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Spindle Cell Lesions

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Abstract

This chapter deals with benign and malignant spindle cell lesions of the breast other than spindle cell carcinoma and fibroepithelial lesions which are dealt with in Chaps. 12 and 8, respectively. It starts with outlining the scheme that should be followed for diagnosing spindle cell lesions in core biopsies. Important benign and malignant lesions are then discussed individually.

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References

  1. Carter MR, Hornick JL, Lester S, Fletcher CDM. Spindle cell (sarcomatoid) carcinoma of the breast. A clinicopathologic and immunohistochemical analysis of 29 cases. Am J Surg Pathol. 2006;30:300–9.

    Article  PubMed  Google Scholar 

  2. Wargotz ES, Norris HJ, Austin RM, Enzinger FM. Fibromatosis of the breast. A clinical and pathological study of 28 cases. Am J Surg Pathol. 1987;11:38–45.

    Article  CAS  PubMed  Google Scholar 

  3. Rosen PP, Ernsberger D. Mammary fibromatosis. A benign spindle-cell tumor with significant risk for local recurrence. Cancer. 1989;63:1363–9.

    Article  CAS  PubMed  Google Scholar 

  4. Balzer BL, Weiss SW. Do biomaterials cause implant-associated mesenchymal tumors of the breast? Analysis of eight new cases and review of the literature. Hum Pathol. 2009;40:15564–1570.

    Article  Google Scholar 

  5. McMenamin ME, DeSchryver K, Fletcher CDM. Fibrous lesions of the breast. Int J Surg Pathol. 2000;8:99–108.

    Article  PubMed  Google Scholar 

  6. Lacroix-Triki M, Geyer FC, Lambros MB, et al. beta-catenin/Wnt signalling pathway in fibromatosis, metaplastic carcinomas and phyllodes tumours of the breast. Mod Pathol. 2010;23:1438–48.

    Article  CAS  PubMed  Google Scholar 

  7. Gobbi H, Tse G, Page DL, Olson SJ, Jensen RA, Simpson JF. Reactive spindle cell nodules of the breast after core biopsy or fine needle aspiration. Am J Clin Pathol. 2000;113:288–94.

    Article  CAS  PubMed  Google Scholar 

  8. Wargotz ES, Weeiss SW, Norris HJ. Myofibroblastoma of the breast. Sixteen cases of a distinctive benign mesenchymal tumor. Am J Surg Pathol. 1987;11:493–502.

    Article  CAS  PubMed  Google Scholar 

  9. Margo G. Epithelioid myofibroblastoma of the breast: expanding the morphologic spectrum. Am J Surg Pathol. 2009;33:1085–92.

    Article  Google Scholar 

  10. Wahbah MM, Gilcrease MZ, Wu Y. Lipomatous variant of myofibroblastoma with epithelioid features: a rare and diagnostically challenging breast lesion. Ann Diag Pathol. 2011;15:454–8.

    Article  Google Scholar 

  11. Ibrahim HAH, Shousha S. Myofibroblastoma of the female breast with admixed but distinct foci of spindle cell lipoma: a case report. Case Reports in Pathology 2013; Article ID 7380b14

    Google Scholar 

  12. Margo G, Bisceglia M, Michal M, Eusebi V. Spindle cell lipoma-like tumor, solitary fibrous tumor and myofibroblastoma of the breast: a clinico-pathological analysis of 13 cases in favor of a unifying histogenetic concept. Virchows Arch. 2002;440:249–60.

    Article  Google Scholar 

  13. Brahim RE, Sciotto CG, Weidner N. Pseudoangiomatous hyperplasia of mammary stroma. Some observations regarding its clinicopathologic spectrum. Cancer. 1989;63:1154–60.

    Article  Google Scholar 

  14. Tomaszewski JE, Brooks JSJ, Hicks D, Livolsi VA. Diabetic mastopathy: a distinctive clinicopathologic entity. Hum Pathol. 1992;23:780–6.

    Article  CAS  PubMed  Google Scholar 

  15. Seidman JD, Schnaper LA, Phillips LE. Mastopathy in insulin-requiring diabetes mellitus. Hum Pathol. 1994;25:817–24.

    Article  Google Scholar 

  16. Shousha S. Diabetic mastopathy: strong CD10+ immunoreactivity of the atypical stromal cells. Histopathology. 2008;52:648–50.

