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Measuring Silica Nanoparticles in the Skin

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Agache's Measuring the Skin

Abstract

Nanotechnology is a rapidly expanding area of research involved in developing science-based solutions for innovative therapeutics. Silica nanoparticles (SNPs) have received wide attention in several industries and medicine. Recently, they are emerging in the fields of cosmetics and dermal preparations. SNP may offer a revolutionized treatment of several skin diseases by controlled and sustained release of drugs to the skin, as well as enhanced skin penetration of encapsulated drug ingredients. SNPs are candidates for transcutaneous vaccination and transdermal gene therapy, too. Yet there exist concerns that while the properties of silica nanoparticles have enabled numerous industrial and medical applications, their toxicological and environmental safety mandates evaluation. The knowledge of passage of silica nanoparticles through the skin following skin exposure (intentionally or unintentionally) and subsequent effects is limited. This review surveys the key experiments on SNP-based formulations in the fields of dermatology and cosmetics with the goal of rationalizing data and informing public health concerns related to silica nanoparticles’ toxicity among scientists and manufacturers handling them while highlighting the research gaps in dermal absorption of these compounds.

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Abbreviations

SC:

Stratum corneum

SNPs:

Silica nanoparticles

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Acknowledgment

The authors appreciate Central Tehran Branch, IAU, Tehran, Iran for support of this work.

Author information

Authors and Affiliations

  1. Department of Chemistry, Central Tehran Branch, IAU, Tehran, Iran

    Shohreh Nafisi

  2. Department of Dermatology, University of California, 90 Medical Center Way, Surge Building Room 110, San Francisco, CA, 94143-0989, USA

    Shohreh Nafisi

  3. Institute of Pharmacy, Pharmacology and Toxicology, FreieUniversität Berlin, Königin-Luise-Strasse 2+4, 14195, Berlin, Germany

    Monika Schäfer-Korting

  4. Department of Dermatology, School of Medicine, University of California, San Francisco, CA, USA

    Howard I. Maibach

Authors
  1. Shohreh Nafisi
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  2. Monika Schäfer-Korting
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  3. Howard I. Maibach
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Corresponding authors

Correspondence to Shohreh Nafisi or Howard I. Maibach .

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Editors and Affiliations

  1. Department of Dermatology, University Hospital of Besançon, Besançon, France

    Philippe Humbert

  2. Center for Study and Research on the Integuments, Department of Dermatology, University Hospital of Besançon, Besançon, France

    Ferial Fanian

  3. Department of Dermatology, School of Medicine, University of California, San Francisco, California, USA

    Howard I. Maibach

  4. Department of Dermatology, University Hospital of Besançon, Besançon, France

    Pierre Agache

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The authors report no conflicts of interest.

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Nafisi, S., Schäfer-Korting, M., Maibach, H.I. (2017). Measuring Silica Nanoparticles in the Skin. In: Humbert, P., Fanian, F., Maibach, H., Agache, P. (eds) Agache's Measuring the Skin. Springer, Cham. https://doi.org/10.1007/978-3-319-32383-1_44

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  • DOI: https://doi.org/10.1007/978-3-319-32383-1_44

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