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Specific Surgical Topics: Surgical Management of Gastrointestinal Stromal Tumors

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Sarcoma
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Abstract

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the GI tract with a new patient diagnosis of 4000–6000 per year in the USA. The pathological characterization of this tumor and the molecular basis of its treatment in the last several decades illustrate the complexity and beauty of targeted treatment for cancer.

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References

  1. Berthet B, Sugarbaker TA, Chang D, Sugarbaker PH. Quantitative methodologies for selection of patients with recurrent abdominopelvic sarcoma for treatment. Eur J Cancer. 1999;35:419–3.

    Article  Google Scholar 

  2. Druker BJ, Lydon NB. Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia. J Clin Invest. 2000;105:3–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Joensuu H, Roberts PJ, et al. Effect of the tyrosine kinase inhibitor STI571 in a patient with metastatic gastrointestinal stromal tumor. N Engl J Med. 2001;344:1052–6.

    Article  CAS  PubMed  Google Scholar 

  4. Sugarbaker PH. Peritonectomy procedures. Ann Surg. 1995;221:29–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Rutkowski P, Bylina E, Wozniak A, et al. Validation of the Joensuu risk criteria for primary resectable gastrointestinal tumor-the impact of tumor rupture on patient outcomes. Eur J Surg Oncol. 2011;37:890–6.

    Article  CAS  PubMed  Google Scholar 

  6. McCarter MD, Antonescu CR, Ballman KV, Maki RG, Pisters PW, Demetri GD, et al. Microscopically positive margins for primary gastrointestinal stromal tumors: analysis of risk factors and tumor recurrence. J Am Coll Surg. 2012;215:53–9.

    Article  PubMed  PubMed Central  Google Scholar 

  7. DeMatteo RP, Ballman KV, Antonescu CR, Corless C, Kolesnikova V, von Mehren M, et al. Long term results of adjuvant imatinib mesylate in localized, high risk, primary gastrointestinal stromal tumor: ACOSOG Z9000 (alliance) intergroup phase 2 trial. Ann Surg. 2013;258:422–9.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Corless CL, Ballman KV, Antonescu CR, Kolesnikova V, Maki RG, Pisters PW, et al. Pathologic and molecular features correlate with long term outcome after adjuvant therapy of resected primary GI stromal tumor: the ACOSOG Z9001 trial. J Clin Oncol. 2014;32:1563–70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Agaimy A, Wunsch PH, Hofstaedter F, et al. Minute gastric sclerosing stromal tumors are common in adults and frequently show c-KIT mutations. Am J Surg Pathol. 2007;31:113–20.

    Article  PubMed  Google Scholar 

  10. Kawanowa K, Sakuma Y, Sakurai S, et al. High incidence of microscopic gastrointestinal stromal tumors in the stomach. Hum Pathol. 2006;37:1527–35.

    Article  PubMed  Google Scholar 

  11. Raut CP, Posner M, Desai J, Morgan JA, George S, Zahrieh D, et al. Surgical management of advanced gastrointestinal stromal tumors after treatment with targeted systemic therapy using kinase inhibitors. J Clin Oncol. 2006;24:2325–31.

    Article  CAS  PubMed  Google Scholar 

  12. Bamboat ZM, Dematteo RP. Metastasectomy for gastrointestinal stromal tumors. J Surg Oncol. 2014;109:23–7.

    Article  PubMed  Google Scholar 

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Correspondence to Mark Steves M.D. .

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Steves, M. (2017). Specific Surgical Topics: Surgical Management of Gastrointestinal Stromal Tumors. In: Henshaw, R. (eds) Sarcoma. Springer, Cham. https://doi.org/10.1007/978-3-319-43121-5_8

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  • DOI: https://doi.org/10.1007/978-3-319-43121-5_8

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-43119-2

  • Online ISBN: 978-3-319-43121-5

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