Abstract
Owing to improved understanding of underlying pathophysiology, treatment regimens, and management strategies, immunosuppressed patients have achieved improved survival and outcomes. As their population continues to increase, it is increasingly likely that the general or acute care surgeon will encounter an immunosuppressed patient during the course of their practice in the emergency setting. Managing these patients can be a challenging endeavor due to the atypical symptoms, uncharacteristic physical exam findings, and discordant laboratory findings with which they present. Causes of immune compromise are diverse and multifactorial. Examples like the human immunodeficiency virus and its more advanced form, acquired immunodeficiency syndrome, solid organ transplantation, steroid use, neutropenia, and more each come with its own unique challenges. A thorough understanding of the immunosuppressed patient, from preoperative evaluation to postoperative management, is a requirement for the competent general surgeon to adequately treat their patient and maximize outcomes.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
McKean J, Ronan-Bentle S. Abdominal pain in the immunocompromised patient-human immunodeficiency virus, transplant, cancer. Emerg Med Clin North Am. 2016;34(2):377–86.
Hammel L, Sebranek J, Hevesi Z. The anesthetic management of adult patients with organ transplants undergoing nontransplant surgery. Adv Anesth. 2010;28(1):211–44.
Hannaman MJ, Ertl MJ. Patients with immunodeficiency. Med Clin North Am. 2013;97(6):1139–59.
Gohh RY, Warren G. The preoperative evaluation of the transplanted patient for nontransplant surgery. Surg Clin North Am. 2006;86(5):1147–66. vi
de'Angelis N, et al. Emergency abdominal surgery after solid organ transplantation: a systematic review. World J Emerg Surg. 2016;11(1):43.
Yang XL, et al. Anesthesia management of surgery for sigmoid perforation and acute peritonitis patient following heart transplantation: case report. Int J Clin Exp Med. 2015;8(7):11632–5.
Carter JT, et al. Thymoglobulin-associated Cd4+ T-cell depletion and infection risk in HIV-infected renal transplant recipients. Am J Transplant. 2006;6(4):753–60.
Bahebeck J, et al. Implant orthopaedic surgery in HIV asymptomatic carriers: management and early outcome. Injury. 2009;40(11):1147–50.
Deneve JL, et al. CD4 count is predictive of outcome in HIV-positive patients undergoing abdominal operations. Am J Surg. 2010;200(6):694.
Günthard HF, et al. Antiretroviral treatment of adult HIV infection: 2014 recommendations of the International Antiviral Society-USA Panel. JAMA. 2014;312(4):23–30.
Ng TB, et al. Pharmacotherapy approaches to antifungal prophylaxis. Expert Opin Pharmacother. 2012;13(12):1695–705.
Dworkin MS, et al. HIV/AIDS – prophylaxis with trimethoprim-sulfamethoxazole for human immunodeficiency virus-infected patients: impact on risk for infectious diseases. Clin Infect Dis. 2001;33(3):393.
Safai B, Diaz B, Schwartz J. Malignant neoplasms associated with human immunodeficiency virus infection. CA Cancer J Clin. 1992;42(2):74–95.
Friedman SL, Wright TL, Altman DF. Gastrointestinal Kaposi’s sarcoma in patients with acquired immunodeficiency syndrome. Endoscopic and autopsy findings. Gastroenterology. 1985;89(1):102–8.
Ziegler JL, et al. Non-Hodgkin’s lymphoma in 90 homosexual men. N Engl J Med. 1984;311(9):565–70.
Robinson G, Wilson SE, Williams RA. Surgery in patients with acquired immunodeficiency syndrome. Arch Surg. 1987;122(2):170–5.
Wexner SD, et al. The surgical management of anorectal diseases in AIDS and pre-AIDS patients. Dis Colon Rectum. 1986;29(11):719–23.
Huppmann AR, Orenstein JM. Opportunistic disorders of the gastrointestinal tract in the age of highly active antiretroviral therapy. Hum Pathol. 2010;41(12):1777–87.
