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The Elephant in the Room: The Role of Microtubules in Cancer

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Cell Division Machinery and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1002))

Abstract

Microtubules are the backbone of all eukaryotic cells cytoskeleton. Their dynamic behaviour constitutes the basis for many biological processes such as cellular motility, cytoplasmic transport and cell division. Some the most effective chemotherapeutics, such as the taxanes, are microtubule interfering drugs. Moreover, many studies suggest that microtubule dynamics are altered in cancer cell divisions and linked to chromosomal instability, aneuploidy and development of drug resistances. The elephant in the room, however, is that despite all these evidences, the exact role of microtubules in malignancies remains elusive, partially due to the lack of clear genetic alterations linking microtubules to cancer. This review will discuss the molecular mechanisms that might alter microtubule dynamics in cancer cells, the pro and cons of the different theories linking these alterations to cancer progression, and the possible directions to address future key questions.

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Acknowledgements

The authors thank Helder Maiato (University of Porto), Carsten Janke (Institut Curie) and the members of the Gotta and Meraldi laboratories for helpful discussions. This work was supported by an SNF-project grant (No 31003A 156013) to M.G., an SNF-project grant (No 31003A_160006) to P.M. and the University of Geneva.

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  1. Department of Cell Physiology and Metabolism, Faculty of Medicine, Geneva University, 1211, Geneva, Switzerland

    Luca Cirillo, Monica Gotta & Patrick Meraldi

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  1. Luca Cirillo
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  2. Monica Gotta
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Correspondence to Monica Gotta or Patrick Meraldi .

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  1. Department of Cell Physiology and Metabolism, Faculty of Medicine, Geneva University, Geneva, Switzerland

    Monica Gotta

  2. Department of Cell Physiology and Metabolism, Faculty of Medicine, Geneva University, Geneva, Switzerland

    Patrick Meraldi

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Cirillo, L., Gotta, M., Meraldi, P. (2017). The Elephant in the Room: The Role of Microtubules in Cancer. In: Gotta, M., Meraldi, P. (eds) Cell Division Machinery and Disease. Advances in Experimental Medicine and Biology, vol 1002. Springer, Cham. https://doi.org/10.1007/978-3-319-57127-0_5

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