray IPC, Ell PJ (eds) Nuclear medicine in clinical diagnosis and treatment, 2nd edn. Churchill Livingstone, London, pp 775–782

    Google Scholar 

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Kim, C.K., Krynyckyi, B.R., Machac, J. (2006). Digestive System 2: Liver and Biliary Tract. In: Elgazzar, A.H. (eds) The Pathophysiologic Basis of Nuclear Medicine. Springer, Berlin, Heidelberg . https://doi.org/10.1007/978-3-540-47953-6_17

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