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Stem Cell Therapy and Regenerative Medicine in the Cornea

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Regenerative Medicine and Stem Cell Therapy for the Eye

Part of the book series: Fundamental Biomedical Technologies ((FBMT))

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Abstract

Currently, full-thickness transplantation with human donor corneas is the most widely accepted treatment for corneal blindness. However, due to a severe shortage of human donor corneas as well as problems associated with the storage, screening, and immune response to allogeneic tissues, there has been a push to develop alternative therapies and materials for corneal tissue repair. Here, we review a range of stem cell-based therapies, prosthetics, and extracellular matrix-derived scaffolds, which have been utilized or are being developed for corneal regeneration in vitro, animal models, and human clinical trials.

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Authors and Affiliations

  1. Maisonneuve-Rosemont Hospital Research Centre, Montreal, QC, Canada

    Christopher D. McTiernan, Isabelle Brunette & May Griffith

  2. Department of Ophthalmology, University of Montreal, Montreal, QC, Canada

    Christopher D. McTiernan, Isabelle Brunette & May Griffith

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  1. Christopher D. McTiernan
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  2. Isabelle Brunette
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  3. May Griffith
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  1. Department Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada

    Brian G. Ballios

  2. Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USA

    Michael J. Young

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McTiernan, C.D., Brunette, I., Griffith, M. (2018). Stem Cell Therapy and Regenerative Medicine in the Cornea. In: Ballios, B., Young, M. (eds) Regenerative Medicine and Stem Cell Therapy for the Eye. Fundamental Biomedical Technologies. Springer, Cham. https://doi.org/10.1007/978-3-319-98080-5_6

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