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Vascular and Cardiac Imaging Techniques and their Applicability to Childhood Hypertension

Pediatric Hypertension
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Abstract

Hypertension-related cardiovascular (CV) disease is a major cause of death in adults throughout the world. Subclinical measures of target organ damage (TOD) including left ventricular hypertrophy, increased carotid intima-media thickness, and elevated arterial stiffness can be measured in middle age and are predictive of later CV events. It has now been shown that high BP-related TOD abnormalities can be found in adolescents and young adults. In this review, we will discuss vascular and cardiac techniques to measure TOD in youth and the evidence linking blood pressure levels to abnormalities in structure and function of the CV system.

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References

  • Aatola H, Koivistoinen T, Hutri-Kahonen N, Juonala M, Mikkila V, Lehtimaki T, Viikari JSA, Raitakari OT, Kahonen M (2010) Lifetime fruit and vegetable consumption and arterial pulse wave velocity in adulthood: the cardiovascular risk in young Finns study. Circulation 122:2521–2528

    Article  PubMed  Google Scholar 

  • Aggoun Y, Farpour-Lambert NJ, Marchand LM, Golay E, Maggio AB, Beghetti M (2008) Impaired endothelial and smooth muscle functions and arterial stiffness appear before puberty in obese children and are associated with elevated ambulatory blood pressure. Eur Heart J 29:792–799

    Article  PubMed  Google Scholar 

  • Agu NC, McNiece Redwine K, Bell C, Garcia KM, Martin DS, Poffenbarger TS, Bricker JT, Portman RJ, Gupta-Malhotra M (2014) Detection of early diastolic alterations by tissue Doppler imaging in untreated childhood-onset essential hypertension. J Am Soc Hypertens 8:303–311

    Article  PubMed  PubMed Central  Google Scholar 

  • Alman AC, Talton JW, Wadwa RP, Urbina EM, Dolan LM, Daniels SR, Hamman RF, D’Agostino RB, Marcovina SM, Mayer-Davis EJ, Dabelea DM (2014) Cardiovascular health in adolescents with type 1 diabetes: the SEARCH CVD study. Pediatr Diabetes 15:502–510

    Article  PubMed  PubMed Central  Google Scholar 

  • Barac A, Campia U, Panza JA (2007) Methods for evaluating endothelial function in humans. Hypertension 49:748–760

    Article  CAS  PubMed  Google Scholar 

  • Bello VD, Giorgi D, Pedrinelli R, Talini E, Palagi C, Donne MGD, Zucchelli G, Dell’Omo G, Cori AD, Dell’Anna R, Caravelli P, Mariani M (2004) Left ventricular hypertrophy and its regression in essential arterial hypertension: a tissue Doppler imaging study. Am J Hypertens 17:882–890

    PubMed  Google Scholar 

  • Briese S, Claus M, Querfeld U (2008) Arterial stiffness in children after renal transplantation. Pediatr Nephrol 23:2241–2245

    Article  PubMed  Google Scholar 

  • Canpolat N, Kasapcopur O, Caliskan S, Gokalp S, Bor M, Tasdemir M, Sever L, Arisoy N (2013) Ambulatory blood pressure and subclinical cardiovascular disease in patients with juvenile-onset systemic lupus erythematosus. Pediatr Nephrol 28:305–313

    Article  PubMed  Google Scholar 

  • Chen W, Srinivasan SR, Li S, Xu J, Berenson GS (2005) Metabolic syndrome variables at low levels in childhood are beneficially associated with adulthood cardiovascular risk: the Bogalusa heart study. Diabetes Care 28:126–131

    Article  PubMed  Google Scholar 

  • Daniels SR, Kimball TR, Morrison JA, Khoury P, Meyer RA (1995) Indexing left ventricular mass to account for differences in body size in children and adolescents without cardiovascular disease. Am J Cardiol 76:699–701

    Article  CAS  PubMed  Google Scholar 

  • Daniels SR, Loggie JM, Khoury P, Kimball TR (1998) Left ventricular geometry and severe left ventricular hypertrophy in children and adolescents with essential hypertension. Circulation 97:1907–1911

    Article  CAS  PubMed  Google Scholar 

  • Dawson JD, Sonka M, Blecha MB, Lin W, Davis PH (2009) Risk factors associated with aortic and carotid intima-media thickness in adolescents and young adults: the Muscatine offspring study. J Am Coll Cardiol 53:2273–2279

    Article  PubMed  PubMed Central  Google Scholar 

  • Dursun I, Poyrazoglu HM, Gunduz Z, Ulger H, Yykylmaz A, Dusunsel R, Patyroglu T, Gurgoze M (2009) The relationship between circulating endothelial microparticles and arterial stiffness and atherosclerosis in children with chronic kidney disease. Nephrol Dial Transplant 24(8):2511

