Abstract
In this study, brain tumor substructures are segmented using 2D fully convolutional neural networks. A number of modifications such as double convolution layers, inception modules, and dense modules were added to a U-Net to achieve a deep architecture and test if the increased depth improves the performance. The experiments show that the deep architectures improve the performance. Also, the performance is enhanced from ensembling across the models trained on images in different orientations and ensembling across the models with different architectures. Even without any data augmentation, the ensembled model achieves a competitive performance and generalizes well on a new dataset. The resulting mean 3D Dice scores (ET/WT/TC) on the BRATS17 validation and test sets are 0.75/0.88/0.73 and 0.72/0.86/0.73.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Menze, B.H., Jakab, A., Bauer, S., Kalpathy-Cramer, J., Farahani, K., Kirby, J., Burren, Y., Porz, N., Slotboom, J., Wiest, R., Lanczi, L., Gerstner, E., Weber, M.A., Arbel, T., Avants, B.B., Ayache, N., Buendia, P., Collins, D.L., Cordier, N., Corso, J.J., Criminisi, A., Das, T., Delingette, H.: Demiralp, Ç., Durst, C.R., Dojat, M., Doyle, S., Festa, J., Forbes, F., Geremia, E., Glocker, B., Golland, P., Guo, X., Hamamci, A., Iftekharuddin, K.M., Jena, R., John, N.M., Konukoglu, E., Lashkari, D., Mariz, J.A., Meier, R., Pereira, S., Precup, D., Price, S.J., Raviv, T.R., Reza, S.M.S., Ryan, M., Sarikaya, D., Schwartz, L., Shin, H.C., Shotton, J., Silva, C.A., Sousa, N., Subbanna, N.K., Szekely, G., Taylor, T.J., Thomas, O.M., Tustison, N.J., Unal, G., Vasseur, F., Wintermark, M., Ye, D.H., Zhao, L., Zhao, B., Zikic, D., Prastawa, M., Reyes, M., Leemput, K.V.: The multimodal brain tumor image segmentation benchmark (BRATS). IEEE Trans. Med. Imaging. 34, 1993–2024 (2015)
Bakas, S., Akbari, H., Sotiras, A., Bilello, M., Rozycki, M., Kirby, J., Freymann, J., Farahani, K., Davatzikos, C.: Advancing the cancer genome atlas glioma MRI collections with expert segmentation labels and radiomic features. Nature Sci. Data 4, 170117 (2017)
Bakas, S., Akbari, H., Sotiras, A., Bilello, M., Rozycki, M., Kirby, J., Freymann, J., Farahani, K., Davatzikos, C.: Segmentation labels for the pre-operative scans of the TCGA-GBM collection. Cancer Imaging Arch. (2017)
Bakas, S., Akbari, H., Sotiras, A., Bilello, M., Rozycki, M., Kirby, J., Freymann, J., Farahani, K., Davatzikos, C.: Segmentation labels for the pre-operative scans of the TCGA-LGG collection. Cancer Imaging Arch. (2017)
Russakovsky, O., Deng, J., Su, H., Krause, J., Satheesh, S., Ma, S., Huang, Z., Karpathy, A., Khosla, A., Bernstein, M., Berg, A.C., Fei-Fei, L.: ImageNet large scale visual recognition challenge. Int. J. Comput. Vis. 115, 211–252 (2015)
Krizhevsky, A., Sutskever, I., Hinton, G.E.: Imagenet classification with deep convolutional neural networks. In: Advances in Neural Information Processing Systems, pp. 1097–1105 (2012)
Simonyan, K., Zisserman, A.: Very deep convolutional networks for large-scale image recognition. arXiv preprint arXiv:1409.1556 (2014)
Szegedy, C., Liu, W., Jia, Y., Sermanet, P., Reed, S., Anguelov, D., Erhan, D., Vanhoucke, V., Rabinovich, A.: Going deeper with convolutions. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 1–9 (2015)
He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 770–778 (2016)
He, K., Zhang, X., Ren, S., Sun, J.: Delving deep into rectifiers: surpassing human-level performance on ImageNet classification. In: Proceedings of the IEEE International Conference on Computer Vision, pp. 1026–1034 (2015)
Bakas, S., et al.: GLISTRboost: combining multimodal MRI segmentation, registration, and biophysical tumor growth modeling with gradient boosting machines for glioma segmentation. In: Crimi, A., Menze, B., Maier, O., Reyes, M., Handels, H. (eds.) BrainLes 2015. LNCS, vol. 9556, pp. 144–155. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-30858-6_13
Maier, O., Wilms, M., Handels, H.: Image features for brain lesion segmentation using random forests. In: Crimi, A., Menze, B., Maier, O., Reyes, M., Handels, H. (eds.) BrainLes 2015. LNCS, vol. 9556, pp. 119–130. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-30858-6_11
