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Liver Transplantation for Common Bile Duct Injury

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Book cover Management of Benign Biliary Stenosis and Injury

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Abstract

Indications for liver transplantation after bile duct injury fall into two major categories: Chronic liver disease due to secondary biliary cirrhosis and acute liver failure due to an associated major vascular injury. The exact incidence of liver transplantation due to biliary injury is difficult to estimate because the etiology of liver failure for these patients is not always adequately captured in current transplant registries. There is a rare but important role and need for liver transplant in highly selected cases of bile duct injury. While the etiology of obstruction leading to secondary biliary cirrhosis is not consistently reported, most cases series describe the use of transplantation as a consequence of iatrogenic injury.

This chapter will review the existing literature, pathogenesis, and histology of liver disease associated with bile duct injury, evaluation of the potential transplant recipient, and technical factors in this patient group.

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References

  1. Ardiles V, McCormack L, Quinonez E, et al. Experience using liver transplantation for the treatment of severe bile duct injuries over 20 years in Argentina: results from a National Survey. HPB (Oxford). 2011;13(8):544–50.

    Article  Google Scholar 

  2. Bacha EA, Stieber AC, Galloway JR, Hunter JG. Non-biliary complication of laparoscopic cholecystectomy. Lancet. 1994;344(8926):896–7.

    Article  PubMed  CAS  Google Scholar 

  3. Barbier L, Souche R, Slim K, Ah-Soune P. Long-term consequences of bile duct injury after cholecystectomy. J Visc Surg. 2014.

    Google Scholar 

  4. de Santibanes E, Ardiles V, Gadano A, Palavecino M, Pekolj J, Ciardullo M. Liver transplantation: the last measure in the treatment of bile duct injuries. World J Surg. 2008;32(8):1714–21.

    Article  PubMed  Google Scholar 

  5. Fernandez JA, Robles R, Marin C, Sanchez-Bueno F, Ramirez P, Parrilla P. Laparoscopic iatrogeny of the hepatic hilum as an indication for liver transplantation. Liver Transpl. 2004;10(1):147–52.

    Article  PubMed  Google Scholar 

  6. Frilling A, Li J, Weber F, et al. Major bile duct injuries after laparoscopic cholecystectomy: a tertiary center experience. J Gastrointest Surg. 2004;8(6):679–85.

    Article  PubMed  Google Scholar 

  7. Loinaz C, Gonzalez EM, Jimenez C, et al. Long-term biliary complications after liver surgery leading to liver transplantation. World J Surg. 2001;25(10):1260–3.

    Article  PubMed  CAS  Google Scholar 

  8. Lubikowski J, Chmurowicz T, Post M, et al. Liver transplantation as an ultimate step in the management of iatrogenic bile duct injury complicated by secondary biliary cirrhosis. Ann Transplant. 2012;17(2):38–44.

    Article  PubMed  Google Scholar 

  9. McCormack L, Quinonez EG, Capitanich P, et al. Acute liver failure due to concomitant arterial, portal and biliary injury during laparoscopic cholecystectomy: is transplantation a valid life-saving strategy? A case report. Patient Saf Surg. 2009;3(1):22.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Nordin A, Makisalo H, Isoniemi H, Halme L, Lindgren L, Hockerstedt K. Iatrogenic lesion at cholecystectomy resulting in liver transplantation. Transplant Proc. 2001;33(4):2499–500.

    Article  PubMed  CAS  Google Scholar 

  11. Oncel D, Ozden I, Bilge O, et al. Bile duct injury during cholecystectomy requiring delayed liver transplantation: a case report and literature review. Tohoku J Exp Med. 2006;209(4):355–9.

    Article  PubMed  Google Scholar 

  12. Parrilla P, Robles R, Varo E, et al. Liver transplantation for bile duct injury after open and laparoscopic cholecystectomy. Br J Surg. 2014;101(2):63–8.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  13. Robertson AJ, Rela M, Karani J, Steger AC, Benjamin IS, Heaton ND. Laparoscopic cholecystectomy injury: an unusual indication for liver transplantation. Transpl Int. 1998;11(6):449–51.

    Article  PubMed  CAS  Google Scholar 

  14. Schmidt SC, Settmacher U, Langrehr JM, Neuhaus P. Management and outcome of patients with combined bile duct and hepatic arterial injuries after laparoscopic cholecystectomy. Surgery. 2004;135(6):613–8.

