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Carbon Nanomaterials for Biomedical Applications pp 481–500Cite as

Biomimetic Approach to Designing Adhesive Hydrogels: From Chemistry to Application

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Part of the book series: Springer Series in Biomaterials Science and Engineering ((SSBSE,volume 5))

Abstract

Marine mussels secrete remarkable underwater adhesives that allow these organisms to anchor to surfaces in turbulent, intertidal zones. A unique amino acid, 3,4-dihydroxyphenylalanine (DOPA), is found in large abundance in these adhesive proteins and DOPA is responsible for both rapid curing of the adhesive and interfacial binding. Chemically linking DOPA and other catechol derivatives onto inert, synthetic polymers has imparted these materials with strong, water-resistant adhesive properties to various biological, metallic, and polymeric substrates. In this chapter, we review the mechanisms behind the unique interfacial binding and intermolecular cross-linking chemistries of DOPA and the use of DOPA in designing adhesive hydrogels with elevated adhesive strength and tunable physical and mechanical properties. The application of these bioadhesives as sealants and adhesives in wound healing, soft tissue reconstruction, immobilization of therapeutic cells, and drug delivery is described.

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Acknowledgment

The authors would like to acknowledge National Institutes of Health (GM104846) for financial support.

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  1. Department of Biomedical Engineering, Michigan Technological University, 1400 Townsend Dr. Houghton, 49931, Houghton, MI, USA

    Yuting Li & Bruce P. Lee

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  1. Yuting Li
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  1. Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA

    Mei Zhang

  2. Soft Matter Materials Branch, Air Force Research Laboratory, Dayton, Ohio, USA

    Rajesh R. Naik

  3. Department of Macromolecular Science, Case Western Reserve University, Cleveland, Ohio, USA

    Liming Dai

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Li, Y., Lee, B. (2016). Biomimetic Approach to Designing Adhesive Hydrogels: From Chemistry to Application. In: Zhang, M., Naik, R., Dai, L. (eds) Carbon Nanomaterials for Biomedical Applications. Springer Series in Biomaterials Science and Engineering, vol 5. Springer, Cham. https://doi.org/10.1007/978-3-319-22861-7_15

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