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Conservative Treatment of ACL Tear

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Abstract

The increase in incidence and identification of skeletally immature anterior cruciate ligament (ACL) injuries has stimulated new interest in treatment options. While nonoperative management of pediatric ACL injury has been historically associated with ongoing instability, lower rates of return to sport, and subsequent cartilage injury, it may be a viable option for some athletes when proper rehabilitation is employed. In the absence of other injuries, a formal and supervised physical therapy program and a functional brace may be considered for all young patients with ACL injury prior to consideration of a surgical procedure. A four-phase physical therapy program utilizing a timeline and functional milestones is recommended. Variable outcomes of nonsurgical treatment have been reported, but select athletes with proper nonoperative management may be able to function at a high level without instability or increased risk of further injury.

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References

  1. Streich NA, Barié A, Gotterbarm T, Keil M, Schmitt H. Transphyseal reconstruction of the anterior cruciate ligament in prepubescent athletes. Knee Surg Sports Traumatol Arthrosc. 2010;18(11):1481–6.

    Article  PubMed  Google Scholar 

  2. Moksnes H, Engebretsen L, Eitzen I, Risberg MA. Functional outcomes following a non-operative treatment algorithm for anterior cruciate ligament injuries in skeletally immature children 12 years and younger. A prospective cohort with 2 years follow-up. Br J Sports Med. 2013;47(8):488–94.

    Article  PubMed  Google Scholar 

  3. Janarv PM, Nyström A, Werner S, Hirsch G. Anterior cruciate ligament injuries in skeletally immature patients. J Pediatr Orthop. 1996;16(5):673–7.

    Article  CAS  PubMed  Google Scholar 

  4. Funahashi KM, Moksnes H, Maletis GB, Csintalan RP, Inacio MCS, Funahashi TT. Anterior cruciate ligament injuries in adolescents with open Physis: effect of recurrent injury and surgical delay on meniscal and cartilage injuries. Am J Sports Med. 2014;42(5):1068–73.

    Article  PubMed  Google Scholar 

  5. McCarroll JR, Rettig AC, Shelbourne KD. Anterior cruciate ligament injuries in the young athlete with open physes. Am J Sports Med. 1988;16(1):44–7.

    Article  CAS  PubMed  Google Scholar 

  6. Angel KR, Hall DJ. Anterior cruciate ligament injury in children and adolescents. Arthroscopy. 1989;5(3):197–200.

    Article  CAS  PubMed  Google Scholar 

  7. Graf BK, Lange RH, Fujisaki CK, Landry GL, Saluja RK. Anterior cruciate ligament tears in skeletally immature patients: meniscal pathology at presentation and after attempted conservative treatment. YJARS. 1992;8(2):229–33.

    CAS  Google Scholar 

  8. Millett PJ, Willis AA, Warren RF. Associated injuries in pediatric and adolescent anterior cruciate ligament tears: does a delay in treatment increase the risk of meniscal tear? Arthroscopy. 2002;18(9):955–9.

    Article  PubMed  Google Scholar 

  9. Lawrence JTR, Argawal N, Ganley TJ. Degeneration of the knee joint in skeletally immature patients with a diagnosis of an anterior cruciate ligament tear: is there harm in delay of treatment? Am J Sports Med. 2011;39(12):2582–7.

    Article  PubMed  Google Scholar 

  10. Dumont GD, Hogue GD, Padalecki JR, Okoro N, Wilson PL. Meniscal and Chondral injuries associated with pediatric anterior cruciate ligament tears: relationship of treatment time and patient-specific factors. Am J Sports Med. 2012;40(9):2128–33.

    Article  PubMed  Google Scholar 

  11. Anderson AF, Anderson CN. Correlation of meniscal and articular cartilage injuries in children and adolescents with timing of anterior cruciate ligament reconstruction. Am J Sports Med. 2015;43(2):275–81.

    Article  PubMed  Google Scholar 

  12. Yellin JL, Fabricant PD, Gornitzky A, Greenberg EM, Conrad S, Dyke JA, et al. Rehabilitation Following Anterior Cruciate Ligament Tears in Children: A Systematic Review. JBJS Reviews. 2016;4(1):e4.