    Article  PubMed  Google Scholar 

  • Dusan P, Tamara I, Goran V, Gordana ML, Amira PA (2015) Left ventricular mass and diastolic function in obese children and adolescents. Pediatr Nephrol 30:645–652

    Article  PubMed  Google Scholar 

  • Edwards NM, Daniels SR, Claytor RP, Khoury PR, Dolan LM, Kimball TR, Urbina EM (2012) Physical activity is independently associated with multiple measures of arterial stiffness in adolescents and young adults. Metabolism: Clinical & Experimental 61:869–872

    Article  CAS  Google Scholar 

  • Elkiran O, Yilmaz E, Koc M, Kamanli A, Ustundag B, Ilhan N (2013) The association between intima media thickness, central obesity and diastolic blood pressure in obese and overweight children: a cross-sectional school-based study. Int J Cardiol 165:528–532

    Article  PubMed  Google Scholar 

  • Expert Panel on Integrated Guidelines for Cardiovascular H, Risk Reduction in C, Adolescents, National Heart L and Blood I (2011) Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report. Pediatrics 128(Suppl 5):S213–S256

    Google Scholar 

  • Falkner B, DeLoach S, Keith SW, Gidding SS (2013) High risk blood pressure and obesity increase the risk for left ventricular hypertrophy in African-American adolescents. J Pediatr 162:94–100

    Article  PubMed  Google Scholar 

  • Feigenbaum H (2010) Feigenbaum’s echocardiography, 7th edn. Lippincott Williams & WIlkins, Philadelphia

    Google Scholar 

  • Geyer H, Caracciolo G, Abe H, Wilansky S, Carerj S, Gentile F, Nesser HJ, Khandheria B, Narula J, Sengupta PP (2010) Assessment of myocardial mechanics using speckle tracking echocardiography: fundamentals and clinical applications. J Am Soc Echocardiogr 23:351–369. quiz 453-5

    Article  PubMed  Google Scholar 

  • Gidding SS, Palermo RA, DeLoach SS, Keith SW, Falkner B (2014) Associations of cardiac structure with obesity, blood pressure, inflammation, and insulin resistance in African-American adolescents. Pediatr Cardiol 35:307–314

    Article  PubMed  Google Scholar 

  • Gomez CA, Ludomirsky A, Ensing GJ, Rocchini AP (2005) Effect of acute changes in load on left ventricular diastolic function during device closure of atrial septal defects. Am J Cardiol 95:686–688

    Article  PubMed  Google Scholar 

  • Gozal D, Kheirandish-Gozal L, Serpero LD, Sans Capdevila O, Dayyat E (2007) Obstructive sleep apnea and endothelial function in school-aged nonobese children: effect of adenotonsillectomy. Circulation 116:2307–2314

    Article  PubMed  Google Scholar 

  • Hanevold C, Waller J, Daniels S, Portman R, Sorof J (2004) The effects of obesity, gender, and ethnic group on left ventricular hypertrophy and geometry in hypertensive children: a collaborative study of the international Pediatric hypertension association. Pediatrics 113:328–333

    Article  PubMed  Google Scholar 

  • Ho CY, Solomon SDA (2006) Clinician’s guide to tissue Doppler imaging. Circulation 113:e396–e398

    Article  PubMed  Google Scholar 

  • Im JA, Lee JW, Shim JY, Lee HR, Lee DC (2007) Association between brachial-ankle pulse wave velocity and cardiovascular risk factors in healthy adolescents. J Pediatr 150:247–251

    Article  PubMed  Google Scholar 

  • Ingul CB, Tjonna AE, Stolen TO, Stoylen A, Wisloff U (2010) Impaired cardiac function among obese adolescents: effect of aerobic interval training. Arch Pediatr Adolesc Med 164:852–859

    Article  PubMed  Google Scholar 

  • Ippisch HM, Inge TH, Daniels SR, Wang B, Khoury PR, Witt SA, Glascock BJ, Garcia VF, Kimball TR (2008) Reversibility of cardiac abnormalities in morbidly obese adolescents. J Am Coll Cardiol 51:1342–1348

    Article  PubMed  Google Scholar 

  • Jarvisalo MJ, Jartti L, Nanto-Salonen K, Irjala K, Ronnemaa T, Hartiala JJ, Celermajer DS, Raitakari OT (2001) Increased aortic intima-media thickness: a marker of preclinical atherosclerosis in high-risk children. Circulation 104:2943–2947