    Article  PubMed  Google Scholar 

  15. Strasberg SM, Gouma DJ. ‘Extreme’ vasculobiliary injuries: association with fundus-down cholecystectomy in severely inflamed gallbladders. HPB (Oxford). 2012;14(1):1–8.

    Article  Google Scholar 

  16. Thomson BN, Parks RW, Madhavan KK, Garden OJ. Liver resection and transplantation in the management of iatrogenic biliary injury. World J Surg. 2007;31(12):2363–9.

    Article  PubMed  CAS  Google Scholar 

  17. Walsh RM, Vogt DP, Ponsky JL, Brown N, Mascha E, Henderson JM. Management of failed biliary repairs for major bile duct injuries after laparoscopic cholecystectomy. J Am Coll Surg. 2004;199(2):192–7.

    Article  PubMed  Google Scholar 

  18. Zaydfudim V, Wright JK, Pinson CW. Liver transplantation for iatrogenic porta hepatis transection. Am Surg. 2009;75(4):313–6.

    PubMed  Google Scholar 

  19. US United Network for Organ Sharing (UNOS) registry. 2014; http://www.srtr.org/. Accessed 1 Oct 2014.

  20. de Santibanes E, Ardiles V, Pekolj J. Complex bile duct injuries: management. HPB (Oxford). 2008;10(1):4–12.

    Article  Google Scholar 

  21. Koffron A, Ferrario M, Parsons W, Nemcek A, Saker M, Abecassis M. Failed primary management of iatrogenic biliary injury: incidence and significance of concomitant hepatic arterial disruption. Surgery. 2001;130(4):722–8. discussion 728-731.

    Article  PubMed  CAS  Google Scholar 

  22. Mirza DF, Narsimhan KL, Ferraz Neto BH, Mayer AD, McMaster P, Buckels JA. Bile duct injury following laparoscopic cholecystectomy: referral pattern and management. Br J Surg. 1997;84(6):786–90.

    Article  PubMed  CAS  Google Scholar 

  23. Chaudhary A, Manisegran M, Chandra A, Agarwal AK, Sachdev AK. How do bile duct injuries sustained during laparoscopic cholecystectomy differ from those during open cholecystectomy. J Laparoendosc Adv Surg Tech A. 2001;11(4):187–91.

    Article  PubMed  CAS  Google Scholar 

  24. Nuzzo G, Giuliante F, Persiani R. The risk of biliary ductal injury during laparoscopic cholecystectomy. J Chir. 2004;141(6):343–53.

    Article  CAS  Google Scholar 

  25. Strasberg SM. Avoidance of biliary injury during laparoscopic cholecystectomy. J Hepatobiliary Pancreat Surg. 2002;9(5):543–7.

    Article  PubMed  Google Scholar 

  26. Yan JQ, Peng CH, Ding JZ, et al. Surgical management in biliary restricture after Roux-en-Y hepaticojejunostomy for bile duct injury. World J Gastroenterol. 2007;13(48):6598–602.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Chapman WC, Abecassis M, Jarnagin W, Mulvihill S, Strasberg SM. Bile duct injuries 12 years after the introduction of laparoscopic cholecystectomy. J Gastrointest Surg. 2003;7(3):412–6.

    Article  PubMed  Google Scholar 

  28. Chapman WC, Halevy A, Blumgart LH, Benjamin IS. Postcholecystectomy bile duct strictures. Management and outcome in 130 patients. Arch Surg. 1995;130(6):597–602. discussion 602-594.

    Article  PubMed  CAS  Google Scholar 

  29. Flum DR, Cheadle A, Prela C, Dellinger EP, Chan L. Bile duct injury during cholecystectomy and survival in medicare beneficiaries. JAMA. 2003;290(16):2168–73.

    Article  PubMed  CAS  Google Scholar 

  30. Kern KA. Medicolegal analysis of bile duct injury during open cholecystectomy and abdominal surgery. Am J Surg. 1994;168(3):217–22.

    Article  PubMed  CAS  Google Scholar 

  31. Nilsson E. Incidence and nature of bile duct injuries following laparoscopic cholecystectomy: an audit of 5913 cases. Br J Surg. 1997;84(3):424.