Michalopoulos N, Triantafillopoulou K, Beretouli E, Laskou S, Papavramidis TS, Pliakos I, Hytiroglou P, Papavramidis ST. Small bowel perforation due to CMV enteritis infection in an HIV-positive patient. BMC Res Notes. 2013;6:45.
Foschi D, et al. Impact of highly active antiretroviral therapy on outcome of cholecystectomy in patients with human immunodeficiency virus infection. Br J Surg. 2006;93(11):1383–9.
Aronson NE, et al. Biliary giardiasis in a patient with human immunodeficiency virus. J Clin Gastroenterol. 2001;33(2):167–70.
Emparan C, et al. Infective complications after abdominal surgery in patients infected with human immunodeficiency virus: role of CD4+ lymphocytes in prognosis. World J Surg. 1998;22(8):778–82.
Savioz D, et al. Preoperative counts of CD4 T-lymphocytes and early postoperative infective complications in HIV-positive patients. Eur J Surg. 1998;164(7):483–7.
Yii MK, Saunder A, Scott DF. Abdominal surgery in HIV/AIDS patients: indications, operative management, pathology and outcome. Aust N Z J Surg. 1995;65(5):320–6.
Albaran RG. CD4 cell counts as a prognostic factor of major abdominal surgery in patients infected with the human immunodeficiency virus. Arch Surg. 1998;133(6):626.
Tran HS, et al. Predictors of operative outcome in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome. Am J Surg. 2000;180(3):228–33.
Csikesz N, et al. Current status of surgical management of acute cholecystitis in the United States. World J Surg. 2008;32(10):2230–6.
Horberg MA, et al. Surgical outcomes in human immunodeficiency virus-infected patients in the era of highly active antiretroviral therapy. Arch Surg. 2006;141(12):1238–45.
Hamandi B, et al. Impact of infectious disease consultation on the clinical and economic outcomes of solid organ transplant recipients admitted for infectious complications. Clin Infect Dis. 2014;59(8):1074–82.
Schmitt S, et al. Infectious diseases specialty intervention is associated with decreased mortality and lower healthcare costs. Clin Infect Dis. 2014;58(1):22–8.
Yoshida D, Caruso JM. Abdominal pain in the HIV infected patient. J Emerg Med. 2002;23(2):111–6.
Zhang L, et al. Prevention and treatment of surgical site infection in HIV-infected patients. BMC Infect Dis. 2012;12:115.
Freeman AF, Holland SM. Antimicrobial prophylaxis for primary immunodeficiencies. Curr Opin Allergy Clin Immunol. 2009;9(6):525–30.
Stewart MW. Optimal management of cytomegalovirus retinitis in patients with AIDS. Clin Ophthalmol. 2010;4:285–99.
Kirk O, et al. Safe interruption of maintenance therapy against previous infection with four common HIV-associated opportunistic pathogens during potent antiretroviral therapy. Ann Intern Med. 2002;137(4):239–50.
Ferguson CM. Surgical complications of human immunodeficiency virus infection. Am Surg. 1988;54(1):4–9.
Gulick RM, et al. Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. N Engl J Med. 1997;337(11):734–9.
Goldberg HJ, et al. Colon and rectal complications after heart and lung transplantation. J Am Coll Surg. 2006;202(1):55–61.
Bravo C, et al. Prevalence and management of gastrointestinal complications in lung transplant patients: MITOS study group. Transplant Proc. 2007;39(7):2409–12.
Paul S, et al. Gastrointestinal complications after lung transplantation. J Heart Lung Transplant. 2009;28(5):475–9.
Whiting J. Perioperative concerns for transplant recipients undergoing nontransplant surgery. Surg Clin North Am. 2006;86(5):1185–94. vi–vii
Bratzler DW, Houck PM, Surgical Infection Prevention Guideline Writers. Antimicrobial prophylaxis for surgery: an advisory statement from the National Surgical Infection Prevention Project. Am J Surg. 2005;189(4):395–404.
Littlewood KE. The immunocompromised adult patient and surgery. Best Pract Res Clin Anaesthesiol. 2008;22(3):585–609.
