Abstract
Heavy metals (HMs) are among the most important environmental pollutants, particularly in areas with strong anthropogenic pressure. For plants, high levels of HMs are extremely toxic since they may act in several different modes: by the direct inhibition of plant growth and biosynthetic pathways or through the production of reactive oxygen species (ROS). Certain metals generate ROS due to their involvement in redox reactions like Fenton and/or Haber–Weiss reactions, while metals without redox capacity enhance ROS production by reducing the antioxidant glutathione pool, activating calcium-dependent systems and influencing iron-mediated processes. ROS production affects lipids, proteins, and DNA and consequently leads to cell death. In response, plants are equipped with complex enzymatic and nonenzymatic mechanisms involved in antioxidative defense to neutralize HM toxicity, and the main components of these mechanisms will be reviewed in this chapter.
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References
Agrawal SB, Mishra S (2009) Effects of supplemental ultraviolet-B and cadmium on growth, antioxidants and yield of Pisum sativum L. Ecotoxicol Environ Saf 72:610–618
Agrawal SB, Agrawal M, Lee EH, Kramer GF, Pillai P (1992) Changes in polyamine and glutathione contents of a green algae, Chlorogonium elongatum (Dang) France exposed to mercur. Environ Exp Bot 32:145–151
Ahamad ZH, Shuhanija SN (2013) Physiological and biochemical responses of a Malaysian red alga, Gracilaria manilaensis treated with copper, lead and mercury. J Environ Res Dev 7:1246–1253
Ahmad P, Sarwat M, Sharma S (2008) Reactive oxygen species, antioxidants and signaling in plants. J Plant Biol 51:167–173
Ahn YO, Kim SH, Lee J, Kim HR, Lee HS, Kwak SS (2012) Three Brassica rapa metallothionein genes are differentially regulated under various stress conditions. Mol Biol Rep 39:2059–2067
Akinci IE, Akinci S (2010) Effect of chromium toxicity on germination and early seedling growth in melon (Cucumis melo L.). Afr J Biotechnol 9:4589–4594
Ali H, Khan E, Sajad MA (2013) Phytoremediation of heavy metals-concepts and applications. Chemosphere 91:869–881
Alloway BJ (2013) Sources of heavy metals and metalloids in soils. In: Alloway BJ (ed) Heavy metals in soils, trace metals and metalloids in soils and their bioavailability. Springer, London
Alloway BJ, Steinnes E (1999) Anthropogenic additions of cadmium to soils. In: McLaughlin MJ, Singh BR (eds) Cadmium in soils and plants, Developments in plants and soils sciences. Kluwer, Dordrecht
Alrawiq N, Khairiah J, Talib ML, Ismail BS, Anizan I (2014) Accumulation and translocation of heavy metals in soil and paddy plant samples collected from rice fields irrigated with recycled and non-recycled water in MADA Kedah, Malaysia. Int J ChemTech Res 6:2347–2356
Alscher RG, Erturk N, Heath LS (2002) Role of superoxide dismutases (SODs) in controlling oxidative stress in plants. J Exp Bot 53:1331–1341
Amin H, Arain BA, Amin F, Surhio MA (2013) Phytotoxicity of chromium on germination, growth and biochemical attributes of Hibiscus esculentus L. Am J Plant Sci 4:2431–2439
Anjum NA, Gill SS, Gill R, Hasanuzzaman M, Duarte AC, Pereira E, Ahmad I, Tuteja R, Tuteja N (2014) Metal/metalloid stress tolerance in plants: role of ascorbate, its redox couple, and associated enzymes. Protoplasma 251:1265–1283
Aravind P, Prasad MNV (2005) Modulation of cadmium-induced oxidative stress in Ceratophyllum demersum by zinc involves ascorbate-glutathione cycle and glutathione metabolism. Plant Physiol Biochem 43:107–116
Arunakumara KKIU, Zhang X (2007) Effect of Pb2+ on phycobiliprotein content of Spirulina platensis, an edible cyanobacterium. Trop Agric Res 19:150–159
Arunakumara KKIU, Zhang X (2008) Heavy metal bioaccumulation and toxicity with special reference to microalgae. J Ocean Univ Chin 7:25–30
Ashraf M, Foolad MR (2007) Roles of glycine betaine and proline in improving plant abiotic stress resistance. Environ Exp Bot 59:206–216
Baccouch S, Chaoui A, El Ferjani E (1998) Nickel-induced oxidative damage and antioxidant responses in Zea mays shoots. Plant Physiol Biochem 36:689–694
Bah AM, Dai H, Zhao J, Sun H, Cao F, Zhang G, Wu F (2011) Effects of cadmium, chromium and lead on growth, metal uptake and antioxidative capacity in Typha angustifolia. Biol Trace Elem Res 142:77–92
Balakrishnan CP, Narayanan CS (2007) Phytotoxicity of heavy metals nickel and lead on the cyanobacterial pigments. Seaweed Res Util 29:217–226
Barondeau DP, Kassmann CJ, Bruns CK, Tainer JA, Getzoff ED (2004) Nickel superoxide dismutase structure and mechanism. Biochemistry 43:8038–8047
Bestwick CS, Al A, Puri N, Mansfield JW (2001) Characterization of lipid peroxidation and changes to pro- and antioxidant enzyme activities during the hypersensitive reaction in lettuce (Lactuca sativa L.). Plant Sci 161:497–506
Bharwana SA, Ali S, Farooq MA, Abbas F, Iqbal N, Ahmad MSA, Shakoor MB (2013) Influence of lead stress on growth, photosynthesis and lead uptake in the seedlings of cotton. Int J Agron Plant Prod 4:2492–2501
Bhattacharjee S (2005) Reactive oxygen species and oxidative burst: roles in stress, senescence and signal transduction in plants. Curr Sci 89:1115–1121
Boominathan R, Doran PM (2002) Ni-induced oxidative stress in roots of the Ni hyperaccumulator, Alyssum bertolonii. New Phytol 156:205–215
Brunetti C, Di Ferdinando M, Fini A, Pollastri S, Tattini M (2013) Flavonoids as antioxidants and developmental regulators: relative significance in plants and humans. Int J Mol Sci 14:3540–3555
Cakmak I, Horst WJ (1991) Effect of aluminium on lipid peroxidation, superoxide dismutase, catalase and peroxidase activities in root tips of soybean (Glycine max). Physiol Planta 83:463–468
Cardoso PF, Gratão PL, Gomes-Junior RA, Medici LO, Azevedo RA (2005) Response of Crotalaria juncea to nickel exposure. Braz J Plant Physiol 17:267–272
