Abstract
The field of aesthetic dermatology has grown significantly over the last two decades, much of the success being led by injectables and non-surgical options for facial rejuvenation. The earliest pioneer within the injectable family is the use of botulinum toxin for dynamic facial rhytids, or expression lines and wrinkles. Over the years, the area of utilization has expanded from the upper central face and forehead to more complex uses around the eyes, mouth, and neck. Complemented with injectable fillers and lasers, botulinum toxin has become a staple in the anti-aging armamentarium. There will also be a discussion on the treatment of hyperhidrosis (excessive sweating) using botulinum toxin, one of the few non-cosmetic uses in a dermatology clinic. The following section discusses both on- and off-label uses of botulinum toxin, which can be utilized safely and effectively. Injection technique and dosage varies from practice to practice based on the provider, but it is essential to know the underlying anatomy and muscles targeted. Equally important is the knowledge of potential side effects. Facial asymmetry and temporary functional impairment are real risks that should be incorporated into patient counseling prior to injections.
Similar content being viewed by others
References
Montecucco C, Molgó J. Botulinal neurotoxins: revival of an old killer. Curr Opin Pharmacol. 2005;5(3):274–9.
Carruthers A, Carruthers J. Clinical indications and injection technique for the cosmetic use of botulinum A exotoxin. Dermatol Surg. 1998;24:1189–94.
Clark RP, Berris CE. Botulinum toxin: a treatment for facial asymmetry caused by facial nerve paralysis. Plast Reconstr Surg. 1989;84(2):353–5.
Lew MF. Review of the FDA-approved uses of botulinum toxins, including data suggesting efficacy in pain reduction. Clin J Pain. 2002;18(6):S142–6.
Glogau R, et al. Results of a randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of a botulinum toxin type A topical gel for the treatment of moderate-to-severe lateral canthal lines. J Drugs Dermatol. 2012;11(1):38–45.
Ting PT, Freiman A. The story of Clostridium botulinum: from food poisoning to Botox. Clin Med. 2004;4(3):258–61.
Small R. Botulinum toxin injection for facial wrinkles. Am Fam Physician. 2014;90(3):168–75.
Walker TJ, Dayan SH. Comparison and overview of currently available neurotoxins. J Clin Aesthet Dermatol. 2014;7(2):31–9.
American Society of Health-System Pharmacists. Botulinum Toxin Type A. 2011. drugs.com .
Hill KK, Smith TJ. Genetic diversity within Clostridium botulinum serotypes, botulinum neurotoxin gene clusters and toxin subtypes. In: Rummel A, Binz T, editors. Botulinum neurotoxins. Heidelberg: Springer; 2013.
Burgen ASV, Dickens F, Zatman LJ. The action of botulinum toxin on the neuro-muscular junction. J Physiol. 1949;109(1–2):10–24.
Wohlfarth K, et al. Botulinum A toxins: units versus units. Naunyn Schmiedeberg’s Arch Pharmacol. 1997;355(3):335–40.
Sampaio C, et al. DYSBOT: A single-blind, randomized parallel study to determine whether any differences can be detected in the efficacy and tolerability of two formulations of botulinum toxin type A—Dysport and Botox—assuming a ratio of 4: 1. Mov Disord. 1997;12(6):1013–8.
Klein AW. Contraindications and complications with the use of botulinum toxin. Clin Dermatol. 2004;22(1):66–75.
Göschel H, et al. Botulinum A toxin therapy: neutralizing and nonneutralizing antibodies—therapeutic consequences. Exp Neurol. 1997;147(1):96–102.
Stanker LH, et al. Development and partial characterization of high-affinity monoclonal antibodies for botulinum toxin type A and their use in analysis of milk by sandwich ELISA. J Immunol Methods. 2008;336(1):1–8.
Siatkowski RM, et al. Serum antibody production to botulinum A toxin. Ophthalmology. 1993;100(12):1861–6.
Coté TR, et al. Botulinum toxin type A injections: adverse events reported to the US Food and Drug Administration in therapeutic and cosmetic cases. J Am Acad Dermatol. 2005;53(3):407–15.
Glogau RG. Review of the use of botulinum toxin for hyperhidrosis and cosmetic purposes. Clin J Pain. 2002;18(6):S191–7.
FDA. FDA Notifies public of adverse reactions linked to Botox use. 2008. Fda.gov .
Chertow DS, et al. Botulism in 4 adults following cosmetic injections with an unlicensed, highly concentrated botulinum preparation. JAMA. 2006;296(20):2476–9.
Heckmann M, et al. Botulinum toxin A for axillary hyperhidrosis (excessive sweating). N Engl J Med. 2001;344:488.
Lowe NJ, Glaser DA, Eadie N, et al. Botulinum toxin type A for axillary hyperhidrosis: a 52-week multicenter double-blind, randomized, placebo-controlled study of efficacy and safety. J Am Acad Dermatol. 2007;56:604.
Goldman A. Treatment of axillary and palmar hyperhidrosis with botulinum toxin. Aesthet Plast Surg. 2000;24:280.
Barankin B, Wasel N. Treatment of inguinal hyperhidrosis with botulinum toxin type A. Int J Dermatol. 2006;45:985.
Lorenc ZP, et al. Understanding the functional anatomy of the frontalis and glabellar complex for optimal aesthetic botulinum toxin type A therapy. Aesthet Plast Surg. 2013;37(5):975–83.