Lin S, Cosgrove CJ. Perioperative management of immunosuppression. Surg Clin North Am. 2006;86(5):1167–83. vi
Popov Z, et al. Postoperative complications following kidney transplantation. Ann Urol (Paris). 2000;34(5):323–9.
Kostopanagiotou G, et al. Anesthetic and perioperative management of adult transplant recipients in nontransplant surgery. Anesth Analg. 1999;89(3):613–22.
Miller LW. Cyclosporine-associated neurotoxicity. The need for a better guide for immunosuppressive therapy. Circulation. 1996;94(6):1209–11.
Sakhuja V, et al. Azathioprine induced myelosuppression in renal transplant recipients: a study of 30 patients. Nephrology. 1995;1(4):285–9.
Connell WR, et al. Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience. Gut. 1993;34(8):1081–5.
Hulzebos CV, et al. Cyclosporine A-induced reduction of bile salt synthesis associated with increased plasma lipids in children after liver transplantation. Liver Transpl. 2004;10(7):872–80.
Moran D, et al. Inhibition of biliary glutathione secretion by cyclosporine A in the rat: possible mechanisms and role in the cholestasis induced by the drug. J Hepatol. 1998;29(1):68–77.
Steck TB, Costanzo-Nordin MR, Keshavarzian A. Prevalence and management of cholelithiasis in heart transplant patients. J Heart Lung Transplant. 1991;10(6):1029–32.
Taghavi S, et al. Postoperative outcomes with cholecystectomy in lung transplant recipients. Surgery. 2015;158(2):373–8.
Kilic A, et al. Outcomes of cholecystectomy in US heart transplant recipients. Ann Surg. 2013;258(2):312–7.
Englesbe MJ, et al. Gallbladder disease in cardiac transplant patients: a survey study. Arch Surg. 2005;140(4):399–403. discussion 404
Graham SM, et al. The utility of prophylactic laparoscopic cholecystectomy in transplant candidates. Am J Surg. 1995;169(1):44–8. discussion 48–9
Kao LS, Kuhr CS, Flum DR. Should cholecystectomy be performed for asymptomatic cholelithiasis in transplant patients? J Am Coll Surg. 2003;197(2):302.
Osawa H, et al. Surgical management of perforated gastrointestinal posttransplantation lymphoproliferative disorder after heart transplantation. Int Surg. 2015;100(2):358–64.
Maurer JR. The spectrum of colonic complications in a lung transplant population. Ann Transplant. 2000;5(3):54–7.
Watson CJ, et al. Early abdominal complications following heart and heart-lung transplantation. Br J Surg. 1991;78(6):699–704.
Rodriguez-Larrain JM, et al. Incidence of adenomatous colorectal polyps in cardiac transplant recipients. Transplantation. 1997;64(3):528–30.
Andreoni KA, et al. Increased incidence of gastrointestinal surgical complications in renal transplant recipients with polycystic kidney disease. Transplantation. 1999;67(2):262–6.
Fleming TW, Barry JM. Bilateral open transperitoneal cyst reduction surgery for autosomal dominant polycystic kidney disease. J Urol. 1998;159(1):44–7.
Merrell SW, et al. Major abdominal complications following cardiac transplantation. Utah Transplantation Affiliated Hospitals Cardiac Transplant Program. Arch Surg. 1989;124(8):889–94.
Beaver TM, et al. Colon perforation after lung transplantation. Ann Thorac Surg. 1996;62(3):839–43.
Stelzner M, et al. Colonic perforations after renal transplantation. J Am Coll Surg. 1997;184(1):63–9.
Detry O, et al. Acute diverticulitis in heart transplant recipients. Transpl Int. 1996;9(4):376–9.
Catena F, et al. Gastrointestinal perforations following kidney transplantation. Transplant Proc. 2008;40(6):1895–6.
Reshef A, et al. Case-matched comparison of perioperative outcomes after surgical treatment of sigmoid diverticulitis in solid organ transplant recipients versus immunocompetent patients. Color Dis. 2012;14(12):1546–52.