    Article  CAS  PubMed  Google Scholar 

  • Jourdan C, Wuhl E, Litwin M, Fahr K, Trelewicz J, Jobs K, Schenk JP, Grenda R, Mehls O, Troger J, Schaefer F (2005) Normative values for intima-media thickness and distensibility of large arteries in healthy adolescents. J Hypertens 23:1707–1715

    Article  CAS  PubMed  Google Scholar 

  • Juonala M, Magnussen CG, Venn A, Dwyer T, Burns TL, Davis PH, Chen W, Srinivasan SR, Daniels SR, Kahonen M, Laitinen T, Taittonen L, Berenson GS, Viikari JS, Raitakari OT (2010) Influence of age on associations between childhood risk factors and carotid intima-media thickness in adulthood: the cardiovascular risk in young Finns study, the childhood determinants of adult health study, the Bogalusa heart study, and the Muscatine study for the international childhood cardiovascular cohort (i3C) consortium. Circulation 122:2514–2520

    Article  PubMed  Google Scholar 

  • Kalaycioglu E, Gokdeniz T, Aykan AC, Gul I, Ugur M, Gursoy OM, Boyaci F, Celik S (2014) The influence of dipper/nondipper blood pressure patterns on global left ventricular systolic function in hypertensive diabetic patients: a speckle tracking study. Blood Press Monit 19:263–270

    Article  PubMed  Google Scholar 

  • Kari JA, Donald AE, Vallance DT, Bruckdorfer KR, Leone A, Mullen MJ, Bunce T, Dorado B, Deanfield JE, Rees L (1997) Physiology and biochemistry of endothelial function in children with chronic renal failure. Kidney Int 52:468–472

    Article  CAS  PubMed  Google Scholar 

  • Kenny D, Polson JW, Martin RP, Caputo M, Wilson DG, Cockcroft JR, Paton JF, Wolf AR (2011) Relationship of aortic pulse wave velocity and baroreceptor reflex sensitivity to blood pressure control in patients with repaired coarctation of the aorta. Am Heart J 162:398–404

    Article  PubMed  Google Scholar 

  • Khan F, Elhadd T, Greene S, Belch J (2000) Impaired skin microvascular function in children, adolescents, and young adults with type 1 diabetes. Diabetes Care 23:215–220

    Article  CAS  PubMed  Google Scholar 

  • Kharod AM, Ramlogan SR, Kumar S, Raghuveer T, Drake W, Dai H, Raghuveer G (2014) Childhood obesity increases left-ventricular mass irrespective of blood pressure status. Pediatr Cardiol 35:353–360

    Article  CAS  PubMed  Google Scholar 

  • Khoury PR, Mitsnefes M, Daniels SR, Kimball TR (2009) Age-specific reference intervals for indexed left ventricular mass in children. J Am Soc Echocardiogr 22:709–714

    Article  PubMed  Google Scholar 

  • Kit BK, Kuklina E, Carroll MD, Ostchega Y, Freedman DS, Ogden CL (2015) Prevalence of and trends in dyslipidemia and blood pressure among US children and adolescents, 1999–2012. JAMA Pediatr 169:272–279

    Article  PubMed  Google Scholar 

  • Klinge A, Allen J, Murray A, O’Sullivan J (2009) Increased pulse wave velocity and blood pressure in children who have undergone cardiac transplantation. J Heart Lung Transplant 28:21–25

    Article  PubMed  Google Scholar 

  • Kollias A, Psilopatis I, Karagiaouri E, Glaraki M, Grammatikos E, Grammatikos EE, Garoufi A, Stergiou GS (2013) Adiposity, blood pressure, and carotid intima-media thickness in Greek adolescents. Obesity 21:1013–1017

    Article  PubMed  Google Scholar 

  • Kollias A, Dafni M, Poulidakis E, Ntineri A, Stergiou GS (2014) Out-of-office blood pressure and target organ damage in children and adolescents: a systematic review and meta-analysis. J Hypertens 32:2315–2331. discussion 2331

    Article  CAS  PubMed  Google Scholar 

  • Kupferman JC, Aronson Friedman L, Cox C, Flynn J, Furth S, Warady B, Mitsnefes M, Group CKS (2014) BP control and left ventricular hypertrophy regression in children with CKD. J Am Soc Nephrol 25:167–174

    Article  PubMed  Google Scholar 

  • Kuvin J, Patel A, Sliney K, Pandian N, Sheffy J, Schnall R, Karas R, Udelson J (2003) Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude. Am Heart J 146:168–174

    Article  PubMed  Google Scholar 

  • Laitinen TT, Pahkala K, Magnussen CG, Viikari JS, Oikonen M, Taittonen L, Mikkila V, Jokinen E, Hutri-Kahonen N, Laitinen T, Kahonen M, Lehtimaki T, Raitakari OT, Juonala M (2012) Ideal cardiovascular health in childhood and cardiometabolic outcomes in adulthood: the cardiovascular risk in young Finns study. Circulation 125:1971–1978