Cetin ES, Babalik Z, Hallac-Turk F, Gokturk-Baydar N (2014) The effects of cadmium chloride on secondary metabolite production in Vitis vinifera cv. cell suspension cultures. Biol Res 47:47
Chaudri AM, Allain CM, Barbosa-Jefferson VL, Nicholson FA, Chambers BJ, McGrath SP (2000) A study of the impacts of Zn and Cu on two rhizobial species in soils of a long term field experiment. Plant Soil 22:167–179
Chen G, Asada K (1992) Inactivation of ascorbate peroxidase by thiols requires hydrogen peroxide. Plant Cell Physiol 33:117–123
Chen YX, He YF, Luo YM, Yu YL, Lin Q, Wong MH (2003) Physiological mechanism of plant roots exposed to cadmium. Chemosphere 50:789–793
Chen F, Wang F, Wu F, Mao W, Zhang G, Zhou M (2010) Modulation of exogenous glutathione in antioxidant defense system against Cd stress in the two barley genotypes differing in Cd tolerance. Plant Physiol Biochem 48:663–672
Chongpraditnun P, Mori S, Chino M (1992) Excess copper induces a cytosolic Cu, Zn-superoxide dismutase in soybean root. Plant Cell Physiol 33:239–244
Chou TS, Chao YY, Huei Kao C (2012) Involvement of hydrogen peroxide in heat shock- and cadmium-induced expression of ascorbate peroxidase and glutathione reductase in leaves of rice seedlings. J Plant Physiol 169:478–486
Ci D, Jiang D, Dai T, Jing Q, Cao W (2009) Effects of cadmium on plant growth and physiological traits in contrast wheat recombinant inbred lines differing in cadmium tolerance. Chemosphere 77:1620–1625
Cobbett CS (2000) Phytochelatins and their role in heavy metal detoxification. Plant Physiol 123:825–832
Corpas FJ, Barroso JB, del Río LA (2001) Peroxisomes as a source of reactive oxygen species and nitric oxide signal molecules in plant cells. Trends Plant Sci 6:145–150
Couée I, Sulmon C, Gouesbet G, El Amrani A (2006) Involvement of soluble sugars in reactive oxygen species balance and responses to oxidative stress in plants. J Exp Bot 57:449–459
Creissen GP, Mullineaux PM (1995) Cloning and characterization of glutathione reductase cDNAs and identification of two genes encoding the tobacco enzyme. Planta 197:422–425
Cuypers A, Vangronsveld J, Clijsters H (2000) Biphasic effect of copper on the ascorbate-glutathione pathway in primary leaves of Phaseolus vulgaris seedlings during the early stages of metal assimilation. Physiol Planta 110:512–517
Cuypers A, Vangronsveld J, Clijsters H (2001) The redox status of plant cells (AsA and GSH) is sensitive to zinc imposed oxidative stress in roots and primary leaves of Phaseolus vulgaris. Plant Physiol Biochem 39:657–664
Cuypers A, Smeets K, Ruytinx J, Opdenakker K, Keunen E, Remans T, Horemans N, Vanhoudt N, Van Sanden S, Van Belleghem F, Guisez Y, Colpaert J, Vangronsveld J (2011) The cellular redox state as a modulator in cadmium and copper responses in Arabidopsis thaliana seedlings. J Plant Physiol 168:309–316
D’Souza RM, Devaraj VR (2012) Induction of oxidative stress and antioxidative mechanisms in Hyacinth bean under zinc stress. Afr Crop Sci J 20:17–29
Dandan L, Dongmei Z, Peng W, Weng Nanyan W, Xiangdong Z (2011) Subcellular Cd distribution and its correlation with antioxidant enzymatic activities in wheat (Triticum aestivum) roots. Ecotoxicol Environ Saf 74:874–881
Das PK, Kar M, Mishra D (1978) Nickel nutrition of plants. 1. Effects of nickel on some oxidase activities during rice (Oryza sativa L.) seed germination. Z Pflanzenphysiol 90:225–233
Daud MK, Mei L, Variath MT, Ali S, Li C, Rafiq MT, Zhu SJ (2014) Chromium (VI) uptake and tolerance potential in cotton cultivars: effect on their root physiology, ultramorphology, and oxidative metabolism. Bio Med Res Int 2014:1–11
Davletova S, Rizhsky L, Liang H, Shengqiang D, Oliver D, Coutu J, Shulaev V, Schlauch K, Mittler R (2004) Cytosolic ascorbate peroxidase 1 is a central component of the reactive oxygen gene network of Arabidopsis. Plant Cell 17:268–281
De Jesus MD, Tabatabai F, Chapman DJ (1989) Taxonomic distribution of copper-zinc superoxide dismutase in green algae and its phylogenetic importance. J Phycol 25:767–772
Degenhardt B, Gimmler H (2000) Cell wall adaptations to multiple environmental stresses in maize roots. J Exp Bot 51:595–603
del Río LA, Scandalio LM, Corpas FJ, Palma JM, Barroso JM (2006) Reactive oxygen species and reactive nitrogen species in peroxisomes, production, scavenging, and role in cell signaling. Plant Physiol 141:330–335
Demirevska-Kepova K, Simova-Stoilova L, Stoyanova Z, Hölzer-Feller RU (2004) Biochemical changes in barley plants after excessive supply of copper and manganese. Environ Exp Bot 52:253–266
Devi Chinmayee M, Anu MS, Mahesh B, Mary Sheeba A, Mini I, Swapna TS (2014) A comparative study of heavy metal accumulation and antioxidant responses in Jatropha curcas L. J Environ Sci Toxicol Food Technol 8:58–67
Dietz KJ, Bair M, Kramer U (1999) Free radical and reactive oxygen species as mediators of heavy metal toxicity in plants. In: Prasad MNV, Hagemeyer J (eds) Heavy metal stress in plants from molecules to ecosystems. Springer, Berlin
Dinakar N, Nagajyothi PC, Suresh S, Udaykiran Y, Damodharam T (2008) Phytotoxicity of cadmium on protein, proline and antioxidant enzyme activities in growing Arachis hypogaea L. seedlings. J Environ Sci 20:199–206
Dixit V, Pandey V, Shyam R (2001) Differential antioxidative responses to cadmium in roots and leaves of pea (Pisum sativum L. cv. Azad). J Exp Bot 52:1101–1119
Duman F (2011) Effects of exogenous glycinebetaine and trehalose on lead accumulation in an aquatic plant (Lemna gibba L.). Int J Phytoremediation 13:492–497
Duman F, Ozturk F (2010) Nickel accumulation and its effect on biomass, protein content and antioxidative enzymes in roots and leaves of watercress (Nasturtium officinale R. Br.). J Environ Sci 22:526–532
Duman F, Aksoy A, Aydin Z, Temizgul R (2011) Effects of exogenous glycinebetaine and trehalose on cadmium accumulation and biological responses of an aquatic plant (Lemna gibba L.). Water Air Soil Pollut 217:545–556