    Article  Google Scholar 

  13. Dodwell ER, Lamont LE, Green DW, Pan TJ, Marx RG, Lyman S. 20 years of pediatric anterior cruciate ligament reconstruction in New York State. Am J Sports Med. 2014;42(3):675–80.

    Article  PubMed  Google Scholar 

  14. Beynnon BD, Vacek PM, Newell MK, Tourville TW, Smith HC, Shultz SJ, et al. The effects of level of competition, sport, and sex on the incidence of first-time noncontact anterior cruciate ligament injury. Am J Sports Med. 2014;42(8):1806–12.

    Article  PubMed  Google Scholar 

  15. Joseph AM, Collins CL, Henke NM, Yard EE, Fields SK, Comstock RD. A multisport epidemiologic comparison of anterior cruciate ligament injuries in high school athletics. J Athl Train. 2013;48(6):810–7.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Beynnon BD, Johnson RJ, Abate JA, Fleming BC, Nichols CE. Treatment of anterior cruciate ligament injuries, part I. Am J Sports Med. 2005;33(10):1579–602.

    Article  PubMed  Google Scholar 

  17. Hudgens JL, Dahm DL. Treatment of anterior cruciate ligament injury in skeletally immature patients. International Journal of Pediatrics. 2012;2012(6):1–6.

    Article  Google Scholar 

  18. Kurosaka M, Yoshiya S, Mizuno T, Mizuno K. Spontaneous healing of a tear of the anterior cruciate ligament. A report of two cases. J Bone Joint Surg Am. 1998;80(8):1200–3.

    Article  CAS  PubMed  Google Scholar 

  19. Steadman JR, Cameron-Donaldson ML, Briggs KK, Rodkey WG. A minimally invasive technique (“healing response”) to treat proximal ACL injuries in skeletally immature athletes. J Knee Surg. 2006;19(1):8–13.

    Article  PubMed  Google Scholar 

  20. Janarv PM, Westblad P, Johansson C, Hirsch G. Long-term follow-up of anterior tibial spine fractures in children. J Pediatr Orthop. 1995;15(1):63–8.

    Article  CAS  PubMed  Google Scholar 

  21. Patel NM, Park MJ, Sampson NR, Ganley TJ. Tibial eminence fractures in children: earlier posttreatment mobilization results in improved outcomes. J Pediatr Orthop. 2012;32(2):139–44.

    Article  PubMed  Google Scholar 

  22. Gans I, Baldwin KD, Ganley TJ. Treatment and management outcomes of Tibial eminence fractures in pediatric patients: a systematic review. Am J Sports Med. 2014;42(7):1743–50.

    Article  PubMed  Google Scholar 

  23. Grindem H, Eitzen I, Moksnes H, Snyder-Mackler L, Risberg MA. A pair-matched comparison of return to pivoting sports at 1 year in anterior cruciate ligament-injured patients after a nonoperative versus an operative treatment course. Am J Sports Med. 2012;40(11):2509–16.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Frank JS, Gambacorta PL. Anterior cruciate ligament injuries in the skeletally immature athlete: diagnosis and management. J Am Acad Orthop Surg. 2013;21(2):78–87.

    Article  PubMed  Google Scholar 

  25. Kocher MS, Smith JT, Iversen MD, Brustowicz K, Ogunwole O, Andersen J, et al. Reliability, validity, and responsiveness of a modified international knee documentation committee subjective knee form (Pedi-IKDC) in children with knee disorders. Am J Sports Med. 2011;39(5):933–9.

    Article  PubMed  Google Scholar 

  26. Mizuta H, Kubota K, Shiraishi M, Otsuka Y, Nagamoto N, Takagi K. The conservative treatment of complete tears of the anterior cruciate ligament in skeletally immature patients. J Bone Joint Surg Br Vol. 1995;77(6):890–4.