    Article  CAS  PubMed  Google Scholar 

  17. Ely KA, Tse G, Simpson JF, Clarfeld R, Page DL. Diabetic mastopathy. A clinicopathologic review. Am J Clin Pathol. 2000;113:541–5.

    Article  CAS  PubMed  Google Scholar 

  18. Weinstein SP, Canant EF, Orel SG, Lawton TJ, Acs G. Diabetic mastopathy in men: imaging findings in two patients. Radiology. 2001;219:797–9.

    Article  CAS  PubMed  Google Scholar 

  19. Nascimento AG, Rosen PP, Karas M, Caron AG. Leiomyoma of the nipple. Am J Surg Pathol. 1979;3:151–4.

    Article  CAS  PubMed  Google Scholar 

  20. Chaudhary KS, Shousha S. Leiomyoma of the nipple, and normal subareolar, muscle fibres, are oestrogen and progesterone receptor positive. Histopathology. 2004;44:626–8.

    Article  CAS  PubMed  Google Scholar 

  21. Fletcher CDM. Inflammatory myofibroblastic tumour. In: Lakhani SR, Ellis IO, Schnitt SJ, Tan PH, van de Vijver, editors. WHO classification of tumours of the breast. Lyon: IARC; 2012. p. 133.

    Google Scholar 

  22. Callery CD, Rosen PP, Kinne DW. Sarcoma of the breast. A study of 32 patients with reappraisal of classification and therapy. Ann Surgery. 1985;201:527–32.

    Article  CAS  Google Scholar 

  23. Blanchard DK, Reynolds CA, Grant CS, Donohue JH. Primary nonphylloides breast sarcomas. Am J Surgery. 2003;186:359–61.

    Article  Google Scholar 

  24. Zelek L, Liombart-Cusssac A, Terrier P, Pivot X, Guinebretiere JM, Le Pechoux C, et al. Prognostic factors in primary breast sarcomas: a series of patients with long-term follow-up. J Clin Oncol. 2003;21:2583–8.

    Article  CAS  PubMed  Google Scholar 

  25. Adem C, Reynolds C, Ingle JN, Nascimento AG. Primary breast sarcoma: clinicopathologic series from the mayo clinic and review of the literature. Brit J Caner. 2004;91:237–41.

    CAS  Google Scholar 

  26. Al-Benna S, Poggeman K, Steinau H-U, Steinstraesser L. Diagnosis and management of primary breast sarcoma. Breast Cancer Res Treat. 2010;122:619–26.

    Article  PubMed  Google Scholar 

  27. Voutsadakis IA, Zaman K, Leyvraz S. Breast sarcomas: current and future perspectives. Breast. 2011;20:199–204.

    Google Scholar 

  28. Jones MW, Norris HJ, Wargotz ES, Weiss SW. Fibrosarcoma-malignant fibrous histiocytoma of the breast. A clinicopathological study of 32 cases. Am J Surg Pathol. 1992;16:667–74.

    Article  CAS  PubMed  Google Scholar 

  29. Leibl S, Moinfar F. Mammary NOS-type sarcoma with CD10 expression. A rare entity with features of myoepithelial differentiation. Am J Surg Pathol. 2006;30:450–6.

    Article  PubMed  Google Scholar 

  30. Kirova YM, Vilcoq JR, Asselian B, Sastre-Garau X, Fourquet A. Radiation-induced sarcomas after radiotherapy for breast carcinoma. Cancer. 2005;104:856–63.

    Article  PubMed  Google Scholar 

  31. Gladdy RA, Qin L-X, Moraco N, Edger MA, Antoneecu CR, Alektiar KM, et al. Do radiation-associated soft tissue sarcomas have the same prognosis as sporadic soft tissue sarcomas? J Clin Oncol. 2010;28:2064–9.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Shousha S, Sinnett HD. Chest wall tumors presenting as breast lumps. Breast J. 2004;10:150–3.

    Article  PubMed  Google Scholar 

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Correspondence to Sami Shousha .

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© 2017 Springer International Publishing Switzerland

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Shousha, S. (2017). Spindle Cell Lesions. In: Shousha, S. (eds) Breast Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28655-6_10

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  • DOI: https://doi.org/10.1007/978-3-319-28655-6_10

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28653-2

  • Online ISBN: 978-3-319-28655-6

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