Ebbs S, Uchil S (2008) Cadmium and zinc induced chlorosis in Indian mustard [Brassica juncea (L.) Czern] involves preferential loss of chlorophyll b. Photosynthetica 46:49–55
Ekmekçi Y, Tanyolaç D, Ayhan B (2008) Effects of cadmium on antioxidant enzyme and photosynthetic activities in leaves of two maize cultivars. J Plant Physiol 165:600–611
Fahr M, Laplaze L, Bendaou N, Hocher V, ElMzibri M, Bogusz D, Smouni A (2013) Effects of lead on root growth. Front Plant Sci 4:175
Falk J, Munné-Bosch S (2010) Tocochromanol functions in plants: antioxidation and beyond. J Exp Bot 61:1549–1566
Farid M, Shakoor MB, Ehsan S, Ali S, Zubair M, Hanif MA (2013) Morphological, physiological and biochemical responses of different plant species to Cd stress. Int J Chem Biochem Sci 3:53–60
Fatima RA, Ahmad M (2005) Certain antioxidant enzymes of Allium cepa as biomarkers for the detection of toxic heavy metals in wastewater. Sci Total Environ 346:256–273
Fernàndez-Martínez J, Zacchini M, Fernández-Marín B, García-Plazaola JI, Fleck I (2014) Gas-exchange, photo- and antioxidant protection, and metal accumulation in I-214 and Eridano Populus sp. clones subjected to elevated zinc concentrations. Environ Exp Bot 107:144–153
Filek M, Keskinen R, Hartikainen H, Szarejko I, Janiak A, Miszalski Z, Golda A (2008) The protective role of selenium in rape seedlings subjected to cadmium stress. J Plant Physiol 165:833–844
Florence TM, Stauber JL (1986) Toxicity of copper complexes to the marine diatom Nitzschia closterium. Aquat Toxicol 8:11–26
Fodor F (2002) Physiological responses of vascular plants to heavy metals. In: Prasad MN, Strzalka K (eds) Physiology and biochemistry of metal toxicity and tolerance in plants. Kluwer, Dordrecht
Foyer CH, Halliwell B (1976) The presence of glutathione and glutathione reductase in chloroplasts. A proposed role in ascorbic acid metabolism. Planta 133:21–25
Foyer CH, Noctor G (2005) Oxidant and antioxidant signalling in plants: a re-evaluation of the concept of oxidative stress in a physiological context. Plant Cell Environ 28:1056–1071
Franklin NM, Stauber JL, Markich SJ, Lim RP (2000) pH-dependent toxicity of copper and uranium to a tropical freshwater alga (Chlorella sp.). Aquat Toxicol 48:275–289
Franklin NM, Adams MS, Stauber JL, Lim RP (2001) Development of a rapid enzyme inhibition bioassay with marine and freshwater microalgae using flow cytometry. Arch Environ Contam Toxicol 40:469–480
Freeman JL, Persans MW, Nieman K, Albrecht C, Peer W, Pickering IJ, Salt DE (2004) Increased glutathione biosynthesis plays a role in nickel tolerance in Thlaspi nickel hyperaccumulators. Plant Cell 16:2176–2191
Gajewska E, Skłodowska M (2005) Antioxidative responses and proline level in leaves and roots of pea plants subjected to nickel stress. Acta Physiol Planta 27:329–339
Gajewska E, Skłodowska M (2007) Effect of nickel on ROS content and antioxidative enzyme activities in wheat leaves. Biometals 20:27–36
Gallego SM, Benavides MP, Tomaro ML (1996) Effect of heavy metal ion excess on sunflower leaves: evidence for involvement of oxidative stress. Plant Sci 121:151–159
Gaur JP, Rai LC (2001) Heavy metal tolerance in algae. In: Rai LC, Gaur JP (eds) Algal adaptation to environmental stresses: physiological, biochemical and molecular mechanisms. Springer, Berlin
Gichner T, Znidar I, Száková J (2008) Evaluation of DNA damage and mutagenicity induced by lead in tobacco plants. Mutat Res 652:186–190
Gill SS, Tuteja N (2010) Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. Plant Physiol Biochem 48:909–930
Gill SS, Khana NA, Tuteja N (2012) Cadmium at high dose perturbs growth, photosynthesis and nitrogen metabolism while at low dose it up regulates sulfur assimilation and antioxidant machinery in garden cress (Lepidium sativum L.). Plant Sci 182:112–120
Gill SS, Gill R, Anjum NA (2014) Target osmoprotectants for abiotic stress tolerance in crop plants-glycine betaine and proline. In: Anjum NA, Gill SS, Gill R (eds) Plant adaptation to environmental change: significance of amino acids and their derivatives. CAB, Wallingford, CT
Gomes-Júnior RA, Moldes CA, Delite FS, Gratão PL, Mazzafera P, Lea PJ, Azevedo RA (2006a) Nickel elicits a fast antioxidant response in Coffea arabica cells. Plant Physiol Biochem 44:420–429
Gomes-Júnior RA, Moldes CA, Delite FS, Pompeu GB, Gratão PL, Mazzafera P, Lea PJ, Azevedo RA (2006b) Antioxidant metabolism of coffee cell suspension cultures in response to cadmium. Chemosphere 65:1330–1337
Gouveia C, Kreusch M, Schmidt ÉC, Felix MR, Osorio LK, Pereira DT, dos Santos R, Ouriques LC, Martins Rde P, Latini A, Ramlov F, Carvalho TJ, Chow F, Maraschin M, Bouzon ZL (2013) The effects of lead and copper on the cellular architecture and metabolism of the red alga Gracilaria domingensis. Microsc Microanal 19:513–524
Grant CA, Buckley WT, Bailey LD, Selles F (1998) Cadmium accumulation in crops. Can J Plant Sci 78:1–17
Gratão PL, Polle A, Lea PJ, Azevedo RA (2005) Making the life of heavy metal-stressed plants a little easier. Funct Plant Biol 32:481–494
Gratão PL, Pompeu GB, Cardoso PF, Lea PJ, Azevedo RA (2006) Plant antioxidant responses to toxic elements. Curr Top Biochem Res 8:41–70
Greger M (2004) Metal availability, uptake, transport and accumulation in plants. In: Prasad MNV (ed) Heavy metal stress in plants: from biomolecules to ecosystems, 2nd edn. Springer, Berlin
Grzesiak M, Filek M, Barbasz A, Kreczmer B, Hartikainen H (2013) Relationships between polyamines, ethylene, osmoprotectants and antioxidant enzymes activities in wheat seedlings after short-term PEG- and NaCl-induced stresses. Plant Growth Regul 69:177–189
Guan LM, Scandalios JG (2000) Hydrogen peroxide-mediated catalase gene expression in response to wounding. Free Radic Biol Med 28:1182–1190
Guan LM, Scandalios JG (2002) Catalase gene expression in response to auxin-mediated developmental signals. Physiol Planta 114:288–295
