Abstract
Combination cancer therapies are emerging treatment modalities, which aim at exploiting additive/synergistic effects due to the simultaneous generation of multiple active species in the same region of space, with the final goal to maximize the therapeutic action and to minimize side effects. Photodynamic therapy (PDT) is a minimally invasive and clinically approved procedure for cancer treatment and its coupling with either conventional chemotherapeutics or unconventional anticancer agents like nitric oxide (NO) may open intriguing horizons towards new and still underexplored multimodal therapies. Engineered polymer nanoparticles (NPs) offer great potential in this respect since they permit to locate a large number of distinct components for therapy at target site without precluding their individual potential and to encourage the release of therapeutics in the same region of space resulting in an enhancement of the therapeutic outcome. We present here an overview of the most recent advances in polymeric NPs devised for bimodal cancer treatments based on the combination of PDT with either light-triggered NO release or chemotherapy, highlighting the logical design and their potential applications in cancer research.
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References
Burrell RA, McGranahan N, Bartek J, Swanton C (2013) Nature 501:338–345
Turner NC, Reis-Filho JS (2012) Lancet Oncol 13:e178–e185
Kemp JA, Shim MS, Heo CY, Kwon YJ (2015) Adv Drug Del Rev. Epub ahead of print
Chen Q, Ke H, Dai Z, Liu Z (2015) Biomaterials 73:214–230
Dolmans DEJG, Fukumura D, Jain RK (2003) Nat Rev Cancer 3:380–387
Agostinis P, Berg K, Cengel KA, Foster TH, Girotti AW, Gollnick SO, Hahn SM, Hamblin MR, Juzeniene A, Kessel D, Korbelik M, Moan J, Mroz P, Nowis D, Piette J, Wilson BC, Golab J (2011) CA Cancer J Clin 61:250–281
Jain KK (2010) BMC Med 8:83
Jain RK, Stylianopoulos T (2010) Nat Rev Clin Oncol 7:653–664
Wang AZ, Langer R, Farokhzad OC (2012) Annu Rev Med 63:185–198
Duncan R, Gaspar R (2011) Mol Pharm 8:2101–2141
Schroeder A, Heller DA, Winslow MM, Dahlman JE, Pratt GW, Langer R, Jacks T, Anderson DG (2012) Nat Rev Cancer 12:39–50
Markman JL, Rekechenetskiy A, Holler E, Ljubimova JY (2013) Adv Drug Deliv Rev 65:1866–1879
Palakurthi S, Yellepeddi VK, Vangara KK (2012) Expert Opin Drug Del 9:287–301
Iyer AK, Singh A, Ganta S, Amiji MM (2013) Adv Drug Del Rev 65:1784–1802
Kamaly N, Xiao Z, Valencia PM, Radovic-Moreno AF, Farokhzad OC (2012) Chem Soc Rev 41:2971–3010
Avci P, Erdem SS, Hamblin MR (2014) J Biomed Nanotechnol 10:1937–1952
Webster DM, Sundaram P, Byrne ME (2013) Eur J Pharm Biopharm 84:1–20
Fang J, Nakamura H, Maeda H (2011) Adv Drug Del Rev 63:136–151
Maeda H (2012) J Control Release 164:138–144
Moghimi SM, Hunter AC, Andresen TL (2012) Annu Rev Pharmacol Toxicol 52:481–503
Bertrand N, Leroux JC (2012) J Control Release 161:152–163
Alexis F, Pridgen E, Molnar LK, Farokhzad OC (2008) Mol Pharm 5:505–515
Huynh NT, Roger E, Lautram N, Benoit JP, Passirani C (2010) Nanomedicine (Lond) 5:1415–1433
Bertrand N, Wu J, Xu X, Kamaly N, Farokhzad OC (2013) Adv Drug Deliv Rev 66:2–25
