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Emerging Radiopharmaceuticals in Clinical Oncology

Nuclear Oncology

Abstract

Over the past two decades, nuclear imaging has transformed cancer care. Positron emission tomography (PET) and single photon emission computed tomography (SPECT) can provide clinicians with functional and biochemical information about tumor tissue that complement the anatomical data acquired through magnetic resonance imaging (MRI) and computed tomography (CT). In this chapter, we highlight a number of emerging radiotracers in oncology that are currently employed in clinical trials in the USA and worldwide yet are awaiting regulatory approval in the USA. The radiotracers discussed range from small molecule probes that target cellular transport mechanisms and metabolic pathways to antibody-based agents that target cell-surface receptors. In order to help the reader appreciate the diversity and potential of each of these imaging agents, we present the underlying mechanisms of each agent’s targeting and trapping in tumor tissue and provide examples of clinical studies in diverse cancer types as well as descriptions of the utility of each tracer for staging and treatment monitoring.

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Authors and Affiliations

  1. Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, USA

    Mirkka Sarparanta, Dustin W. Demoin & Brendon E. Cook

  2. Laboratory of Radiochemistry, Department of Chemistry, University of Helsinki, Helsinki, Finland

    Mirkka Sarparanta

  3. Department of Chemistry, Hunter College of the City University of New York, New York, NY, USA

    Brendon E. Cook & Brian M. Zeglis

  4. Ph.D. Program in Chemistry, Graduate Center of the City University of New York, New York, NY, USA

    Brendon E. Cook & Brian M. Zeglis

  5. Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Jason S. Lewis

  6. Department of Radiology, Weill Cornell Medical College, New York, NY, USA

    Jason S. Lewis & Brian M. Zeglis

  7. Department of Pharmacology, Weill Cornell Medical College, New York, NY, USA

    Jason S. Lewis

  8. Radiochemistry and Imaging Sciences Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, USA

    Jason S. Lewis & Brian M. Zeglis

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  1. Mirkka Sarparanta
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  2. Dustin W. Demoin
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  4. Jason S. Lewis
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Correspondence to Mirkka Sarparanta , Dustin W. Demoin , Brendon E. Cook , Jason S. Lewis or Brian M. Zeglis .

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Editors and Affiliations

  1. Attending Emeritus, Memorial Sloan-Kettering Cancer Center Dept. Radiology, New York, New York, USA

    H. William Strauss

  2. Professor Emeritus, University of Pisa, Pisa, Italy

    Giuliano Mariani

  3. Associate Professor and Director of Nuclear Medicine, University of Pisa, Pisa, Italy

    Duccio Volterrani

  4. Attending Physician, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Steven M. Larson

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Sarparanta, M., Demoin, D.W., Cook, B.E., Lewis, J.S., Zeglis, B.M. (2016). Emerging Radiopharmaceuticals in Clinical Oncology. In: Strauss, H., Mariani, G., Volterrani, D., Larson, S. (eds) Nuclear Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-26067-9_87-1

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  • DOI: https://doi.org/10.1007/978-3-319-26067-9_87-1

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    Novel Positron-Emitting Radiopharmaceuticals
    Published:
    16 July 2022

    DOI: https://doi.org/10.1007/978-3-319-26067-9_87-3

  2. Novel Positron Emitting Radiopharmaceuticals
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    DOI: https://doi.org/10.1007/978-3-319-26067-9_87-2

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    Emerging Radiopharmaceuticals in Clinical Oncology
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    DOI: https://doi.org/10.1007/978-3-319-26067-9_87-1

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