Guo TR, Zhang GP, Zhang YH (2007) Physiological changes in barley plants under combined toxicity of aluminum, copper and cadmium. Colloids Surf B Biointerfaces 57:182–188
Gupta M, Cuypers A, Vangronsveld J, Clijsters H (1999) Copper affects the enzymes of the ascorbate-glutathione cycle and its related metabolites in the roots of Phaseolus vulgaris. Physiol Planta 106:262–267
Gupta DK, Nicoloso FT, Schetinger M, Rossato L, Pereira LB, Castro G, Srivastava S, Tripathi RD (2009) Antioxidant defense mechanism in hydroponically grown Zea mays seedlings under moderate lead stress. J Hazard Mater 172:479–484
Gupta DK, Huang HG, Yang XE, Razafindrabe BHN, Inouhe M (2010) The detoxification of lead in Sedum alfredii H. is not related to phytochelatins but the glutathione. J Hazard Mater 177:437–444
Gupta DK, Vandenhove H, Inouhe M (2013) Role of phytochelatins in heavy metal stress and detoxification mechanisms in plants. In: Gupta DK, Corpas FJ, Palma JM (eds) Heavy metal stress in plants. Springer, Berlin
Gururani MA, Upadhyaya CP, Strasser RJ, Yu JW, Park SW (2013) Evaluation of abiotic stress tolerance in transgenic potato plants with reduced expression of PSII manganese stabilizing protein. Plant Sci 198:7–16
Hajimahmoodi M, Ali Faramarzi M, Mohammadi N, Soltani N, Oveisi R, Nastaran M, Nafissi-Varcheh N (2009) Evaluation of antioxidant properties and total phenolic contents of some strains of microalgae. J Appl Phycol 22:43–50
Hao F, Wang X, Chen J (2006) Involvement of plasma-membrane NADPH oxidase in nickel-induced oxidative stress in roots of wheat seedlings. Plant Sci 170:151–158
Hare PD, Cress WA (1997) Metabolic implications of stress-induced proline accumulations in plants. Plant Growth Regul 21:79–102
Hassinen VH, Tervahauta AI, Schat H, Karenlampi SO (2011) Plant metallothioneins—metal chelators with ROS scavenging activity? Plant Biol 13:225–232
Hédiji H, Djebali W, Cabasson C, Maucourt M, Baldet P, Bertrand A, Zoghlami LB, Deborde C, Moing A, Brouquisse R, Chaïbi W, Gallusci P (2010) Effects of long-term cadmium exposure on growth and metabolomic profile of tomato plants. Ecotoxicol Environ Saf 73:1965–1974
Hegedüs A, Erdei S, Horváth G (2001) Comparative studies of H2O2 detoxifying enzymes in green and greening barley seedlings under cadmium stress. Plant Sci 160:1085–1093
Heidari M, Saran S (2011) Effects of lead and cadmium on seed germination, seedling growth and antioxidant enzymes activities of mustard (Sinapis arvensis L.). J Agric Biol Sci 6:6–11
Hirata T, Tanaka M, Ooike M, Tsunomura T, Sakaguchi M (1999) Radical scavenging activities of phycocyanobilin prepared from a cyanobacterium, Spirulina platensis. Fish Sci 65:971–972
Hirata T, Tanaka M, Ooike M, Tsunomura T, Sakaguchi M (2000) Antioxidant activities of phycocyanobilin prepared from Spirulina platensis. J App Phycol 12:435–439
Hong Z, Lakkineni K, Zhang Z, Verma DP (2000) Removal of feedback inhibition of delta(1)-pyrroline-5-carboxylate synthetase results in increased proline accumulation and protection of plants from osmotic stress. Plant Physiol 122:1129–1136
Hou W, Chen X, Song G, Wang Q, Chang CC (2007) Effects of copper and cadmium on heavy metal polluted waterbody restoration by duckweed (Lemna minor). Plant Physiol Biochem 45:62–69
Ikenaka Y, Nakayama SMM, Muzandu K, Choongo K, Teraoka H, Mizuno N, Ishizuka M (2010) Heavy metal contamination of soil and sediment in Zambia. Afr J Environ Sci Technol 4:729–739
Ip PF, Chen F (2005) Employment of reactive oxygen species to enhance astaxanthin formation in Chlorella zofingiensis in heterotrophic culture. Process Biochem 40:3491–3496
Islam MM, Hoque A, Okuma E, Banu NA, Shimoishi Y, Nakamura Y, Murata Y (2009) Exogenous proline and glycine betaine increase antioxidant enzyme activities and confer tolerance to cadmium stress in cultured tobacco cells. J Plant Physiol 166:1587–1597
Jain RS, Srivastava S, Solomon S, Shrivastava AK, Chandra A (2010) Impact of excess zinc on growth parameters, cell division, nutrient accumulation, photosynthetic pigments and oxidative stress of sugarcane (Saccharum spp.). Acta Physiol Plant 32:979–986
Janicka-Russak M, Kabala K, Burzyński M, Klobus G (2008) Response of plasma membrane H+-ATPase to heavy metal stress in Cucumis sativus roots. J Exp Bot 59:3721–3728
Karpinski S, Reynolds H, Karpinska B, Wingsle G, Creissen G, Mullineaux P (1999) Systemic signaling and acclimation in response to excess excitation energy in Arabidopsis. Science 284:654–657
Karuppanapandian T, Sinha PB, Haniya AMK, Manoharan K (2006) Differential antioxidative responses of ascorbate-glutathione cycle enzymes metabolites to chromium stress in greengram (Vigna radiata L. Wilczek) leaves. J Plant Biol 49:440–447
Keilig K, Ludwig-Müller J (2009) Effect of flavonoids on heavy metal tolerance in Arabidopsis thaliana seedlings. Bot Stud 50:311–318
Keunen E, Remans T, Bohler S, Vangronsveld J, Cuypers A (2011) Metal-induced oxidative stress and plant mitochondria. Int J Mol Sci 12:6894–6918
Khraiwesh B, Arif MA, Seumel GI, Ossowski S, Weigel D, Reski R (2010) Transcriptional control of gene expression by microRNAs. Cell 140:111–122
Kováčik J, Babula P, Hedbavny J, Kryštofová O, Provaznik I (2015) Physiology and methodology of chromium toxicity using alga Scenedesmus quadricauda as model object. Chemosphere 120:23–30
Krämer U, Cotter-Howells JD, Charnock JM, Baker AJM, Smith AC (1996) Free histidine as a metal chelator in plants that accumulate nickel. Nature 379:635–638
Kruk J, Holländer-Czytko H, Oettmeier W, Trebst A (2005) Tocopherol as singlet oxygen scavenger in photosystem II. J Plant Physiol 162:749–757
Kubiś J (2008) Exogenous spermidine differentially alters activities of some scavenging system enzymes, H2O2 and superoxide radical levels in water-stressed cucumber leaves. J Plant Physiol 165:397–406