Kwon IK, Lee SC, Han B, Park K (2012) J Control Release 164:108–114
Florence AT (2012) J Control Release 164:115–124
Ruenraroengsak P, Cook JM, Florence AT (2010) J Control Release 141:265–276
Torchilin V (2009) Eur J Pharm Biopharm 71:431–444
Mura S, Nicolas J, Couvreur P (2013) Nat Mater 12:991–1003
Kim CS, Duncan B, Creran B, Rotello VM (2013) Nano Today 8:439–447
Gao W, Chan JM, Farokhzad OC (2010) Mol Pharm 7:1913–1920
Tian L, Bae YH (2012) Colloids Surf B-Biointerfaces 99:116–126
Du JZ, Mao CQ, Yuan YY, Yang XZ, Wang J (2013) Biotechnol Adv 32:78–803
Nowag S, Haag R (2014) Angew Chem Int Ed Engl 53:49–51
Abulateefeh SR, Spain SG, Aylott JW, Chan WC, Garnett MC, Alexander C (2011) Macromol Biosci 11:1722–1734
Bozic I, Reiter JG, Allen B, Antal T, Chatterjee K, Shah P, Moon YS, Yaqubie A, Kelly N, Le DT, Lipson EJ, Chapman PB, Diaz LA, Vogelstein B, Nowak MA (2013) eLife Sci 2:e00747
Hu CMJ, Zhang L (2012) Biochem Pharmacol 83:1104–1111
Zheng M, Yue C, Ma Y, Gong P, Zhao P, Zheng C, Sheng Z, Zhang P, Wang Z, Cai L (2013) ACS Nano 7:2056–2067
d’Angelo I, Conte C, Miro A, Quaglia F, Ungaro F (2013) Expert Opin Drug Del 11:283–297
Stylianopoulos T, Soteriou K, Fukumura D, Jain RK (2013) Ann Biomed Eng 41:68–77
Yim H, Park SJ, Bae YH, Na K (2013) Biomaterials 34:7674–7682
Gref R, Domb A, Quellec P, Blunk T, Muller RH, Verbavatz JM, Langer R (2012) Adv Drug Del Rev 64:316–326
Monopoli MP, Aberg C, Salvati A, Dawson KA (2012) Nat Nanotechnol 7:779–786
Lee H, Fonge H, Hoang B, Reilly RM, Allen C (2010) Mol Pharm 7:1195–1208
Sakhtianchi R, Minchin RF, Lee KB, Alkilany AM, Serpooshan V, Mahmoudi M (2013) Adv Colloid Interfac 201–202:18–29
Mukherjee S, Ghosh RN, Maxfield FR (1997) Physiol Rev 77:759–803
Fleige E, Quadir MA, Haag R (2012) Adv Drug Del Rev 64:866–884
Tammam SN, Azzazy HME, Lamprecht A (2015) J Biomed Nanotechnol 11:555–577
Conte C, Maiolino S, Silva Pellosi D, Miro A, Ungaro F, Quaglia F (2015) Top Curr Chem. in press
Amoozgar Z, Yeo Y (2012) Wiley Interdiscip Rev Nanomed Nanobiotechnol 4:219–233
Knop K, Hoogenboom R, Fischer D, Schubert US (2010) Angew Chem Int Ed 49:6288–6308
Pasquier E, Kavallaris M, Andre N (2010) Nat Rev Clin Oncol 7:455–465
Li J, Wang Y, Zhu Y, Oupicky D (2013) J Control Release 172:589–600
Muthu MS, Wilson B (2012) Nanomedicine 7:307–309
Saraf S (2009) Expert Opin Drug Del 6:187–196
Anton N, Benoit JP, Saulnier P (2008) J Control Release 128:185–199
Valencia PM, Hanewich-Hollatz MH, Gao WW, Karim F, Langer R, Karnik R, Farokhzad OC (2011) Biomaterials 32:6226–6233
Fonte PF, Soares S, Sousa F, Sousa FF, Costa AF, Seabra VF, Reis S FAU – Sarmento B, Sarmento B (2014) Biomacromolecules 15:3753–3765
Wainmwright M (2009) Photosensitizers in Biomedicine. Wiley-Blackwell
Wilson BC, Patterson MS (2008) Phys Med Biol 53:R61–R109
Castano AP, Demidova TN, Hamblin MR (2004) Photodiagn Photodyn Ther 1:279–293
Castano AP, Demidova TN, Hamblin MR (2005) Photodiagn Photodyn Ther 2:91–106
Castano AP, Demidova TN, Hamblin MR (2005) Photodiagn Photodyn Ther 2:1–23
Castano AP, Mroz P, Hamblin MR (2006) Nat Rev Cancer 6:535–545