    Article  PubMed  Google Scholar 

  • Lande MB, Carson NL, Roy J, Meagher CC (2006) Effects of childhood primary hypertension on carotid intima media thickness: a matched controlled study. Hypertension 48:40–44

    Article  CAS  PubMed  Google Scholar 

  • Lee SH, Kim JH, Kang MJ, Lee YA, Won Yang S, Shin CH (2011) Implications of nocturnal hypertension in children and adolescents with type 1 diabetes. Diabetes Care 34:2180–2185

    Article  PubMed  PubMed Central  Google Scholar 

  • Liao D, Arnett DK, Tyroler HA, Riley WA, Chambless LE, Szklo M, Heiss G (1999) Arterial stiffness and the development of hypertension. The ARIC study. Hypertension 34:201–206

    Article  CAS  PubMed  Google Scholar 

  • Lilien MR, Koomans HA, Schroder CH (2005) Hemodialysis acutely impairs endothelial function in children. Pediatr Nephrol 20:200–204

    Article  PubMed  Google Scholar 

  • Lindstedt IH, Edvinsson ML, Edvinsson L (2006) Reduced responsiveness of cutaneous microcirculation in essential hypertension – a pilot study. Blood Press 15:275–280

    Article  PubMed  Google Scholar 

  • Litwin M, Trelewicz J, Wawer Z, Antoniewicz J, Wierzbicka A, Rajszys P, Grenda R (2004) Intima-media thickness and arterial elasticity in hypertensive children: controlled study. Pediatr Nephrol 19:767–774

    Article  PubMed  Google Scholar 

  • Litwin M, Wuhl E, Jourdan C, Trelewicz J, Niemirska A, Fahr K, Jobs K, Grenda R, Wawer ZT, Rajszys P, Troger J, Mehls O, Schaefer F (2005) Altered morphologic properties of large arteries in children with chronic renal failure and after renal transplantation. J Am Soc Nephrol 16:1494–1500

    Article  PubMed  Google Scholar 

  • Lonn E, Shaikholeslami R, Yi Q, Bosch J, Sullivan B, Tanser P, Magi A, Yusuf S (2004) Effects of ramipril on left ventricular mass and function in cardiovascular patients with controlled blood pressure and with preserved left ventricular ejection fraction: a substudy of the heart outcomes prevention evaluation (HOPE) trial. J Am Coll Cardiol 43:2200–2206

    Article  CAS  PubMed  Google Scholar 

  • Lurbe E, Torro I, Garcia-Vicent C, Alvarez J, Fernandez-Fornoso JA, Redon J (2012) Blood pressure and obesity exert independent influences on pulse wave velocity in youth. Hypertension 60:550–555

    Article  CAS  PubMed  Google Scholar 

  • Madueme PC, Khoury PR, Urbina EM, Kimball TR (2013) Predictors of exaggerated exercise-induced systolic blood pressures in young patients after coarctation repair. Cardiol Young 23:416–422

    Google Scholar 

  • Magnussen CG, Koskinen J, Juonala M, Chen W, Srinivasan SR, Sabin MA, Thomson R, Schmidt MD, Nguyen QM, Xu JH, Skilton MR, Kahonen M, Laitinen T, Taittonen L, Lehtimaki T, Ronnemaa T, Viikari JS, Berenson GS, Raitakari OT (2012) A diagnosis of the metabolic syndrome in youth that resolves by adult life is associated with a normalization of high carotid intima-media thickness and type 2 diabetes mellitus risk the Bogalusa heart and cardiovascular risk in young Finns studies. J Am Coll Cardiol 60:1631–1639

    Article  PubMed  Google Scholar 

  • Manov E, Shabani R, Naydenov SN, Runev NM, Donova TI (2012) Effects of aliskiren on blood pressure and myocardial function assessed by global longitudinal strain in patients with arterial hypertension and diastolic dysfunction. Folia Med (Plovdiv) 54:30–34

    Google Scholar 

  • Marwick TH, Gillebert TC, Aurigemma G, Chirinos J, Derumeaux G, Galderisi M, Gottdiener J, Haluska B, Ofili E, Segers P, Senior R, Tapp RJ, Zamorano JL (2015) Recommendations on the use of echocardiography in adult hypertension: a report from the European Association of Cardiovascular Imaging (EACVI) and the American Society of Echocardiography (ASE)dagger. Eur Heart J Cardiovasc Imaging 16:577–605

