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Neuropeptide and Kinin Antagonists

  • Chapter
Analgesia

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 177))

Abstract

Neuropeptides and kinins are important messengers in the nervous system and—on the basis of their anatomical localisation and the effects produced when the substances themselves are administered, to animals or to human subjects—a significant number of them have been suggested to have a role in pain and inflammation. Experiments in gene deletion (knock-out or null mutant) mice and parallel experiments with pharmacological receptor antagonists in a variety of species have strengthened the evidence that a number of peptides, notably substance P and calcitonin gene-related peptide (CGRP), and the kinins have a pathophysiological role in nociception. Clinical studies with non-peptide pharmacological antagonists are now in progress to determine if blocking the action of these peptides might have utility in the treatment of pain.

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Authors and Affiliations

  1. Merck, Sharp and Dohme Research Laboratories, Terlings Park, Harlow, Essex, CM20 2QR, UK

    R. G. Hill & K. R. Oliver

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  1. R. G. Hill
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  2. K. R. Oliver
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Correspondence to R. G. Hill .

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  1. Department of Anesthesiology and Critical Care Medicine Charité — Campus Benjamin Franklin, Free University Berlin, Hindenburgdamm 30, 12200, Berlin, Germany

    Christoph Stein

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© 2006 Springer-Verlag Berlin Heidelberg

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Hill, R.G., Oliver, K.R. (2006). Neuropeptide and Kinin Antagonists. In: Stein, C. (eds) Analgesia. Handbook of Experimental Pharmacology, vol 177. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-33823-9_7

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