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Photonics in Drug Delivery

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Polymer and Photonic Materials Towards Biomedical Breakthroughs

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Abstract

This chapter is focused on the application of photonics in medicine, namely, in the systems designed to facilitate delivery of bioactive agents (drugs, photosensitizers). The introduction of the carrier into such systems allows to increase their efficiency, to reduce side-effects and to precisely control the dose, the place and time of delivery inside the patient’s body. Three main aspects of the problem are analysed in this chapter: (1) using light-sensitive probes to study pharmacokinetics of drugs; (2) the choice of the application route for the photosensitizers used in photodynamic therapy (PDT), including prodrugs, micelles, inorganic and hybrid nanoparticles and virus capsids; and (3) achieving targeted delivery and precise control over the release profiles by the application of the systems containing photoresponsive carriers. The basic mechanisms of the photophysical and photochemical processes involved are discussed, including PDT, photoinduced NO delivery and light-triggered release of drugs from liposomes, prodrugs and other specific systems. The most interesting examples are described, and the advantages and limitations of using various systems are discussed.

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Authors and Affiliations

  1. Department of Chemistry, Jagiellonian University, Cracow, Poland

    Anna Karewicz & Aneta Pietraszek

  2. AGH University of Science and Technology, Cracow, Poland

    Dorota Lachowicz

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  1. Anna Karewicz
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  2. Dorota Lachowicz
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  3. Aneta Pietraszek
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Correspondence to Anna Karewicz .

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Editors and Affiliations

  1. Polymer Chemistry & Biomaterials Group, Centre of Macromolecular Chemistry, Department of Organic and Macromolecular Chemistry, Ghent University, Ghent, Belgium

    Jasper Van Hoorick

  2. Brussels Photonics, Department of Applied Physics and Photonics, Vrije Universiteit Brussel, Brussel, Belgium

    Heidi Ottevaere

  3. Brussels Photonics, Department of Applied Physics and Photonics, Vrije Universiteit Brussel, Brussel, Belgium

    Hugo Thienpont

  4. Polymer Chemistry & Biomaterials Group, Centre of Macromolecular Chemistry, Department of Organic and Macromolecular Chemistry, Ghent University, Ghent, Belgium

    Peter Dubruel

  5. Polymer Chemistry & Biomaterials Group, Centre of Macromolecular Chemistry, Department of Organic and Macromolecular Chemistry, Ghent University, Ghent, Belgium

    Sandra Van Vlierberghe

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Karewicz, A., Lachowicz, D., Pietraszek, A. (2018). Photonics in Drug Delivery. In: Van Hoorick, J., Ottevaere, H., Thienpont, H., Dubruel, P., Van Vlierberghe, S. (eds) Polymer and Photonic Materials Towards Biomedical Breakthroughs. Micro- and Opto-Electronic Materials, Structures, and Systems. Springer, Cham. https://doi.org/10.1007/978-3-319-75801-5_5

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