    PubMed  Google Scholar 

  • Masugata H, Senda S, Goda F, Yamagami A, Okuyama H, Kohno T, Yukiiri K, Noma T, Hosomi N, Imai M, Kohno M (2009) Influences of hypertension and diabetes on normal age-related changes in left ventricular function as assessed by tissue Doppler echocardiography. Clin Exp Hypertens 31:400–414

    Article  CAS  PubMed  Google Scholar 

  • Matteucci MC, Chinali M, Rinelli G, Wuhl E, Zurowska A, Charbit M, Pongiglione G, Schaefer F, Group ET (2013) Change in cardiac geometry and function in CKD children during strict BP control: a randomized study. Clin J Am Soc Nephrol 8:203–210

    Article  CAS  PubMed  Google Scholar 

  • McNiece KL, Gupta-Malhotra M, Samuels J, Bell C, Garcia K, Poffenbarger T, Sorof JM, Portman RJ (2007) Left ventricular hypertrophy in hypertensive adolescents: analysis of risk by 2004 National High Blood Pressure Education Program Working Group staging criteria. Hypertension 50:392–395

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Meng L, Hou D, Zhao X, Hu Y, Liang Y, Liu J, Yan Y, Mi J (2015) Cardiovascular target organ damage could have been detected in sustained pediatric hypertension. Blood Press 24:284–292

    Article  PubMed  Google Scholar 

  • Mirchandani D, Bhatia J, Leisman D, Kwon EN, Cooper R, Chorny N, Frank R, Infante L, Sethna C (2014) Concordance of measures of left-ventricular hypertrophy in pediatric hypertension. Pediatr Cardiol 35:622–626

    Article  CAS  PubMed  Google Scholar 

  • Mitchell GF, Hwang SJ, Vasan RS, Larson MG, Pencina MJ, Hamburg NM, Vita JA, Levy D, Benjamin EJ (2010) Arterial stiffness and cardiovascular events: the Framingham heart study. Circulation 121:505–511

    Article  PubMed  PubMed Central  Google Scholar 

  • Mitsnefes MM, Kimball TR, Witt SA, Glascock BJ, Khoury PR, Daniels SR (2004) Abnormal carotid artery structure and function in children and adolescents with successful renal transplantation. Circulation 110:97–101

    Article  PubMed  Google Scholar 

  • Mitsnefes MM, Kimball TR, Kartal J, Witt SA, Glascock BJ, Khoury PR, Daniels SR (2005) Cardiac and vascular adaptation in pediatric patients with chronic kidney disease: role of calcium-phosphorus metabolism. J Am Soc Nephrol 16:2796–2803

    Article  CAS  PubMed  Google Scholar 

  • Miyai N, Arita M, Miyashita K, Morioka I, Takeda S (2009) The influence of obesity and metabolic risk variables on brachial-ankle pulse wave velocity in healthy adolescents. J Hum Hypertens 23:444–450

    Article  CAS  PubMed  Google Scholar 

  • Mogelvang R, Sogaard P, Pedersen SA, Olsen NT, Schnohr P, Jensen JS (2009) Tissue Doppler echocardiography in persons with hypertension, diabetes, or ischaemic heart disease: the Copenhagen City heart study. Eur Heart J 30:731–739

    Article  PubMed  Google Scholar 

  • Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, Das SR, de Ferranti S, Després J-P, Fullerton HJ, Howard VJ, Huffman MD, Isasi CR, Jiménez MC, Judd SE, Kissela BM, Lichtman JH, Lisabeth LD, Liu S, Mackey RH, Magid DJ, McGuire DK, Mohler ER, Moy CS, Muntner P, Mussolino ME, Nasir K, Neumar RW, Nichol G, Palaniappan L, Pandey DK, Reeves MJ, Rodriguez CJ, Rosamond W, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Woo D, Yeh RW, Turner MB (2016) Heart disease and stroke statistics – 2016 update: a report from the American Heart Association. Circulation 133:447–454

    Google Scholar 

  • Niboshi A, Hamaoka K, Sakata K, Inoue F (2006) Characteristics of brachial-ankle pulse wave velocity in Japanese children. Eur J Pediatr 165(9):625

    Article  PubMed  Google Scholar 

  • Nichols W (2005) McDonald’s blood flow in arteries: theoretical, experimental, and clinical principles. Hodder Arnold, London

    Google Scholar 

  • Niemirska A, Litwin M, Feber J, Jurkiewicz E (2013) Blood pressure rhythmicity and visceral fat in children with hypertension. Hypertension 62:782–788

    Article  CAS  PubMed  Google Scholar 

  • Nilsson PM (2012) The J-shaped curve in secondary prevention. Hypertension 59:8–9

    Article  CAS  PubMed  Google Scholar 

  • O’Leary D, Polack J, Kronmal R, Kittner S, Bong M, Wolfson S, Bommer W, Price T, Gardin J, Savage P (1992) Distribution and correlates of songraphically detected carotid artery disease in the cardiovascular health study. Stroke 23:1752–1760