Kumar H, Sharma D, Kumar V (2012) Nickel-induced oxidative stress and role of antioxidant defence in barley roots and leaves. Int J Environ Biol 2:121–128
Kumar D, Yusuf MA, Singh P, Sardar M, Sarin NB (2013) Modulation of antioxidant machinery in α-tocopherol-enriched transgenic Brassica juncea plants tolerant to abiotic stress conditions. Protoplasma 250:1079–1089
Lane TW, Saito MA, George GN, Pickering IJ, Prince RC, Morel FMM (2005) A cadmium enzyme from a marine diatom. Nature 435:42
Lang M, Zhang Y, Chai T (2005) Identification of genes up-regulated in response to Cd exposure in Brassica juncea L. Gene 363:151–158
Larkum AWD (2003) Light harvesting systems in algae. In: Larkum AWD, Douglas SE, Raven JA (eds) Photosynthesis in algae. Kluwer, Dordrecht
Lee MY, Shin HW (2003) Cadmium-induced changes in antioxidant enzymes from the marine alga Nannochloropsis oculata. J Appl Phycol 15:13–19
Leszczyszyn OI, Imam HT, Blindauer CA (2013) Diversity and distribution of plant metallothioneins: a review of structure, properties and functions. Metallomics 5:1146–1169
Li D, Zhou D, Wang P, Weng N, Zhu X (2011) Subcellular Cd distribution and its correlation with antioxidant enzymatic activities in wheat (Triticum aestivum) roots. Ecotoxicol Environ Saf 74:874–881
Li X, Yang Y, Jia L, Chen H, Wei X (2013) Zinc-induced oxidative damage, antioxidant enzyme response and proline metabolism in roots and leaves of wheat plants. Ecotoxicol Environ Saf 89:150–157
Liu D, Zou J, Wang M, Jiang W (2008) Hexavalent chromium uptake and its effects on mineral uptake, antioxidant defence system and photosynthesis in Amaranthus viridis L. Bioresour Technol 99:2628–2636
Lopez-Millan A, Sagardoy R, Solanas M, Abadia A, Abadia J (2009) Cadmium toxicity in tomato (Lycopersicon esculentum) plants grown in hydroponics. J Environ Exp Bot 65:376–385
Ma M, Zhu W, Wang Z, Witkaamp GJ (2003) Accumulation, assimilation and growth inhibition of copper on fresh-water alga (Scenedesmus subspicatus 86.81 SAG) in the presence of EDTA and fulvic acid. Aquat Toxicol 63:221–228
Malar S, Vikram SS, Favas PJC, Perumal V (2014) Lead heavy metal toxicity induced changes on growth and antioxidative enzymes level in water hyacinths [Eichhornia crassipes (Mart.)]. Bot Stud 55:54
Malešev D, Kuntić V (2007) Investigation of metal-flavonoid chelates and the determination of flavonoids via metal-flavonoid complexing reactions. J Serb Chem Soc 72:921–939
Mallick N (2004) Copper-induced oxidative stress in the chlorophycean microalga Chlorella vulgaris: response of the antioxidant system. J Plant Physiol 161:591–597
Mallick N, Mohn FH (2000) Reactive oxygen species: response of algal cells. J Plant Physiol 157:183–193
Mallick N, Mohn FH (2003) Use of chlorophyll fluorescence in metal-stress research: a case study with the green microalga Scenedesmus. Ecotoxicol Environ Saf 55:64–69
Mallory AC, Bouché N (2008) MicroRNA-directed regulation: to cleave or not to cleave. Trends Plant Sci 13:359–367
Mano J (2002) Early events in environmental stresses in plants: induction mechanisms of oxidative stress. In: Inzé D (ed) Oxidative stress in plants. Taylor and Francis, London
Marques AP, Rangel AO, Castro PM (2007) Zinc accumulation in plant species indigenous to a Portuguese polluted site: relation with soil contamination. J Environ Qual 36:646–653
Matringe M, Ksas B, Rey P, Havaux M (2008) Tocotrienols, the unsaturated forms of vitamin E, can function as antioxidants and lipid protectors in tobacco leaves. Plant Physiol 147:764–778
Mehta SK, Gaur JP (1999) Heavy metal induced proline accumulation and its role in ameliorating metal toxicity in Chlorella vulgaris. New Phytol 143:253–259
Mijovilovich A, Leitenmaier B, Meyer-Klaucke W, Kroneck PMH, Gotz B, Kupper H (2009) Complexation and toxicity of copper in higher plants. II. Different mechanisms for copper versus cadmium detoxification in the copper-sensitive cadmium/zinc hyperaccumulator Thlaspi caerulescens (Ganges ecotype). Plant Physiol 151:715–731
Millar AH, Mittova V, Kiddle G, Heazlewood L, Bartoli CG, Theodoulou FL, Foyer CH (2003) Control of ascorbate synthesis by respiration and its implications for stress responses. Plant Physiol 133:443–447
Miranda MS, Sato S, Mancini-Filho J (2001) Antioxidant activity of the microalga Chlorella vulgaris cultured on special conditions. Boll Chim Farm 140:165–168
Mishra S, Srivastava S, Tripathi RD, Kumar R, Seth CS, Gupta DK (2006) Lead detoxification by coontail (Ceratophyllum demersum L.) involves induction of phytochelatins and antioxidant system in response to its accumulation. Chemosphere 65:1027–1039
Mittler R (2002) Oxidative stress, antioxidants and stress tolerance. Trends Plant Sci 7:405–410
Mittler R, Vanderauwera S, Gollery M, Van Breusegem F (2004) Reactive oxygen gene network of plants. Trends Plant Sci 9:490–498
Mohan BS, Hosetti BB (1997) Potential phytotoxicity of lead and cadmium to Lemna minor grown in sewage stabilization ponds. Environ Pollut 98:233–238
Morelli E, Scarano G (2004) Copper-induced changes of non-protein thiols and antioxidant enzymes in the marine microalga Phaeodactylum tricornutum. Plant Sci 167:289–296
Moura DJ, Péres VF, Jacques RA, Saffi J (2012) Heavy metal toxicity: oxidative stress parameters and DNA repair. In: Gupta DK, Sandalio LM (eds) Metal toxicity in plants: perception, signaling and remediation. Springer, Heidelberg
Nadgórska-Socha A, Kafel A, Kandziora-Ciupa M, Gospodarek J, Zawisza-Raszka A (2013) Accumulation of heavy metals and antioxidant responses in Vicia faba plants grown on monometallic contaminated soil. Environ Sci Pollut Res Int 20:1124–1134
Nagalakshmi N, Prasad MNV (2001) Responses of glutathione cycle enzymes and glutathione metabolism to copper stress in Scenedesmus bijugatus. Plant Sci 160:291–299
Naser AH (2013) Assessment and management of heavy metal pollution in the marine environment of the Arabian Gulf: a review. Mar Pollut Bull 72:6–13
