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The Neurocognitive and Behavioural Impact of Comorbid Obsessive–Compulsive Syndrome in Schizophrenia

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Obsessive-Compulsive Symptoms in Schizophrenia

Abstract

In this chapter, we review the results of neurocognitive and behavioural studies in patients with OCD and schizophrenia and use these data to attempt to identify the key neuropsychological mechanisms. We explore the extent to which associated neuro-behavioural changes may characterise schizo–OCD either as a distinct and clinically relevant schizophrenia subgroup, a more severe form of schizophrenia or a true comorbidity that integrates the psychopathology of both its parent disorders. We conclude that, compared to schizophrenia, schizo–OCD may be associated with additional executive deficits (neurocognitive double jeopardy) featuring impaired performance on specific executive tasks, notably tasks measuring attentional set-shifting and cognitive flexibility and likely to involve fronto-striatal neurocircuitry known to be linked to OCD. However, whilst patients with schizo–OCD and OCD share most OC ritualistic attributes, they also demonstrate behavioural differences, which imply a separate phenotype for the compulsions of schizo–OCD. These differences represent an easily evaluable clinical sign that could contribute toward an improved nosological classification of a range of OC spectrum disorders.

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Authors and Affiliations

  1. School of Life and Medical Sciences, University of Hertfordshire, Hertfordshire, England, UK

    Yana Varlakova, Devina D. Patel & Keith R. Laws

  2. Highly Specialized Obsessive Compulsive and Related Disorders Service, Hertfordshire Partnership University NHS Foundation Trust, Rosanne House, 2nd floor, Parkway, Welwyn Garden City, Hertfordshire, AL8 7JE, UK

    Yana Varlakova, Devina D. Patel, Kaushik Mukhopadhaya, Kaur Sukwinder & Naomi A. Fineberg

  3. School of Health and Human Studies, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, England, UK

    Devina D. Patel

  4. Department of Zoology, Tel-Aviv University, Tel-Aviv, Ramat-Aviv, 69978, Israel

    Eilam David

  5. School of Life and Medical Sciences, Postgraduate Medical School, University of Hertfordshire, College Lane, Hatfield, Hertfordshire, AL10 9AB, UK

    Naomi A. Fineberg

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  1. Yana Varlakova
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  2. Devina D. Patel
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  3. Kaushik Mukhopadhaya
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  4. Keith R. Laws
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  5. Eilam David
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  6. Kaur Sukwinder
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  7. Naomi A. Fineberg
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Corresponding author

Correspondence to Naomi A. Fineberg .

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Editors and Affiliations

  1. Dept. of Psychiatry, University of Amsterdam, Academic Medical Centre, Amsterdam, The Netherlands

    Lieuwe De Haan

  2. Department of Psychiatry, University of Amsterdam, Academic Medical Centre, Amsterdam, The Netherlands

    Frederike Schirmbeck

  3. Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany

    Mathias Zink

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Varlakova, Y. et al. (2015). The Neurocognitive and Behavioural Impact of Comorbid Obsessive–Compulsive Syndrome in Schizophrenia. In: De Haan, L., Schirmbeck, F., Zink, M. (eds) Obsessive-Compulsive Symptoms in Schizophrenia. Springer, Cham. https://doi.org/10.1007/978-3-319-12952-5_7

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  • DOI: https://doi.org/10.1007/978-3-319-12952-5_7

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