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Autism Spectrum and Other Developmental Disorders and ADHD

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Moodiness in ADHD

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Abstract

There is significant comorbidity between autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). For children with ASD, their functional impairment becomes more pronounced when ADHD is present. Despite ASD and ADHD being different disorders, they share etiological factors such as environmental factors, genetic factors, and neural pathways. If the referral questions regard ASD and ADHD, the clinician should establish a multistep approach for determining the presence, absence, or co-occurrence of these disorders. Assessment strategies for children with ASD and ADHD such as utilizing rating scales, obtaining a detailed history and examination of the child are reviewed. Furthermore, psychosocial interventions and psychopharmacologic interventions for children with ASD and ADHD are also discussed.

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References

  1. Murray MJ. Attention-deficit/hyperactivity disorder in the context of autism spectrum disorders. Curr Psychiatry Rep. 2010;12(5):382–8.

    Article  PubMed  Google Scholar 

  2. Sinzig J, Morsch D, Bruning N, Schmidt MH, Lehmkuhl G. Inhibition, flexibility, working memory and planning in autism spectrum disorders with and without comorbid ADHD-symptoms. Child Adolesc Psychiatry Ment Health. 2008;2(1):4.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Gadow KD, DeVincent CJ, Pomeroy J. ADHD symptom subtypes in children with pervasive developmental disorder. J Autism Dev Disord. 2006;36(2):271–83.

    Article  PubMed  Google Scholar 

  4. Visser JC, Rommelse NN, Greven CU, Buitelaar JK. Autism spectrum disorder and attention-deficit/hyperactivity disorder in early childhood: a review of unique and shared characteristics and developmental antecedents. Neurosci Biobehav Rev. 2016;65:229–63.

    Article  PubMed  Google Scholar 

  5. Pearson DA, Santos CW, Aman MG, Arnold LE, Casat CD, Mansour R, et al. Effects of extended release methylphenidate treatment on ratings of attention-deficit/hyperactivity disorder (ADHD) and associated behavior in children with autism spectrum disorders and ADHD symptoms. J Child Adolesc Psychopharmacol. 2013 Jun;23(5):337–51.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Sikora DM, Vora P, Coury DL, Rosenberg D. Attention-deficit/hyperactivity disorder symptoms, adaptive functioning, and quality of life in children with autism spectrum disorder. Pediatrics. 2012;130(Suppl 2):S91–7.

    Article  PubMed  Google Scholar 

  7. Miodovnik A, Harstad E, Sideridis G, Huntington N. Timing of the diagnosis of attention-deficit/hyperactivity disorder and Autism Spectrum Disorder. Pediatrics. 2015 Oct;136(4):e830–7.

    Article  PubMed  Google Scholar 

  8. Elsheshtawy E, Tobar S, Sherra K, Atallah S, Elkasaby R. Study of some biomarkers in hair of children with autism. Middle East Curr Psychiatry. 2011;18(1):6–10.

    Article  Google Scholar 

  9. Desoto MC, Hitlan RT. Sorting out the spinning of autism: heavy metals and the question of incidence. Acta Neurobiol Exp (Wars). 2010;70(2):165–76.

    Google Scholar 

  10. Geier DA, Geier MR. A prospective study of mercury toxicity biomarkers in autistic spectrum disorders. J Toxicol Environ Health. 2007;70(20):1723–30.

    Article  CAS  Google Scholar 

  11. Priya MD, Geetha A. Level of trace elements (copper, zinc, magnesium and selenium) and toxic elements (lead and mercury) in the hair and nail of children with autism. Biol Trace Elem Res. 2011;142(2):148–58.

    Article  Google Scholar 

  12. Desoto MC, Hitlan RT. Blood levels of mercury are related to diagnosis of autism: a reanalysis of an important data set. J Child Neurol. 2007;22(11):1308–11.

    Article  PubMed  Google Scholar 

  13. Kern JK, Grannemann BD, Trivedi MH, Adams JB. Sulfhydryl-reactive metals in autism. J Toxicol Environ Health A. 2007;70(8):715–21.