Navari-Izzo F, Quartacci MF, Sgherri C (2002) Lipoic acid: a unique anti-oxidant in the detoxification of activated oxygen species. Plant Physiol Biochem 40:463–470
Neill JS, Desikan R, Clarke A, Hurst RD, Hanckok JT (2002) Hydrogen peroxide and nitric oxide as signaling molecules in plants. J Exp Bot 53:1237–1247
Nematshahi N, Lahouti M, Ganjeali A (2012) Accumulation of chromium and its effect on growth of (Allium cepa cv. Hybrid). Eur J Exp Biol 2:969–974
Noctor G, Foyer CH (1998) Ascorbate and glutathione: keeping active oxygen under control. Annu Rev Plant Physiol Plant Mol Biol 49:249–279
Noctor G, Gomez L, Vanacker H, Foyer CH (2002) Interactions between biosynthesis, compartmentation and transport in the control of glutathione homeostasis and signalling. J Exp Bot 53:1283–1304
Oancea S, Foca N, Airinei A (2005) Effects of heavy metals on plant growth and photosynthetic activity. Analele Univ. “Al. I. Cuza”, Tom I, s, Biofizica, Fizica medicala si fizica mediului, pp 107–110
Obroucheva NV, Bystrova EI, Ivanov VB, Antipova OV, Seregin IV (1998) Root growth responses to lead in young maize seedlings. Plant Soil 200:55–61
Okamoto OK, Colepicolo P (1998) Response of superoxide dismutase to pollutant metal stress in the marine dinoflagellate Gonyaulax polyedra. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 119:67–73
Panda SK, Chaudhury I, Khan MH (2003) Heavy metals induce lipid peroxidation and affect antioxidants in wheat leaves. Biol Plant 46:289–294
Pandey N, Sharma CP (2002) Effect of heavy metals Co2+, Ni2+ and Cd2+ on growth and metabolism of cabbage. Plant Sci 163:753–758
Papadakis AK, Roubelakis-Angelakis KA (2005) Polyamines inhibit NADPH oxidase-mediated superoxide generation and putrescine prevents programmed cell death induced by polyamine oxidase-generated hydrogen peroxide. Planta 220:826–837
Parida BK, Chhibba IM, Nayyar VK (2003) Influence of nickel-contaminated soils on fenugreek (Trigonella corniculata L.) growth and mineral composition. Sci Hortic 98:113–119
Parmar P, Kumari N, Sharma V (2013) Structural and functional alterations in photosynthetic apparatus of plants under cadmium stress. Bot Stud 54:45
Passardi F, Longet D, Penel C, Dunand C (2004) The class III peroxidase multigene family in rice and its evolution in land plants. Phytochemistry 65:1879–1893
Pawlik-Skowrońska B (2001) Phytochelatin production in freshwater algae Stigeoclonium in response to heavy metals contained in mining water; effects of some environmental factors. Aquat Toxicol 52:241–249
Perl-Treves R, Perl A (2002) Oxidative stress: an Introduction. In: Inzé D (ed) Oxidative stress in plants. Taylor and Francis, London
Pinto E, Sigaud-Kutner TCS, Leitão MAS, Okamoto OK, Morse D, Colepicolo P (2003) Heavy metal-induced oxidative stress in algae. J Phycol 39:1008–1018
Poniedziałek M, Sękara A, Ciura J, Jędrszczyk E (2005) Nickel and manganese accumulation and distribution in organs of nine crops. Folia Hortic 17:11–22
Prasad TK, Anderson MD, Martin BA, Steward CR (1994) Evidence for chilling-induced oxidative stress in maize seedlings and a regulatory role for hydrogen peroxide. Plant Cell 6:65–74
Pumas C, Vacharapiyasophon P, Peerapornpisal Y, Leelapornpisid P, Boonchum W, Ishii M, Khanongnuch C (2011) Thermostability of phycobiliproteins and antioxidant activity from four thermotolerant cyanobacteria. Phycol Res 59:166–174
Radotic K, Ducic T, Mutavdzic D (2000) Changes in peroxidase activity and isoenzymes in spruce needles after exposure to different concentrations of cadmium. Environ Exp Bot 44:105–113
Rafati M, Khorasani N, Moattar F, Shirvany A, Moraghebi F, Hosseinzadeh S (2011) Phytoremediation potential of Populus alba and Morus alba for cadmium, chromium and nickel absorption from polluted soil. Int J Environ Res 5:961–970
Rascio N, Navari-Izzo F (2011) Heavy metal hyperaccumulating plants: how and why do they do it? And what makes them so interesting? Plant Sci 180:169–181
Rijstenbil JW, Derksen JWM, Gerringa LJA, Poortvliet TCW, Sandee A, Van den Berg M, Van Drie J, Wijnholds JA (1994) Oxidative stress induced by copper: defense and damage in the marine planktonic diatom Ditylum brightwellii (Grunow) West, grown in continuous cultures with high and low zinc levels. Mar Biol 119:583–590
Rivelli AR, De Maria S, Puschenreiter M, Gherbin P (2012) Accumulation of cadmium, zinc, and copper by Helianthus annuus L.: impact on plant growth and uptake of nutritional elements. Int J Phytoremediation 14:320–334
Rodríguez-Serrano M, Romero-Puertas MC, Zabalza A, Corpas FJ, Gómez M, del Río LA, Sandalio LM (2006) Cadmium effect on oxidative metabolism of pea (Pisum sativum L.) roots. Imaging of reactive oxygen species and nitric oxide accumulation in vivo. Plant Cell Environ 29:1532–1544
Romero-Puertas MC, Rodríguez-Serrano M, Corpas F, Gomez M, del Rio L, Sandalio LM (2004) Cadmium-induced subcellular accumulation of O2 •− and H2O2 in pea leaves. Plant Cell Environ 27:1122–1134
Romero-Puertas MC, Corpas F, Rodríguez-Serrano M, Gómez M, del Rio L, Sandalio LM (2007) Differential expression and regulation of antioxidative enzymes by Cd in pea plants. J Plant Physiol 164:1346–1357
Rosa M, Prado C, Podazza G, Interdonato R, González JA, Hilal M, Prado FE (2009) Soluble sugars—metabolism, sensing and abiotic stress: a complex network in the life of plants. Plant Signal Behav 4:388–393
Sabatini SE, Juarez AB, Eppis MR, Bianchi L, Luquet CM, Rios de Molina MC (2009) Oxidative stress and antioxidant defenses in two green microalgae exposed to copper. Ecotoxicol Environ Saf 72:1200–1206
Sandalio LM, Dalurzo HC, Gómez M, Romero-Puertas MC, del Río LA (2001) Cadmium-induced changes in the growth and oxidative metabolism of pea plants. J Exp Bot 52:2115–2126
Sarma AD, Sreelakshimi Y, Sharma R (1997) Antioxidant ability of anthocyanins against ascorbic acid oxidation. Phytochemistry 45:671–674
