Abstract
Of the many physiologic events that occur with senescence, perhaps the most apparent change is the universal decrement of strength and locomotor coordination. What was once a simple joy of lifting a child has now become a major, if not unrealistic task to accomplish. Such an age change is a multi-faceted phenomenon in origin, that involves not only muscle but also central and peripheral nervous systems.
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References
Alnaqeeb, M.A. and Goldspink, G. Changes in fiber type, number and diameter in developing and aging skeletal muscle. J. Anat. 153: 31–45, 1987.
Alshuaib, W.G. and Fahim, MA Effects of exercise on physiological age-related change at mouse neuromuscular junctions. NeurobioL Aging., II: 555–561, 1990.
Alshuaib, W.B. and Fahim, M.A. Depolarization reverses age-related decrease of spontaneous transmitter release. J. Appl. Physiol., ZO: 2066–2071, 1991.
Andonian, M.H. and Fahim, M.A. Effects of endurance exercise on the morphology of mouse neuromuscular junctions during aging. J. NeurocytoL, 16: 589–599, 1987.
Andonian, M.H. and Fahim, M.A. Nerve terminal morphology in C57BL/6NNia mice at different ages. J. Gerontol. 44(2): B43–51, 1989.
Anis, N.A. and Robbins, N. General and strain-specific age changes at mouse limb neuromuscular junctions. NeurobioL Aging. 8: 309–318, 1987.
Ansved, T. and Larsson, L. Quantitative and qualitative morphological properties of the soleus motor nerve and the L5 ventral root in young and old rats. Relation to the number of soleus muscle fibers. J. Neurol. Sci., 96: 269–282, 1990.
Ansved, T., Wallner, P. and Larsson, L. Spatial distribution of motor unit fibers in fast and slow-twitch rat muscles with specific reference to age. Acta Physiological Scandinavica. 143(3): 345–354, 1991.
Arabadjis, P.G., Heffner, R.R. Jr., and Prendergast, D.R. Morphologic and functional alterations in aging rat muscle. Journal of Neuropathology and Experimental Neurology. 49(6): 600–9, 1990.
Atwood, H.L. Age-dependent alterations of synaptic performance and plasticity in crustacean motor systems. Experimental Gerontology. 27(1): 51–61, 1992.
Banker, B.Q., Kelly, S.S. and Robbins, N. Neuromuscular transmission and correlative morphology in young and old mice. J. Physiol. (Lond.), 339: 355–375, 1983.
Barker, P.C.H. The aging neuromuscular system. Seminars in Neuro 9: 50–59, 1989.
Bischoff, C., Machetanz, J. and Conrad, B. Is there an age-dependent continuous increase in the duration of the motor unit action potential? Electroencephalography and Clinical Neurophysiology, 81(4): 304–311, 1991.
Brown, M. Resistance exercise effects on aging skeletal muscle in rats. Physical Therapy. 69(1): 46–53, 1989.
Cardasis, CA. Ultrastructural evidence of continued reorganization at the aging (11-26 months) rat soleus neuromuscular junction. Anat Rec., 207: 399–415, 1983.
DeLuca, C., Mambrini, M. and Conte Camerino, D. Changes in membrane ionic conductances and excitability characteristics of rat skeletal muscle during aging. Pflugers Archiv — European Journal of Physiology, 415(5): 642–644, 1990.
DeLuca, A. and Conte Camerino, D. Effects of aging on the mechanical threshold of rat skeletal muscle fibers. Pflugers Archiv — European Journal of Physiology, 420(3-4): 407–409, 1992.
Fahim, MA and Robbins, N. Ultrastructural studies of young and old mouse neuromuscular junction. J. Neurocytel., 11: 641–656, 1982.
Fahim, MA., Holley, J.A. and Robbins, N. Scanning and light microscopic study of age changes at a neuromuscular junction. J. Cell Biol., 12: 13–25, 1983.
Fahim, MA., Robbins, N. and Price, R. Fixation effects of synaptic vesicle density in neuromuscular junctions of young and old mice. NeurobioL Aging, 8: 71–75, 1987.
Fahim, M.A. Rapid neuromuscular remodelling following limb immobilization. Anat. Rec. 221: 102–109, 1989.
Frontera, W.R., Meredith, C.N., O’Reilly, K.P., Knuttgen, H.G. and Evans, W.J. Strength conditioning in older men: skeletal muscle hypertrophy and improved function. J. Appl. Physiol., 64: 1038–1044, 1988.
Grimby, G. and Saltin, B. The aging muscle. Clinical Physiol., 3: 209–218, 1983.
Grimby, G., Aniansson, A., Zetterberg., D. and Satin, B. Is there a change in relative muscle fiber composition with age? Clin. Physiol., 4: 189–194, 1984.
Grinnell, A. D. and Herrera, A.A. Specific and plasticity of neuromuscular connections; long-term regulation of motoneuron function. Pro. NeurobioL. 17: 263–282, 1981.
Härtung, V. and Asmussen, G. The influence of life span on extra and intrafusal muscle fibres in the soleus muscle of the rat. Z. Mikrosk. Anat. Forch., 102: 677–693, 1988.
Hashizume, K., Kanda, K. and Burke, R.E. Medial gastrocnemius motor nucleus in the rat age-related changes in the number and size of motoneurons. J. Comp. Neurol., 262: 425–430, 1988.