    Article  CAS  PubMed  Google Scholar 

  14. Taylor MJ, Charman T, Ronald A. Where are the strongest associations between autistic traits and traits of ADHD? Evidence from a community-based twin study. Eur Child Adolesc Psychiatry. 2015 Sep;24(9):1129–38.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Ronald A, Simonoff E, Kuntsi J, Asherson P, Plomin R. Evidence for overlapping genetic influences on autistic and ADHD behaviours in a community twin sample. J Child Psychol Psychiatry. 2008 May;49(5):535–42.

    Article  PubMed  Google Scholar 

  16. Musser ED, Hawkey E, Kachan-Liu SS, Lees P, Roullet JB, Goddard K, et al. Shared familial transmission of autism spectrum and attention-deficit/hyperactivity disorders. J Child Psychol Psychiatry. 2014 Jul;55(7):819–27.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Wilcox J, Tsuang MT, Ledger E, Algeo J, Schnurr T. Brain perfusion in autism varies with age. Neuropsychobiology. 2002;46(1):13–6.

    Article  PubMed  Google Scholar 

  18. Gupta SK, Ratnam BV. Cerebral perfusion abnormalities in children with autism and mental retardation: a segmental quantitative SPECT study. Indian Pediatr. 2009;46(2):161–4.

    PubMed  Google Scholar 

  19. Kim BN, Kim JW, Kang H, Cho SC, Shin MS, Yoo HJ, et al. Regional differences in cerebral perfusion associated with the alpha-2A-adrenergic receptor genotypes in attention deficit hyperactivity disorder. J Psychiatry Neurosci. 2010;35(5):330–6.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Amen DG, Hanks C, Prunella J. Preliminary evidence differentiating ADHD using brain SPECT imaging in older patients. J Psychoactive Drugs. 2008;40(2):139–46.

    Article  PubMed  Google Scholar 

  21. Rommelse NN, Geurts HM, Franke B, Buitelaar JK, Hartman CA. A review on cognitive and brain endophenotypes that may be common in autism spectrum disorder and attention-deficit/hyperactivity disorder and facilitate the search for pleiotropic genes. Neurosci Biobehav Rev. 2011 May;35(6):1363–96.

    Article  CAS  PubMed  Google Scholar 

  22. D'Agati E, Casarelli L, Pitzianti MB, Pasini A. Overflow movements and white matter abnormalities in ADHD. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(3):441–5.

    Article  PubMed  Google Scholar 

  23. Stavrinos D, Biasini FJ, Fine PR, Hodgens JB, Khatri S, Mrug S, et al. Mediating factors associated with pedestrian injury in children with attention-deficit/hyperactivity disorder. Pediatrics. 2011;128(2):296–302.

    Article  PubMed  Google Scholar 

  24. Wolraich ML, Lambert W, Doffing MA, Bickman L, Simmons T, Worley K. Psychometric properties of the Vanderbilt ADHD diagnostic parent rating scale in a referred population. J Pediatr Psychol. 2003;28(8):559–68.

    Article  PubMed  Google Scholar 

  25. Achenbach TM, Rescorla LA. Manual for the ASEBA School-Age Forms and Profiles. Burlington: University of Vermont, Research Center for Children, Youth, & Families; 2001.

    Google Scholar 

  26. Pelham WE Jr, Fabiano GA, Massetti GM. Evidence-based assessment of attention deficit hyperactivity disorder in children and adolescents. J Clin Child Psychol. 2005;34(3):449–76.

    Article  Google Scholar 

  27. Erford B. The disruptive behavior rating scale (DBRS): parent and teacher version. East Aurora: Slosson Educational Publications; 1993.

    Google Scholar 

  28. Norris M, Lecavalier L. Screening accuracy of level 2 autism spectrum disorder rating scales. A review of selected instruments. Autism. 2010;14(4):263–84.

    Article  PubMed  Google Scholar 

  29. Constantino JN, Todd RD. Intergenerational transmission of subthreshold autistic traits in the general population. Biol Psychiatry. 2005;57(6):655–60.