Meier, R., Karamitsou, V., Habegger, S., Wiest, R., Reyes, M.: Parameter learning for CRF-based tissue segmentation of brain tumors. In: Crimi, A., Menze, B., Maier, O., Reyes, M., Handels, H. (eds.) BrainLes 2015. LNCS, vol. 9556, pp. 156–167. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-30858-6_14
Song, B., Chou, C.-R., Chen, X., Huang, A., Liu, M.-C.: Anatomy-guided brain tumor segmentation and classification. In: Crimi, A., Menze, B., Reyes, M., Winzeck, S., Handels, H. (eds.) BrainLes 2016. LNCS, vol. 10154, pp. 162–170. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-55524-9_16
Zeng, K., et al.: Segmentation of gliomas in pre-operative and post-operative multimodal magnetic resonance imaging volumes based on a hybrid generative-discriminative framework. In: Crimi, A., Menze, B., Maier, O., Reyes, M., Winzeck, S., Handels, H. (eds.) BrainLes 2016. LNCS, vol. 10154, pp. 184–194. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-55524-9_18
Havaei, M., Dutil, F., Pal, C., Larochelle, H., Jodoin, P.-M.: A convolutional neural network approach to brain tumor segmentation. In: Crimi, A., Menze, B., Maier, O., Reyes, M., Handels, H. (eds.) BrainLes 2015. LNCS, vol. 9556, pp. 195–208. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-30858-6_17
Pereira, S., Pinto, A., Alves, V., Silva, C.A.: Deep convolutional neural networks for the segmentation of gliomas in multi-sequence MRI. In: Crimi, A., Menze, B., Maier, O., Reyes, M., Handels, H. (eds.) BrainLes 2015. LNCS, vol. 9556, pp. 131–143. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-30858-6_12
Chang, P.D.: Fully convolutional deep residual neural networks for brain tumor segmentation. In: Crimi, A., Menze, B., Maier, O., Reyes, M., Winzeck, S., Handels, H. (eds.) BrainLes 2016. LNCS, vol. 10154, pp. 108–118. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-55524-9_11
Kamnitsas, K., et al.: DeepMedic for brain tumor segmentation. In: Crimi, A., Menze, B., Maier, O., Reyes, M., Winzeck, S., Handels, H. (eds.) BrainLes 2016. LNCS, vol. 10154, pp. 138–149. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-55524-9_14
Zhao, X., Wu, Y., Song, G., Li, Z., Fan, Y., Zhang, Y.: Brain tumor segmentation using a fully convolutional neural network with conditional random fields. In: Crimi, A., Menze, B., Maier, O., Reyes, M., Winzeck, S., Handels, H. (eds.) BrainLes 2016. LNCS, vol. 10154, pp. 75–87. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-55524-9_8
Havaei, M., Davy, A., Warde-Farley, D., Biard, A., Courville, A., Bengio, Y., Pal, C., Jodoin, P.-M., Larochelle, H.: Brain tumor segmentation with deep neural networks. Med. Image Anal. 35, 18–31 (2016)
Kamnitsas, K., Ledig, C., Newcombe, V.F.J., Simpson, J.P., Kane, A.D., Menon, D.K., Rueckert, D., Glocker, B.: Efficient multi-scale 3D CNN with fully connected CRF for accurate brain lesion segmentation. Med. Image Anal. 36, 61–78 (2017)
Ciresan, D., Giusti, A., Gambardella, L.M., Schmidhuber, J.: Deep neural networks segment neuronal membranes in electron microscopy images. In: Advances in Neural Information Processing Systems, pp. 2843–2851 (2012)
Long, J., Shelhamer, E., Darrell, T.: Fully convolutional networks for semantic segmentation. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 3431–3440 (2015)
Ronneberger, O., Fischer, P., Brox, T.: U-Net: convolutional networks for biomedical image segmentation. In: Navab, N., Hornegger, J., Wells, W.M., Frangi, A.F. (eds.) MICCAI 2015. LNCS, vol. 9351, pp. 234–241. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-24574-4_28
Milletari, F., Navab, N., Ahmadi, S.-A.: V-Net: fully convolutional neural networks for volumetric medical image segmentation. arXiv:1606.04797 [cs] (2016)
Huang, G., Liu, Z., Weinberger, K.Q., van der Maaten, L.: Densely connected convolutional networks. arXiv:1608.06993 [cs] (2016)
Acknowledgement
We thank NVIDIA for their kind donation of a TitanX GPU.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this paper
Cite this paper
Kim, G. (2018). Brain Tumor Segmentation Using Deep Fully Convolutional Neural Networks. In: Crimi, A., Bakas, S., Kuijf, H., Menze, B., Reyes, M. (eds) Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries. BrainLes 2017. Lecture Notes in Computer Science(), vol 10670. Springer, Cham. https://doi.org/10.1007/978-3-319-75238-9_30
Download citation
DOI: https://doi.org/10.1007/978-3-319-75238-9_30
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-75237-2
Online ISBN: 978-3-319-75238-9
eBook Packages: Computer ScienceComputer Science (R0)