Abstract
Osteochondral lesions represent one of the major causes of disabilities in the world. These defects are due to degenerative or inflammatory arthritis, but both affect the articular cartilage and the underlying subchondral bone. Defects from trauma or degenerative pathology frequently cause severe pain, joint deformity, and loss of joint motion. Osteochondral defects are a significant challenge in orthopedic surgery, due to the cartilage complexity and unique structure, as well as its exposure to high pressure and motion. Although there are treatments routinely performed in the clinical practice, they present several limitations. Tissue engineering can be a suitable alternative for osteochondral defects since bone and cartilage engineering had experienced a notable advance over the years. Allied with nanotechnology, osteochondral tissue engineering (OCTE) can be leveled up, being possible to create advanced structures similar to the OC tissue. In this chapter, the current strategies using nanoparticles-based systems are overviewed. The results of the studies herein considered confirm that advanced nanomaterials will undoubtedly play a crucial role in the design of strategies for treatment of osteochondral defects in the near future.
Keywords
*These authors contributed equally to this chapter.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Castro NJ, Hacking SA, Zhang LG (2012) Recent progress in interfacial tissue engineering approaches for osteochondral defects. Ann Biomed Eng 40(8):1628–1640
Khan MS, Vishakante GD, Siddaramaiah H (2013) Gold nanoparticles: a paradigm shift in biomedical applications. Adv Colloid Interface Sci 199–200:44–58. https://doi.org/10.1016/j.cis.2013.06.003
Panseri S, Russo A, Cunha C et al (2012) Osteochondral tissue engineering approaches for articular cartilage and subchondral bone regeneration. Knee Surg SportTraumatol Arthrosc 20(6):1182–1191
Amini AR, Adams DJ, Laurencin CT, Nukavarapu SP (2012) Optimally porous and biomechanically compatible scaffolds for large-area bone regeneration. Tissue Eng Part A 18:1376. https://doi.org/10.1089/ten.tea.2011.0076
Nukavarapu SP, Amini AR (2011) Optimal scaffold design and effective progenitor cell identification for the regeneration of vascularized bone. In: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, Boston, MA, USA.
Nejadnik H, Daldrup-Link HE (2012) Engineering stem cells for treatment of osteochondral defects. Skeletal Radiol 41:1
Martin I, Miot S, Barbero A et al (2007) Osteochondral tissue engineering. J Biomech 40(4):750–765
Makris EA, Gomoll AH, Malizos KN et al (2014) Repair and tissue engineering techniques for articular cartilage. Nat Rev Rheumatol 11:21. https://doi.org/10.1038/nrrheum.2014.157
Camarero-Espinosa S, Cooper-White J (2017) Tailoring biomaterial scaffolds for osteochondral repair. Int J Pharm 523:476. https://doi.org/10.1016/j.ijpharm.2016.10.035
Nukavarapu SP, Dorcemus DL (2013) Osteochondral tissue engineering: current strategies and challenges. Biotechnol Adv 31:706. https://doi.org/10.1016/j.biotechadv.2012.11.004
Degoricija L, Bansal PN, Söntjens SHM et al (2008) Hydrogels for osteochondral repair based on photocrosslinkable carbamate dendrimers. Biomacromolecules 9:2863. https://doi.org/10.1021/bm800658x
Nicolas J, Mura S, Brambilla D et al (2013) Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery. Chem Soc Rev 42:1147–1235. https://doi.org/10.1039/C2CS35265F
Vieira S, Vial S, Reis RL, Oliveira JM (2017) Nanoparticles for bone tissue engineering. Biotechnol Prog 33:590–611. https://doi.org/10.1002/btpr.2469
Alves Cardoso D, Jansen JA, Leeuwenburgh SCG (2012) Synthesis and application of nanostructured calcium phosphate ceramics for bone regeneration. J Biomed Mater Res Part B Appl Biomater 100B:2316–2326. https://doi.org/10.1002/jbm.b.32794
Yan L-P, Silva-Correia J, Correia C et al (2012) Bioactive macro/micro porous silk fibroin/nano-sized calcium phosphate scaffolds with potential for bone-tissue-engineering applications. Nanomedicine 8:359–378. https://doi.org/10.2217/nnm.12.118
Amadori S, Torricelli P, Panzavolta S et al (2015) Multi-layered scaffolds for osteochondral tissue engineering: in vitro response of co-cultured human mesenchymal stem cells. Macromol Biosci 15:1535–1545. https://doi.org/10.1002/mabi.201500165
Gaharwar AK, Dammu SA, Canter JM et al (2011) Highly extensible, tough, and elastomeric nanocomposite hydrogels from poly(ethylene glycol) and hydroxyapatite nanoparticles. Biomacromolecules 12:1641–1650. https://doi.org/10.1021/bm200027z