Patel H, et al. Posttransplant lymphoproliferative disorder in adult liver transplant recipients: a report of seventeen cases. Leuk Lymphoma. 2007;48(5):885–91.
Younes BS, et al. The involvement of the gastrointestinal tract in posttransplant lymphoproliferative disease in pediatric liver transplantation. J Pediatr Gastroenterol Nutr. 1999;28(4):380–5.
Fonseca-Neto OC, et al. Acute apendicitis in liver transplant recipients. Arq Bras Cir Dig. 2016;29(1):30–2.
Andrade RdO, et al. Acute appendicitis after liver transplant: a case report and review of the literature. OJOTS. 2014;04(04):29–32.
Wei CK, et al. Acute appendicitis in organ transplantation patients: a report of two cases and a literature review. Ann Transplant. 2014;19:248–52.
Hoekstra HJ, et al. Gastrointestinal complications in lung transplant survivors that require surgical intervention. Br J Surg. 2001;88(3):433–8.
Sikalias N, et al. Acute abdomen in a transplant patient with tuberculous colitis: a case report. Cases J. 2009;2:9305.
Lebon D, et al. Gastrointestinal emergencies in critically ill cancer patients. J Crit Care. 2017;40:69–75.
Arain MR, Buggy DJ. Anaesthesia for cancer patients. Curr Opin Anaesthesiol. 2007;20(3):247–53.
Lefor AT. Surgical problems affecting the patient with cancer : interdisciplinary management. Philadelphia: Lippincott-Raven; 1996.
Ganz WI, et al. Review of tests for monitoring doxorubicin-induced cardiomyopathy. Oncology. 1996;53(6):461–70.
Donat SM, Levy DA. Bleomycin associated pulmonary toxicity: is perioperative oxygen restriction necessary? JURO. 1998;160(4):1347–52.
Huettemann E, Sakka SG. Anaesthesia and anti-cancer chemotherapeutic drugs. Curr Opin Anaesthesiol. 2005;18(3):307–14.
Freifeld AG, et al. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2011;52(4):427–31.
Hayden DM, et al. Patient factors may predict anastomotic complications after rectal cancer surgery. Anastomotic complications in rectal cancer. Ann Med Surg. 2015;4(1):11–6.
Midura EF, et al. Risk factors and consequences of anastomotic leak after colectomy: a national analysis. Dis Colon Rectum. 2015;58(3):333–8.
Cloutier RL. Neutropenic enterocolitis. Hematol Oncol Clin North Am. 2010;24(3):577–84.
Gravante G, Yahia S. Medical influences, surgical outcomes: role of common medications on the risk of perforation from untreated diverticular disease. World J Gastroenterol. 2013;19(36):5947–52.
Wang AS, Armstrong EJ, Armstrong AW. Corticosteroids and wound healing: clinical considerations in the perioperative period. Am J Surg. 2013;206(3):410–7.
Humes DJ, et al. Concurrent drug use and the risk of perforated colonic diverticular disease: a population-based case-control study. Gut. 2011;60(2):219–24.
Fadul CE, et al. Perforation of the gastrointestinal tract in patients receiving steroids for neurologic disease. Neurology. 1988;38(3):348–52.
Kaya B, et al. Steroid-induced sigmoid diverticular perforation in a patient with temporal arteritis: a rare clinical pathology. Clin Med Insights Pathol. 2012;5:11–4.
Behrman SW. Management of complicated peptic ulcer disease. Arch Surg. 2005;140(2):201–8.
Piekarek K, Israelsson LA. Perforated colonic diverticular disease: the importance of NSAIDs, opioids, corticosteroids, and calcium channel blockers. Int J Color Dis. 2008;23(12):1193–7.
Kouyialis A, et al. Delayed diagnosis of steroid-induced colon diverticulum perforation. N Z Med J. 2003;116(1183):U631.
Merry WH, et al. Postoperative acute adrenal failure caused by transient corticotropin deficiency. Surgery. 1994;116(6):1095–100.
