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Thioredoxin Attenuates Post-ischemic Damage in Ventricular and Mitochondrial Function

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Book cover Biochemistry of Oxidative Stress

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 16))

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Abstract

Thioredoxin (Trx) is an important antioxidant cellular system that plays an important role in cardioprotection against ischemia/reperfusion injury. The cardioprotective effects include a reduction of infarct size and an amelioration of ventricular and mitochondrial dysfunction that occurs in myocardial stunning. Particularly, Trx1 plays a protective role against the oxidative stress caused by an increase of reactive oxygen species concentration, as occurs during the reperfusion after an ischemic episode, and also could activate proteins related to pro-survival pathways such as MAP-kinases, Akt and GSK3-β. It has been also shown that, at least partially, Trx1 takes part of cardioprotective mechanisms such as ischemic preconditioning (PC) and postconditioning (PostC). However, comorbidities such as aging can modify this powerful cellular defense, leading to decrease cardioprotection, and even ischemic PC and PostC induced in aged animal models failed to decrease infarct size. Therefore, the lack of success of antioxidants therapies to treat ischemic heart disease could be solved avoiding the damage of Trx system.

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Authors and Affiliations

  1. Institute of Biochemistry and Molecular Medicine (IBIMOL, UBA-CONICET) and Institute of Cardiovascular Physiopathology, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina

    Veronica D’Annunzio, Virginia Perez, Tamara Mazo & Ricardo Jorge Gelpi

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  1. Veronica D’Annunzio
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  2. Virginia Perez
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  3. Tamara Mazo
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  4. Ricardo Jorge Gelpi
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Correspondence to Ricardo Jorge Gelpi .

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  1. School of Medicine, University of Buenos Aires, Buenos Aires, Argentina

    Ricardo Jorge Gelpi

  2. School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina

    Alberto Boveris

  3. Instituto de Inmunología, Genética y Metabolismo (INIGEM, UBA–CONICET), Laboratorio de Metabolismo del Oxígeno, Hospital Universitario, Universidad de Buenos Aires, Buenos Aires, Argentina

    Juan José Poderoso

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D’Annunzio, V., Perez, V., Mazo, T., Gelpi, R.J. (2016). Thioredoxin Attenuates Post-ischemic Damage in Ventricular and Mitochondrial Function. In: Gelpi, R., Boveris, A., Poderoso, J. (eds) Biochemistry of Oxidative Stress. Advances in Biochemistry in Health and Disease, vol 16. Springer, Cham. https://doi.org/10.1007/978-3-319-45865-6_12

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