    Article  PubMed  Google Scholar 

  • O’Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr (1999) Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular health study collaborative research group. N Engl J Med 340:14–22

    Article  PubMed  Google Scholar 

  • Patange AR, Valentini RP, Du W, Pettersen MD (2012) Vitamin D deficiency and arterial wall stiffness in children with chronic kidney disease. Pediatr Cardiol 33:122–128

    Article  PubMed  Google Scholar 

  • Peters SA, Bots ML, Lind L, Groenewegen KA, de Korte C, den Ruijter HM, METEOR study group (2013) The impact of variability in ultrasound settings on the measured echolucency of the carotid intima-media. J Hypertens 31:1861–1867

    Article  CAS  PubMed  Google Scholar 

  • Phillips AA, Chirico D, Coverdale NS, Fitzgibbon LK, Shoemaker JK, Wade TJ, Cairney J, O’Leary DD (2015) The association between arterial properties and blood pressure in children. Appl Physiol Nutr Metab 40:72–78

    Article  PubMed  Google Scholar 

  • Pieruzzi F, Antolini L, Salerno FR, Giussani M, Brambilla P, Galbiati S, Mastriani S, Rebora P, Stella A, Valsecchi MG, Genovesi S (2015a) The role of blood pressure, body weight and fat distribution on left ventricular mass, diastolic function and cardiac geometry in children. J Hypertens 33:1182–1192

    Article  CAS  PubMed  Google Scholar 

  • Pieruzzi F, Antolini L, Salerno FR, Giussani M, Brambilla P, Galbiati S, Mastriani S, Rebora P, Stella A, Valsecchi MG, Genovesi S (2015b) The role of blood pressure, body weight and fat distribution on left ventricular mass, diastolic function and cardiac geometry in children. J Hypertens 33:1182–1192

    Article  CAS  PubMed  Google Scholar 

  • Pruette CS, Fivush BA, Flynn JT, Brady TM (2013) Effects of obesity and race on left ventricular geometry in hypertensive children. Pediatr Nephrol 28:2015–2022

    Article  PubMed  Google Scholar 

  • Ribeiro MM, Silva AG, Santos NS, Guazzelle I, Matos LN, Trombetta IC, Halpern A, Negrao CE, Villares SM (2005) Diet and exercise training restore blood pressure and vasodilatory responses during physiological maneuvers in obese children. Circulation 111:1915–1923

    Article  PubMed  Google Scholar 

  • Rietzschel ER, De Buyzere ML, Duprez DA, Clement DL (2001) Interchangeability of carotid and femoral intima-media thickness in risk stratification. Int Angiol 20:38–46

    CAS  PubMed  Google Scholar 

  • Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Makuc DM, Marcus GM, Marelli A, Matchar DB, Moy CS, Mozaffarian D, Mussolino ME, Nichol G, Paynter NP, Soliman EZ, Sorlie PD, Sotoodehnia N, Turan TN, Virani SS, Wong ND, Woo D, Turner MB (2012) Executive summary: heart disease and stroke statistics – 2012 update: a report from the American Heart Association. Circulation 125:188–197

    Article  PubMed  Google Scholar 

  • Sanchez A (2000) The carotid artery wall thickness in teenagers is related to their diet and the typical risk factors of heart disease among young adults. Arteriosclerosis 152:265–266

    Article  CAS  Google Scholar 

  • Scavarda VT, Pinheiro AC, Costa SD, de Andrade ZM, Carvalhaes JT, Campos O, Carvalho AC, Moises VA (2014) Children with chronic renal disease undergoing dialysis or conservative treatment – differences in structural and functional echocardiographic parameters. Echocardiography 31:1131–1137

    Article  PubMed  Google Scholar 

  • Seeman T, Gilik J, Vondrak K, Simkova E, Flogelova H, Hladikova M, Janda J (2007) Regression of left-ventricular hypertrophy in children and adolescents with hypertension during ramipril monotherapy. Am J Hypertens 20:990–996

    Article  CAS  PubMed  Google Scholar 

  • Sharma AP, Mohammed J, Thomas B, Lansdell N, Norozi K, Filler G (2013) Nighttime blood pressure, systolic blood pressure variability, and left ventricular mass index in children with hypertension. Pediatr Nephrol 28:1275–1282

    Article  PubMed  Google Scholar 

  • de Simone G, Devereux RB, Daniels SR, Koren MJ, Meyer RA, Laragh JH (1995) Effect of growth on variability of left ventricular mass: assessment of allometric signals in adults and children and their capacity to predict cardiovascular risk. J Am Coll Cardiol 25:1056–1062