Salem M, et al. Perioperative glucocorticoid coverage. A reassessment 42 years after emergence of a problem. Ann Surg. 1994;219(4):416–25.
Mathis AS, Shah NK, Mulgaonkar S. Stress dose steroids in renal transplant patients undergoing lymphocele surgery. Transplant Proc. 2004;36(10):3042–5.
Kelly KN, Domajnko B. Perioperative stress-dose steroids. Clin Colon Rectal Surg. 2013;26(3):163–7.
MacKenzie CR, Goodman SM. Stress dose steroids: myths and perioperative medicine. Curr Rheumatol Rep. 2016;18(7):47.
Huzar TF, et al. Pneumatosis intestinalis in patients with severe thermal injury. J Burn Care Res. 2011;32(3):e37–44.
Diabetes C, et al. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329(14):977–86.
Duggan EW, et al. The Emory University Perioperative Algorithm for the management of hyperglycemia and diabetes in non-cardiac surgery patients. Curr Diab Rep. 2016;16(3)
Abdelmalak BB, et al. Preoperative blood glucose concentrations and postoperative outcomes after elective non-cardiac surgery: an observational study. Br J Anaesth. 2014;112(1):79–88.
Sivrikoz E, et al. The effect of diabetes on outcomes following emergency appendectomy in patients without comorbidities: a propensity score-matched analysis of National Surgical Quality Improvement Program database. Am J Surg. 2015;209(1):206–11.
Gusberg RJ, Moley J. Diabetes and abdominal surgery: the mutual risks. Yale J Biol Med. 1983;56(4):285–91.
Stewart CL, Wood CL, Bealer JF. Characterization of acute appendicitis in diabetic children. J Pediatr Surg. 2014;49(12):1719–22.
Bach L, et al. Appendicitis in diabetics: predictors of complications and their incidence. Am Surg. 2016;82(8):753–8.
Noel RA, et al. Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes: a retrospective cohort study. Diabetes Care. 2009;32(5):834–8.
Paajanen H, et al. Laparoscopic versus open cholecystectomy in diabetic patients and postoperative outcome. Surg Endosc. 2011;25(3):764–70.
Landau O, et al. The risk of cholecystectomy for acute cholecystitis in diabetic patients. Hepato-Gastroenterology. 1992;39(5):437–8.
Shpitz B, et al. Acute cholecystitis in diabetic patients. Am Surg. 1995;61(11):964–7.
Karamanos E, et al. Effect of diabetes on outcomes in patients undergoing emergent cholecystectomy for acute cholecystitis. World J Surg. 2013;37(10):2257–64.
Gelbard R, et al. Effect of delaying same-admission cholecystectomy on outcomes in patients with diabetes. Br J Surg. 2014;101(2):74–8.
Tarchouli M, et al. Analysis of prognostic factors affecting mortality in Fournier’s gangrene: a study of 72 cases. Can Urol Assoc J. 2015;9(11–12):E800–4.
Silvestri M, et al. Modifiable and non-modifiable risk factors for surgical site infection after colorectal surgery: a single-center experience. Surg Today. 2018;48(3):338–45.
Kato S, et al. Aspects of immune dysfunction in end-stage renal disease. Clin J Am Soc Nephrol. 2008;3(5):1526–33.
Toh Y, et al. Abdominal surgery for patients on maintenance hemodialysis. Surg Today. 1998;28(3):268–72.
Ozel L, et al. Elective and emergency surgery in chronic hemodialysis patients. Ren Fail. 2011;33(7):672–6.
Conflict of Interest
The authors report no proprietary or commercial interest in any product mentioned or concept discussed in this chapter.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
Tejiram, S., Sava, J.A. (2019). Emergency General Surgery in the Immunocompromised Surgical Patient. In: Brown, C., Inaba, K., Martin, M., Salim, A. (eds) Emergency General Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-96286-3_42
Download citation
DOI: https://doi.org/10.1007/978-3-319-96286-3_42
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-96285-6
Online ISBN: 978-3-319-96286-3
eBook Packages: MedicineMedicine (R0)