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The Potential Use of PGC-1α and PGC-1β to Protect the Retina by Stimulating Mitochondrial Repair

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Retinal Degenerative Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 854))

Abstract

Damage to mitochondria is a common mechanism of cell death in inherited neurodegenerative disorders. Therefore, mitochondrial protection and mitochondrial repair are promising strategies to induce retinal neuroprotection. Peroxisome proliferator-activated receptor γ coactivator-α (PGC-1α) and β (PGC-1β) are transcriptional coactivators that are the main regulators of mitochondrial biogenesis. We propose that PGC-1α and PGC-1β could play a role in regulating retina cell survival, and may be important therapeutic targets to prevent retinal degeneration.

The original version of this chapter was revised. An erratum to this chapter can be found at DOI10.1007/978-3-319-17121-0_107

An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-3-319-17121-0_107

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Abbreviations

PGC-1α:

Peroxisome proliferator-activated receptor γ coactivator-α

PGC-1β:

Peroxisome proliferator-activated receptor γ coactivator-β

ROS:

Reactive oxygen species

mtDNA:

Mitochondrial DNA

NRF-1 and NRF-2:

Nuclear respiratory factors -1 and 2

PPAR:

Peroxisome proliferator-activated receptor

AMPK:

Adenosine mono-phoshpate-dependent Kinase

UCP:

Uncoupling protein

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Author information

Authors and Affiliations

  1. Department of Environmental Horticulture Research, University of Florida, 32611-0670, Gainesville, FL, USA

    Carolina Abrahan

  2. Department of Ophthalmology, University of Florida, ARB-RG232, 1600 SW Archer Rd, 32610, Gainesville, FL, USA

    Assoc. Prof. John D. Ash PhD

Authors
  1. Carolina Abrahan
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  2. Assoc. Prof. John D. Ash PhD
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Corresponding author

Correspondence to John D. Ash PhD .

Editor information

Editors and Affiliations

  1. Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA

    Catherine Bowes Rickman

  2. Beckman Vision Center, University of California, San Francisco School of Medicine, San Francisco, California, USA

    Matthew M. LaVail

  3. Dean A. McGee Eye Inst., University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA

    Robert E. Anderson

  4. University Hospital Zurich, Zurich, Switzerland

    Christian Grimm

  5. Case Western Reserve University Cleveland Clinic Lerner College of Med, Cleveland, Ohio, USA

    Joe Hollyfield

  6. Univ of Florida Dept of Ophthalmology/Arb R112, Gainesville, Florida, USA

    John Ash

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Abrahan, C., Ash, J. (2016). The Potential Use of PGC-1α and PGC-1β to Protect the Retina by Stimulating Mitochondrial Repair. In: Bowes Rickman, C., LaVail, M., Anderson, R., Grimm, C., Hollyfield, J., Ash, J. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 854. Springer, Cham. https://doi.org/10.1007/978-3-319-17121-0_53

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