Nowicki MA, Castro NJ, Plesniak MW, Zhang LG (2016) 3D printing of novel osteochondral scaffolds with graded microstructure. Nanotechnology 27:414001. https://doi.org/10.1088/0957-4484/27/41/414001
Pina S, Oliveira JM, Reis RL (2015) Natural-based nanocomposites for bone tissue engineering and regenerative medicine: a review. Adv Mater 27:1143–1169. https://doi.org/10.1002/adma.201403354
Verma S, Domb AJ, Kumar N (2011) Nanomaterials for regenerative medicine. Nanomedicine (Lond) 6:157–181. https://doi.org/10.2217/nnm.10.146
Mellor LF, Mohiti-Asli M, Williams J et al (2015) Extracellular calcium modulates Chondrogenic and osteogenic differentiation of human adipose-derived stem cells: A novel approach for osteochondral tissue engineering using a single stem cell source. Tissue Eng Part A 21:2323. https://doi.org/10.1089/ten.tea.2014.0572
Fan J, Tan Y, Jie L et al (2013) Biological activity and magnetic resonance imaging of superparamagnetic iron oxide nanoparticles-labeled adipose-derived stem cells. Stem Cell Res Ther 4:44. https://doi.org/10.1186/scrt191
Lalande C, Miraux S, Derkaoui SM et al (2011) Magnetic resonance imaging tracking of human adipose derived stromal cells within three-dimensional scaffolds for bone tissue engineering. Eur Cell Mater 21:341–354
Meir R, Motiei M, Popovtzer R (2014) Gold nanoparticles for in vivo cell tracking. Nanomedicine 9:2059–2069. https://doi.org/10.2217/nnm.14.129
Shen Y, Shao Y, He H et al (2013) Gadolinium3+−doped mesoporous silica nanoparticles as a potential magnetic resonance tracer for monitoring the migration of stem cells in vivo. Int J Nanomedicine 8:119–127. https://doi.org/10.2147/IJN.S38213
Wegner KD, Hildebrandt N (2015) Quantum dots: bright and versatile in vitro and in vivo fluorescence imaging biosensors. Chem Soc Rev 44:4792. https://doi.org/10.1039/C4CS00532E
Shin T-H, Choi Y, Kim S, Cheon J (2015) Recent advances in magnetic nanoparticle-based multi-modal imaging. Chem Soc Rev 44:4501. https://doi.org/10.1039/C4CS00345D
Colombo M, Carregal-Romero S, Casula MF et al (2012) Biological applications of magnetic nanoparticles. Chem Soc Rev 41:4306
Pandey RK, Prajapati VK (2018) Molecular and immunological toxic effects of nanoparticles. Int J Biol Macromol 107(Pt A):1278–1293
Su JY, Chen SH, Chen YP, Chen WC (2017) Evaluation of magnetic nanoparticle-labeled chondrocytes cultivated on a type II collagen–chitosan/poly(lactic-co-glycolic) acid biphasic scaffold. Int J Mol Sci 18. https://doi.org/10.3390/ijms18010087
Monteiro N, Martins A, Reis RL, Neves NM (2015) Nanoparticle-based bioactive agent release systems for bone and cartilage tissue engineering. Regen Ther 1:109. https://doi.org/10.1016/j.reth.2015.05.004
Zhang W, Yang G, Wang X et al (2017) Magnetically controlled growth-factor-immobilized multilayer cell sheets for complex tissue regeneration. Adv Mater 29:1703795. https://doi.org/10.1002/adma.201703795
Lee Y-H, Wu H-C, Yeh C-W et al (2017) Enzyme-crosslinked gene-activated matrix for the induction of mesenchymal stem cells in osteochondral tissue regeneration. Acta Biomater 63:210–226. https://doi.org/10.1016/J.ACTBIO.2017.09.008
Yoo HS, Kim TG, Park TG (2009) Surface-functionalized electrospun nanofibers for tissue engineering and drug delivery. Adv Drug Deliv Rev 61:1033–1042. https://doi.org/10.1016/j.addr.2009.07.007
Rao JP, Geckeler KE (2011) Polymer nanoparticles: Preparation techniques and size-control parameters. Prog Polym Sci 36:887–913. https://doi.org/10.1016/j.progpolymsci.2011.01.001
Wang C, Hou W, Guo X et al (2017) Two-phase electrospinning to incorporate growth factors loaded chitosan nanoparticles into electrospun fibrous scaffolds for bioactivity retention and cartilage regeneration. Mater Sci Eng C 79:507. https://doi.org/10.1016/j.msec.2017.05.075
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
Oliveira, I., Vieira, S., Oliveira, J.M., Reis, R.L. (2018). Nanoparticles-Based Systems for Osteochondral Tissue Engineering. In: Oliveira, J., Pina, S., Reis, R., San Roman, J. (eds) Osteochondral Tissue Engineering. Advances in Experimental Medicine and Biology, vol 1059. Springer, Cham. https://doi.org/10.1007/978-3-319-76735-2_9
Download citation
DOI: https://doi.org/10.1007/978-3-319-76735-2_9
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-76734-5
Online ISBN: 978-3-319-76735-2
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)