    Article  PubMed  Google Scholar 

  • Singh S, Goyal A (2007) The origin of echocardiography: a tribute to Inge Edler. Tex Heart Inst J 34:431–438

    PubMed  PubMed Central  Google Scholar 

  • Sinha MD, Keehn L, Milne L, Sofocleous P, Chowienczyk PJ (2015) Decreased arterial elasticity in children with nondialysis chronic kidney disease is related to blood pressure and not to glomerular filtration rate. Hypertension 66:809–815

    Article  CAS  PubMed  Google Scholar 

  • Sorof JM, Cardwell G, Franco K, Portman RJ (2002) Ambulatory blood pressure and left ventricular mass index in hypertensive children. Hypertension 39:903–908

    Article  CAS  PubMed  Google Scholar 

  • Sorof JM, Alexandrov AV, Garami Z, Turner JL, Grafe RE, Lai D, Portman RJ (2003) Carotid ultrasonography for detection of vascular abnormalities in hypertensive children. Pediatr Nephrol 18:1020–1024

    Article  PubMed  Google Scholar 

  • Stabouli S, Kotsis V, Papamichael C, Constantopoulos A, Zakopoulos N (2005) Adolescent obesity is associated with high ambulatory blood pressure and increased carotid intimal-medial thickness. J Pediatr 147:651–656

    Article  PubMed  Google Scholar 

  • Stabouli S, Papakatsika S, Kotronis G, Papadopoulou-Legbelou K, Rizos Z, Kotsis V (2015) Arterial stiffness and SBP variability in children and adolescents. J Hypertens 33:88–95

    Article  CAS  PubMed  Google Scholar 

  • Stanton T, Leano R, Marwick TH (2009) Prediction of all-cause mortality from global longitudinal speckle strain: comparison with ejection fraction and wall motion scoring. Circ Cardiovasc Imaging 2:356–364

    Article  PubMed  Google Scholar 

  • Suzuki T, Hirata K, Elkind MSV, Jin Z, Rundek T, Miyake Y, Boden-Albala B, Di Tullio MR, Sacco R, Homma S (2008) Metabolic syndrome, endothelial dysfunction, and risk of cardiovascular events: the northern Manhattan study (NOMAS). Am Heart J 156:405–410

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tawadrous H, Kamran H, Salciccioli L, Schoeneman MJ, Lazar J (2012) Evaluation of arterial structure and function in pediatric patients with end-stage renal disease on dialysis and after renal transplantation. Pediatr Transplant 16(5):480

    Article  PubMed  Google Scholar 

  • Totaro S, Khoury PR, Kimball TR, Dolan LM, Urbina EM (2015) Arterial stiffness is increased in young normotensive subjects with high central blood pressure. J Am Soc Hypertens 9:285–292

    Article  PubMed  Google Scholar 

  • Tracy RE, Newman WP 3rd, Wattigney WA, Srinivasan SR, Strong JP, Berenson GS (1995) Histologic features of atherosclerosis and hypertension from autopsies of young individuals in a defined geographic population: the Bogalusa heart study. Atherosclerosis 116:163–179

    Article  CAS  PubMed  Google Scholar 

  • Urbina EM (2016) Abnormalities of vascular structure and function in pediatric hypertension. Pediatr Nephrol 31:1061–1070

    Article  PubMed  Google Scholar 

  • Urbina EM, Gidding SS, Bao W, Pickoff AS, Berdusis K, Berenson GS (1995) Effect of body size, ponderosity, and blood pressure on left ventricular growth in children and young adults in the Bogalusa heart study. Circulation 91:2400–2406

    Article  CAS  PubMed  Google Scholar 

  • Urbina EM, Williams RV, Alpert BS, Collins RT, Daniels SR, Hayman L, Jacobson M, Mahoney L, Mietus-Snyder M, Rocchini A, Steinberger J, McCrindle B (2009) Noninvasive assessment of subclinical atherosclerosis in children and adolescents: recommendations for standard assessment for clinical research: a scientific statement from the American Heart Association. Hypertension 54:919–950

    Article  CAS  PubMed  Google Scholar 

  • Urbina EM, Wadwa RP, Davis C, Snively BM, Dolan LM, Daniels SR, Hamman RF, Dabelea D (2010a) Prevalence of increased arterial stiffness in children with type 1 diabetes mellitus differs by measurement site and sex: the SEARCH for diabetes in youth study. J Pediatr 156:731–737. 737 e1

    Article  PubMed  Google Scholar 

  • Urbina EM, Kimball TR, Khoury PR, Daniels SR, Dolan LM (2010b) Increased arterial stiffness is found in adolescents with obesity or obesity-related type 2 diabetes mellitus. J Hypertens 28(8):1692