Hennig, R. and Lomo, T. Firing patterns of motor units in normal rats. Nature. 234: 164–166, 1985.
Herscovich, S. and Gershon, D. Effects of aging and physical training on the neuromuscular junction of the mouse. Gerontology. 33: 7–13, 1987.
Heuser, J.E. and Reese, T. Evidence for recycling of synaptic vesicle membrane during transmitter release at the frog neuromuscular junction. L. Cell Biol., 57: 315–344, 1973.
Hinz, I. and Wernig, A. Prolonged nerve stimulation causes changes in transmitter release at the frog neuromuscular junction. Journal of Physiol. (Lond.). 401: 557–565, 1988.
HoUoszy, J.O. Aging and exercise: physiological interactions. Federation Proc., 46: 1823, 1987.
Howald, H., Hoppeler, H., Claasen, H., Mathieu, O. and Sträub, R. Influences of endurance training on the ultrastructural composition of the different muscle fiber type in humans. Pflugers Arch., 403: 369–376, 1985.
Irintchev, A. and Wernig, A. Muscle damage and repair in voluntary running mice: strain and muscle differences. Cell Tissue Res., 249: 509–521, 1987.
Kanda, K., Hashizume, K., Nomoto, E. and Askaki, S. Effects of aging on physiological properties of fast and slow motor units in rat gastrocnemius muscle. Neurosci. Res., 3: 242–246, 1986.
Kanda, K. and Hashizume, K. Changes in properties of medial gastrocnemius motor units in aging rats. J. PhysioL., 61: 737–746, 1989.
Kobayashi, H., Robbins, N. and Rutishauser, U. Neural cell adhesion molecule in aged mouse muscle. Neuroscience. 48(1): 237–248, 1992.
Larsson, L. and Edstrom, L. Effects of age on enzyme — histochemical fiber spectra and contractile properties of fast and slow-twitch skeletal muscles in the rat. J. Neurol. Sci., 76: 69–89, 1986.
Larsson, L. and Ansved, T. Effect of age on the motor unit. A study on single motor units in the rat. In: Central determinants of age-related declines in motor function. Ed. Joseph, J.A. Ann. N.Y. Acad. Sci., 515: 303–313, 198
Larsson, L., Ansved, T., Edstrom, L., Gorza, L. and Schiaffino, S. Effects of age on physiological, immunohistochemical and biochemical properties of fast-twitch single motor units in the rat. Journal of Physiology., 443: 257–275, 199
Oudet, C., Petrovic, A., Champy, M. and Kahn, J.L. Is the myosin type altered in the aging platysma? Journal of Cranio-Maxillo-Facial Surgery. 17(4): 190–194, 1989.
Pachter, B.R. and Eberstein, A. Neuromuscular plasticity following limb immobilization. J. Neurocyt., 12: 1013–1025, 198
Robbins, N. and Fahim, M.A. Progression of age changes in mature mouse motor nerve terminals and its relation to locomotor activity. J. Neurocytel., 14: 1019–1036, 1985
Rosenheimer, J.L. Effects of chronic stress and exercise on age-related changes in end-plate architecture. J. Neurophysiol., 53(6): 1582–1589, 1985.
Rosenheimer, J.L. and Smith, D.O. Differential changes in the end-plate architecture of functionally diverse muscles during aging. J. Neurophysiol., 53: 1567–1581, 1985.
Rosenheimer, J.L. Factors affecting denervation-like changes at the neuromuscular junction during aging. Int. J. Devel. Neuroscience., 8: 643–654, 1990.
Silbermann, M., Finkelbrand, S., Weiss, A., Gershon, D. and Reznick, A. Morphometry analysis of aging skeletal muscle following endurance training. Muscle Nerve. 6: 136–142, 1983.
Smith, D.O. and Chapman, Mil. Acetylcholine receptor binding properties at the rat neuromuscular junction during aging. J. Neurochem., 48: 1834–1841, 1987.
Smith, D.O. and Weiler, M.H. Acetylcholine metabolism and choline availability at the neuromuscular junction of mature adult and aged rats. L. Physiol. (Lond.)., 383: 693–709, 1987.
Walters, T.J., Sweeny, H.L. and Farrar, R.P. Aging does not affect contractile properties of the Type IIb FDL muscle in F344 rats. Am. I. Physiol., 258: 1031–1035, 1990.
Washio, H., Imazato-Tanaka, C., Kanda, K. and Nomoto, S. Choline acetyltransferase and acetylcholinesterase activities in muscles of aged mice. Brain Res., 416: 69–74, 1987.
Wokke, J.H., Jennekens, F.G., Van den Oord, C.J. Morphological changes in the human end plate with age. J. Neurol. Sci., 95(3): 291–310, 1990.
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© 1996 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH, Braunschweig/Wiesbaden
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Fahim, M.A. (1996). Synaptic Plasticity During Aging of the Neuromuscular Junction. In: Ghista, D.N. (eds) Biomedical and Life Physics. Vieweg+Teubner Verlag. https://doi.org/10.1007/978-3-322-85017-1_52
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DOI: https://doi.org/10.1007/978-3-322-85017-1_52
Publisher Name: Vieweg+Teubner Verlag
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