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Mechanisms of Irritant and Allergic Contact Dermatitis

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Contact Dermatitis

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Abstract

The skin forms a barrier that protects the organism against infection, UV light, and other challenges. Resident and recruited immune cells maintain the immunologic homeostasis and react to its disturbance by injury, infection, irritant chemicals and contact allergens, and many other challenges. Chemical irritants and contact allergens cause skin inflammation resulting in T cell-independent irritant or T cell-mediated allergic contact dermatitis. Understanding the structure and function of the skin barrier, the role of different immune cell types and the mechanisms of inflammation will promote the development of mechanism-based treatment strategies for contact dermatitis.

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Authors and Affiliations

  1. Medical Center, Faculty of Medicine, Allergy Research Group, Department of Dermatology, University of Freiburg, Freiburg, Germany

    Stefan F. Martin

  2. The LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

    Charlotte M. Bonefeld

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  1. Stefan F. Martin
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Correspondence to Stefan F. Martin .

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Editors and Affiliations

  1. Amtssygehuset Gentofte Dept. Dermatology, Hellerup, Denmark

    Jeanne Duus Johansen

  2. Federal Institute for Vaccines & Biomed, Paul Ehrlich Institut Federal Institute for Vaccines & Biomed, Langen, Bayern, Germany

    Vera Mahler

  3. Institut le Bel Labo. Dermatochimie, Strasbourg CX, France

    Jean-Pierre Lepoittevin

  4. Hautklinik, Städtische Kliniken Dortmund Klinikzentrum Mitte, Dortmund, Germany

    Peter J. Frosch

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Martin, S.F., Bonefeld, C.M. (2020). Mechanisms of Irritant and Allergic Contact Dermatitis. In: Johansen, J., Mahler, V., Lepoittevin, JP., Frosch, P. (eds) Contact Dermatitis. Springer, Cham. https://doi.org/10.1007/978-3-319-72451-5_59-1

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