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Vasculitis and Strokes

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Management of Cerebrovascular Disorders

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Abstract

Systemic vasculitis is one of the most perplexing categories of diseases known to the medical field. Since the early twentieth century, the involvement of central nervous system (CNS) has been known to occur in systemic inflammatory conditions of the blood vessels. Over the past several decades, we have increased our knowledge in understanding more about the pathogenesis, natural course, and treatment of such disorder. However, several key questions are still unanswered; making a timely accurate diagnosis of vasculitis as an etiology for stroke remains one of the biggest challenges in the world of cerebrovascular diseases. Due to the paucity of vasculitis cases, large-scale studies have been lacking. To solve this issue, an international, multicenter research infrastructure was created in 2003 by the National Institutes of Health (NIH) known as the “Vasculitis Clinical Research Consortium (VCRC).” VCRC provides a knowledge base and resource for researchers worldwide. Use of this database has resulted in translational and clinical studies focusing on vasculitis. There are currently several ongoing studies assessing various aspects of several vasculitic syndromes. A giant clinical data and bio-sample repository have also been established. It already contains over 48,000 patient samples of serum, plasma, DNA, and urine invaluable for biomarkers research. There are several ongoing studies in the area of noninvasive diagnostic methods such as the TABUL study in GCA. Additionally, several ongoing studies on the topic of neuropsychiatric SLE assess the utility of several advanced neuroimaging methods including diffusion tensor imaging and PET scans with novel glutamate receptor ligands.

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Acknowledgment

We would like to thank Drs. Forrest Lowes and James Sawers for their generous inputs and comments to this book chapter. We also thank Drs. Angelos Katramados and Daniel Miller, MD, for providing case images.

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Authors and Affiliations

  1. Department of Neurology, University of New Mexico, Albuquerque, NM, USA

    Tarun Girotra

  2. Department of Neurology, Duke University School of Medicine, Durham, NC, USA

    Wuwei Feng

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  1. Tarun Girotra
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Correspondence to Tarun Girotra .

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Editors and Affiliations

  1. Department of Neurosurgery, Medical University of South Carolina, Charleston, SC, USA

    Alejandro M. Spiotta

  2. Department of Neurosurgery, Medical University of South Carolina, Charleston, SC, USA

    Raymond D. Turner

  3. Department of Neurosurgery, Medical University of South Carolina, Charleston, SC, USA

    M. Imran Chaudry

  4. Department of Neurosurgery, Medical University of South Carolina, Charleston, SC, USA

    Aquilla S. Turk

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Girotra, T., Feng, W. (2019). Vasculitis and Strokes. In: Spiotta, A., Turner, R., Chaudry, M., Turk, A. (eds) Management of Cerebrovascular Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-99016-3_39

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  • Online ISBN: 978-3-319-99016-3

  • eBook Packages: MedicineMedicine (R0)

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