Abstract
Our society is doomed to struggle against pandemic of civilization diseases. One of the most common of them is osteoporosis. There are several reasons for it, one of the most significant of which is lengthening of human lifespan. In eighteenth century, life expectancy in Europe was 39 years, while two centuries later, it was already 80 years. In 1900, the age median in the USA was 23 years, and a century later, it was already 36 years. Civilization diseases in fact reflect maladaptation to this phenomenon. In connection with the longer life expectancy, the lifestyle of population in advanced countries has dramatically changed – starting from unhealthy dietary habits over to the development of technologies allowing substantial reduction of physical activity in most human activities. Pandemic incidence of involutional osteoporosis and its implications have therefore become in recent decades one of the main healthcare priorities. Although a number of diagnostic (DXA, FRAX) and therapeutic procedures have been developed, we are increasingly aware of the need for a comprehensive approach to what we call “osteoporosis” and its incorporation into the context of the current geriatric medicine [2, 5, 35].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Aspray TJ. New horizons in fracture risk assessment. Age Ageing. 2013;42:548–54.
Binkley N, Krueger D, Buehring B. What is in the name revisited: should osteoporosis and sarcopenia be considered components of “dysmobility syndrome”. Osteoporos Int. 2013;24(12):2955–9.
Bischoff-Ferrari HA. Prevention of falls. Primer on the metabolic bone diseases and disorders of mineral metabolism. Am Soc Bone Miner Res. 2013;8:389–95.
Black DM, Rosen CJ. Following the bone density trail: a clinical perspective. J Clin Endocrinol Metab. 2012;97:1176–8.
Cooper C, Dere W, Evans W, et al. Frailty and sarcopenia: definitions and outcome parameters. Osteoporos Int. 2012;23:1839–48.
Cummings SR, Black DM, Newitt MC, et al. Appendicular bone density and age predict hip fracture in women. The Study of Osteoporotic Fractures Research Group. JAMA. 1990;263(5):665–8.
Crilly RG, Kloseck M, Chesworth B, et al. Comparison of hip fracture and osteoporosis medication prescription rates across Canadian provinces. Osteoporos Int. Publ online 02 Aug 2013.
Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: european consensus on definition and diagnosis. Age Ageing. 2010;39:412–23.
Dukas L, Bischoff HA, Lindpaintner LS, et al. Alfacalcidol reduces the number of fallers in a community – dwelling elderly population with a minimum calcium intake of more than 500 mg daily. J Am Geriatr Soc. 2004;52:230–6.
Dukas L, Schacht E, Mazor T, et al. Treatment with alfacalcidol in elderly people significantly decreases the high risk of falls associated with a low creatinine clearance of bellow 65 ml/min. Osteoporos Int. 2005;16:198–203.
Evans WJ. Skeletal muscle effects on the skeleton. Primer on the metabolic bone diseases and disorders of mineral metabolism. Am Soc Bone Miner Res. 2013;8:978–85.
Fried LP. Frailty. In: Hazzards geriatric medicine and gerontology. New York: McGraw Hill; 2009. p. 631–45.
Fried LP, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med. 2001;56:146–56.
Gast U, Belavy DL, Armbrecht G, et al. Bone density and neuromuscular function in older competitive athletes depend on running distance. Osteoporos Int. 2013;24:2033–42.
Gregson CL, Dennison EM, Compston JE, et al. Disease specific perception of fracture risk and incident fracture rates: GLOW cohort study. Osteoporos Int. 2014;25(1):85–95.
Gojda J. Úbytek svalové hmoty – kachexie vs. sarkopenie: komentovaný překlad. DMEV. 2011;14:97–8.
Guillemin F, Martinez L, Calvert M, et al. Fear of falling, fracture history, and comorbidities are associated with health-related quality of life among European and US women with osteoporosis in a large international study. Osteoporos Int. 2013;24(12):3001–10.
Janssen I, et al. The healthcare costs of sarcopenia in the United States. J Am Geriatr Soc. 2004;52:80–5.
Kemmler W, Haberle L, von Stengel S. Effects of exercise on fracture reduction in older adults. Osteoporos Int. 2013;24:1937–50.
Kemmler W, von Stengel S, Bebenek M, et al. Exercise and fractures in postmenopausal women: a 12-year results of the Erlangen Fitness and Osteoporosis Prevention Study (EFOPS). Osteoporos Int. 2012;23:1267–76.