Schat H, Sharma SS, Vooijs R (1997) Heavy metal-induced accumulation of free proline in a metal-tolerant and a nontolerant ecotype of Silene vulgaris. Physiol Planta 101:477–482
Schat H, Llugany M, Vooijs R, Hartley-Whitaker J, Bleeker PM (2002) The role of phytochelatins in constitutive and adaptive heavy metal tolerances in hyperaccumulator and non-hyperaccumulator metallophytes. J Exp Bot 53:2381–2392
Scheidegger C, Sigg L, Behra R (2011) Characterization of lead induced metal–phytochelatin complexes in Chlamydomonas reinhardtii. Environ Toxicol Chem 30:2546–2552
Schreck E, Foucault Y, Sarret G, Sobanska S, Cécillon L, Castrec-Rouelle M, Uzu G, Dumat C (2012) Metal and metalloid foliar uptake by various plant species exposed to atmospheric industrial fallout: mechanisms involved for lead. Sci Tot Environ 427–428:253–262
Schützendübel A, Polle A (2002) Plant responses to abiotic stresses: heavy metal-induced oxidative stress and protection by mycorrhization. J Exp Bot 53:1351–1365
Schützendübel A, Schwanz P, Teichmann T, Gross K, Langenfeld-Heyser R, Godbold DL, Polle A (2001) Cadmium induced changes in antioxidative systems, hydrogen peroxide content, and differentiation in Scots pine roots. Plant Physiol 127:887–898
Semane B, Cuypers A, Smeets K, Van Belleghem F, Horemans N, Schat H, Vangronsveld J (2007) Cadmium responses in Arabidopsis thaliana: glutathione metabolism and antioxidative defence system. Physiol Planta 129:519–528
Senden MHMN, van der Meer AJGM, Verburg TG, Wolterbeek HT (1995) Citric acid in tomato plant roots and its effect on cadmium uptake and distribution. Plant Soil 17:333–339
Shah KH, Ritambhara GK, Verma S, Dubey RS (2001) Effect of cadmium on lipid peroxidation, superoxide anion generation and activities of antioxidant enzymes in growing rice seedlings. Plant Sci 161:1135–1144
Shahid M, Pinelli E, Pourrut B, Silvestre J, Dumat C (2011) Lead-induced genotoxicity to Vicia faba L. roots in relation with metal cell uptake and initial speciation. Ecotoxicol Environ Saf 74:78–84
Sharma SS, Dietz KJ (2006) The significance of amino acids and amino acid-derived molecules in plant responses and adaptation to heavy metal stress. J Exp Bot 57:711–726
Sharma SS, Dietz KJ (2009) The relationship between metal toxicity and cellular redox imbalance. Trends Plant Sci 14:43–50
Sharma P, Dubey RS (2005) Lead toxicity in plants. Braz J Plant Physiol 17:35–52
Sharma SS, Schat H, Vooijs R (1998) In vitro alleviation of heavy metal-induced enzyme inhibition by proline. Phytochemistry 49:15311–15535
Sheldon AR, Menzies NW (2005) The effect of copper toxicity on the growth and root morphology of Rhodes grass (Chloris gayana Knuth.) in resin buffered solution culture. Plant Soil 278:341–349
Shu X, Yan Yin L, Fa Zhang Q, Bo Wang W (2011) Effect of Pb toxicity on leaf growth, antioxidant enzyme activities, and photosynthesis in cuttings and seedlings of Jatropha curcas L. Environ Sci Pollut Res 19:893–902
Shukla UC, Murthy RC, Kakkar P (2008) Combined effect of ultraviolet-B radiation and cadmium contamination on nutrient uptake and photosynthetic pigments in Brassica campestris L. seedlings. Environ Toxicol 23:712–719
Siedlecka A, Krupa Z (1999) Cd/Fe interactions in higher plants - Its consequences for the photosynthetic apparatus. Photosynth Res 36:321–331
Singh VP (2005) Metal toxicity and tolerance in plants and animals. Sarup, New Delhi
Skowroński T, De Knecht JA, Simons J, Verkleji JAC (1998) Phytochelatin synthesis in response to cadmium uptake in Vaucheria (Xanthophyceae). Eur J Phycol 33:87–91
Ślesak I, Libik M, Karpinska B, Karpinski S, Miszalski Z (2007) The role of hydrogen peroxide in regulation of plant metabolism and cellular signaling in response to environmental stresses. Acta Biochim Pol 54:39–50
Smeets K, Ruytinx J, Semane B, Van Belleghem F, Remans T, Van Sanden S, Vangronsveld J, Cuypers A (2008) Cadmium-induced transcriptional and enzymatic alterations related to oxidative stress. Environ Exp Bot 63:1–8
Smirnoff N, Wheeler GL (2000) Ascorbic acid in plants: biosynthesis and function. Crit Rev Biochem Mol Biol 35:291–314
Stroiński A, Kozłowska M (1997) Cadmium induced oxidative stress in potato tuber. Acta Soc Bot Pol 66:189–195
Su C, LiQin J, WenJun Z (2014) A review on heavy metal contamination in the soil worldwide: situation, impact and remediation techniques. Environ Skep Crit 3:24–38
Sun Q, Ye ZH, Wang XR, Wong MH (2007) Cadmium hyperaccumulation leads to an increase of glutathione rather than phytochelatins in the cadmium hyperaccumulator Sedum alfredii. J Plant Physiol 164:1489–1498
Surosz W, Palinska KA (2005) Effects of heavy-metal stress on cyanobacterium Anabaena flos-aquae. Arch Environ Contam Toxicol 48:40–48
Tahara S (2007) A journey of twenty-five years through the ecological biochemistry of flavonoids. Biosci Biotechnol Biochem 71:1387–1404
Taiz L, Zeiger E (2002) Plant physiology. Sinauer, Sunderland, MA
Tamás L, Dudíková J, Ďurčeková K, Halušková L, Huttová J, Mistrík I, Olle M (2008) Alterations of the gene expression, lipid peroxidation, proline and thiol content along the barley root exposed to cadmium. J Plant Physiol 165:1193–1203
Tang YL, Ren WW, Zhang L, Tang KX (2011) Molecular cloning and characterization of gene coding for γ-tocopherol methyltransferase from lettuce (Lactuca sativa). Genet Mol Res 10:320–412
Teklić T, Engler M, Cesar V, Lepeduš H, Parađiković N, Lončarić Z, Štolfa I, Marotti T, Mikac N, Žarković N (2008a) Influence of excess copper on lettuce (Lactuca sativa L.) grown in soil and nutrient solution. J Food Agric Environ 6:439–444
Teklić T, Hancock JT, Engler M, Parađiković N, Cesar V, Lepeduš H, Štolfa I, Bešlo D (2008b) Antioxidative responses in radish (Raphanus sativus L.) plants stressed by copper and lead in nutrient solution and soil. Acta Biol Cracov Bot 50:79–86
