Abstract
Hemodiafiltration (HDF) is a safe and highly efficient renal replacement therapy that allows diffusive and convective clearance of uremic toxins across a wide molecular weight range. Advances in technology with the availability of dialysis machines that allow controlled ultrafiltration (UF) and smaller dialysis filters and lines have enabled the use of HDF as a safe technique of routine renal replacement therapy even in small children. In this chapter the technique, advantages and clinical studies on HDF in children are described. We depict our experience in the developing and refining of the HDF technique in children over four decades, and clinical outcomes of intensified daily on-line HDF, particularly on growth. Careful attention to achieving the highest possible convective volume is important as this is likely to improve patient outcome. A clinical trial comparing the outcomes of HDF versus conventional hemodialysis (HD) in children is in progress.
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Fischbach, M., Zaloszyc, A., Shroff, R. (2016). Hemodiafiltration in Children. In: Nubé, M., Grooteman, M., Blankestijn, P. (eds) Hemodiafiltration. Springer, Cham. https://doi.org/10.1007/978-3-319-23332-1_20
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DOI: https://doi.org/10.1007/978-3-319-23332-1_20
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