Lang PO, Michel JP, Zekry D. Frailty syndrome: a transitional state in a dynamic process. Gerontology. 2009;55:539–49.
Leavy B, Aberg AC, Melhus H, et al. When and where do hip fractures occur? Osteoporos Int. 2013;24:2387–96.
Leslie WD, Lix LM. Comparison between various fracture risk assessment tools. Comparison between various fracture risk assessment tools. Osteoporos Int. 2014;25(1):1–21.
Masud T, Binkley N, Boonen S, et al. Official positions for FRAX clinical regarding falls and frailty: can falls and frailty be used in FRAX? J Clin Densitom. 2011;14:194–204.
Morley JE, Kim MJ, Haren MT, et al. Frailty and the ageing male. Ageing Male. 2005;8:135–40.
Morley JE. Developing novel therapeutic approaches to frailty. Curr Prarm Des. 2009;15:3384–95.
Richy F, Dukas L, Schacht E. Differential effects of D-hormone analogs and native vitamin D on the risk of falls: a comparative meta-analysis. Calcif Tissue Int. 2008;82:102–7.
Rolland Y, Van Kan GA, Gillete-Guyonnet S, et al. Strontium ranelate and risk of vertebral fractures in frail osteoporotic women. Bone. 2011;48(2):332–8.
Rosen C. Frailty: a D-ficiency syndrome of ageing. J Clin Endocrinol Metab. 2010;95:5210–2.
Runge M, Hunter G. Determinants of musculoskeletal frailty and risk of falls in old age. J Musculoskeletal Neurola Interact. 2006;6:167–73.
Saltvedt I, Prestmo A, Einarsen E, et al. Development and delivery of patient treatment in the Trondheim Hip Fracture Trial. A new geriatric in-hospital pathway for elderly patients with hip fracture. BMC Res Notes. 2012;5:355.
Schacht E, Ringe JD. Alfacalcidol improves muscle power, muscle function and balance in elderly patients with reduced bone mass. Rheumatol Int. 2012;32(1):207–15.
Schacht E. Reduction of falls and osteoporotic fractures: plain vitamin D or hormone analogs? Geriatr Gerontol Int. 2008;8 Suppl 1:S16–25.
Siris E, et al. Bone mineral density thresholds for pharmacological intervention to prevent fractures. Arch Intern Med. 2004;164:1108–12.
Siris ES, Boonen S, Mitchell PJ, et al. What is in the name? What constitutes the clinical diagnosis of osteoporosis? Osteoporos Int. 2012;23:2093–7. 2005;20(10):1813–9. Epub 2005 Jun 20.
Sornay- Rendu E, Munoz F, Garnero P, et al. Identification of osteopenic women at high risk of fracture: the OFELY Study. J Bone Miner Res. 2005;20(10):1813–9. Epub 2005 Jun 20.
Studenski S, Perera S, Patel K, et al. Gait speed and survival rate in older adults. JAMA. 2011;305:50–8.
Syddall HE, Roberts HC, Evandrou M, et al. Prevalence and correlates of frailty among community – dwelling older men and women: findings from the Hertfordshire Cohort Study. Age Ageing. 2010;39(2):197–203.
Syddall HE, Simmonds SJ, Martin HJ, et al. Cohort profile. The Hertfordshire ageing study. Int J Epidemiol. 2010;39:36–43.
Tom SE, Adachi JD, Anderson FA, et al. Frailty and fracture, disability, and falls: a multiple country study from the Global Longitudinal Study of osteoporosis in women. J Am Geriatr Soc. 2013;61:327–34.
Topinkova E. Aging, disability and frailty. Ann Nutr Metab. 2008;52:6–11.
de Vries OJ, Peeters GMEE, Lips P, et al. Does frailty predict increased risk of falls and fractures? Osteoporos Int. 2013;24:2397–404.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Jenšovský, J. (2017). Involutional Osteoporosis: Sarcopenia, Frailty Syndrome and Falls. In: Rovenský, J. (eds) Gerontorheumatology. Springer, Cham. https://doi.org/10.1007/978-3-319-31169-2_34
Download citation
DOI: https://doi.org/10.1007/978-3-319-31169-2_34
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-31167-8
Online ISBN: 978-3-319-31169-2
eBook Packages: MedicineMedicine (R0)