    CAS  Google Scholar 

  27. Kocher MS, Garg S, Micheli LJ. Physeal sparing reconstruction of the anterior cruciate ligament in skeletally immature prepubescent children and adolescents. Surgical technique. J Bone Joint Surg Am. 2006;88(Suppl 1 Pt 2):283–93.

    Article  PubMed  Google Scholar 

  28. Samora WP, Palmer R, Klingele KE. Meniscal pathology associated with acute anterior cruciate ligament tears in patients with open physes. J Pediatr Orthop. 2011;31(3):272–6.

    Article  PubMed  Google Scholar 

  29. Atanda A, Reddy D, Rice JA, Terry MA. Injuries and chronic conditions of the knee in young athletes. Pediatrics in review/American Academy of Pediatrics. 2009;30(11):419–28. quiz 29-30

    Article  Google Scholar 

  30. Tjoumakaris FP, Donegan DJ, Sekiya JK. Partial tears of the anterior cruciate ligament: diagnosis and treatment. American journal of orthopedics. 2011;40(2):92–7.

    PubMed  Google Scholar 

  31. Mall NA, Paletta GA. Pediatric ACL injuries: evaluation and management. Curr Rev Muscoskelet Med. 2013;6(2):132–40.

    Article  Google Scholar 

  32. Swirtun LR, Jansson A, Renström P. The effects of a functional knee brace during early treatment of patients with a nonoperated acute anterior cruciate ligament tear: a prospective randomized study. Clinical journal of sport medicine. 2005;15(5):299–304.

    Article  PubMed  Google Scholar 

  33. Colville MR, Lee CL, Ciullo JV. The Lenox Hill brace. An evaluation of effectiveness in treating knee instability. Am J Sports Med. 1986;14(4):257–61.

    Article  CAS  PubMed  Google Scholar 

  34. Herrington L, Fowler E. A systematic literature review to investigate if we identify those patients who can cope with anterior cruciate ligament deficiency. Knee. 2006;13(4):260–5.

    Article  PubMed  Google Scholar 

  35. Chalmers PN, Mall NA, Moric M, Sherman SL, Paletta GP, Cole BJ, et al. Does ACL reconstruction Alter natural history?: a systematic literature review of long-term outcomes. The Journal of Bone and Joint Surgery (American). 2014;96(4):292–300.

    Article  Google Scholar 

  36. Kaplan Y. Identifying individuals with an anterior cruciate ligament-deficient knee as Copers and Noncopers: a narrative literature review. J Orthop Sports Phys Ther. 2011;41(10):758–66.

    Article  PubMed  Google Scholar 

  37. Gaulrapp HM, Haus J. Intraarticular stabilization after anterior cruciate ligament tear in children and adolescents: results 6 years after surgery. Knee Surg Sports Traumatol Arthrosc. 2006;14(5):417–24.

    Article  CAS  PubMed  Google Scholar 

  38. O’Connor DP, Laughlin MS, Woods GW. Factors related to additional knee injuries after anterior cruciate ligament injury. Arthroscopy. 2005;21(4):431–8.

    Article  PubMed  Google Scholar 

  39. Henry J, Chotel F, Chouteau J, Fessy MH, Bérard J, Moyen B. Rupture of the anterior cruciate ligament in children: early reconstruction with open physes or delayed reconstruction to skeletal maturity? Knee surgery, sports traumatology. Arthroscopy. 2009;17(7):748–55.

    Google Scholar 

  40. Woods GW. Delayed anterior cruciate ligament reconstruction in adolescents with open Physes. Am J Sports Med. 2004;32(1):201–10.

    Article  PubMed  Google Scholar 

  41. Frosch KH, Stengel D, Brodhun T, Stietencron I, Holsten D, Jung C, et al. Outcomes and risks of operative treatment of rupture of the anterior cruciate ligament in children and adolescents. YJARS. 2010;26(11):1539–50.

    Google Scholar 

  42. LJ DS, Padua DA, Blackburn JT, Garrett WE, Guskiewicz KM, Marshall SW. Integrated injury prevention program improves balance and vertical jump height in children. J Strength Cond Res. 2010;24(2):332–4.

