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Optimizing the Formulation of Poorly Water-Soluble Drugs

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Book cover Formulating Poorly Water Soluble Drugs

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 22))

Abstract

With as high as 60 % of drugs in company pipelines exhibiting poor aqueous solubility, the ability to successfully develop a poorly water-soluble drug has become essential. Gaining a detailed understanding of a compound through preformulation studies can be especially challenging for poorly water-soluble drugs limiting their development. Therefore, this chapter focuses on the application of preformulation studies essential in understanding a poorly water-soluble drug, including solubility studies, solid-state characterization of the active ingredient and formulations thereof, and in vitro and in vivo testing of the lead formulations.

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Authors and Affiliations

  1. Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, 2409 West University Avenue, PHR 4.214, Austin, TX, 78712, USA

    Daniel Ellenberger & Robert O. Williams III

  2. DisperSol Technologies, LLC, Georgetown, TX, USA

    Daniel Ellenberger

  3. The Dow Chemical Company, Dow Pharma & Food Solutions, Midland, MI, USA

    Kevin P. O’Donnell

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  1. Daniel Ellenberger
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  2. Kevin P. O’Donnell
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  3. Robert O. Williams III
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Correspondence to Robert O. Williams III .

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  1. Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, Austin, Texas, USA

    Robert O. Williams III

  2. Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, Austin, Texas, USA

    Alan B. Watts

  3. DisperSol Technologies, LLC, Georgetown, Texas, USA

    Dave A. Miller

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Ellenberger, D., O’Donnell, K.P., Williams, R.O. (2016). Optimizing the Formulation of Poorly Water-Soluble Drugs. In: Williams III, R., Watts, A., Miller, D. (eds) Formulating Poorly Water Soluble Drugs. AAPS Advances in the Pharmaceutical Sciences Series, vol 22. Springer, Cham. https://doi.org/10.1007/978-3-319-42609-9_2

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