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Drug Delivery by Polymer Nanoparticles: The Challenge of Controlled Release and Evaluation

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Polymer Nanoparticles for Nanomedicines

Abstract

The controlled release of the drugs at the site of action is a key issue for nanoparticulate carriers. The purpose of this chapter is to review the current strategies used to control the release profiles of polymer nanoparticles . Based on 12 representative drugs with hydrophobic or hydrophilic properties, the mechanisms controlling the drug release are described, the different ways to tune the release profile are analyzed, and the methods for evaluating drug release from nanoparticles are discussed. In conclusion, based on the physicochemical properties of the drugs, the types and characteristics of nanoformulations, and the route of administration, promising tracks for tuning release profiles can be proposed. Suggestions for choosing the most appropriate methods for studying drug release are also presented.

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Authors and Affiliations

  1. Faculté de Pharmacie de l’Université Paris Descartes, Unité de Technologies Chimiques et Biologiques pour la Santé UTCBS, CNRS UMR8258 – Inserm U1022, 4 avenue de l’Observatoire, 75270, Paris Cedex 06, France

    Christine Charrueau

  2. Institut Galien Paris Sud, UMR CNRS 8612, Univ. Paris Sud, Université Paris-Saclay, Châtenay-Malabry, France

    Christelle Zandanel

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  1. Christine Charrueau
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  2. Christelle Zandanel
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Correspondence to Christine Charrueau .

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  1. Institut Galien Paris Sud, Faculty of Pharmacy, CNRS, University of Paris-Sud, University Paris Saclay, Châtenay-Malabry Cedex, France

    Christine Vauthier

  2. Institut Galien Paris Sud, Faculty of Pharmacy, CNRS, University of Paris-Sud, University Paris Saclay, Châtenay-Malabry Cedex, France

    Gilles Ponchel

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Charrueau, C., Zandanel, C. (2016). Drug Delivery by Polymer Nanoparticles: The Challenge of Controlled Release and Evaluation. In: Vauthier, C., Ponchel, G. (eds) Polymer Nanoparticles for Nanomedicines. Springer, Cham. https://doi.org/10.1007/978-3-319-41421-8_14

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