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Grapes and Cancer

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Grapes and Health

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Abstract

Grape consumption has been linked to beneficial effects in the prevention or treatment of various different cancers in laboratory animals and humans. Several phytochemicals in the skin and seeds of grapes have been implicated in having anticancer activity including resveratrol, quercetin, and proanthocyanidins, among others. These components promote tumor cell apoptosis, have antiproliferative effects through cell cycle arrest, disrupt intracellular signaling including Wnt and PI3K/AKT pathways, suppress inflammatory responses, and display anti-angiogenic activity. The best studied individual component of grapes with anticancer properties is resveratrol which can inhibit intestinal tumorigenesis, hepatocellular cancer, and skin cancer in rodent models. Only a handful of human studies have been performed with resveratrol, but these have demonstrated activity on key proliferative pathways in target organs despite questions about bioavailability and attainable serum concentrations of specific grape-derived phytochemicals. Overall, based on epidemiologic evidence, laboratory studies in vitro and in model organisms, and direct human studies, grapes or specific components of grapes hold promise for both cancer prevention and treatment.

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Authors and Affiliations

  1. Tisch Cancer Institute, Mount Sinai Health System, Mount Sinai Medical Center, 1 Gustav L. Levy Place, Box 1128, New York, NY, 10029, USA

    Randall F. Holcombe M.D, MBA.

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  1. Randall F. Holcombe M.D, MBA.
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Correspondence to Randall F. Holcombe M.D, MBA. .

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  1. A & M Schwartz Coll of Pharm & Health Sc, Long Island University, Hilo, Hawaii, USA

    John M. Pezzuto

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Holcombe, R.F. (2016). Grapes and Cancer. In: Pezzuto, J. (eds) Grapes and Health. Springer, Cham. https://doi.org/10.1007/978-3-319-28995-3_6

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