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Urbina EM, Khoury PR, McCoy C, Daniels SR, Kimball TR, Dolan LM (2011a) Cardiac and vascular consequences of pre-hypertension in youth. J Clin Hypertens 13:332–342

    Article  Google Scholar 

  • Urbina EM, Dolan LM, McCoy CE, Khoury PR, Daniels SR, Kimball TR (2011b) Relationship between elevated arterial stiffness and increased left ventricular mass in adolescents and young adults. J Pediatr 158:715–721

    Article  PubMed  PubMed Central  Google Scholar 

  • Urbina EM, Gao Z, Khoury PR, Martin LJ, Dolan LM (2012) Insulin resistance and arterial stiffness in healthy adolescents and young adults. Diabetologia 55:625–631

    Article  CAS  PubMed  Google Scholar 

  • Vlachopoulos C, Aznaouridis K, O’Rourke MF, Safar ME, Baou K, Stefanadis C (2010) Prediction of cardiovascular events and all-cause mortality with central haemodynamics: a systematic review and meta-analysis. Eur Heart J 31:1865–1871

    Article  PubMed  Google Scholar 

  • Wang M, Yip GW, Wang AY, Zhang Y, Ho PY, Tse MK, Lam PK, Sanderson JE (2003) Peak early diastolic mitral annulus velocity by tissue Doppler imaging adds independent and incremental prognostic value. J Am Coll Cardiol 41:820–826

    Article  PubMed  Google Scholar 

  • Whincup PH, Gilg JA, Donald AE, Katterhorn M, Oliver C, Cook DG, Deanfield JE (2005) Arterial distensibility in adolescents: the influence of adiposity, the metabolic syndrome, and classic risk factors. Circulation 112:1789–1797

    Article  CAS  PubMed  Google Scholar 

  • Wiegman A, Hutten BA, de Groot E, Rodenburg J, Bakker HD, Buller HR, Sijbrands EJ, Kastelein JJ (2004) Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized controlled trial. JAMA 292:331–337

    Article  CAS  PubMed  Google Scholar 

  • World Health Organization. http://www.who.int/mediacentre/factsheets/fs310/en/index.html

  • Wunsch R, de Sousa G, Toschke AM, Reinehr T (2006) Intima-media thickness in obese children before and after weight loss. Pediatrics 118:2334–2340

    Article  PubMed  Google Scholar 

  • Yang WI, Park S, Youn JC, Son NH, Lee SH, Kang SM, Jang Y (2011) Augmentation index association with reactive hyperemia as assessed by peripheral arterial tonometry in hypertension. Am J Hypertens 24:1234–1238

    Article  PubMed  Google Scholar 

  • Yip G, Abraham T, Belohlavek M, Khandheria BK (2003) Clinical applications of strain rate imaging. J Am Soc Echocardiogr 16:1334–1342

    Article  PubMed  Google Scholar 

  • Yu M-C, Yu M-S, Yu M-K, Lee F, Huang W-H (2011) Acute reversible changes of brachial-ankle pulse wave velocity in children with acute poststreptococcal glomerulonephritis. Pediatr Nephrol 26:233–239

    Article  PubMed  Google Scholar 

  • Zhu H, Yan W, Ge D, Treiber FA, Harshfield GA, Kapuku G, Snieder H, Dong Y (2007) Cardiovascular characteristics in American youth with prehypertension. Am J Hypertens 20:1051–1057

    Article  PubMed  Google Scholar 

  • Zoroufian A, Razmi T, Savandroomi Z, Tokaldany ML, Sadeghian H, Sahebjam M, Jalali A (2014) Correlation between systolic deformation and dyssynchrony indices and the grade of left ventricular hypertrophy in hypertensive patients with a preserved systolic ejection fraction undergoing coronary angiography, based on tissue Doppler imaging. J Ultrasound Med 33:119–128

    Article  PubMed  Google Scholar 

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Urbina, E.M. (2017). Vascular and Cardiac Imaging Techniques and their Applicability to Childhood Hypertension. In: Flynn, J., Ingelfinger, J., Redwine, K. (eds) Pediatric Hypertension. Springer, Cham. https://doi.org/10.1007/978-3-319-31420-4_53-1

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  • DOI: https://doi.org/10.1007/978-3-319-31420-4_53-1

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  1. Latest

    Cardiovascular Assessment of Childhood Hypertension
    Published:
    17 March 2022

    DOI: https://doi.org/10.1007/978-3-319-31420-4_53-2

  2. Original

    Vascular and Cardiac Imaging Techniques and their Applicability to Childhood Hypertension
    Published:
    14 June 2017

    DOI: https://doi.org/10.1007/978-3-319-31420-4_53-1