Definition
Are Polymorphisms of genes encoding enzymes involved in the metabolism of carcinogens or anticarcinogens. These are predisposing gene variations with relatively low penetrance that may result in a moderate increase in the risk of specific cancers. The scientific interest in such genes (e.g. sequence alterations in genes encoding cytochrome p450, null-polymorphisms for genes encoding Glutathione S-transferase, or phenotypic alterations of the activities of N-acetyltransferases) is based on the possibility of identifying population subgroups that are at elevated risk of developing environmentally induced cancer.
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© 2008 Springer-Verlag Berlin Heidelberg New York
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(2008). Metabolic Polymorphisms. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-47648-1_3656
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DOI: https://doi.org/10.1007/978-3-540-47648-1_3656
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-36847-2
Online ISBN: 978-3-540-47648-1
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences