Role of Radiation in DNA Damage and Radiation Induced Cancer

Chandel, Vaishali; Seth, Gaurav; Shukla, Priyank; Kumar, Dhruv

doi:10.1007/978-3-319-96511-6_1

Vaishali Chandel⁵,
Gaurav Seth⁵,
Priyank Shukla⁶ &
…
Dhruv Kumar⁵

Part of the book series: Environmental Science and Engineering ((ENVSCIENCE))

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Abstract

Radiation has been reported to be a proven carcinogen which is responsible for more than half of all malignancies. The incident rates, morbidity and mortality of these cancers are increasing and thus reflects a serious health concern in public. Ionizing and Non-ionizing radiation exposure both lead to the development of cancer. Ultraviolet radiation (UVR) which is a non-ionizing radiation damages the DNA and causes genetic mutations. Exposure to Ionizing radiation results in the various oxidizing events altering the structure of atoms through direct interactions of the radiation with the target molecules or via the product of radiolysis of water. In this chapter we have discussed about the role of radiation in DNA damage and related mechanisms associated with cancer.

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Amity Institute of Molecular Medicine and Stem Cell Research (AIMMSCR), Amity University Uttar Pradesh, Sec-125, Noida, India
Vaishali Chandel, Gaurav Seth & Dhruv Kumar
Northern Ireland Centre for Stratified Medicine, Biomedical Sciences Research Institute, Ulster University, C-TRIC Building, Altnagelvin Area Hospital, Glenshane Road, BT47 6SB, Derry/Londonderry, Northern Ireland, UK
Priyank Shukla

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Vaishali Chandel
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Department of Applied Physics, Department of Bioproducts and Biosystems, Aalto University, Espoo, Finland
Kavindra Kumar Kesari

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Chandel, V., Seth, G., Shukla, P., Kumar, D. (2019). Role of Radiation in DNA Damage and Radiation Induced Cancer. In: Kesari, K. (eds) Networking of Mutagens in Environmental Toxicology. Environmental Science and Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-319-96511-6_1

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