    Article  Google Scholar 

  43. Grandstrand SL, Pfeiffer RP, Sabick MB, DeBeliso M, Shea KG. The effects of a commercially available warm-up program on landing mechanics in female youth soccer players. J Strength Cond Res. 2006;20(2):331–5.

    PubMed  Google Scholar 

  44. Eitzen I, Moksnes H, Snyder-Mackler L, Risberg MA. A progressive 5-week exercise therapy program leads to significant improvement in knee function early after anterior cruciate ligament injury. J Orthop Sports Phys Ther. 2010;40(11):705–21.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Guy JA, Micheli LJ. Strength training for children and adolescents. J Am Acad Orthop Surg. 2001;9(1):29–36.

    Article  CAS  PubMed  Google Scholar 

  46. Myklebust G, Engebretsen L, Braekken IH, Skjølberg A, Olsen OE, Bahr R. Prevention of anterior cruciate ligament injuries in female team handball players: a prospective intervention study over three seasons. Clin J Sport Med. 2003;13(2):71–8.

    Article  PubMed  Google Scholar 

  47. Kilding AE, Tunstall H, Kuzmic D. Suitability of FIFA’s “The 11” Training Programme for Young Football Players - Impact on Physical Performance. J Sports Sci Med. 2008;7(3):320–6.

    PubMed  PubMed Central  Google Scholar 

  48. Rössler R, Donath L, Bizzini M, Faude O. A new injury prevention programme for children’s football – FIFA 11+ kids – can improve motor performance: a cluster-randomised controlled trial. J Sports Sci. 2015;34(6):549–56.

    Article  PubMed  Google Scholar 

  49. Stanitski CL. Conservative treatment of complete ACL tears. J Bone Joint Surg. 1996;78(4):681.

    CAS  Google Scholar 

  50. Moksnes H, Engebretsen L, Risberg MA. Management of Anterior Cruciate Ligament Injuries in skeletally immature individuals. J Orthop Sports Phys Ther. 2012;42(3):172–83.

    Article  PubMed  Google Scholar 

  51. Kocher MS, Micheli LJ, Zurakowski D, Luke A. Partial tears of the anterior cruciate ligament in children and adolescents. Am J Sports Med. 2002;30(5):697–703.

    Article  PubMed  Google Scholar 

  52. van Grinsven S, van Cingel REH, Holla CJM, van Loon CJM. Evidence-based rehabilitation following anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc. 2010;18(8):1128–44.

    Article  PubMed  Google Scholar 

  53. Major NM, Beard LN, Helms CA. Accuracy of MR imaging of the knee in adolescents. AJR Am J Roentgenol. 2003;180(1):17–9.

    Article  PubMed  Google Scholar 

  54. Khayambashi K, Ghoddosi N, Straub RK, Powers CM. Hip muscle strength predicts noncontact anterior cruciate ligament injury in male and female athletes: a prospective study. Am J Sports Med. 2016;44(2):355–61.

    Article  PubMed  Google Scholar 

  55. Merlini L, Dell’Accio D, Granata C. Reliability of dynamic strength knee muscle testing in children. J Orthop Sports Phys Ther. 1995;22(2):73–6.

    Article  CAS  PubMed  Google Scholar 

  56. Wiggin M, Wilkinson K, Habetz S, Chorley J, Watson M. Percentile values of isokinetic peak torque in children six through thirteen years old. Pediatr Phys Ther. 2006;18(1):3–18.

    Article  PubMed  Google Scholar 

  57. De Ste CM, Deighan M, Armstrong N. Assessment and interpretation of isokinetic muscle strength during growth and maturation. Sports medicine. 2003;33(10):727–43.

    Article  Google Scholar 

  58. Balyi I, Way R, Higgs C. Long-term athletic development: Sheridan books; 2013.

    Google Scholar 

  59. Noyes FR, Barber SD, Mangine RE. Abnormal lower limb symmetry determined by function hop tests after anterior cruciate ligament rupture. Am J Sports Med. 1991;19(5):513–8.