    Article  PubMed  Google Scholar 

  30. Constantino J, Gruber C. Social responsiveness scale. 2nd ed. Los Angeles: Western Psychological Services; 2012.

    Google Scholar 

  31. Duvekot J, van der Ende J, Verhulst FC, Greaves-Lord K. The Screening Accuracy of the Parent and Teacher-Reported Social Responsiveness Scale (SRS): comparison with the 3Di and ADOS. J Autism Dev Disord. 2015;45(6):1658–72.

    Article  PubMed  Google Scholar 

  32. Cholemkery H, Kitzerow J, Rohrmann S, Freitag CM. Validity of the social responsiveness scale to differentiate between autism spectrum disorders and disruptive behaviour disorders. Child Adolesc Psychiatry. 2014;23(2):81–93.

    Article  Google Scholar 

  33. Bradstreet LE, Juechter JI, Kamphaus RW, Kerns CM, Robins DL. Using the BASC-2 Parent Rating Scales to Screen for Autism Spectrum Disorder in toddlers and preschool-aged children. J Abnorm Child Psychol. 2016;14:1–2.

    Google Scholar 

  34. Chi TC, Hinshaw SP. Mother-child relationships of children with ADHD: the role of maternal depressive symptoms and depression-related distortions. J Abnorm Child Psychol. 2002 Aug;30(4):387–400.

    Article  PubMed  Google Scholar 

  35. Gadow KD, Nolan EE, Sprafkin J, Schwartz J. Tics and psychiatric comorbidity in children and adolescents. Dev Med Child Neurol. 2002;44(5):330–8.

    Article  PubMed  Google Scholar 

  36. Lord C, Rutter M, DiLavore PC, Risi S, Gotham K, Bishop S. Autism diagnostic observation schedule. 2nd ed. Torrance: Western Psychological Services; 2012.

    Google Scholar 

  37. Wasserman T, Wasserman LD. The sensitivity and specificity of neuropsychological tests in the diagnosis of attention deficit hyperactivity disorder. Appl Neuropsychol Child. 2012;1(2):90–9.

    Article  PubMed  Google Scholar 

  38. Pennington BF. Diagnosing learning disorders: a neuropsychological framework. New York: Guilford Press; 2008.

    Google Scholar 

  39. Loukusa S, Makinen L, Kuusikko-Gauffin S, Ebeling H, Moilanen I. Theory of mind and emotion recognition skills in children with specific language impairment, autism spectrum disorder and typical development: group differences and connection to knowledge of grammatical morphology, word-finding abilities and verbal working memory. Commun Disord. 2014;49(4):498–507.

    Article  Google Scholar 

  40. Kanne SM, Randolph JK, Farmer JE. Diagnostic and assessment findings: a bridge to academic planning for children with autism spectrum disorders. Neuropsychol Rev. 2008;18(4):367–84.

    Article  PubMed  Google Scholar 

  41. Hinshaw SP, Arnold LE, MTA Cooperative Group. Attention-deficit hyperactivity disorder, multimodal treatment, and longitudinal outcome: evidence, paradox, and challenge. Wiley Interdiscip Rev Cogn Sci. 2015;6(1):39–52.

    Article  PubMed Central  Google Scholar 

  42. Sonuga-Barke EJ, Brandeis D, Cortese S, Daley D, Ferrin M, Holtmann M, et al. Nonpharmacological interventions for ADHD: systematic review and meta-analyses of randomized controlled trials of dietary and psychological treatments. Am J Psychiatry. 2013;170(3):275–89.

    Article  PubMed  Google Scholar 

  43. Hoza B, Smith AL, Shoulberg EK, Linnea KS, Dorsch TE, Blazo JA, et al. A randomized trial examining the effects of aerobic physical activity on attention-deficit/hyperactivity disorder symptoms in young children. J Abnorm Child Psychol. 2015;43(4):655–67.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Smith AL, Hoza B, Linnea K, McQuade JD, Tomb M, Vaughn AJ, et al. Pilot physical activity intervention reduces severity of ADHD symptoms in young children. J Atten Disord. 2013;17(1):70–82.

    Article  PubMed  Google Scholar 

  45. Pelham WE Jr, Fabiano GA. Evidence-based psychosocial treatments for attention-deficit/hyperactivity disorder. J Clin Child Adolesc Psychol. 2008;37(1):184–214.

