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Serotonin Receptor Ligands: Treatments of Acute Migraine and Cluster Headache

  • Chapter
Analgesia

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 177))

Abstract

Fuelled by the development of the serotonin 5-HT1B/1D receptor agonists, the triptans, the last 15 years has seen an explosion of interest in the treatment of acute migraine and cluster headache. Sumatriptan was the first of these agonists, and it launched a wave of therapeutic advances. These medicines are effective and safe. Triptans were developed as cranial vasoconstrictors to mimic the desirable effects of serotonin, while avoiding its side-effects. It has subsequently been shown that the triptans’major action is neuronal, with both peripheral and central trigeminal inhibitory effects, as well as actions in the thalamus and at central modulatory sites, such as the periaqueductal grey matter. Further refinements may be possible as the 5-HT1D and 5-HT1F receptor agonists are explored. Serotonin receptor pharmacology has contributed much to the better management of patients with primary headache disorders.

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Authors and Affiliations

  1. Institute of Neurology, Queen Square, London, WC1N 3BG, UK

    P. J. Goadsby

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  1. P. J. Goadsby
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  1. Department of Anesthesiology and Critical Care Medicine Charité — Campus Benjamin Franklin, Free University Berlin, Hindenburgdamm 30, 12200, Berlin, Germany

    Christoph Stein

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Goadsby, P.J. (2006). Serotonin Receptor Ligands: Treatments of Acute Migraine and Cluster Headache. In: Stein, C. (eds) Analgesia. Handbook of Experimental Pharmacology, vol 177. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-33823-9_5

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