Tian S, Lu L, Yang X, Huang H, Wang K, Brown P (2011) Root adaptations to cadmium-induced oxidative stress contribute to Cd tolerance in the hyperaccumulator Sedum alfredii. Biol Plant 56:344–350
Tomašević M, Aničić M (2010) Trace element content in urban tree leaves and sem-edax characterization of deposited particles. FU Phys Chem Technol 8:1–13
Trebst A, Depka B, Holländer-Czytko H (2002) A specific role for tocopherol and of chemical singlet oxygen quenchers in the maintenance of photosystem II structure and function in Chlamydomonas reinhardtii. FEBS Lett 516:156–160
Tripathi BN, Gaur JP (2006) Physiological behavior of Scenedesmus sp. during exposure to elevated levels of Cu and Zn and after withdrawal of metal stress. Protoplasma 229:1–9
Tripathi BN, Mehta SK, Amar A, Gaur JP (2006) Oxidative stress in Scenedesmus sp. during short- and long-term exposure to Cu2+ and Zn2+. Chemosphere 62:538–544
Tripathy BC, Oelmüller R (2012) Reactive oxygen species generation and signaling in plants. Plant Signal Behav 7:1621–1633
Tsuji N, Hirayanagi N, Okada M, Miyasaka H, Hirata K, Zenk MH, Miyamoto K (2002) Enhancement of tolerance to heavy metals and oxidative stress in Dunaliella tertiolecta by Zn-induced phytochelatin synthesis. Biochem Biophys Res Commun 293:653–659
Van Assche F, Clijsters H (1990) Effect of metal on enzyme activity on plants. Plant Cell Environ 13:195–206
Van Assche F, Put C, Clijsters HMM (1986) Heavy metals induce specific isozyme patterns of peroxidase in Phaseolus vulgaris L. Arch Int Physiol Biochim 94:60
Van den Ende W, Valluru R (2009) Sucrose, sucrosyl oligosaccharides, and oxidative stress: scavenging and salvaging? J Exp Bot 60:9–18
Verma S, Dubey RS (2003) Lead toxicity induces lipid peroxidation and alters the activities of antioxidant enzymes in growing rice plants. Plant Sci 164:645–655
Viehweger K (2014) How plants cope with heavy metals. Bot Stud 55:35
Volland S, Lütz C, Michalkec B, Lütz-Meindl U (2012) Intracellular chromium localization and cell physiological response in the unicellular alga Micrasterias. Aquat Toxicol 109:59–69
Wada N, Sakamoto T, Matsugo S (2013) Multiple roles of photosynthetic and sunscreen pigments in cyanobacteria focusing on the oxidative stress. Metabolites 3:463–483
Wang Y, Fang J, Leonard SS, Murali Krishna Rao K (2004) Cadmium inhibits the electron transfer chain and induces reactive oxygen species. Free Radic Biol Med 36:1434–1443
Wang R, Gao F, Guo BQ, Huang JC, Wang L, Zhou YJ (2013) Short term chromium stress induced alterations in the maize leaf proteome. Int J Mol Sci 14:11125–11144
Weckx EJ, Clijsters H (1996) Oxidative damage and defense mechanisms in primary leaves of Phaseolus vulgaris as a result of root assimilation of toxic amounts of copper. Physiol Plant 96:506–512
Willkenes H, Chamnongpol S, Davey M, Schraudner M, Langebartels C, Van Montagu M, Inzé D, Van Camp W (1997) Catalase is a sink for H2O2 and is indispensable for stress defence in C3 plants. EMBO J 16:4806–4816
Wu TM, Hsu YT, Lee TM (2009) Effects of cadmium on the regulation of antioxidant enzyme activity, gene expression, and antioxidant defences in the marine macroalga Ulva fasciata. Bot Stud 50:25–34
Xiang C, Oliver DJ (1998) Glutathione metabolic genes coordinately respond to heavy metals and jasmonic acid in Arabidopsis. Plant Cell 10:1539–1550
Xiong ZT (1998) Lead uptake and effects on seed germination and plant growth in a Pb hyperaccumulator Brassica pekinensis Rupr. Bull Environ Contam Toxicol 60:285–291
Xue T, Li X, Zhu W, Wu C, Yang G, Zheng C (2009) Cotton metallothionein GhMT3a, a reactive oxygen species scavenger, increased tolerance against abiotic stress in transgenic tobacco and yeast. J Exp Bot 60:339–349
Yamamoto HY, Bassi R (1996) Carotenoids: localization and function. In: Ort DR, Yocum CF (eds) Oxygenic photosynthesis: the light reactions. Kluwer, Dordrecht
Yan R, Gao S, Yang W, Cao M, Wang S, Chen F (2008) Nickel toxicity induced antioxidant enzyme and phenylalanine ammonia-lyase activities in Jatropha curcas L. cotyledons. Plant Soil Environ 54:294–300
Yang Y, Wei X, Lu J, You J, Wang W, Shi R (2010) Lead-induced phytotoxicity mechanism involved in seed germination and seedling growth of wheat (Triticum aestivum L.). Ecotoxicol Environ Saf 73:1982–1987
Yannarelli GG, Fernández-Alvarez AJ, Santa-Cruz DM, Tomaro ML (2007) Glutathione reductase activity and isoforms in leaves and roots of wheat plants subjected to cadmium stress. Phytochemistry 68:505–512
Yilmaz DD, Parlak KU (2011) Antioxidative parameters in the opposite-leaved pondweed (Gronlendia densa) in response to nickel stress. Chem Spec Bioavail 23:71–79
Yusuf MA, Sarin NB (2007) Antioxidant value addition in human diets: genetic transformation of Brassica juncea with γ-TMT gene for increased α-tocopherol content. Transgenic Res 16:109–113
Zengin F (2013) Physiological behaviour of bean (Phaseolus vulgaris L.) seedlings under metal stress. Biol Res 46:79–85
Zengin FK, Munzuroglu O (2005) Effects of some heavy metals on content of chlorophyll, proline and some antioxidant chemicals in bean (Phaseolus vulgaris L.) seedlings. Acta Biol Cracov Ser Bot 47:157–164
Zhou ZP, Liu LN, Chen XL, Wang JX, Chen M, Zheng YZ, Zhou BC (2005) Factors that affect antioxidant activity of c-phycocyanins from Spirulina platensis. J Food Biochem 29:313–322
Zou J, Yu K, Zhang Z, Jiang W, Liu D (2009) Antioxidant response system and chlorophyll fluorescence in chromium (VI)-treated Zea mays (L.) seedlings. Acta Biol Cracov Bot 51:23–33
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Štolfa, I., Pfeiffer, T.Ž., Špoljarić, D., Teklić, T., Lončarić, Z. (2015). Heavy Metal-Induced Oxidative Stress in Plants: Response of the Antioxidative System. In: Gupta, D., Palma, J., Corpas, F. (eds) Reactive Oxygen Species and Oxidative Damage in Plants Under Stress. Springer, Cham. https://doi.org/10.1007/978-3-319-20421-5_6
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