    Article  PubMed  Google Scholar 

  46. A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. The MTA Cooperative Group. Multimodal Treatment Study of Children with ADHD. Arch Gen Psychiatry. 1999;56(12):1073–86.

    Google Scholar 

  47. Zwi M, Jones H, Thorgaard C, York A, Dennis JA. Parent training interventions for Attention Deficit Hyperactivity Disorder (ADHD) in children aged 5 to 18 years. Cochrane Libr. 2011;(12):CD003018.

    Google Scholar 

  48. Ospina MB, Krebs Seida J, Clark B, Karkhaneh M, Hartling L, Tjosvold L, et al. Behavioural and developmental interventions for autism spectrum disorder: a clinical systematic review. PLoS One. 2008;3(11):e3755.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Barnes CS, Mellor JR, Rehfeldt RA. Implementing the Verbal Behavior Milestones Assessment and Placement Program (VB-MAPP): teaching assessment techniques. Anal Verbal Behav. 2014;30(1):36–47.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Reichow B, Steiner AM, Volkmar F. Cochrane review: social skills groups for people aged 6 to 21 with autism spectrum disorders (ASD). Evid Based Child Health. 2013;8:266–315.

    Article  PubMed  Google Scholar 

  51. Leaf JB, Kassardjian A, Oppenheim-Leaf ML, Cihon JH, Taubman M, Leaf R, et al. Social thinking(R): science, pseudoscience, or antiscience? Behav Anal Pract. 2016;9(2):152–7.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Research Units on Pediatric Psychopharmacology Autism Network. Randomized, controlled, crossover trial of methylphenidate in pervasive developmental disorders with hyperactivity. Arch Gen Psychiatry. 2005;62(11):1266–74.

    Article  Google Scholar 

  53. Greenhill LL, Swanson JM, Vitiello B, Davies M, Clevenger W, Wu M, et al. Impairment and deportment responses to different methylphenidate doses in children with ADHD: the MTA titration trial. J Am Acad Child Adolesc Psychiatry. 2001;40(2):180–7.

    Article  CAS  PubMed  Google Scholar 

  54. Fankhauser MP, Karumanchi VC, German ML, Yates A, Karumanchi SD. A double-blind, placebo-controlled study of the efficacy of transdermal clonidine in autism. J Clin Psychiatry. 1992;53(3):77–82.

    CAS  PubMed  Google Scholar 

  55. Jaselskis CA, Cook EH Jr, Fletcher KE, Leventhal BL. Clonidine treatment of hyperactive and impulsive children with autistic disorder. J Clin Psychopharmacol. 1992;12(5):322–7.

    Article  CAS  PubMed  Google Scholar 

  56. Handen BL, Sahl R, Hardan AY. Guanfacine in children with autism and/or intellectual disabilities. J Dev Behav Pediatr. 2008 Aug;29(4):303–8.

    Article  PubMed  Google Scholar 

  57. Scahill L, McCracken JT, King BH, Rockhill C, Shah B, Politte L, et al. Extended-release Guanfacine for hyperactivity in children with autism spectrum disorder. Am J Psychiatry. 2015 Dec;172(12):1197–206.

    Article  PubMed  Google Scholar 

  58. Handen BL, Aman MG, Arnold LE, Hyman SL, Tumuluru RV, Lecavalier L, et al. Atomoxetine, parent training, and their combination in children with autism Spectrum disorder and attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2015 Nov;54(11):905–15.

    Article  PubMed  PubMed Central  Google Scholar 

  59. Harfterkamp M, Van de Loo-Neus G, Minderaa RB, Van der Gaag RJ, Escobar R, Schacht A, et al. A randomized double-blind study of atomoxetine versus placebo for attention-deficit/hyperactivity disorder symptoms in children with autism spectrum disorder. J Am Acad Child Adolesc Psychiatry. 2012;51(7):733–41.

    Article  PubMed  Google Scholar 

  60. Arnold LE, Aman MG, Cook AM, Witwer AN, Hall KL, Thompson S, et al. Atomoxetine for hyperactivity in autism spectrum disorders: placebo-controlled crossover pilot trial. J Am Acad Child Adolesc Psychiatry. 2006;45(10):1196–205.

