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Engineering the Nanoparticle-Protein Interface for Cancer Therapeutics

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Nanotechnology-Based Precision Tools for the Detection and Treatment of Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 166))

Abstract

Intracellular delivery of functional proteins using nanoparticles can be a game-changing approach for cancer therapy. However, cytosolic release of functional protein is still a major challenge. In addition, formation of protein corona on the surface of the nanoparticles can also alter the behavior of the nanoparticles. Here, we will review recent strategies for protein delivery into the cell. Finally we will discuss the issue of protein corona formation in light of nanoparticle-protein interactions.

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Authors and Affiliations

  1. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

    Amir Ata Saie

  2. Faculty of Pharmacy, Nanotechnology Research Center and Department of Nanotechnology, Tehran University of Medical Sciences, Tehran, Iran

    Amir Ata Saie & Morteza Mahmoudi

  3. Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA

    Morteza Mahmoudi

  4. Division of Cardiology, Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA, USA

    Morteza Mahmoudi

  5. Department of Chemistry, University of Massachusetts, Amherst, 710 North Pleasant Street, Amherst, MA, 01003, USA

    Moumita Ray & Vincent M. Rotello

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  1. Amir Ata Saie
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  2. Moumita Ray
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  3. Morteza Mahmoudi
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  4. Vincent M. Rotello
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Correspondence to Vincent M. Rotello .

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Editors and Affiliations

  1. Department of Chemistry and International Institute for Nanotechnology, Northwestern University, Evanston, Illinois, USA

    Chad A. Mirkin

  2. Department of Chemistry and International Institute for Nanotechnology, Northwestern University, Evanston, Illinois, USA

    Thomas J. Meade

  3. Department of Chemistry and International Institute for Nanotechnology, Northwestern University, Evanston, Illinois, USA

    Sarah Hurst Petrosko

  4. Department of Neurology, Robert H. Lurie Comprehensive Cancer Center and International Institute for Nanotechnology, Northwestern University Robert H. Lurie Comp. Cancer Center, Chicago, Illinois, USA

    Alexander H. Stegh

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Saie, A.A., Ray, M., Mahmoudi, M., Rotello, V.M. (2015). Engineering the Nanoparticle-Protein Interface for Cancer Therapeutics. In: Mirkin, C., Meade, T., Petrosko, S., Stegh, A. (eds) Nanotechnology-Based Precision Tools for the Detection and Treatment of Cancer. Cancer Treatment and Research, vol 166. Springer, Cham. https://doi.org/10.1007/978-3-319-16555-4_11

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