    Article  PubMed  CAS  Google Scholar 

  32. Alves A, Farges O, Nicolet J, Watrin T, Sauvanet A, Belghiti J. Incidence and consequence of an hepatic artery injury in patients with postcholecystectomy bile duct strictures. Ann Surg. 2003;238(1):93–6.

    PubMed  PubMed Central  Google Scholar 

  33. Blumgart LH, Kelley CJ, Benjamin IS. Benign bile duct stricture following cholecystectomy: critical factors in management. Br J Surg. 1984;71(11):836–43.

    Article  PubMed  CAS  Google Scholar 

  34. Vellar ID. The blood supply of the biliary ductal system and its relevance to vasculobiliary injuries following cholecystectomy. Aust N Z J Surg. 1999;69(11):816–20.

    Article  PubMed  CAS  Google Scholar 

  35. Mercado MA, Chan C, Orozco H, Tielve M, Hinojosa CA. Acute bile duct injury. The need for a high repair. Surg Endosc. 2003;17(9):1351–5.

    Article  PubMed  CAS  Google Scholar 

  36. Kaman L, Behera A, Singh R, Katariya RN. Management of major bile duct injuries after laparoscopic cholecystectomy. Surg Endosc. 2004;18(8):1196–9.

    Article  PubMed  CAS  Google Scholar 

  37. Pitt HA, Miyamoto T, Parapatis SK, Tompkins RK, Longmire Jr WP. Factors influencing outcome in patients with postoperative biliary strictures. Am J Surg. 1982;144(1):14–21.

    Article  PubMed  CAS  Google Scholar 

  38. Walsh RM, Henderson JM, Vogt DP, Brown N. Long-term outcome of biliary reconstruction for bile duct injuries from laparoscopic cholecystectomies. Surgery. 2007;142(4):450–6. discussion 456-457.

    Article  PubMed  Google Scholar 

  39. Johnson SR, Koehler A, Pennington LK, Hanto DW. Long-term results of surgical repair of bile duct injuries following laparoscopic cholecystectomy. Surgery. 2000;128(4):668–77.

    Article  PubMed  CAS  Google Scholar 

  40. Thompson CM, Saad NE, Quazi RR, Darcy MD, Picus DD, Menias CO. Management of iatrogenic bile duct injuries: role of the interventional radiologist. Radiographics. 2013;33(1):117–34.

    Article  PubMed  Google Scholar 

  41. Abraham SC, Kamath PS, Eghtesad B, Demetris AJ, Krasinskas AM. Liver transplantation in precirrhotic biliary tract disease: Portal hypertension is frequently associated with nodular regenerative hyperplasia and obliterative portal venopathy. Am J Surg Pathol. 2006;30(11):1454–61.

    Article  PubMed  Google Scholar 

  42. Saad WE. Percutaneous management of postoperative anastomotic biliary strictures. Tech Vasc Interv Radiol. 2008;11(2):143–53.

    Article  PubMed  Google Scholar 

  43. Sikora SS, Srikanth G, Agrawal V, et al. Liver histology in benign biliary stricture: fibrosis to cirrhosis … and reversal? J Gastroenterol Hepatol. 2008;23(12):1879–84.

    Article  PubMed  Google Scholar 

  44. Weinbren K, Hadjis NS, Blumgart LH. Structural aspects of the liver in patients with biliary disease and portal hypertension. J Clin Pathol. 1985;38(9):1013–20.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  45. Corvera CU, Alemi F, Jarnagin W. Benign Biliary Strictures. In: editor-in-chief WRJae, Jacques Belghiti … [and others]; editor emeritus, Leslie H. Blumgart, ed. Blumgart’s surgery of the liver, biliary tract, and pancreas. 5th Edition ed. Philadelphia: Elsevier Saunders; 2012.

    Google Scholar 

  46. Adson MA, Wychulis AR. Portal hypertension in secondary biliary cirrhosis. Arch Surg. 1968;96(4):604–12.

    Article  PubMed  CAS  Google Scholar 

  47. Negi SS, Sakhuja P, Malhotra V, Chaudhary A. Factors predicting advanced hepatic fibrosis in patients with postcholecystectomy bile duct strictures. Arch Surg. 2004;139(3):299–303.

    Article  PubMed  Google Scholar 

  48. Hammel P, Couvelard A, O’Toole D, et al. Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct. N Engl J Med. 2001;344(6):418–23.