    Article  PubMed  Google Scholar 

  61. King BH, Wright DM, Handen BL, Sikich L, Zimmerman AW, McMahon W, et al. Double-blind, placebo-controlled study of amantadine hydrochloride in the treatment of children with autistic disorder. J Am Acad Child Adolesc Psychiatry. 2001;40(6):658–65.

    Article  CAS  PubMed  Google Scholar 

  62. Gordon CT, State RC, Nelson JE, Hamburger SD, Rapoport JL. A double-blind comparison of clomipramine, desipramine, and placebo in the treatment of autistic disorder. Arch Gen Psychiatry. 1993;50(6):441–7.

    Article  CAS  PubMed  Google Scholar 

  63. Gordon CT, Rapoport JL, Hamburger SD, State RC, Mannheim GB. Differential response of seven subjects with autistic disorder to clomipramine and desipramine. Am J Psychiatry. 1992;149(3):363–6.

    Article  CAS  PubMed  Google Scholar 

  64. Brasic JR, Barnett JY, Sheitman BB, Tsaltas MO. Adverse effects of clomipramine. J Am Acad Child Adolesc Psychiatry. 1997;36(9):1165–6.

    Article  CAS  PubMed  Google Scholar 

  65. Sanchez LE, Campbell M, Small AM, Cueva JE, Armenteros JL, Adams PB. A pilot study of clomipramine in young autistic children. J Am Acad Child Adolesc Psychiatry. 1996;35(4):537–44.

    Article  CAS  PubMed  Google Scholar 

  66. McCracken JT, McGough J, Shah B, Cronin P, Hong D, Aman MG, et al. Risperidone in children with autism and serious behavioral problems. N Engl J Med. 2002;347(5):314–21.

    Article  CAS  PubMed  Google Scholar 

  67. Shea S, Turgay A, Carroll A, Schulz M, Orlik H, Smith I, et al. Risperidone in the treatment of disruptive behavioral symptoms in children with autistic and other pervasive developmental disorders. Pediatrics. 2004;114(5):e634–41.

    Article  PubMed  Google Scholar 

  68. Marcus RN, Owen R, Kamen L, Manos G, McQuade RD, Carson WH, et al. A placebo-controlled, fixed-dose study of aripiprazole in children and adolescents with irritability associated with autistic disorder. J Am Acad Child Adolesc Psychiatry. 2009 Nov;48(11):1110–9.

    Article  PubMed  Google Scholar 

  69. Owen R, Sikich L, Marcus RN, Corey-Lisle P, Manos G, McQuade RD, et al. Aripiprazole in the treatment of irritability in children and adolescents with autistic disorder. Pediatrics. 2009 Dec;124(6):1533–40.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Psychiatry, Geisel School of Medicine at Dartmouth, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH, 03756, USA

    Jennifer L. McLaren M.D., Jonathan D. Lichtenstein Psy.D., M.B.A. & Fern Baldwin Ph.D.

  2. Geisel School of Medicine at Dartmouth, 1 Rope Ferry Road, Hanover, NH, USA

    Sarah Y. Bessen M.P.H.

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  1. Jennifer L. McLaren M.D.
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  2. Jonathan D. Lichtenstein Psy.D., M.B.A.
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  3. Sarah Y. Bessen M.P.H.
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  4. Fern Baldwin Ph.D.
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Correspondence to Jennifer L. McLaren M.D. .

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  1. Department of Psychiatry, Dartmouth Hitchcock Medical Center, Dartmouth Geisel School of Medicine, Lebanon, New Hampshire, USA

    W. Burleson Daviss

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McLaren, J.L., Lichtenstein, J.D., Bessen, S.Y., Baldwin, F. (2018). Autism Spectrum and Other Developmental Disorders and ADHD. In: Daviss, W. (eds) Moodiness in ADHD. Springer, Cham. https://doi.org/10.1007/978-3-319-64251-2_9

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  • DOI: https://doi.org/10.1007/978-3-319-64251-2_9

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