Carruthers J, Fagien S, Matarasso SL. Consensus recommendations on the use of botulinum toxin type A in facial aesthetics. Plast Reconstr Surg. 2004;114(6):1S–22S.
Fagien S. Botox for the treatment of dynamic and hyperkinetic facial lines and furrows: adjunctive use in facial aesthetic surgery. Plast Reconstr Surg. 1999;103(2):701–13.
Lowe NJ, et al. Double-blind, randomized, placebo-controlled, dose-response study of the safety and efficacy of botulinum toxin type A in subjects with crow’s feet. Dermatol Surg. 2005;31(3):257–62.
Ahn MS, Catten M, Maas CS. Temporal brow lift using botulinum toxin A. Plast Reconstr Surg. 2000;105(3):1129–35.
Maas CS, Kim EJ. Temporal brow lift using botulinum toxin A: an update. Plast Reconstr Surg. 2003;112(5):109S–12S.
Wollina U, Konrad H. Managing adverse events associated with botulinum toxin type a. Am J Clin Dermatol. 2005;6(3):141–50.
Koch RJ, Troell RJ, Goode RL. Contemporary management of the aging brow and forehead. Laryngoscope. 1997;107(6):710–5.
Matarasso A, Hutchinson OH. Evaluating rejuvenation of the forehead and brow: an algorithm for selecting the appropriate technique. Plast Reconstr Surg. 2000;106(3):687–94.
Sarrabayrouse MA. Indications and limitations for the use of botulinum toxin for the treatment of facial wrinkles. Aesthet Plast Surg. 2002;26(4):233–8.
Huilgol SC, Carruthers A, Carruthers JD. Raising eyebrows with botulinum toxin. Dermatol Surg. 1999;25(5):373–6.
Tamura BM, et al. Treatment of nasal wrinkles with botulinum toxin. Dermatol Surg. 2005;31(3):271–5.
Ghavami A, Janis JE, Guyuron B. Regarding the treatment of dynamic nasal tip ptosis with botulinum toxin A. Plast Reconstr Surg. 2006;118(1):263–4.
Goldman A, Wollina U. Elevation of the corner of the mouth using botulinum toxin type A. J Cutan Aesthet Surg. 2010;3(3):145.
Park MY, Ahn KY, Jung DS. Botulinum toxin type A treatment for contouring of the lower face. Dermatol Surg. 2003;29(5):477–83.
Semchyshyn N, Sengelmann RD. Botulinum toxin A treatment of perioral rhytides. Dermatol Surg. 2003;29(5):490–5.
Carruthers A, et al. A validated grading scale for marionette lines. Dermatol Surg. 2008;34(Suppl 2):S167–72.
Cohen JL, et al. OnabotulinumtoxinA dose-ranging study for hyperdynamic perioral lines. Dermatol Surg. 2012;38(9):1497–505.
Polo M. Botulinum toxin type A (Botox) for the neuromuscular correction of excessive gingival display on smiling (gummy smile). Am J Orthod Dentofac Orthop. 2008;133(2):195–203.
Hwang W-S, et al. Surface anatomy of the lip elevator muscles for the treatment of gummy smile using botulinum toxin. Angle Orthod. 2009;79(1):70–7.
Levy PM. The ‘Nefertiti lift’: a new technique for specific re-contouring of the jawline. J Cosmet Laser Ther. 2007;9(4):249–52.
Petchngaovilai C. Midface lifting with botulinum toxin: intradermal technique. J Cosmet Dermatol. 2009;8(4):312–6.
Beer K, Yohn M, Closter J. A double-blinded, placebo-controlled study of Botox for the treatment of subjects with chin rhytids. J Drugs Dermatol. 2004;4(4):417–22.
von Lindern JJ, et al. Type A botulinum toxin for the treatment of hypertrophy of the masseter and temporal muscles: an alternative treatment. Plast Reconstr Surg. 2001;107(2):327–32.
Castro WH, et al. Botulinum toxin type A in the management of masseter muscle hypertrophy. J Oral Maxillofac Surg. 2005;63(1):20–4.
Ahn J, Horn C, Blitzer A. Botulinum toxin for masseter reduction in Asian patients. Arch Facial Plast Surg. 2004;6(3):188–91.
Kane MAC. Nonsurgical treatment of platysmal bands with injection of botulinum toxin A. Plast Reconstr Surg. 1999;103(2):656–63.
Matarasso A, et al. Botulinum A exotoxin for the management of platysma bands. Plast Reconstr Surg. 1999;103(2):645–52.
Brandt FS, Bellman B. Cosmetic use of botulinum A exotoxin for the aging neck. Dermatol Surg. 1998;24(11):1232–4.
Matarasso SL. Complications of botulinum A exotoxin for hyperfunctional lines. Dermatol Surg. 1998;24(11):1249–54.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this chapter
Cite this chapter
Wang, J.Y. (2018). Clinical Uses of Botulinum Toxin in the Skin. In: Jabbari, B. (eds) Botulinum Toxin Treatment in Clinical Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-56038-0_13
Download citation
DOI: https://doi.org/10.1007/978-3-319-56038-0_13
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-56037-3
Online ISBN: 978-3-319-56038-0
eBook Packages: MedicineMedicine (R0)