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Phage Device Coatings

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Bacteriophage Applications - Historical Perspective and Future Potential

Part of the book series: SpringerBriefs in Biochemistry and Molecular Biology ((BRIEFSBIOCHEM))

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Abstract

The presence of biofilms and their associated antimicrobial resistance provides a challenge to various industries where new and affective device coating strategies are required. Bacteriophages have the natural capacity to act as antibacterials and have been used extensively for this purpose, including in device coatings, since the beginning of the 20th century. This Chapter explores the emerging industry of phage-coated medical devices. An extensive review on the biology and challenges behind biofilm formations, including the contributors to biofilm resistance and current antimicrobial strategies will be covered. Alternative medical device coating strategies will also be explored, including the benefits, challenges, and promise of phage-based device coatings as bioactive agents.

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Authors and Affiliations

  1. School of Pharmacy, University of Waterloo, Waterloo, ON, Canada

    Jessica Nicastro, Peggy Lam & Jonathan Blay

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  1. Jessica Nicastro
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  2. Peggy Lam
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  3. Jonathan Blay
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Correspondence to Jessica Nicastro .

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Nicastro, J., Lam, P., Blay, J. (2016). Phage Device Coatings. In: Bacteriophage Applications - Historical Perspective and Future Potential. SpringerBriefs in Biochemistry and Molecular Biology. Springer, Cham. https://doi.org/10.1007/978-3-319-45791-8_3

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