    Article  CAS  PubMed  Google Scholar 

  60. Plisky PJ, Rauh MJ, Kaminski TW, Underwood FB. Star excursion balance test as a predictor of lower extremity injury in high school basketball players. J Orthop Sports Phys Ther. 2006;36(12):911–9.

    Article  PubMed  Google Scholar 

  61. Plisky PJ, Gorman PP, Butler RJ, Kiesel KB, Underwood FB, Elkins B. The reliability of an instrumented device for measuring components of the star excursion balance test. N Am J Sports Phys Ther. 2009;4(2):92–9.

    PubMed  PubMed Central  Google Scholar 

  62. Smith CA, Chimera NJ, Warren M. Association of Y Balance Test Reach Asymmetry and Injury in division I athletes. Med Sci Sports Exerc. 2015;47(1):136–41.

    Article  PubMed  Google Scholar 

  63. Butler RJ, Lehr ME, Fink ML, Kiesel KB, Plisky PJ. Dynamic balance performance and noncontact lower extremity injury in college football players: an initial study. Sports Health: A Multidisciplinary Approach. 2013;5(5):417–22.

    Article  Google Scholar 

  64. Lehr ME, Plisky PJ, Butler RJ, Fink ML, Kiesel KB, Underwood FB. Field-expedient screening and injury risk algorithm categories as predictors of noncontact lower extremity injury. Scand J Med Sci Sports. 2013;23(4):e225–32.

    Article  CAS  PubMed  Google Scholar 

  65. Breen EO, Howell DR, Stracciolini A, Dawkins C, Meehan WP 3rd. Examination of Age-Related Differences on Clinical Tests of Postural Stability. Sports health. SAGE Journals. 2016;8(3):244–9.

    Google Scholar 

  66. Ziebarth K, Kolp D, Kohl S, Slongo T. Anterior cruciate ligament injuries in children and adolescents: a review of the recent literature. Eur J Pediatr Surg. 2013;23(06):464–9.

    Article  PubMed  Google Scholar 

  67. Ardern CL, Taylor NF, Feller JA, Whitehead TS, Webster KE. Psychological responses matter in returning to preinjury level of sport after anterior cruciate ligament reconstruction surgery. Am J Sports Med. 2013;41(7):1549–58.

    Article  PubMed  Google Scholar 

  68. Webster KE, Feller JA, Lambros C. Development and preliminary validation of a scale to measure the psychological impact of returning to sport following anterior cruciate ligament reconstruction surgery. Physical therapy in sport. 2008;9(1):9–15.

    Article  PubMed  Google Scholar 

  69. Johnson U, Ekengren J, Andersen MB. Injury prevention in Sweden: Helping soccer players at risk. Journal of Sport & Exercise Psychology. 2005;27:32–8.

    Article  Google Scholar 

  70. Mummery WK, Schofield G, Perry C. Bouncing back: the role of coping style, social support, and self-concept in resilience of sport performance. Athletic Insight. 2004;6:1–18.

    Google Scholar 

  71. Newcomer RR, Perna FM. Features of posttraumatic distress among adolescent athletes. J Athl Train. 2003;38(2):163–6.

    PubMed  PubMed Central  Google Scholar 

  72. Duda JL, Smart AE, Tappe MK. Predictors of adherence in the rehabilitation of athletic injuries: an application of personal investment theory. J Sport Exerc Psychol. 1989;11:367–81.

    Article  Google Scholar 

  73. Morrey MA, Stuart MJ, Smith AM, Wiese-Bjornstal DM. A longitudinal examination of athletes’ emotional and cognitive responses to anterior cruciate ligament injury. Clinical Journal of Sport Medicine. 1999;9(2):63–9.

    Article  CAS  PubMed  Google Scholar 

  74. Johnson U. Coping strategies among long-term injured competitive athletes. A study of 81 men and women in team and individual sports. Scand J Med Sci Sports. 1997;7(6):367–72.

    Article  CAS  PubMed  Google Scholar 

  75. Udry E, Donald Shelbourne K, Gray T. Psychological readiness for anterior cruciate ligament surgery: describing and comparing the adolescent and adult experiences. J Athl Train. 2003;38(2):167–71.

