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Advances in Cell Seeding of Tissue Engineered Vascular Grafts

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Tissue-Engineered Vascular Grafts

Part of the book series: Reference Series in Biomedical Engineering ((TIENRE))

Abstract

From the advent of tissue engineered vascular grafts (TEVG), cells have often been included in the fabrication process in order to provide biological signals to the host and ultimately lead to improved outcomes. How the cells are integrated into the TEVG varies; in this review, we summarize the advances in cell-based TEVG research over the past decade with a focus on cell seeding techniques. In addition to describing methods for cell incorporation, this review will also briefly cover considerations of cell choice, highlighting the use of pluripotent stem cells in TEVGs.

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Acknowledgments

The authors would like to acknowledge their sources of support: NIH Vascular Training Grant to DGH (T32 HL098036; Dr. Edith Tzeng, PI) and NIH grants to DAV (NIH R21 EB016138, R21 HL130784, RO1 HL130077).

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Authors and Affiliations

  1. Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA

    Justin S. Weinbaum, Talya F. Mandelkern & David A. Vorp

  2. Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA

    Justin S. Weinbaum

  3. Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA

    Darren G. Haskett & David A. Vorp

  4. Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, USA

    David A. Vorp

  5. Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, PA, USA

    David A. Vorp

  6. McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA

    Justin S. Weinbaum & David A. Vorp

Authors
  1. Justin S. Weinbaum
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  2. Darren G. Haskett
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  3. Talya F. Mandelkern
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  4. David A. Vorp
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Corresponding author

Correspondence to David A. Vorp .

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Editors and Affiliations

  1. Dept. of Cardiovascular Surgery, University Hospital Dept. of Cardiovascular Surgery, Geneva 14, Switzerland

    Beat Walpoth

  2. Center for Biomedical Research, Medical University Vienna Center for Biomedical Research, Vienna, Wien, Austria

    Helga Bergmeister

  3. Dept of Biomedical Engineering, University of Memphis Dept of Biomedical Engineering, Memphis, TN, USA

    Gary Bowlin

  4. Nankai University, Tianjin, China

    Deling Kong

  5. Zuid-Holland, Leiden University Medical Center Zuid-Holland, Leiden, The Netherlands

    Joris Rotmans

  6. University of Cape Town, Cape Town, Saudi Arabia

    Peter Zilla

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Weinbaum, J.S., Haskett, D.G., Mandelkern, T.F., Vorp, D.A. (2020). Advances in Cell Seeding of Tissue Engineered Vascular Grafts. In: Walpoth, B., Bergmeister, H., Bowlin, G., Kong, D., Rotmans, J., Zilla, P. (eds) Tissue-Engineered Vascular Grafts. Reference Series in Biomedical Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-319-71530-8_10-1

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