    Article  PubMed  CAS  Google Scholar 

  49. Abdel-Aziz G, Lebeau G, Rescan PY, et al. Reversibility of hepatic fibrosis in experimentally induced cholestasis in rat. Am J Pathol. 1990;137(6):1333–42.

    PubMed  CAS  PubMed Central  Google Scholar 

  50. Conzen K, Doyle MBM, Chapman WC. Orthotopic Liver Transplantation In: editor-in-chief WRJae, Jacques Belghiti … [and others]; editor emeritus, Leslie H. Blumgart, ed. Blumgart’s surgery of the liver, biliary tract, and pancreas. Fifth edition ed. Philadelphia Elsevier Saunders; 2012.

    Google Scholar 

  51. Merkel FK, Jonasson O, Bergan JJ. Procurement of cadaver donor organs: evisceration technique. Transplant Proc. 1972;4(4):585–9.

    PubMed  CAS  Google Scholar 

  52. Starzl TE, Hakala TR, Shaw Jr BW, et al. A flexible procedure for multiple cadaveric organ procurement. Surg Gynecol Obstet. 1984;158(3):223–30.

    PubMed  CAS  PubMed Central  Google Scholar 

  53. Starzl TE, Miller C, Broznick B, Makowka L. An improved technique for multiple organ harvesting. Surg Gynecol Obstet. 1987;165(4):343–8.

    PubMed  CAS  PubMed Central  Google Scholar 

  54. Porte RJ, Lerut J. Orthotopic liver transplant In: editors P-AC, Michael G. Sarr, and Yuman Fong; Panco Georgiev (associate editor), ed. Atlas of upper gastrointestinal and hepato-pancreato-biliary surgery. New York: Springer-Verlag; 2007

    Google Scholar 

  55. Steib A, Freys G, Lehmann C, Meyer C, Mahoudeau G. Intraoperative blood losses and transfusion requirements during adult liver transplantation remain difficult to predict. Can J Anaesth. 2001;48(11):1075–9.

    Article  PubMed  CAS  Google Scholar 

  56. Adam R, Azoulay D, Castaing D, et al. Liver resection as a bridge to transplantation for hepatocellular carcinoma on cirrhosis: a reasonable strategy? Ann Surg. 2003;238(4):508–18. discussion 518-509.

    PubMed  PubMed Central  Google Scholar 

  57. Cherqui D, Laurent A, Mocellin N, et al. Liver resection for transplantable hepatocellular carcinoma: long-term survival and role of secondary liver transplantation. Ann Surg. 2009;250(5):738–46.

    Article  PubMed  Google Scholar 

  58. Neuberger J, Gunson B, Komolmit P, Davies MH, Christensen E. Pretransplant prediction of prognosis after liver transplantation in primary sclerosing cholangitis using a Cox regression model. Hepatology. 1999;29(5):1375–9.

    Article  PubMed  CAS  Google Scholar 

  59. Burdick JF, Pitt HA, Colombani PM, et al. Superior mesenteric vein inflow for liver transplantation when the portal vein is occluded. Surgery. 1990;107(3):342–5.

    PubMed  CAS  Google Scholar 

  60. Tzakis A, Todo S, Starzl TE. The anterior route for arterial graft conduits in liver transplantation. Transpl Int. 1989;2(2):121.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Section of Transplantation, Department of Surgery, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8109, St. Louis, MO, 63110, USA

    Kelly M. Collins M.D. & William C. Chapman M.D.

Authors
  1. Kelly M. Collins M.D.
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  2. William C. Chapman M.D.
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Correspondence to William C. Chapman M.D. .

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Editors and Affiliations

  1. Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada

    Elijah Dixon

  2. Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Charles M. Vollmer Jr.

  3. Division of Gastroenterology, St. Michael's Hospital, Toronto, Ontario, Canada

    Gary R. May

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Collins, K.M., Chapman, W.C. (2015). Liver Transplantation for Common Bile Duct Injury. In: Dixon, E., Vollmer Jr., C., May, G. (eds) Management of Benign Biliary Stenosis and Injury. Springer, Cham. https://doi.org/10.1007/978-3-319-22273-8_34

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  • DOI: https://doi.org/10.1007/978-3-319-22273-8_34

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-22272-1

  • Online ISBN: 978-3-319-22273-8

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