    PubMed  PubMed Central  Google Scholar 

  76. Mayer SW, Queen RM, Taylor D, Moorman CT 3rd, Toth AP, Garrett WE Jr, et al. Functional testing differences in anterior cruciate ligament reconstruction patients released versus not released to return to sport. Am J Sports Med. 2015;43(7):1648–55.

    Article  PubMed  Google Scholar 

  77. Mandelbaum BR. Effectiveness of a neuromuscular and proprioceptive training program in preventing anterior cruciate ligament injuries in female athletes: 2-year follow-up. Am J Sports Med. 2005;33(7):1003–10.

    Article  PubMed  Google Scholar 

  78. Milewski MD, Beck NA, Lawrence JT, Ganley TJ. Anterior cruciate ligament reconstruction in the young athlete: a treatment algorithm for the skeletally immature. CSM. 2011;30(4):801–10.

    Google Scholar 

  79. Kocher MS, Sterett WI, Briggs KK, Zurakowski D, Steadman JR. Effect of functional bracing on subsequent knee injury in ACL-deficient professional skiers. J Knee Surg. 2003;16(2):87–92.

    PubMed  Google Scholar 

  80. Wojtys EM, Kothari SU, Huston LJ. Anterior cruciate ligament functional brace use in sports. Am J Sports Med. 1996;24(4):539–46.

    Article  CAS  PubMed  Google Scholar 

  81. Branch TP, Hunter R, Donath M. Dynamic EMG analysis of anterior cruciate deficient legs with and without bracing during cutting. Am J Sports Med. 1989;17(1):35–41.

    Article  CAS  PubMed  Google Scholar 

  82. Ramski DE, Kanj WW, Franklin CC, Baldwin KD, Ganley TJ. Anterior cruciate ligament tears in children and adolescents: a meta-analysis of nonoperative versus operative treatment. Am J Sports Med. 2014;42(11):2769–76.

    Article  PubMed  Google Scholar 

  83. Vavken P, Murray MM. Treating anterior cruciate ligament tears in skeletally immature patients. Arthroscopy. 2011;27(5):704–16.

    Article  PubMed  PubMed Central  Google Scholar 

  84. Barrack RL, Buckley SL, Bruckner JD, Kneisl JS, Alexander AH. Partial versus complete acute anterior cruciate ligament tears. The results of nonoperative treatment. J Bone Joint Surg. 1990;72(4):622–4.

    CAS  Google Scholar 

  85. Aichroth PM, Patel DV, Zorrilla P. The natural history and treatment of rupture of the anterior cruciate ligament in children and adolescents. A prospective review. J Bone Joint Surg Br Vol. 2002;84(1):38–41.

    Article  CAS  Google Scholar 

  86. Tandogan RN, Taser O, Kayaalp A, Taskiran E, Pinar H, Alparslan B, et al. Analysis of meniscal and chondral lesions accompanying anterior cruciate ligament tears: relationship with age, time from injury, and level of sport. Knee surgery, sports traumatology, arthroscopy. 2004;12(4):262–70.

    Article  PubMed  Google Scholar 

  87. Arbes S, Resinger C, Vécsei V, Nau T. The functional outcome of total tears of the anterior cruciate ligament (ACL) in the skeletally immature patient. Int Orthop. 2006;31(4):471–5.

    Article  PubMed  PubMed Central  Google Scholar 

  88. Moksnes H, Engebretsen L, Risberg MA. Prevalence and incidence of new meniscus and cartilage injuries after a nonoperative treatment algorithm for ACL tears in skeletally immature children: a prospective MRI study. Am J Sports Med. 2013;41(8):1771–9.

    Article  PubMed  Google Scholar 

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Ellis, H., Vite, L., Wilson, P. (2018). Conservative Treatment of ACL Tear. In: Parikh, S. (eds) The Pediatric Anterior Cruciate Ligament. Springer, Cham. https://doi.org/10.1007/978-3-319-64771-5_8

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