Celli JP, Spring BQ, Rizvi I, Evans CL, Samkoe KS, Verma S, Pogue BW, Hasan T (2010) Chem Rev 110:2795–2838
Nowis D, Makowski M, Stoklosa T, Legat M, Issat T, Golab J (2005) Acta Biochim Pol 52:339–352
Pandey R, Zhen G (2015) The porphyrin handbook. Academic, San Diego
Awuah SG, You Y (2012) RSC Adv 2:11169–11183
Kamkaew A, Lim SH, Lee HB, Kiew LV, Chung LY, Burgess K (2013) Chem Soc Rev 42:77–88
Wang SZ, Gao RM, Zhou FM, Selke M (2004) J Mater Chem 14:487–493
Chatterjee DK, Fong LS, Zhang Y (2008) Adv Drug Deliv Rev 60:1627–1637
Davis ME, Chen ZG, Shin DM (2008) Nat Rev Drug Discov 7:771–782
Allison RR, Bagnato VS, Sibata CH (2010) Future Oncol 6:929–940
Allison RR, Downie GH, Cuenca R, Hu XH, Childs CJ, Sibata CH (2004) Photodiagn Photodyn 1:27–42
Aggarwal LPF, Borissevitch IE (2006) Spectrochim Acta A 63:227–233
Gabrielli D, Belisle E, Severino D, Kowaltowski AJ, Baptista MS (2004) Photochem Photobiol 79:227–232
Gelderblom H, Verweij J, Nooter K, Sparreboom A (2001) Eur J Cancer 37:1590–1598
Tang W, Xu H, Kopelman R, Philbert MA (2005) Photochem Photobio 81:242–249
Ignarro LJ (2010) Nitric oxide: Biology and pathobiology. Elsevier
Ignarro LJ (2009) Arch Pharm Res 32:1099–1101
Fukumura D, Kashiwagi S, Jain RK (2006) Nat Rev Cancer 6:521–534
Hickok JR, Thomas DD (2010) Curr Pharm Des 16:381–391
Chang CF, Diers AR, Hogg N (2015) Free Radic Biol Med 79:324–336
(2005) Nitric oxide donors for pharmaceutical and biological applications. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Riccio DA, Schoenfisch MH (2012) Chem Soc Rev 41:3731–3741
Jen MC, Serrano MC, van Lith R, Ameer GA (2012) Adv Funct Mater 22:239–260
Seabra AB, Duran N (2010) J Mater Chem 20:1624–1637
Kim J, Saravanakumar G, Choi HW, Park D, Kim WJ (2014) J Mater Chem B 2:341–356
Fraix A, Marino N, Sortino S (2015) Top Curr Chem. in press
Ostrowski AD, Lin BF, Tirrell MV, Ford PC (2012) Mol Pharm 9:2950–2955
Ford PC (2008) Acc Chem Res 41:190–200
Sortino S (2010) Chem Soc Rev 39:2903–2913
Fry NL, Mascharak PK (2011) Acc Chem Res 44:289–298
Ford PC (2013) Nitric Oxide Biol Ch 34:56–64
Sortino S (2012) J Mater Chem 22:301–318
Klan P, Solomek T, Bochet CG, Blanc A, Givens R, Rubina M, Popik V, Kostikov A, Wirz J (2013) Chem Rev 113:119–191
Caruso EB, Petralia S, Conoci S, Giuffrida S, Sortino S (2007) J Am Chem Soc 129:480–481
Conoci S, Petralia S, Sortino S (2006) EP2051935A1/US20090191284
Fraix A, Sortino S (2015) Chem-Asian J 10:1116–1125
Suzuki T, Nagae O, Kato Y, Nakagawa H, Fukuhara K, Miyata N (2005) J Am Chem Soc 127:11720–11726
Kitamura K, Ieda N, Hishikawa K, Suzuki T, Miyata N, Fukuhara K, Nakagawa H (2014) Bioorg Med Chem Lett 24:5660–5662
Swaminathan S, Garcia-Amoros J, Fraix A, Kandoth N, Sortino S, Raymo FM (2014) Chem Soc Rev 43:4167–4178
Caruso EB, Cicciarella E, Sortino S (2007) Chem Commun 47:5028–5030
Kandoth N, Vittorino E, Sciortino MT, Parisi T, Colao I, Mazzaglia A, Sortino S (2012) Chem-Eur J 18:1684–1690
Fraix A, Goncalves AR, Cardile V, Graziano ACE, Theodossiou TA, Yannakopoulou K, Sortino S (2013) Chem-Asian J 8:2634–2641
Fraix A, Manet I, Ballestri M, Guerrini A, Dambruoso P, Sotgiu G, Varchi G, Camerin M, Coppellotti O, Sortino S (2015) J Mater Chem B 3:3001–3010
Anand R, Manoli F, Manet I, Daoud-Mahammed S, Agostoni V, Gref R, Monti S (2012) Photochem Photobio Sci 11:1285–1292
Daoud-Mahammed S, Grossiord JL, Bergua T, Amiel C, Couvreur P, Gref R (2008) J Biomed Mater Res A 86A:736–748
Othman M, Bouchemal K, Couvreur P, Desmaele D, Morvan E, Pouget T, Gref R (2011) J Biomed Mater Res A 354:517–527
Renard E, Deratani A, Volet G, Sebille B (1997) Eur Polym J 33:49–57
Gref R, Amiel C, Molinard K, Daoud-Mahammed S, Sebille B, Gillet B, Beloeil JC, Ringard C, Rosilio V, Poupaert J, Couvreur P (2006) J Control Release 111:316–324
Battistini E, Gianolio E, Gref R, Couvreur P, Fuzerova S, Othman M, Aime S, Badet B, Durand P (2008) Chem Eur J 14:4551–4561
Kirejev V, Kandoth N, Gref R, Ericson MB, Sortino S (2014) J Mater Chem B 2:1190–1195
Deniz E, Kandoth N, Fraix A, Cardile V, Graziano ACE, Lo Furno D, Gref R, Raymo FM, Sortino S (2012) Chem Eur J 18:15782–15787
Fraix A, Guglielmo S, Cardile V, Graziano ACE, Gref R, Rolando B, Fruttero R, Gasco A, Sortino S (2014) RSC Adv 4:44827–44836
Kandoth N, Kirejev V, Monti S, Gref R, Ericson MB, Sortino S (2014) Biomacromolecules 15:1768–1776
Mir Y, van Lier JE, Allard JF, Morris D, Houde D (2009) Photochem Photobio Sci 8:391–395
Uchiyama S, Santa T, Imai K (1999) J Chem Soc Perk T 2 11:2525–2532
Fraix A, Kandoth N, Manet I, Cardile V, Graziano ACE, Gref R, Sortino S (2013) Chem Commun 49:4459–4461
Allison RR (2014) Future Oncol 10:123–142
Kessel D, Erickson C (1992) Photochem Photobio 55:397–399
Kessel D (1992) J Photoch Photobio B 12:203–204
Zuluaga MF, Lange N (2008) Cur Med Chem 15:1655–1673
Peng CL, Lai PS, Lin FH, Yueh-Hsiu WS, Shieh MJ (2009) Biomaterials 30:3614–3625
Khdair A, Di C, Patil Y, Ma L, Dou QP, Shekhar MPV, Panyam J (2010) J Control Release 141:137–144
Khdair A, Gerard B, Handa H, Mao G, Shekhar MPV, Panyam J (2008) Mol Pharm 5:795–807
Conte C, Ungaro F, Maglio G, Tirino P, Siracusano G, Sciortino MT, Leone N, Palma G, Barbieri A, Arra C, Mazzaglia A, Quaglia F (2013) J Control Release 167:40–52
Quaglia F, Ostacolo L, De Rosa G, La Rotonda MI, Ammendola M, Nese G, Maglio G, Palumbo R, Vauthier C (2006) Int J Pharm 324:56–66
Xiang GH, Hong GB, Wang Y, Cheng D, Zhou JX, Shuai XT (2013) Int J Nanomed 8:4613–4622
Venkataraman S, Hedrick JL, Ong ZY, Yang C, Ee PL, Hammond PT, Yang YY (2011) Adv Drug Deliv Rev 63:1228–1246
Maiolino S, Moret F, Conte C, Fraix A, Tirino P, Ungaro F, Sortino S, Reddi E, Quaglia F (2015) Nanoscale 7:5643–5653
Maiolino S, Russo A, Pagliara V, Conte C, Ungaro F, Russo G, Quaglia F (2015) J Nanobiotech 13:29
Acknowledgements
We thank AIRC (Project IG-12834 and IG-15764) and the MIUR (PRIN 2010-2011, 2010C4R8M8 2010H834LS) for financial support.
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Quaglia, F., Sortino, S. (2016). Polymer Nanoparticles for Cancer Photodynamic Therapy Combined with Nitric Oxide Photorelease and Chemotherapy. In: Bergamini, G., Silvi, S. (eds) Applied Photochemistry. Lecture Notes in Chemistry, vol 92. Springer, Cham. https://doi.org/10.1007/978-3-319-31671-0_9
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